Allele Dmel\elA¹

General Information
Symbol	Dmel\elA¹	Species	D. melanogaster
Name		FlyBase ID	FBal0003613
Feature type	allele	Associated gene	Dmel\elA
Also Known As	el¹

Allele class
Mutagen	spontaneous, ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Dorfman et al., 2002) spontaneous (Ashburner, 1992, Davis et al., 1997, Ashburner et al., 1999.10.12)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference 25kb deletion. (Davis et al., 1997, Ashburner et al., 1999.10.12)
Caused by aberration	Df(2L)el1 (Weihe et al., 2004)
Cytology
Phenotypic Data
Phenotypic Class
	viable (Dorfman et al., 2002) visible (Dorfman et al., 2002)
Phenotype Manifest In
	alula (Davis et al., 1997) costal cell (Davis et al., 1997) dorsal row (Davis et al., 1997) wing (Davis et al., 1997, Dorfman et al., 2002) wing vein L1 (Davis et al., 1997) wing vein L4 (Davis et al., 1997) wing vein L5 (Davis et al., 1997)
Detailed Description
	Statement Reference Class ii allele. (Davis, 2003.5.6) Mutants have smaller wings than normal. (Dorfman et al., 2002) Both the anterior and posterior wing are severely reduced in hemizygotes, wing vein L4 is shortened, and wing vein L5 and the alulae are absent. The submarginal cell (between L2 and L3) appears relatively normal. In some wings the costal cell is extended and wing vein L1 reaches the wing margin more distally than normal. The triple row is reduced in the dorsal rows but not the ventral row. elA¹/Df(2L)b83d29a adults are wild-type. elA¹/Df(2L)b84a2 adults have an "elbow" phenotype. (Davis et al., 1997) Strong; class i (Davis, 2003.5.6, personal communication to FlyBase provides contradictory, class ii, assignment). (Ashburner, 1992)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference elA¹, nub¹ has visible phenotype (Cifuentes and Garcia-Bellido, 1997, Cifuentes and Garcia-Bellido, 1997) elA¹, nub² has visible phenotype (Cifuentes and Garcia-Bellido, 1997, Cifuentes and Garcia-Bellido, 1997)
Phenotype Manifest In
NOT suppressed by
Statement Reference elA¹ has phenotype, non-suppressible by su(Hw)² (Lindsley and Grell, 1968)
Other
Statement Reference elA¹, nub¹ has wing phenotype (Cifuentes and Garcia-Bellido, 1997, Cifuentes and Garcia-Bellido, 1997) elA¹, nub² has wing phenotype (Cifuentes and Garcia-Bellido, 1997, Cifuentes and Garcia-Bellido, 1997)
Additional Comments
Genetic Interactions
Statement Reference Does not enhance "Sco" alleles, nor shows the "noc" phenotype with noc alleles. (Davis, 2003.5.6) Double mutant clones with nub¹ or nub² cause dramatic reduction of cell number in the wing pouch. (Cifuentes and Garcia-Bellido, 1997)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 7 )
Bloomington	289 b¹ elA¹ rd^s pr¹ cn¹ or^49h 1022 b¹ elA¹ rd^s Mhc⁵ pr¹ Bl¹/CyO 3593 b¹ Orc5² elA¹ rd^s pr¹ cn¹/CyO 5376 b¹ elA¹ rd^s cub² pr¹ cn¹/CyO, P{en1}wg^en11
Kyoto	105837 b¹ elA¹ rd^s pr¹ cn¹ or^49h 106170 b¹ elA¹ rd^s Mhc⁵ pr¹ Bl¹/CyO 107117 b¹ Orc5² elA¹ rd^s pr¹ cn¹/CyO
Notes on Origin
Discoverer	E. Wallace, 1st April 1935.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Df(2L)el1 (Davis et al., 1990) el¹ (Weihe et al., 2004, Davis, 2003.5.6, Ashburner et al., 1999, Davis et al., 1997, Ashburner, 1992, Ashburner et al., 1983, Ashburner et al., 1982) el^A1 (Culi et al., 2006) elA¹ (Christensen and Cook, 2008.4.15) elB¹ (Dorfman et al., 2002)
Name Synonym
Secondary FlyBase IDs
	FBal0141143
References ( 14 )
Research paper	Culi et al., 2006, Genetics 173(1): 255--266 jing is required for wing development and to establish the proximo-distal axis of the leg in Drosophila melanogaster. [FBrf0194382] Weihe et al., 2004, Development 131(4): 767--774 Proximodistal subdivision of Drosophila legs and wings: the elbow-no ocelli gene complex. [FBrf0174589] Dorfman et al., 2002, Development 129(15): 3585--3596 Elbow and Noc define a family of zinc finger proteins controlling morphogenesis of specific tracheal branches. [FBrf0151266] Ashburner et al., 1999, Genetics 153(1): 179--219 An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster. The Adh region. [FBrf0111326] Cifuentes and Garcia-Bellido, 1997, Proc. Natl. Acad. Sci. U.S.A. 94(21): 11405--11410 Proximo-distal specification in the wing disc of Drosophila by the nubbin gene. [FBrf0098758] Davis et al., 1997, Hereditas 126(1): 67--75 Genetic and phenotypic analysis of the genes of the elbow-no-ocelli region of chromosome 2L of Drosophila melanogaster. [FBrf0093413] Davis et al., 1990, Genetics 126: 105--119 The molecular analysis of the el-noc complex of Drosophila melanogaster. [FBrf0051916] Ashburner et al., 1983, Genetics 104: 405--431 The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. [FBrf0039455] Ashburner et al., 1982, Genetics 102: 401--420 The genetics of a small chromosome region of Drosophila melanogaster containing the structural gene for Alcohol dehydrogenase. [FBrf0038047]
Review	Ashburner, 1992, Lindsley, Zimm, 1992: 194--195 [Entry for el.] [FBrf0056834]
Personal communication to FlyBase	Christensen and Cook, 2008.4.15, Isolation and characterization of Df(2L)BSC300. Isolation and characterization of Df(2L)BSC300. [FBrf0204501] Davis, 2003.5.6, elbow gene. elbow gene. [FBrf0159881] Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153]
Book	Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp Genetic variations of Drosophila melanogaster. [FBrf0020044]

Allele Dmel\elA1

Allele Dmel\elA¹