FB2025_01 , released February 20, 2025
Allele: Dmel\eve4
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General Information
Symbol
Dmel\eve4
Species
D. melanogaster
Name
FlyBase ID
FBal0003886
Feature type
allele
Associated gene
Dmel\eve
Associated Insertion(s)
Carried in Construct
Also Known As
eve3.77.17, eve3.77
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Tremml and Bienz, 1989, DiNardo and O'Farrell, 1987)
Mutagen
X ray
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Deletion leading to frame shift at codon 134, C-terminal residues are replaced by 79 extraneous ones.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous eve4 larvae have a normal number of S phase neuroblasts per brain lobe.

      (Park et al., 1998)

      Interacts with RpII140wimp maternal effect.

      (Parkhurst and Ish-Horowicz, 1991)

      Embryos retain segmentation.

      (Tremml and Bienz, 1989)

      Even numbered denticle bands are missing.

      (Jack et al., 1988)

      Intermediate allele.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      eve4 is an enhancer of lethal | embryonic stage | maternal effect phenotype of Gug03928

      (Zhang et al., 2002)

      eve4 is an enhancer of lethal | embryonic stage | maternal effect phenotype of Guge46-2

      (Zhang et al., 2002)

      eve4 is an enhancer of lethal | embryonic stage | maternal effect phenotype of Gug01323a

      (Zhang et al., 2002)

      eve4 is an enhancer of lethal | embryonic stage | maternal effect phenotype of GugrO154a

      (Zhang et al., 2002)

      eve[+]/eve4 is an enhancer of partially lethal - majority die phenotype of trol13

      (Park et al., 1998)
      Suppressor of
      Statement
      Reference

      eve[+]/eve4 is a suppressor of decreased occurrence of cell division | larval stage phenotype of trolsd

      (Park et al., 1998)
      Other
      Phenotype Manifest In
      Other
      Statement
      Reference

      eve4, trol13 has larval brain & neuroblast phenotype

      (Park et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Dominantly enhances the semi-lethality of trol13/Y males and shows a transheterozygous effect in trol13/+ females, resulting in a reduction in viability. Hemizygous trol13 male larvae have a normal number of S phase neuroblasts per brain lobe. If the larvae are also heterozygous for eve4 then the number of S phase neuroblasts per brain lobe is reduced. Neuroblasts in the trolsd larval brain show a proliferation defect. This phenotype is not affected if the larvae are also heterozygous for eve4.

      (Park et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      eve5

      (Park et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Weak eve allele.

      (Tremml and Bienz, 1989)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (14)