Allele Dmel\ewg¹¹

General Information
Symbol	Dmel\ewg¹¹	Species	D. melanogaster
Name		FlyBase ID	FBal0003897
Feature type	allele	Associated gene	Dmel\ewg
Also Known As	ewg^l6

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (DeSimone et al., 1996)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Fleming et al., 1989) lethal \| recessive (DeSimone et al., 1996, de Simone and White, 1993)
Phenotype Manifest In

Detailed Description
	Statement Reference Myoblasts are present, migrate normally and get distributed over the persistent thoracic larval muscles in animals expressing ewg^elav.NS in an ewg¹¹ background, but splitting of the persistent larval muscles does not occur in some genetic backgrounds. Fusion of the imaginal myoblasts with the larval muscles occurs normally, but the wild-type progressive alignment of fused myoblast nuclei into longitudinal columns does not occur in these animals. (Roy and VijayRaghavan, 1998) Lethality occurs during early embryo and larval stages. There are occasional adult escapers. (DeSimone et al., 1996)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	ewg¹¹ is rescued by ewg^elav.NS (DeSimone et al., 1996) ewg¹¹ is rescued by ewg^hs.PD (de Simone and White, 1993)
Comments	Lethality can be rescued by ewg^elav.NS. Rescued adults do not exhibit an erect wing phenotype. (DeSimone et al., 1996) ewg^hs.PD rescues lethality associated with ewg¹¹. (de Simone and White, 1993) ewg¹¹ complements at least partially ewg⁴, ewg⁵, ewg¹⁰, and ewg¹².
Stocks ( 0 )

Notes on Origin
Discoverer	White.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	ewg¹¹ ewg^l6 (DeSimone et al., 1996, de Simone and White, 1993, Fleming et al., 1989, )
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Roy and VijayRaghavan, 1998, J. Cell Biol. 141(5): 1135--1145 Patterning muscles using organizers: larval muscle templates and adult myoblasts actively interact to pattern the dorsal longitudinal flight muscles of Drosophila. [FBrf0103022] DeSimone et al., 1996, Development 122(1): 31--39 ERECT WING, the Drosophila member of a family of DNA binding proteins is required in imaginal myoblasts for flight muscle development. [FBrf0084950] de Simone and White, 1993, Mol. Cell. Biol. 13(6): 3641--3649 The Drosophila erect wing gene, which is important for both neuronal and muscle development, encodes a protein which is similar to the sea urchin P3A2 DNA binding protein. [FBrf0059052] Fleming et al., 1989, Mol. Cell. Biol. 9: 719--725 Molecular isolation and analysis of the erect wing locus in Drosophila melanogaster. [FBrf0050547] Fleming et al., 1983, Dev. Genet. 3(4): 347--364 Developmental genetic analysis of lethal alleles at the ewg locus and their effects on muscle development in Drosophila melanogaster. [FBrf0039235]

Allele Dmel\ewg11

Allele Dmel\ewg¹¹