FlyBase Allele Report: Dmel\eyg[1]

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Allele: Dmel\eyg¹

General Information

Symbol

Dmel\eyg¹

Species

D. melanogaster

Name

FlyBase ID

FBal0003939

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death

(Jang et al., 2003)

partially lethal - majority die

(Inoue, 1980)

Phenotype Manifest In

(Chao et al., 2004, Jang et al., 2003)

eye (with eyg^M3-12)

(Chao et al., 2004, Jang et al., 2003)

eye (with In(3L)gv^U)

(Jang et al., 2003)

(Jang et al., 2003, Hazelett et al., 1998)

eye disc (with Df(3L)eyg^C1)

(Anderson et al., 2006)

photoreceptor neuron (with Df(3L)iro-2)

(Hazelett et al., 1998)

retina (with Df(3L)eyg^C1)

(Anderson et al., 2006)

Detailed Description

Statement

Reference

eyg¹/Df(3L)eyg^C1 mutants have a small eye disc and show a complete loss of the retina.

(Anderson et al., 2006)

eyg¹/eyg^M3-12 flies have no eyes, whereas eyg¹ homozygotes have small eyes.

(Chao et al., 2004)

eyg¹ homozygotes, eyg¹/In(3L)gv^U and eyg¹/eyg^M3-12 animals exhibit a small eye phenotype. Increased apoptosis can be seen anterior to the morphogenetic furrow in the developing eye-disc in homozygous mutant larvae.

(Jang et al., 2003)

The eye disc does not reach its normal size and shape in mutant flies and no photoreceptors differentiate. Photoreceptor development proceeds normally in most homozygous clones in the eye disc. eyg¹/Df(3L)iro-2 hemizygous eye discs completely lack photoreceptors.

(Hazelett et al., 1998)

Homozygotes show reduced larval and pupal survival.

(Inoue, 1980)

Eyes and head much smaller than normal. Considerable pupal mortality, probably from inability to push open pupa cases. Adults normal in viability and productivity. Character subject to genetic modifiers and possibly environmental influences. Expression varies from complete absence of facets to formation of about 100 facets. RK2.

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

ey¹, eyg¹ has lethal phenotype

(Hunt, 1970)

Phenotype Manifest In

Suppressed by

Statement

Reference

eyg¹/eyg^M3-12 has eye phenotype, suppressible | partially by N^ICN.UAS/Scer\GAL4^dpp.blk1

(Chao et al., 2004)

eyg¹/eyg^M3-12 has eye phenotype, suppressible | partially by Scer\GAL4^dpp.blk1/Su(H)^UAS.cNa

(Chao et al., 2004)

eyg¹/eyg^M3-12 has eye phenotype, suppressible by Scer\GAL4^dpp.blk1/upd1^UAS.cZa

(Chao et al., 2004)

eyg¹/eyg^M3-12 has eye phenotype, suppressible | partially by H[+]/H^E31

(Chao et al., 2004)

eyg¹/eyg^M3-12 has eye phenotype, suppressible | partially by ey^UAS.cHa/Scer\GAL4^ey.PH

(Jang et al., 2003)

eyg¹/Df(3L)iro-2 has eye disc phenotype, suppressible by Scer\GAL4^dpp.PH/sgg^S9A.UAS

(Hazelett et al., 1998)

eyg¹/Df(3L)iro-2 has photoreceptor neuron phenotype, suppressible by Scer\GAL4^dpp.PH/sgg^S9A.UAS

(Hazelett et al., 1998)

eyg¹/Df(3L)iro-2 has eye disc phenotype, suppressible by pan^ΔN.UAS/Scer\GAL4^dpp.PH

(Hazelett et al., 1998)

eyg¹/Df(3L)iro-2 has photoreceptor neuron phenotype, suppressible by pan^ΔN.UAS/Scer\GAL4^dpp.PH

(Hazelett et al., 1998)

eyg¹/Df(3L)iro-2 has eye disc phenotype, suppressible by Ras85D^V12.UAS/Scer\GAL4^dpp.PH

(Hazelett et al., 1998)

eyg¹/Df(3L)iro-2 has photoreceptor neuron phenotype, suppressible by Ras85D^V12.UAS/Scer\GAL4^dpp.PH

(Hazelett et al., 1998)

NOT suppressed by

Statement

Reference

eyg¹/eyg^M3-12 has eye phenotype, non-suppressible by Scer\GAL4^ey.PH/BacA\p35^UAS.cHa

(Jang et al., 2003)

eyg¹/eyg^M3-12 has eye phenotype, non-suppressible by Scer\GAL4^dpp.blk1/BacA\p35^UAS.cHa

(Jang et al., 2003)

Enhancer of

Statement

Reference

eyg¹/eyg¹ is an enhancer of eye phenotype of Df(1)os¹

(Chao et al., 2004)

Other

Statement

Reference

eyg¹, eym¹ has eye phenotype

Additional Comments

Genetic Interactions

Statement

Reference

H^E31/+ partially restores eye development in eyg¹/eyg^M3-12 flies, as does N^ICN.Scer\UAS; Scer\GAL4^dpp.blk1 or Su(H)^Scer\UAS.cNa; Scer\GAL4^dpp.blk1. upd1^Scer\UAS.cZa; Scer\GAL4^dpp.blk1 completely restores eye development in eyg¹/eyg^M3-12 flies. Df(1)os¹; eyg¹ double homozygotes lack eyes.

(Chao et al., 2004)

The addition of ey^Scer\UAS.cHa driven by Scer\GAL4^ey.PH can partially rescue the eyg^M3-12/eyg¹ mutant eye phenotype.

(Jang et al., 2003)

Photoreceptor development in eyg¹/Df(3L)iro-2 discs is not rescued by tkv^{Q253D.Scer\UAS.cNb}, dpp^Scer\UAS.cFa or hh^Scer\UAS.cAa expressed under the control of Scer\GAL4^dpp.PH. Photoreceptor development in eyg¹/Df(3L)iro-2 discs is rescued by sgg^S9A.Scer\UAS, pan^ΔN.Scer\UAS or Ras85D^V12.Scer\UAS expressed under the control of Scer\GAL4^dpp.PH.

(Hazelett et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

(Jang et al., 2003)

(Jang et al., 2003)

(Jang et al., 2003)

Rescued by

eyg¹/eyg^M3-12 is rescued by Scer\GAL4^upd1-E132/eyg^UAS.lune

(Jang et al., 2003)

eyg¹/eyg^M3-12 is rescued by Scer\GAL4^ey.PH/eyg^UAS.lune

(Jang et al., 2003)

eyg¹/eyg^M3-12 is rescued by eyg^hs.lune

(Jang et al., 2003)

Partially rescued by

eyg¹/eyg^M3-12 is partially rescued by Scer\GAL4^eyg.E2-EX/eyg^UAS.lune

(Chao et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

503

sna^Sco/CyO; eyg¹

105943

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

eyg¹

(Christensen et al., 2009.2.28, Christensen et al., 2007.10.29, Anderson et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections