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General Information
Symbol
Dmel\fl(2)d1
Species
D. melanogaster
Name
FlyBase ID
FBal0004018
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G13821303A

Reported nucleotide change: Amino acid change:

D177N | fl(2)d-PA; D53N | fl(2)d-PB; D53N | fl(2)d-PC; D53N | fl(2)d-PD

Reported amino acid change: Comment:

translation of the reference sequence results in a protein 3 amino acids shorter than the one predicted from accession GB:AJ243599 and in FBrf0127272

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Nucleotide substitution: G939A. Amino acid replacement: D180N.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

fl(2)d1 homozygotes are female lethal.

fl(2)d1/+ suppresses position effect variegation at the w locus caused by P{SUPor-P}KV00108.

Does not interact with Sxldlf, fl(1)3535, fl(1)3546 or l(1)4343.

Males are semi-lethal at 29oC and females are semi-lethal at 18oC. fl(2)d1/fl(2)d2 heterozygotes are female lethal at 29oC and females have reduced viability at 18oC.

50% of homozygous males and no homozygous females survive at 29oC. Lethality is during the larval stage (animals can survive until the third instar stage). 75% of homozygous males and 16% of homozygous females survive at 18oC. The females that survive at 18oC are sterile (males are fertile at both temperatures). The temperature sensitive period in females is the whole of development. fl(2)d1/fl(2)d2 females show temperature-sensitive lethality, and males show temperature-sensitive semi-lethality. The lethality of homozygous and fl(2)d1/fl(2)d2 females is partially suppressed by SxlM1. The semi-lethality of homozygous and fl(2)d1/fl(2)d2 males is independent of Sxl function. The lethality of SxlM1 males is partially suppressed in homozygous fl(2)d1 and fl(2)d1/fl(2)d2 flies. Partially suppresses the female germline phenotype of ovoD1rv23 flies.

Lethal in females and semi-lethal in males at 29oC, semi-lethal in females and nearly fully viable in males at 18oC. Homozygous adult females have reduced viability at both 18oC and 29oC, although females shifted to 29oC die earlier than flies kept at 18oC. Homozygous females also carrying SxlM1 have normal viability. Homozygous adult males have normal viability at both 18oC and 29oC, and have a slower developmental rate than wild-type. Homozygous females are inseminated less than wild-type females, this phenotype is suppressed by SxlM1. Homozygous males are able to inseminate females. Homozygous females developing at 18oC are sterile, with oogenesis arrested at the previtellogenic stages. This sterility is suppressed by SxlM1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

fl(2)d1 has lethal | recessive | female phenotype, suppressible | partially by Mettl3Delta22-3/Ime4[+]

Suppressor of
Statement
Reference

fl(2)d[+]/fl(2)d1 is a suppressor of partially lethal | dominant | female phenotype of SxlN.Hsp83.lacZ

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The female lethality characteristic for fl(2)d1 homozygotes is rescued to a high degree by combination with a single copy of Ime4Δ22-3.

The reduced viability of females carrying SxlN.Hsp83.T:Ecol\lacZ is completely suppressed by fl(2)d1/+.

The female progeny of fl(2)d1/+ females mated to SxlfP7B0/Y males show only 65.3% viability.

The female progeny of snfJ210/+ ; fl(2)d1/+ females mated to SxlfP7B0/Y males show only 27.6% viability.

The female progeny of snf148/+ ; fl(2)d1/+ females mated to SxlfP7B0/Y males show only 11.1% viability.

The female progeny of snfJ210/+ ; fl(2)d1/+ ; snf5MER females mated to SxlfP7B0/Y males show 16.1% viability.

The female progeny of U2af38ΔE18/fl(2)d1 females mated to SxlfP7B0/Y males show only 25.8% viability.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

The amount of RNA transcribed from the dosage-compensated X-linked Sgs4 gene compared with that transcribed from the autosomal Sgs3 gene in fl(2)d1 heterozygotes and homozygotes has been measured. It shows that fl(2)d1 affects dosage compensation; it causes hypertranscription of the two X chromosomes in females.

Germline clonal analysis suggests that fl(2)d1 autonomously affects the development of the germline.

Homozygous larvae and heteroallelic larvae with fl(2)d2, reared at 25oC, have msl-1 and mle associated with numerous sites along the paired X chromosomes.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (13)