fl(2)d1 homozygotes are female lethal.
Males are semi-lethal at 29oC and females are semi-lethal at 18oC. fl(2)d1/fl(2)d2 heterozygotes are female lethal at 29oC and females have reduced viability at 18oC.
50% of homozygous males and no homozygous females survive at 29oC. Lethality is during the larval stage (animals can survive until the third instar stage). 75% of homozygous males and 16% of homozygous females survive at 18oC. The females that survive at 18oC are sterile (males are fertile at both temperatures). The temperature sensitive period in females is the whole of development. fl(2)d1/fl(2)d2 females show temperature-sensitive lethality, and males show temperature-sensitive semi-lethality. The lethality of homozygous and fl(2)d1/fl(2)d2 females is partially suppressed by SxlM1. The semi-lethality of homozygous and fl(2)d1/fl(2)d2 males is independent of Sxl function. The lethality of SxlM1 males is partially suppressed in homozygous fl(2)d1 and fl(2)d1/fl(2)d2 flies. Partially suppresses the female germline phenotype of ovoD1rv23 flies.
Lethal in females and semi-lethal in males at 29oC, semi-lethal in females and nearly fully viable in males at 18oC. Homozygous adult females have reduced viability at both 18oC and 29oC, although females shifted to 29oC die earlier than flies kept at 18oC. Homozygous females also carrying SxlM1 have normal viability. Homozygous adult males have normal viability at both 18oC and 29oC, and have a slower developmental rate than wild-type. Homozygous females are inseminated less than wild-type females, this phenotype is suppressed by SxlM1. Homozygous males are able to inseminate females. Homozygous females developing at 18oC are sterile, with oogenesis arrested at the previtellogenic stages. This sterility is suppressed by SxlM1.