FB2020_06, released Dec 22, 2020

Allele: Dmel\fliI5

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General Information
Symbol
Dmel\fliI5
Species
D. melanogaster
Name
FlyBase ID
FBal0004039
Feature type
allele
Associated gene
Dmel\fliI
Associated Insertion(s)
Carried in Construct
Also Known As
fltO2
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Miklos and de Couet, 1990)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
X:21,341,623..21,341,623 [+]
Nucleotide change:

G21341623A

Amino acid change:

G523S | fliI-PA

Reported amino acid change:

G523S

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(de Couet et al., 1995)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference

      Amino acid replacement: G523S.

      (de Couet et al., 1995)
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygotes have normal viability. fliI5/Df(1)18-80, fliI5/fliI14, fliI5/fliI10 and fliI5/fliI21 flies are flightless.

      (Miklos and de Couet, 1990)

      Homozygous viable. Homozygous germline clones display no maternal effect. Embryos derived from heterozygous mothers have CNS and PNS defects.

      (Perrimon et al., 1989)

      Indirect flight muscles have abnormal arrangement of myofibrils and distorted Z bands. fliI5/fliI8 flies are flightless.

      (de Couet et al., 1987)

      fliIsdby/fliI5 flies hold their wings normally but are completely flightless.

      (Deak et al., 1982)

      Mosaic analysis with suggests primary defect in thoracic muscles.

      (Koana and Hotta, 1978)

      Moderate allele.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Koana.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      O2
      (Perrimon et al., 1989)
      fliO2
      (Perrimon et al., 1989)
      fliI5
      fliO2
      (de Couet et al., 1995)
      fltO2
      (Miklos and de Couet, 1990, de Couet et al., 1987, Miklos et al., 1987, Deak et al., 1982)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)