adult cuticle & adult thorax
The flw1/Y ; pucA251.1F3/+ combination is viable. 30% of these flies have wing phenotypes that range from slight defects in the posterior part of the wing to stumps. Flies with the most severe wing phenotypes sometimes have third leg malformations.
The wing defects caused by expression of hepCA.Scer\UAS under the control of Scer\GAL4vg.PU are enhanced in a flw1/Y background; the wings are much smaller and are frequently notched and blistered. The double mutant flies are only 10% viable relative to their flw1/+ ; hepCA.Scer\UAS, Scer\GAL4vg.PU control siblings.
The synthetic lethality resulting from the overexpression of Nop17lScer\UAS.T:Zzzz\His6,T:Hsap\MYC under the control of Scer\GAL4arm.PS in a hemizygous flw1 mutant background can be rescued by the co-expression of flwScer\UAS.T:Ivir\HA1.
The flw1 mutation is lethal in combination with the phosphomimetic sqhE20.E21 mutation. Most flw1/Y; sqhE21.T:Zzzz\FLAG/+ flies are viable, but have a crumpled wing phenotype, resembling that of stronger flw alleles. The Mbs3 mutation does not affect the viability of flw1 mutants.