|Feature type||allele||Associated gene||Dmel\fs(1)h|
|Map ( GBrowse )|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
pr_change=G33D | fs(1)h-PA; G33D | fs(1)h-PB; G33D | fs(1)h-PC; G33D | fs(1)h-PD; G33D | fs(1)h-PE; G33D | fs(1)h-PF
comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: G33D.
|Phenotype Manifest In|
fs(1)h female homozygotes are able to lay eggs at 18[o]C, but lose fertility at 26.5[o]C. fs(1)h[rnc]/fs(1)h females are fertile at 18[o]C, but are unable to lay eggs at 22[o]C. fs(1)h[PA]/fs(1)h females are fertile at 18[o]C, but lose fertility at 25[o]C. Df(1)C128/fs(1)h females are fertile at 18[o]C, but lose fertility at 25[o]C. fs(1)h/fs(1)h females are fertile at 18[o]C, but lose fertility at 26.5[o]C. Progeny from fs(1)h[PA]/fs(1)h mothers, raised at semipermissive temperatures (22[o]C), do not hatch. Cuticle analysis reveals very severe head defects, and 95% show segmental fusion of the second abdominal segment. Defects are rarely observed in other segments. The filzkorper is often deleted or malformed. Progeny from fs(1)h[rnc]/fs(1)h mothers, raised at semipermissive temperatures (22[o]C), do not hatch. Cuticle analysis reveals that the second abdominal segment is deleted or fused in all of these animals, and most show fusion and mid-line defects in additional segments. The filzkorper is deleted or malformed in 95% of animals. Head structures are often indiscernible and occasionally absent altogether. Approximately 50% of progeny from fs(1)h/fs(1)h mothers, raised at semipermissive temperatures (22[o]C), do not survive embryogenesis. Cuticle analysis reveals a weak pair-rule phenotype, which is most consistently observed in even parasegments. 75% of defects seen involve the second abdominal segment.
Progeny derived from homozygous fs(1)h1 mothers in which oogenesis occurred at an intermediate temperature (23oC) exhibit missing halteres and/or missing third legs or a low frequency of homeotic transformations of the haltere to wing and third to second leg.
Females hemizygous for fs(1)h1 that also carry Df(3R)red-P93 give rise to progeny with a high frequency of homeotic transformation of T3 to T2. Females heterozygous for fs(1)h1 that also carry Df(3R)red-P93 give rise to progeny with a low but significant frequency of homeotic transformation of T3 to T2.
|Phenotype Manifest In|
10+/-2% of KrIf-1/+ flies born to fs(1)h1/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers.
|Complementation & Rescue Data|
|Fails to complement|
|Stocks ( 2 )|
|Notes on Origin|
Relative strengths of the mutant alleles estimated as follows: fs(1)h2 > fs(1)h6 > fs(1)h1 for the temperature sensitive alleles, Df(1)C128 = fs(1)h5 = fs(1)h4 > fs(1)h18 > fs(1)h3 > fs(1)h8 > fs(1)h17 for the non-conditional alleles.
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 6 )|
|Secondary FlyBase IDs|
|References ( 8 )|