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General Information
Symbol
Dmel\fs(1)K101
Species
D. melanogaster
Name
FlyBase ID
FBal0004297
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
fs(1)K10
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant females produce outwardly dorsalised eggs.

Eggs laid by fs(1)K101 mothers are dorsalised. Dorsal appendage material expands to form a collar surrounding the ventral side of the egg. The dorsal gap between the pair of dorsal appendages remains but shifts ventrally.

Females produce eggs with ventrally fused dorsal appendages.

A ring of dorsal appendage material encircles the anterior end of the eggshell in fs(1)K101 eggs.

Mothers lay dorsalised eggs, the dorsal appendages form a collar around the entire circumference of the egg.

Dorsalised egg chambers.

Homozygous females lay dorsalised eggs that develop into dorsalised embryos if fertilised.

Embryos exhibit a dorsalised phenotype.

Eggs produced by fs(1)K101 grkED22 double mutant females are more ventralised than eggs produced by grkED22 single mutant females. Most double mutant eggs contain no or only a node of dorsal appendage material positioned on the dorsal midline, whereas grkED22 single mutant eggs have at least one dorsal appendage that usually extends anteriorly beyond the anterior tip of the egg.

Homozygous females lay dorsalised embryos, dorsal appendages are fused in a ring at the anterior end and eggs are smaller and more spherical than wild type.

Eggs laid by homozygous females are dorsalised and develop into dorsalised embryos. Females double mutant for fs(1)K101 and Dsor1ts1 lay eggs with fused dorsal appendages at 18oC, at 29oC the dorsalised eggshell phenotype is strongly suppressed to varying degrees, some eggs are fertilised.

Egg shells strongly dorsalized with 84% of eggs having ventrally fused dorsal appendages. Less than 1% of eggs contain embryos, which have reduced or no filzkorper, and show an expansion of ventral epidermis posteriorly.

Weak allele. Homozygous females lay eggs with a partially dorsalised chorion. The phenotype is stronger anteriorly, as the most posterior segments of the embryos produced have narrow ventral denticle belts. The phenotype is enhanced, resulting in the loss of ventral structures posteriorly, in embryos derived from hemizygous females. 2-5% of the eggs laid by homozygous females are fertilised. fs(1)K101 heterozygous or homozygous females also homozygous for grk3, grk6 or Egfrt1 produce eggs with a ventralised phenotype. fs(1)K101 homozygous females also heterozygous for Egfrt1 produce eggs with a dorsalised phenotype.

Embryos from double mutants with sqdix43 are strongly dorsalised.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

fs(1)K101 has egg chamber phenotype, suppressible by Cf2s.hs

Additional Comments
Genetic Interactions
Statement
Reference

When piphs.PS is expressed in fs(1)K101 females, ventralised embryos carrying ventral denticle material are produced inside dorsalised egg shells.

Double mutants with spn-B1, mus301422 or spn-D2 display an indistinguishable phenotype from fs(1)K101 single mutants.

Overexpression of Cf2s.hs can reduce the dorsalising effects, 10% of eggs display two distinct dorsal appendages. Overexpression during oogenesis similarly rescues the maternal dorsalising effect so 12% of embryos have restored ventral denticles.

fs(1)K101; Egfrtop-18A or fs(1)K101; grk3 double mutant females produce eggs with ventralised eggshells and embryos. fs(1)K101/fs(1)K101; Ras85Dix13b/Ras85De2F females lay eggs that range from strongly dorsalised to weakly ventralised, indistinguishable from Ras85D mutant eggs. The embryos range from strongly dorsalised to weakly dorsalised, to almost normal with slight head defects.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Wieschaus, Marsh and Gehring (1978).

Comments
Comments

Mutation does not affect posterior follicle cell determination.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (30)