Allele Dmel\fs(1)K10¹

General Information
Symbol	Dmel\fs(1)K10¹	Species	D. melanogaster
Name		FlyBase ID	FBal0004297
Feature type	allele	Associated gene	Dmel\fs(1)K10
Also Known As	fs(1)K10

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Forlani et al., 1993, Haenlin et al., 1995)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	chorion (Brand and Perrimon, 1994, Forlani et al., 1993) dorsal appendage (Dobens et al., 1997, Brand and Perrimon, 1994, Gonzalez-Reyes et al., 1997, Deng and Bownes, 1997, Roth and Schupbach, 1994, Zhao and Bownes, 1999) dorsal appendage \| ectopic (Zhao and Bownes, 1999) egg (Zhao and Bownes, 1999, Sen et al., 2000, Forlani et al., 1993) egg chamber (Hsu et al., 1996) embryo (Brand and Perrimon, 1994, Forlani et al., 1993) epidermis \| ventral (Roth and Schupbach, 1994) filzkorper (Roth and Schupbach, 1994)
Detailed Description
	Statement Reference Mutant females produce outwardly dorsalised eggs. (Sen et al., 2000) Eggs laid by fs(1)K10¹ mothers are dorsalised. Dorsal appendage material expands to form a collar surrounding the ventral side of the egg. The dorsal gap between the pair of dorsal appendages remains but shifts ventrally. (Zhao and Bownes, 1999) Females produce eggs with ventrally fused dorsal appendages. (Deng and Bownes, 1997) A ring of dorsal appendage material encircles the anterior end of the eggshell in fs(1)K10¹ eggs. (Dobens et al., 1997) Mothers lay dorsalised eggs, the dorsal appendages form a collar around the entire circumference of the egg. (Gonzalez-Reyes et al., 1997) Dorsalised egg chambers. (Hsu et al., 1996) Homozygous females lay dorsalised eggs that develop into dorsalised embryos if fertilised. (Schnorr and Berg, 1996) Embryos exhibit a dorsalised phenotype. (Gonzalez-Reyes et al., 1995) Eggs produced by fs(1)K10¹ grk^ED22 double mutant females are more ventralised than eggs produced by grk^ED22 single mutant females. Most double mutant eggs contain no or only a node of dorsal appendage material positioned on the dorsal midline, whereas grk^ED22 single mutant eggs have at least one dorsal appendage that usually extends anteriorly beyond the anterior tip of the egg. (Serano et al., 1995) Homozygous females lay dorsalised embryos, dorsal appendages are fused in a ring at the anterior end and eggs are smaller and more spherical than wild type. (Brand and Perrimon, 1994) Eggs laid by homozygous females are dorsalised and develop into dorsalised embryos. Females double mutant for fs(1)K10¹ and Dsor1^ts1 lay eggs with fused dorsal appendages at 18^oC, at 29^oC the dorsalised eggshell phenotype is strongly suppressed to varying degrees, some eggs are fertilised. (Hsu and Perrimon, 1994) Egg shells strongly dorsalized with 84% of eggs having ventrally fused dorsal appendages. Less than 1% of eggs contain embryos, which have reduced or no filzkorper, and show an expansion of ventral epidermis posteriorly. (Roth and Schupbach, 1994) Weak allele. Homozygous females lay eggs with a partially dorsalised chorion. The phenotype is stronger anteriorly, as the most posterior segments of the embryos produced have narrow ventral denticle belts. The phenotype is enhanced, resulting in the loss of ventral structures posteriorly, in embryos derived from hemizygous females. 2-5% of the eggs laid by homozygous females are fertilised. fs(1)K10¹ heterozygous or homozygous females also homozygous for grk³, grk⁶ or Egfr^t1 produce eggs with a ventralised phenotype. fs(1)K10¹ homozygous females also heterozygous for Egfr^t1 produce eggs with a dorsalised phenotype. (Forlani et al., 1993) Embryos from double mutants with sqd^ix43 are strongly dorsalised. (Kelley, 1993)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement Reference fs(1)K10¹ has egg chamber phenotype, suppressible by Cf2^s.hs (Hsu et al., 1996)
Additional Comments
Genetic Interactions
Statement Reference When pip^hs.PS is expressed in fs(1)K10¹ females, ventralised embryos carrying ventral denticle material are produced inside dorsalised egg shells. (Sen et al., 2000) Double mutants with spn-B¹, mus301⁴²² or spn-D² display an indistinguishable phenotype from fs(1)K10¹ single mutants. (Gonzalez-Reyes et al., 1997) Overexpression of Cf2^s.hs can reduce the dorsalising effects, 10% of eggs display two distinct dorsal appendages. Overexpression during oogenesis similarly rescues the maternal dorsalising effect so 12% of embryos have restored ventral denticles. (Hsu et al., 1996) fs(1)K10¹; Egfr^top-18A or fs(1)K10¹; grk³ double mutant females produce eggs with ventralised eggshells and embryos. fs(1)K10¹/fs(1)K10¹; Ras85D^ix13b/Ras85D^e2F females lay eggs that range from strongly dorsalised to weakly ventralised, indistinguishable from Ras85D mutant eggs. The embryos range from strongly dorsalised to weakly dorsalised, to almost normal with slight head defects. (Schnorr and Berg, 1996)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Kyoto	101905 fs(1)K10¹ w¹ / ClB / Dp(1;Y)B^S ; mwh¹ se¹ e¹
Notes on Origin
Discoverer	Wieschaus, Marsh and Gehring (1978).

Comments
	Mutation does not affect posterior follicle cell determination. (Gonzalez-Reyes et al., 1995)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	fs(1)K10 (Zhao and Bownes, 1999, Reich et al., 1999, Dobens et al., 1997, Schnorr and Berg, 1996, Neuman-Silberberg and Schupbach, 1993, Lin et al., 2007) fs(1)K10¹ (Andreu et al., 2012) K10¹ (Gonzalez-Reyes et al., 1997)
Name Synonym
Secondary FlyBase IDs

References ( 27 )

Generate a list of	All references relating to this allele ( 27 )

List References by type	Research paper ( 26 ) Review ( 1 )
Recent research papers ( 1 )
	Andreu et al., 2012, Development 139(6): 1110--1114 Mirror represses pipe expression in follicle cells to initiate dorsoventral axis formation in Drosophila. [FBrf0217527] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Dmel\fs(1)K101

Allele Dmel\fs(1)K10¹