Allele Dmel\Sxl^K1274-1

General Information
Symbol	Dmel\Sxl^K1274-1	Species	D. melanogaster
Name		FlyBase ID	FBal0004305
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\Sxl

Allele class
Mutagen	ethyl methanesulfonate
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Assay mode
Cytology
Phenotypic Data
Phenotypic Class
	female sterile \| recessive (Sugimura et al., 1994) female sterile \| conditional - heat sensitive (Perrimon and Gans, 1983)
Phenotype Manifest In
	ovary (Sugimura et al., 1994)
Detailed Description
	Statement Reference females produce few if any eggs. temperature-sensitive recessive female-sterile Viability good at 29^oC but ovaries of homozygous females severely atrophied, probably with tumorous follicles. At 25^oC cysts contain 16 nurse cells and no oocyte; females fertile when raised at 23^oC. Mosaic studies indicate germ-line function of gene (Perrimon and Gans, 1983). At the non-permissive temperature homozygous females lay no eggs. (Perrimon and Gans, 1983) Previously the females were described as having severely atrophied ovaries at 29^oC and at 23^oC females are fertile (FBrf0039483). Now females are sterile between 18^oC and 29^oC. Sxl^K1274-1/Sxl^f1 individuals are lethal. Double homozygous snf^- Sxl^K1274-1 females are semi-lethal and survivors have tumorous egg chambers. (Sugimura et al., 1994)
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	4554 C(1)RA, cin¹ y¹/Dp(1;Y)y⁺/Sxl^K1274-1 v²⁴
Notes on Origin
Discoverer

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	fs(1)K1274 (Perrimon and Gans, 1983) fs(1)K1274¹ Sxl^K1274-1 unnamed (Sugimura et al., 1994)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Sugimura et al., 1994, D. I. S. 75: 147--148 On the allelism of fs(1)K1274 and Sex-lethal mutations. [FBrf0074564] Perrimon and Gans, 1983, Dev. Biol. 100: 365--373 Clonal analysis of the tissue specificity of recessive female sterile mutations of Drosophila melanogaster using a dominant female-sterile mutation. [FBrf0039213]

Allele Dmel\SxlK1274-1

Allele Dmel\Sxl^K1274-1