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General Information
Symbol
Dmel\fs(1)M31901
Species
D. melanogaster
Name
FlyBase ID
FBal0004380
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
fs(1)ph1901
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

T5961512A

Amino acid change:

Y783N | fs(1)M3-PA

Reported amino acid change:

Y742N

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Position differs slightly from author statement.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Y742N.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous mutant mothers produce embryos with a terminal loss-of-function phenotype. The embryo lacks all structures posterior to abdominal segment 8 and the head skeleton is reduced in size.

Embryos derived from homozygous females fail to develop structures posterior to the seventh abdominal segment as well as anterior-most structures, including the head skeleton.

Embryos derived from homozygous females show a terminal phenotype.

Posterior defect is significantly suppressed, in a dose-dependent manner, by Dsor1Su1.

Collapsed egg phenotype. Little or no tll expression is detected in the posterior of syncytial or cellular blastoderm embryos, at the anterior the early tll cap does not appear and an abnormal anterior tll stripe appears by the late syncytial blastoderm.

Failure to differentiate cuticular structures derived from the anterior and posterior regions of the egg. Double homozygous females fs(1)N12, fs(1)M31901 produce embryos with the terminal cuticle phenotype.

A hole is seen in the blastoderm layer below the pole cells in embryos. The ventral furrow is extended posteriorly. Segments A8 to the telson are deleted. Segments A5 to A7 are expanded. Some twisting of the germband is seen. Labral and acron-derived structures are deleted. There is cell death in the head and tail region. Cephalic furrow and anterior midgut invagination are shifted anteriorly.

Terminal holes in embryo. Embryonic defects detectable at preblastoderm stages. Eggs are laid and some collapse on deposition.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

Dsor1Su1, fs(1)M31901 has embryo | posterior phenotype, enhanceable by rl[+]/rl9

Dsor1Su1, fs(1)M31901 has embryo | posterior phenotype, enhanceable by rl[+]/rl10a

NOT Enhanced by
Suppressed by
Statement
Reference

fs(1)M31901 has embryo | posterior phenotype, suppressible by Dsor1Su1

NOT suppressed by
Statement
Reference
Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

The addition of tslScer\UAS.cSa driven by Scer\GAL4ET3 has no effect on the terminal phenotype seen in embryos laid by fs(1)M31901 mothers.

The fs(1)M31901 posterior embryo defect is significantly suppressed if the female is also carrying one copy of Dsor1Su1; an eighth abdominal segment is formed. This suppression is significantly reduced if the females are also carrying one copy of rl9, rl10a or Df(2R)rl10b. The posterior defects of embryos derived from homozygous fs(1)M31901 females are not suppressed if the females are also carrying one copy of rlSu23 or one or two copies of rlSu14.

Embryos derived from fs(1)M31901 females carrying tsltor.PF show no rescue of the fs(1)M31901 phenotype and do not show deletions of the middle segments ("splice" phenotype seen in wild-type embryos carrying tsltor.PF).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

A strong allele of fs(1)M3.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (14)