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General Information
Symbol
Dmel\ldsHor-D
Species
D. melanogaster
Name
FlyBase ID
FBal0004758
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
G7923311A
Reported nucleotide change:
G2424A
Amino acid change:
A777T | lds-PA
Reported amino acid change:
A777T
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Amino acid replacement: A777T.
Nucleotide substitution: G2424A.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
The rate of Y chromosome loss in the developing wing imaginal disc in heterozygous males is significantly higher than that seen in wild type.
Heterozygous females deposit normal numbers of normal-looking eggs. However, cleavage divisions do not occur in more than 90% of the eggs. In those eggs in which cleavage divisions are seen, only approximately 12 scattered chromosomes appear, along with unusual microtubule bundles. Abnormal segregation of the chromosomes is already apparent during both the first and second meiotic divisions. Cytoplasm from newly deposited eggs laid by heterozygous females induces defects during division when injected into lds[+] embryos, producing chromosome tangling during anaphase and telophase, the formation of chromatin bridges, abnormally shaped and positioned nuclei and free centrosomes. 9.1% of the offspring of heterozygous males are XX//X0 mosaics. Hemizygous flies are viable and emerge with the expected frequency. The females deposit normal numbers of normal-looking eggs which are fertilised, but embryogenesis never commences in these eggs. Fertility of hemizygous males is also strongly reduced. 6.7% of the offspring of ldsHor-D/Df(3R)dsx15 males are XX//X0 mosaics. XX//X0 mosaics are seen in the progeny of ldsHor-D/lds3 males at a low frequency. Analysis of germ-line chimeras indicates that the ldsHor-D defects are due to an effect in germ-line cells and not in somatic cells.
Gynandromorph formation is a consequence of the mutation. The gynandromorphs originate through loss and not nondisjunction of the paternally derived X chromosome. Unknown genetic factors contributed by both parents can alter the frequency of X chromosome loss in the zygote. The presence of factors renders the fourth chromosome highly or moderately sensitive to chromosome loss causing haplo-4 mosaics. The second and third chromosomes can also be rendered unstable, Y chromosome remain stable. Derived XO males originate through the fertilization of X eggs by nullo-X sperm, mutation induces mostly equational nondisjunction during spermatogenesis. Males showing abnormal cysts have sperm bundles in which the spermatid heads are not attached to the sperm tails and are abnormally distributed.
Female viability and male fertility are not reduced. The female and male pronuclei approach each other and almost fuse, however that do not divide. Phenotype is not fully penetrant so some embryos develop to the blastoderm stage.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Eggs derived from ldsHor-D/+ females carrying ldst5.1 develop cuticle fragments in 93% of cases.
Images (0)
Mutant
Wild-type
Stocks (5)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)