Open Close
General Information
Symbol
Dmel\ft15
Species
D. melanogaster
Name
FlyBase ID
FBal0004801
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ftsz44
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    complex substitution
    Comment:

    A 31 bp deletion and a 14 bp insertion leads to a frameshift and early translation termination.

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Contains a 31 bp deletion and a 14bp insertion in the 32nd cadherin domain. The consequence of these alterations is to produce a truncated form of the fat protein.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    ft15/ft12 mutants exhibit largely depolarized denticle belts.

    In the anterior compartments of the tergites, ft15 somatic clones tend to disturb and reverse polarity behind the clone, while, in the posterior compartments, they tend to reverse in front. However, when anterior ft15 clones abut the compartment boundary they fail to reverse the polarity of posterior compartment cells behind. Similarly, when posterior ft15 clones abut the compartment boundary they fail to reverse the polarity of anterior compartment cells in front.

    ft15/ft8 transheterozygotes die at the pupal stage, and the larvae have overgrown imaginal discs.

    embryonic lethal

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Enhanced by
    Statement
    Reference

    Scer\GAL4αTub84B.PL, dsUAO71, ft15, ftUAS.cMa has trichome & tergite | cell non-autonomous | somatic clone phenotype, enhanceable | somatic clone by fjUAS.cZa/Scer\GAL4αTub84B.PL

    ft12/ft15 has denticle belt phenotype, enhanceable by dsUAO71

    ft12/ft15 has denticle row 5 phenotype, enhanceable by dsUAO71

    ft12/ft15 has denticle row 6 phenotype, enhanceable by dsUAO71

    Suppressed by
    Statement
    Reference

    Scer\GAL4αTub84B.PL, dsUAO71, dsecto.UAS, ft15 has trichome & tergite | cell non-autonomous | somatic clone phenotype, suppressible | somatic clone by fjUAS.cZa/Scer\GAL4αTub84B.PL

    Enhancer of
    Statement
    Reference

    ft15 is an enhancer of denticle belt phenotype of dsUAO71

    ft15 is an enhancer of denticle row 5 phenotype of dsUAO71

    ft15 is an enhancer of denticle row 6 phenotype of dsUAO71

    Other
    Statement
    Reference

    Scer\GAL4αTub84B.PL, dsUAO71, dsecto.UAS, ft15 has trichome & tergite | somatic clone | cell non-autonomous phenotype

    Scer\GAL4αTub84B.PL, dsUAO71, ft15, ftUAS.cMa has trichome & tergite | somatic clone | cell non-autonomous phenotype

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    dsUAO71 ft15 double mutant clones in the dorsal adult abdomen where the clones are also expressing dsecto.Scer\UAS under the control of Scer\GAL4αTub84B.PL strongly repolarise hairs behind the clone, reversing their polarity (100% of clones repolarise with a maximum range of up to seven cells). This repolarisation is largely suppressed by co-expression of fjScer\UAS.cZa within the clone (48% of clones show some repolarisation with a range of one to three cells).

    dsUAO71 ft15 double mutant clones in the dorsal adult abdomen where the clones are also expressing ftScer\UAS.cMa under the control of Scer\GAL4αTub84B.PL cause repolarisation in front of the clones, so that hairs point away from the clone (64% of clones repolarise with a maximum range of seven cells). Co-expression of fjScer\UAS.cZa within these clones strengthens the repolarisation (95% of clones repolarise with a maximum range of seven cells).

    dsUAO71 ft15 double mutants exhibit largely depolarized denticle belts (with rows 5 and 6 more disturbed than in dsUAO71 mutants). In addition to the orientation defects, the rows partially lose their distinctive characteristics.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    References (8)