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General Information
Symbol
Dmel\ftG-rv
Species
D. melanogaster
Name
FlyBase ID
FBal0004805
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
fatG-rv, ftGrv, Grv
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
There is an mdg3 retrotransposon inserted in position S2929 that introduces a stop codon in the 27th cadherin domain. It also contains additional rearrangements in the first intron and an insertion in the 33rd cadherin domain.
As for ftG with an additional rearrangement that has not yet been fully characterized.
Insertion components
412{}ftG-rv
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
mesothoracic tergum & chaeta | somatic clone
wing & chaeta | somatic clone
Detailed Description
Statement
Reference
ftG-rv homozygotes are lethal. ftG-rv/ft8 transheterozygous pharates exhibit severe hair orientation defects in the anterior dorsal abdomen, as compared to controls.
ftG-rv/ftG-rv eyes (created by the EGUF method in otherwise heterozygous animals) contain significantly increased number of interomatidial cells (IOC) in the pupal retina compared to wild-type, the size and shape of adult eyes is also affected. ftG-rv/ft8 transheterozygotes rarely survive to third instar larval stage (but never to adulthood) and the survivors display decreased number of photoreceptor cells in the eye disc and overgrown wing discs compared to wild-type.
ftG-rv homozygous mutant embryos display a significant increase in the frequency of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage.
ftG-rv/ft8; ftT:SV5\V5 wings are normal; ftG-rv/ft8; ftΔD.T:SV5\V5 wings are slightly overgrown, rounder and have decreased spacing between the crossveins compared to controls; ftG-rv/ft8; ftΔF.T:SV5\V5 wings are not enlarged but have greatly reduced spacing between the crossveins. ft8/ftG-rv and ft8/ft61 imaginal discs are larger and have more folds than controls.
ftG-rv/ft8 mutant larvae show a decrease in the number of glial cells in the eye disc and a lack of glial overgrowth.
ftG-rv mutant MARCM clones contain 5-7 cells per clone, compared to 2-3 cells in wild-type clones. These clones contain differentiated absorptive enterocytes and secretory enteroendocrine cells indicating that intestine stem cell differentiation continues as in wild-type.
ftG-rv/ft8 stage 16 embryos have shorter dorsal trunks than normal, although they are contiguous.
Wing and eye imaginal discs show overgrowth in ft8/ftG-rv pupae. The pupal abdomens are not overgrown, but show planar cell polarity defects.
ftG-rv homozygous mutant clones generated in the male germline develop normally. 16 cells are observed per cyst, and cell size and morphology are indistinguishable from neighbouring control cells.
In ft8/ftG-rv mutants, the polarity of hairs and bristles on the adult cuticle is disturbed, resulting in swirling patterns of hairs and bristles in many tissues.
The wing discs of ftG-rv/ft8 larvae show extensive tissue overgrowth during the late third instar. Expression of ftΔICD.Scer\UAS.T:Ivir\HA1, under the control of either Scer\GAL4Act5C.PI or Scer\GAL4da.G32, enhances the wing disc tissue overgrowth phenotype of ftG-rv/ft8 mutants. Large ftG-rv clones in the distal region of the wing blade between L2 and L3 show planar cell polarity defects. The abdomens of ftG-rv/ft8 mutants have fairly normal morphology at the pharate stages although they have a characteristic swirl of hairs that have lost their normal polarity.
ft8/ftG-rv mutant animals die during the early stages of pupal development and show severely overgrown imaginal disc derivatives.
Mutant wing and eye discs exhibit an overgrowth phenotype. ftG-rv homozygous mutant eyes (created as clones) are slightly larger than normal with duplicated bristle cells and severe morphological defects. The distribution of cell cycle phases and cell size in ftG-rv mutants are indistinguishable from wild-type.
Late third instar ft8/ftG-rv wing discs exhibit disproportionate overgrowth of the proximal wing pouch compared to other parts of the wing disc.
ft1/ftG-rv transheterozygotes are short lived as compared to controls.
About 50% of ommatidia within somatic clones in the adult eye frequently have reversed dorsal ventral polarity. Occasional reversals of polarity are also seen in wild-type ommatidia bordering the polar side of the mutant tissue. When homozygous mutant clones are made specifically in the equatorial R3/R4 precursor, almost all (96%) of the consequent ommatidia are in the reverse polarity. When clones are made specifically in the polar R3/R4 precursor, all of the consequent ommatidia are in the wild-type polarity. The mutant photoreceptor precursor eventually becomes an R4 photoreceptor 98% of the time (50% in wild-type).
ftG-rv/Df(2L)sc19-1 larvae reach the pupal stage at 7-9 days and show hyperplastic discs. ftk07918/ftG-rv larvae show a delay in pupariation of 1-2 days and have a maximal disc size similar to that of ftk07918 homozygotes. Wing discs from ft4/ftG-rv larvae are larger, they pupate at 7-9 days and die as pupae. Somatic wing clones of homozygous ftG-rv in a M(2)24F1 background tend to fill one or several intervein sectors but a fraction do cross the dorsal ventral boundary. The clones tend to fill proximal regions of the wing. The distal borders of clones are rounded, and are smooth in contrast with the indented borders found in control clones. Inn all of these features ftk07918 and ftG-rv are more extreme than ft4. Trichome density in clones is higher than wild-type clones - about 1.7 times that of wild-type, indicating that cell size is smaller than wild-type. Somatic clones in the notum (of homozygous ft4 in a M(2)24F1 background) are large, with more cells than control clones, leading to an increase in the total notum surface. They contain many more chaetae (1.6 times wild-type) and higher cell density (1.4 times). Similar deviations occur in the legs and head capsule. tergite clones however shoe normal patterns of pigment chaetae and trichomes.
Hemizygous ftG-rv and transheterozygous ftG-rv/ftG animals die at the pupal stage and the larvae have overgrown discs.
Does not show G phenotype. Does not exaggerate ft. Lethal in combination with G. RK2.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Suppressed by
Statement
Reference
ftG-rv has lethal phenotype, suppressible by Dlishc/Dlishc
ft8/ftG-rv has hyperplasia phenotype, suppressible | partially by wgspd-fg
NOT suppressed by
Enhancer of
NOT Enhancer of
Statement
Reference
ftG-rv/ftG-rv is a non-enhancer of size defective phenotype of Dlishc
Suppressor of
NOT Suppressor of
Statement
Reference
ftG-rv is a non-suppressor of lethal | pupal stage phenotype of Cskj1D8/CskS030003
Other
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Suppressed by
Statement
Reference
ft8/ftG-rv has eye disc | pupal stage phenotype, suppressible by appe6
ft8/ftG-rv has wing disc phenotype, suppressible | partially by wgspd-fg
NOT suppressed by
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference
ftG-rv/ftG-rv is a non-enhancer of wing phenotype of Dlishc
Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference
The lethality of ftG-rv homozygotes is suppressed by the additional homozygosity for Dlishc, but adults are recovered only at about one third of the expected frequency. Additional homozygosity for ftG-rv does not exacerbate the small wing area phenotype and mild abdomen hair orientation defects observed in Dlishc single homozygotes.
The supernumerary inter-ommatidial cells in the pupal retina phenotype characteristic for ftG-rv/ftG-rv eyes (created by the EGUF method in otherwise heterozygous animals) can be partially suppressed by combination with ZyxΔ41/ZyxΔ41 but this does not affect the size of the mutant adult eyes. The low rate of survival of ftG-rv/ft8 transheterozygotes to third instar larval stage (and never to adulthood), the loss of photoreceptor cells in the eye discs or the overgrowth of the wing disc cannot be suppressed by combination with ZyxΔ41/ZyxΔ41.
The proportion of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage is significantly increased in cno2/+;ftG-rv/+ double heterozygous embryos compared to either of the single heterozygotes or wild type.
Scer\GAL4αTub84B.PL-mediated expression of Fbxl7Scer\UAS.T:Zzzz\FLAG does not suppress ft8/ftG-rv phenotypes.
Flies expressing wtsScer\UAS.T:Hsap\MYC under the control of Scer\GAL4αTub84B.PL rescue the lethality and third instar larval wing disc overgrowth phenotypes seen in ft8/ftG-rv mutants, but the wing hair phenotypes are still present. Rather than pointing distally as in wild type, the wing hairs in these flies are misoriented and swirling patterns can be observed. A strong planar cell polarity defect is also seen in the abdominal hairs and the wing anterior-posterior crossvein distance is reduced. Expression of ftT:SV5\V5 fully rescues the planar cell polarity defects seen in ft8/ftG-rv mutant wings and abdomens expressing wtsScer\UAS.T:Hsap\MYC under the control of Scer\GAL4αTub84B.PL. The reduced anterior-posterior crossvein distance phenotype is also suppressed. Flies expressing ftΔEGF.T:SV5\V5 (co-expressed with wtsScer\UAS.T:Hsap\MYC under the control of Scer\GAL4αTub84B.PL) in a ft8/ftG-rv mutant background do not exhibit any wing phenotypes compared to flies expressing wtsScer\UAS.T:Hsap\MYC alone. Expression of ftΔICD.T:SV5\V5 partially rescues the planar cell polarity defects seen in ft8/ftG-rv mutant wings and abdomens expressing wtsScer\UAS.T:Hsap\MYC under the control of Scer\GAL4αTub84B.PL. The reduction in anterior-posterior crossvein distance appears to be partially rescued, although crossveins are often incomplete, making it difficult to calculate. The abdominal and wing hair polarity defects are also partially suppressed.
Expression of btl::ftftICD.T:Ivir\HA1,T:λ\cI-DD under the control of Scer\GAL4Act.PU in ftG-rv/ft8 animals rescues disc overgrowth, allows eclosion and improves hair planar cell polarity defects in the wing and abdomen. Expression of dsScer\UAS.cTa under the control of Scer\GAL4Act.PU in ftG-rv/ft8 animals does not detectably improve hair planar cell polarity defects in the abdomen.
dmScer\UAS.cZa overexpression clones (under the control of Scer\GAL4hh.PU) found in the posterior of the wing disc strongly enhance the proliferative activity of ftG-rv mutant cells. In addition these cells are larger in dmScer\UAS.cZa clones than in a wild-type background.
The lethality and overgrowth phenotypes of ftG-rv/ft8 animals are rescued by Scer\GAL4tub.PU-mediated overexpression of wtsScer\UAS.T:Hsap\MYC. However, these animals still show obvious planar cell polarity phenotypes in multiple tissues.
The disc overgrowth phenotypes of ft8/ftG-rv pupae are suppressed by appe6 and the abdominal planar cell polarity (PCP) and lethality phenotypes are reduced in the double mutants compared to the ft8/ftG-rv single mutant. The double mutant adults have PCP defects in proximal portions of the wing, but not in the distal wing.
ftG-rv allows recovery of Df(1)su(s)R194/+ clones in the adult eye in animals with mosaic eyes containing two genotypes of cells with respect to RpL36; cells which are Df(1)su(s)R194/+ and cells in which the haplo-insufficiency of Df(1)su(s)R194/+ for RpL36 has been rescued by RpL36+t4 (in a wild-type background the Df(1)su(s)R194/+ clones are eliminated by cell competition and are not seen in the adult eye in these animals).
dsUAO71, ftG-rv/ft8 double mutant larvae show an enhancement of the wing disc overgrowth phenotype of ftG-rv/ft8 single mutants.
One copy of exe1 enhances the lethality of ft8/ftG-rv animals. Those that are wild-type for exe1 but mutant for ft8/ftG-rv emerge as 0.32% of the progeny, whereas those that are also mutant for exe1 emerge as 0.269% of the progeny, a small, but statistically significant difference.
Nearly all ft8 ykiB5/ftG-rv mutant animals develop into adults, although they do not hatch from the pupal case as they have some leg defects and head overgrowths. In contrast, all ft8/ftG-rv mutant animals die during the early stages of pupal development and show severely overgrown imaginal disc derivatives. This indicates that ykiB5 suppresses the overgrowth phenotypes of ft8/ftG-rv mutant imaginal discs.
When rhoScer\UAS.cdCa is driven by Scer\GAL4dpp.blk1 in a ftG-rv background a significant enhancement is seen in the ftG-rv overgrowth phenotype in the Scer\GAL4dpp.blk1 expression territory. When phlScer\UAS.F179 is driven by Scer\GAL4dpp.blk1 in a ftG-rv background a significant enhancement is seen in the ftG-rv overgrowth phenotype, throughout the whole imaginal disc. When phlK497M.Scer\UAS is driven by Scer\GAL4dpp.blk1 in a ftG-rv background a suppression is seen in the ftG-rv overgrowth phenotype in the eye disc, but no effect is seen in the wing disc. An increase in cell non-autonomous cell death is seen in these discs. When rhoScer\UAS.cdCa is driven by Scer\GAL4ey.PH in ftG-rv mutant eyes, significantly enlarged eyes are seen. When phlK497M.Scer\UAS is driven by Scer\GAL4ey.PH in ftG-rv mutant eyes, eyes are significantly smaller than wild-type. However eye bristle duplications are still seen.
Overgrowth of the proximal wing disc in ft8/ftG-rv animals is suppressed by wgspd-fg/wgspd-fg.
Reduction in the distance between anterior and posterior cross-veins in fjt14.T:Hsap\GALNT3 flies is enhanced by ftG-rv/+.
The short lived phenotype of ft1/ftG-rv transheterozygotes is enhanced by Gug11 heterozygosity.
fzScer\UAS.cAa; Scer\GAL4dpp.blk1 flies have a zone extending anterior to the dpp expression domain in which wing hairs point away from the fz overexpressing cells. When such wings have somatic clones of ftG-rv in the anterior of the wing, this zone enlarges to fill the clone.
When ftG-rv/dsUAO71 homozygous mutant clones are made specifically in the equatorial R3/R4 precursor, most (64%) of the consequent ommatidia are in the reverse polarity. When clones are made specifically in the polar R3/R4 precursor, almost all (97.5%) of the consequent ommatidia are in the wild-type polarity. The mutant photoreceptor precursor eventually becomes an R4 photoreceptor 80% of the time (50% in wild-type).
Xenogenetic Interactions
Statement
Reference
Expression of ft::Hsap\FAT4T:SV5\V5 partially rescues the planar cell polarity defects seen in ft8/ftG-rv mutant wings expressing wtsScer\UAS.T:Hsap\MYC under the control of Scer\GAL4αTub84B.PL. The abdominal hair defects are completely rescued and the reduction in anterior-posterior crossvein distance is partially suppressed. Expression of one copy of ft::Hsap\FAT4T:SV5\V5 fails to suppress the wing overgrowth phenotypes seen in ft8/ftG-rv mutant flies expressing one copy of ftΔD.T:SV5\V5. Expression of one copy of ft::Hsap\FAT4T:SV5\V5 partially suppresses the wing crossvein spacing and hair polarity phenotypes seen in ft8/ftG-rv mutant flies expressing one copy of ftΔF.T:SV5\V5.
Complementation and Rescue Data
Fails to complement
Partially rescued by
ft8/ftG-rv is partially rescued by ftΔD.Tag:V5
ft8/ftG-rv is partially rescued by ftΔF.Tag:V5
ft8/ftG-rv is partially rescued by ftΔE.Tag:V5
ft8/ftG-rv is partially rescued by ftΔD.Tag:V5
ft8/ftG-rv is partially rescued by ftΔF.Tag:V5
ft8/ftG-rv is partially rescued by ftmV.Tag:V5
Comments
Expression of ftΔA.T:SV5\V5 rescues the lethality associated with ft8/ftG-rv. The rescued animals appear morphologically normal and only a negligible wing hair planar cell polarity phenotype is seen. The abdominal hair polarity phenotype is fully rescued. The intercellular ridges that run from anterior to posterior in the ft8/ftG-rv mutant posterior wings run proximally to distal in rescue animals, as is seen in wild type. Expression of ftΔB.T:SV5\V5 rescues the lethality associated with ft8/ftG-rv. The rescued animals appear morphologically normal and only a negligible wing hair planar cell polarity phenotype is seen. The abdominal hair polarity phenotype is fully rescued. The intercellular ridges that run from anterior to posterior in the ft8/ftG-rv mutant posterior wings run proximally to distal in rescue animals, as is seen in wild type. Expression of ftΔC.T:SV5\V5 rescues the lethality associated with ft8/ftG-rv. The rescued animals appear morphologically normal and only a negligible wing hair planar cell polarity phenotype is seen. The abdominal hair polarity phenotype is fully rescued. The intercellular ridges that run from anterior to posterior in the ft8/ftG-rv mutant posterior wings run proximally to distal in rescue animals, as is seen in wild type. Expression of ftΔD.T:SV5\V5 rescues the lethality associated with ft8/ftG-rv. However the wings of the rescued flies are 29% larger than normal and the distance between the anterior and posterior crossveins in 73% of wild type. Only a negligible wing hair planar cell polarity phenotype is seen. The abdominal hair polarity phenotype is fully rescued. The intercellular ridges continue to run from anterior to posterior as in the ft8/ftG-rv mutant posterior wings, rather than proximally to distal, as is seen in wild type. Expression of ftΔE.T:SV5\V5 rescues the lethality associated with ft8/ftG-rv. However the wings of the rescued flies are 8% larger than normal and the distance between the anterior and posterior crossveins in 87% of wild type. Only a negligible wing hair planar cell polarity phenotype is seen. The abdominal hair polarity phenotype is fully rescued. The intercellular ridges that run from anterior to posterior in the ft8/ftG-rv mutant posterior wings run proximally to distal in rescue animals, as is seen in wild type. Expression of ftΔF.T:SV5\V5 rescues the lethality associated with ft8/ftG-rv. However the wings of the rescued flies are 4% larger than normal and shorter and wider than normal wings. The distance between the anterior and posterior crossveins is also reduced. Wing hair planar cell polarity phenotypes are still present, with the most proximal part of the wing, the costa, the most severely affected. A subtle phenotype is observed in the abdomen. The intercellular ridges continue to run from anterior to posterior as in the ft8/ftG-rv mutant posterior wings, rather than proximally to distal, as is seen in wild type. Expression of ftΔEGF.T:SV5\V5 fails to rescue the lethality associated with ft8/ftG-rv. Expression of one copy of ftΔF.T:SV5\V5 partially suppresses the wing overgrowth phenotype seen in ft8/ftG-rv mutant flies expressing one copy of ftΔD.T:SV5\V5. Expression of one copy of ftΔD.T:SV5\V5 partially suppresses the wing crossvein spacing and hair polarity phenotypes seen in ft8/ftG-rv mutant flies expressing one copy of ftΔF.T:SV5\V5. Expression of ftΔICD.T:SV5\V5 fails to rescue the lethality associated with ft8/ftG-rv and the wing discs these flies are overgrown compared to controls. Expression of ftP32.T:SV5\V5 rescues the lethality and wing overgrowth phenotype associated with ft8/ftG-rv. Expression of ftmI.T:SV5\V5 rescues the lethality associated with ft8/ftG-rv. However the wings of the rescued flies are 18% larger than normal. Wing hair polarity defects are partially rescued and the abdominal hair defects are fully rescued. Expression of ftmV.T:SV5\V5 rescues the lethality associated with ft8/ftG-rv. However the wings of the rescued flies are larger than normal. Expression of ftmIV.T:SV5\V5 rescues the lethality associated with ft8/ftG-rv. The abdominal and wing hair polarity phenotypes are fully rescued.
for both ft alleles in GA22: Expression of ftScer\UAS.cMa under the control of Scer\GAL4Act.PU in ftG-rv/ft8 animals substantially improves hair planar cell polarity defects in the abdomen. Expression of ftΔECD.Scer\UAS.T:Ivir\HA1 or ftΔECD2.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act.PU in ftG-rv/ft8 animals rescues disc overgrowth, allows eclosion and substantially improves hair planar cell polarity defects in the wing and abdomen. Expression of ftICD.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act.PU in ftG-rv/ft8 animals does not rescue disc overgrowth or eclosion and does not detectably improve hair planar cell polarity defects in the abdomen. Expression of ftΔECDΔN-1.Scer\UAS.T:Ivir\HA1 or ftΔECDΔN-2.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act.PU in ftG-rv/ft8 animals rescues eclosion and very weakly improves hair planar cell polarity defects in the abdomen. Expression of ftΔECDΔN-4.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act.PU in ftG-rv/ft8 animals rescues eclosion but does not detectably improve hair planar cell polarity defects in the abdomen. Expression of ftΔECDΔN-5.Scer\UAS.T:Ivir\HA1, ftΔECDΔN-6.Scer\UAS.T:Ivir\HA1 or ftΔECDΔICD.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act.PU in ftG-rv/ft8 animals does not rescue eclosion and does not detectably improve hair planar cell polarity defects in the abdomen. Expression of ftΔECDΔ9-C.Scer\UAS.T:Ivir\HA1, ftΔECDΔ8-C.Scer\UAS.T:Ivir\HA1, ftΔECDΔ7-C.Scer\UAS.T:Ivir\HA1, ftΔECDΔ6-C.Scer\UAS.T:Ivir\HA1, ftΔECDΔ1-3.Scer\UAS.T:Ivir\HA1, ftΔECDΔ3-4.Scer\UAS.T:Ivir\HA1, ftΔ9-C.Scer\UAS.T:Ivir\HA1 or ftΔ7-C.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act.PU in ftG-rv/ft8 animals rescues eclosion and strongly improves hair planar cell polarity defects in the abdomen. Expression of ftΔECDΔ5-C.Scer\UAS, ftΔECDΔ4-C.Scer\UAS.T:Ivir\HA1, ftΔECDΔ2-C.Scer\UAS.T:Ivir\HA1, ftΔECDΔ1-C.Scer\UAS.T:Ivir\HA1, ftΔECDΔ5-6.Scer\UAS.T:Ivir\HA1, ftΔECDΔ3-5.Scer\UAS.T:Ivir\HA1, ftΔECDΔ1-5.Scer\UAS.T:Ivir\HA1, ftΔ6-C.Scer\UAS.T:Ivir\HA1 or ftΔ5-C.Scer\UAS under the control of Scer\GAL4Act.PU in ftG-rv/ft8 animals does not rescue eclosion but strongly improves hair planar cell polarity defects in the abdomen of pharate adults. Expression of ftΔECDΔN-1.Scer\UAS.T:Ivir\HA1 or ftΔECDΔN-2.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act.PU in ftG-rv/ft8 animals does not rescue hair planar cell polarity defects in the wing. Expression of ftΔN-1.Scer\UAS.T:Ivir\HA1 or ftΔN-2.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act.PU in ftG-rv/ft8 animals rescues eclosion and weakly improves hair planar cell polarity defects in the abdomen. Expression of ftΔN-4.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act.PU in ftG-rv/ft8 animals weakly rescues eclosion and very weakly improves hair planar cell polarity defects in the abdomen. Expression of ftΔN-5.Scer\UAS.T:Ivir\HA1, ftΔN-6.Scer\UAS.T:Ivir\HA1 or ftΔICD.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act.PU in ftG-rv/ft8 animals does not rescue eclosion but very weakly improves hair planar cell polarity defects in the abdomen of pharate adults. Expression of ftΔ8-C.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act.PU in ftG-rv/ft8 animals weakly rescues eclosion and strongly improves hair planar cell polarity defects in the abdomen.
Expression of ftScer\UAS.cMa or ftΔECD.Scer\UAS in the posterior wing pouch, driven by Scer\GAL4en-e16E, rescues the overgrowth phenotype of ftG-rv/ft8 mutants in this region, but does not rescue overgrowth in the anterior. Expression of ftΔECD.Scer\UAS, under the control of either Scer\GAL4Act5C.PI or Scer\GAL4da.G32, rescues the lethality of ftG-rv/ft8 mutants and is effective in rescuing the wing disc overgrowth phenotype. Expression of ftΔECD.Scer\UAS under the control of Scer\GAL4Act5C.PI in ftG-rv/ft8 mutants partially rescues the abdominal planar cell polarity defect. Expression of ftScer\UAS.cMa under the control of Scer\GAL4Act5C.PI rescues the lethality and wing disc overgrowth phenotype of ftG-rv/ft8 mutants and partially rescues the abdominal planar cell polarity defect.
ftScer\UAS.cMa; Scer\GAL4da.G32 rescues the pupal lethality of ftG-rv/ft8 and substantially rescues planar cell polarity and tarsal segment defects in these animals.
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
Bridges, 1930.
Revertant.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (11)
References (45)