FlyBase Allele Report: Dmel\ft[G-rv]

General Information

Symbol

Dmel\ft^G-rv

Species

D. melanogaster

Name

FlyBase ID

FBal0004805

Feature type

allele

Associated gene

Dmel\ft

Associated Insertion(s)

412{}ft^G-rv

Carried in Construct

Also Known As

fat^G-rv, ft^Grv, G^rv

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Mahoney et al., 1991)

loss of function allele

(Willecke et al., 2006)

Mutagen

spontaneous

(Mahoney et al., 1991, Bryant et al., 1988)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

ft^G

(Mahoney et al., 1991)

Cytology

Nature of the lesion

Statement

Reference

There is an mdg3 retrotransposon inserted in position S2929 that introduces a stop codon in the 27th cadherin domain. It also contains additional rearrangements in the first intron and an insertion in the 33rd cadherin domain.

(Matakatsu and Blair, 2006)

As for ft^G with an additional rearrangement that has not yet been fully characterized.

(Mahoney et al., 1991)

Insertion components

412{}ft^G-rv

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates dentatorubral-pallidoluysian atrophy

modeled by Gug^75QN.UAS

(Napoletano et al., 2011)

model of carcinoma

is exacerbated by Raf^UAS.F179

(Garoia et al., 2005)

is exacerbated by rho^UAS.cdCa

(Garoia et al., 2005)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity (with ft⁸)

(Mao et al., 2006)

abnormal cell polarity | cell non-autonomous | somatic clone

(Yang et al., 2002)

abnormal cell polarity | pharate adult stage (with ft⁸)

(Matakatsu and Blair, 2006)

abnormal cell polarity | somatic clone

(Matakatsu and Blair, 2006, Yang et al., 2002)

abnormal neuroanatomy | embryonic stage

(Keder et al., 2015)

abnormal planar polarity (with ft⁸)

(Matakatsu and Blair, 2012)

abnormal planar polarity | adult stage | somatic clone, with Scer\GAL4^ey.PH

(Brittle et al., 2012)

abnormal planar polarity | pharate adult stage (with ft⁸)

(Misra and Irvine, 2016)

abnormal planar polarity | pupal stage (with ft⁸)

(Matakatsu and Blair, 2008)

abnormal planar polarity | somatic clone

(Fanto et al., 2003)

abnormal size (with ft⁸), with ft^ΔD.Tag:V5

(Bosch et al., 2014)

abnormal size | larval stage (with ft⁸)

(Bosch et al., 2014)

abnormal size | third instar larval stage (with ft⁸)

(Matakatsu and Blair, 2006)

abnormal size | third instar larval stage (with ft⁸), with Scer\GAL4^Act5C.PI, ft^{ΔICD.UAS.Tag:HA}

(Matakatsu and Blair, 2006)

abnormal size | third instar larval stage (with ft⁸), with Scer\GAL4^da.G32, ft^{ΔICD.UAS.Tag:HA}

(Matakatsu and Blair, 2006)

decreased cell number | third instar larval stage (with ft⁸)

(Reddy and Irvine, 2011)

hyperplasia

(Ziosi et al., 2010)

hyperplasia (with ft⁴)

(Garoia et al., 2000)

hyperplasia (with ft⁸)

(Cho and Irvine, 2004)

hyperplasia | somatic clone

(Garoia et al., 2000)

increased cell number

(Garoia et al., 2005)

increased cell number | somatic clone

(Ren et al., 2010)

increased cell number | somatic clone (with ft⁸)

(Willecke et al., 2006)

lethal

(Misra and Irvine, 2016)

lethal (with ft⁸)

(Gaspar et al., 2015, Bosch et al., 2014, Brittle et al., 2012)

lethal | recessive

(Mahoney et al., 1991)

lethal - all die before end of pupal stage

(Matakatsu and Blair, 2006)

lethal - all die before end of pupal stage (with Df(2L)sc19-1)

(Garoia et al., 2000)

lethal - all die before end of pupal stage (with ft⁸)

(Matakatsu and Blair, 2008, Willecke et al., 2006)

lethal - all die during embryonic stage | recessive

(Bryant et al., 1988)

partially lethal - majority die (with ft⁸)

(Silva, 2006)

short lived (with ft¹)

(Fanto et al., 2003)

some die during embryonic stage | recessive

(Bryant et al., 1988)

some die during pupal stage

(Matakatsu and Blair, 2006)

some die during pupal stage (with Df(2L)sc19-1)

(Garoia et al., 2000)

some die during pupal stage (with ft⁸)

(Matakatsu and Blair, 2008, Willecke et al., 2006)

visible | adult stage | somatic clone

(Gaspar et al., 2015)

visible | somatic clone

(Fanto et al., 2003)

Phenotype Manifest In

abdomen | pupal stage (with ft⁸)

(Matakatsu and Blair, 2008)

abdominal tergite marginal bristle | pharate adult stage (with ft⁸)

(Misra and Irvine, 2016)

adult thorax | somatic clone

(Fanto et al., 2003)

embryonic/larval dorsal trunk (with ft⁸)

(Chung et al., 2009)

embryonic/larval glial cell | third instar larval stage (with ft⁸)

(Reddy and Irvine, 2011)

external sensory organ (with ft⁸)

(Matakatsu and Blair, 2006)

eye | adult stage | somatic clone

(Gaspar et al., 2015)

eye | somatic clone

(Garoia et al., 2005)

eye disc

(Garoia et al., 2005)

eye disc | pupal stage (with ft⁸)

(Matakatsu and Blair, 2008)

eye disc | third instar larval stage (with ft⁸)

(Gaspar et al., 2015)

imaginal disc (with Df(2L)sc19-1)

(Garoia et al., 2000)

imaginal disc (with ft⁸)

(Bosch et al., 2014, Willecke et al., 2006)

interommatidial bristle | somatic clone | increased number

(Garoia et al., 2005)

interommatidial cell | pupal stage | somatic clone | increased number

(Gaspar et al., 2015)

intestinal stem cell | somatic clone

(Ren et al., 2010)

macrochaeta (with ft⁸)

(Mao et al., 2006)

mesothoracic tergum & chaeta | somatic clone

(Garoia et al., 2000)

mesothoracic tergum | somatic clone

(Garoia et al., 2000)

microchaeta (with ft⁸)

(Mao et al., 2006)

ommatidium | adult stage | somatic clone, with Scer\GAL4^ey.PH

(Brittle et al., 2012)

ommatidium | cell non-autonomous | somatic clone

(Yang et al., 2002)

ommatidium | somatic clone

(Yang et al., 2002)

photoreceptor cell R3 | somatic clone

(Yang et al., 2002)

photoreceptor cell R4 | ectopic | somatic clone

(Yang et al., 2002)

RP2 motor neuron | embryonic stage

(Keder et al., 2015)

wing (with ft⁸), with ft^ΔD.Tag:V5

(Bosch et al., 2014)

wing (with ft⁸), with ft^ΔF.Tag:V5

(Bosch et al., 2014)

wing & chaeta | somatic clone

(Garoia et al., 2000)

wing | somatic clone

(Matakatsu and Blair, 2006, Fanto et al., 2003, Garoia et al., 2000)

wing disc

(Garoia et al., 2005)

wing disc (with ft⁸)

(Matakatsu and Blair, 2006, Cho and Irvine, 2004)

wing disc (with ft⁸), with Scer\GAL4^Act5C.PI, ft^{ΔICD.UAS.Tag:HA}

(Matakatsu and Blair, 2006)

wing disc (with ft⁸), with Scer\GAL4^da.G32, ft^{ΔICD.UAS.Tag:HA}

(Matakatsu and Blair, 2006)

wing disc | pupal stage (with ft⁸)

(Matakatsu and Blair, 2008)

wing disc | third instar larval stage (with ft⁸)

(Gaspar et al., 2015)

wing vein | somatic clone

(Garoia et al., 2000)

Detailed Description

Statement

Reference

ft^G-rv homozygotes are lethal.

ft^G-rv/ft⁸ transheterozygous pharates exhibit severe hair orientation defects in the anterior dorsal abdomen, as compared to controls.

(Misra and Irvine, 2016)

ft^G-rv/ft^G-rv eyes (created by the EGUF method in otherwise heterozygous animals) contain significantly increased number of interomatidial cells (IOC) in the pupal retina compared to wild-type, the size and shape of adult eyes is also affected.

ft^G-rv/ft⁸ transheterozygotes rarely survive to third instar larval stage (but never to adulthood) and the survivors display decreased number of photoreceptor cells in the eye disc and overgrown wing discs compared to wild-type.

(Gaspar et al., 2015)

ft^G-rv homozygous mutant embryos display a significant increase in the frequency of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage.

(Keder et al., 2015)

ft^G-rv/ft⁸; ft^T:SV5\V5 wings are normal; ft^G-rv/ft⁸; ft^ΔD.T:SV5\V5 wings are slightly overgrown, rounder and have decreased spacing between the crossveins compared to controls; ft^G-rv/ft⁸; ft^ΔF.T:SV5\V5 wings are not enlarged but have greatly reduced spacing between the crossveins.

ft⁸/ft^G-rv and ft⁸/ft⁶¹ imaginal discs are larger and have more folds than controls.

(Bosch et al., 2014)

ft^G-rv/ft⁸ mutant larvae show a decrease in the number of glial cells in the eye disc and a lack of glial overgrowth.

(Reddy and Irvine, 2011)

ft^G-rv mutant MARCM clones contain 5-7 cells per clone, compared to 2-3 cells in wild-type clones. These clones contain differentiated absorptive enterocytes and secretory enteroendocrine cells indicating that intestine stem cell differentiation continues as in wild-type.

(Ren et al., 2010)

ft^G-rv/ft⁸ stage 16 embryos have shorter dorsal trunks than normal, although they are contiguous.

(Chung et al., 2009)

Wing and eye imaginal discs show overgrowth in ft⁸/ft^G-rv pupae. The pupal abdomens are not overgrown, but show planar cell polarity defects.

(Matakatsu and Blair, 2008)

ft^G-rv homozygous mutant clones generated in the male germline develop normally. 16 cells are observed per cyst, and cell size and morphology are indistinguishable from neighbouring control cells.

(Sun et al., 2008)

In ft⁸/ft^G-rv mutants, the polarity of hairs and bristles on the adult cuticle is disturbed, resulting in swirling patterns of hairs and bristles in many tissues.

(Mao et al., 2006)

The wing discs of ft^G-rv/ft⁸ larvae show extensive tissue overgrowth during the late third instar.

Expression of ft^{ΔICD.Scer\UAS.T:Ivir\HA1}, under the control of either Scer\GAL4^Act5C.PI or Scer\GAL4^da.G32, enhances the wing disc tissue overgrowth phenotype of ft^G-rv/ft⁸ mutants.

Large ft^G-rv clones in the distal region of the wing blade between L2 and L3 show planar cell polarity defects.

The abdomens of ft^G-rv/ft⁸ mutants have fairly normal morphology at the pharate stages although they have a characteristic swirl of hairs that have lost their normal polarity.

(Matakatsu and Blair, 2006)

ft⁸/ft^G-rv mutant animals die during the early stages of pupal development and show severely overgrown imaginal disc derivatives.

(Willecke et al., 2006)

Mutant wing and eye discs exhibit an overgrowth phenotype. ft^G-rv homozygous mutant eyes (created as clones) are slightly larger than normal with duplicated bristle cells and severe morphological defects. The distribution of cell cycle phases and cell size in ft^G-rv mutants are indistinguishable from wild-type.

(Garoia et al., 2005)

Late third instar ft⁸/ft^G-rv wing discs exhibit disproportionate overgrowth of the proximal wing pouch compared to other parts of the wing disc.

(Cho and Irvine, 2004)

ft¹/ft^G-rv transheterozygotes are short lived as compared to controls.

(Fanto et al., 2003)

About 50% of ommatidia within somatic clones in the adult eye frequently have reversed dorsal ventral polarity. Occasional reversals of polarity are also seen in wild-type ommatidia bordering the polar side of the mutant tissue. When homozygous mutant clones are made specifically in the equatorial R3/R4 precursor, almost all (96%) of the consequent ommatidia are in the reverse polarity. When clones are made specifically in the polar R3/R4 precursor, all of the consequent ommatidia are in the wild-type polarity. The mutant photoreceptor precursor eventually becomes an R4 photoreceptor 98% of the time (50% in wild-type).

(Yang et al., 2002)

ft^G-rv/Df(2L)sc19-1 larvae reach the pupal stage at 7-9 days and show hyperplastic discs. ft^k07918/ft^G-rv larvae show a delay in pupariation of 1-2 days and have a maximal disc size similar to that of ft^k07918 homozygotes. Wing discs from ft⁴/ft^G-rv larvae are larger, they pupate at 7-9 days and die as pupae. Somatic wing clones of homozygous ft^G-rv in a M(2)24F¹ background tend to fill one or several intervein sectors but a fraction do cross the dorsal ventral boundary. The clones tend to fill proximal regions of the wing. The distal borders of clones are rounded, and are smooth in contrast with the indented borders found in control clones. Inn all of these features ft^k07918 and ft^G-rv are more extreme than ft⁴. Trichome density in clones is higher than wild-type clones - about 1.7 times that of wild-type, indicating that cell size is smaller than wild-type. Somatic clones in the notum (of homozygous ft⁴ in a M(2)24F¹ background) are large, with more cells than control clones, leading to an increase in the total notum surface. They contain many more chaetae (1.6 times wild-type) and higher cell density (1.4 times). Similar deviations occur in the legs and head capsule. tergite clones however shoe normal patterns of pigment chaetae and trichomes.

(Garoia et al., 2000)

Hemizygous ft^G-rv and transheterozygous ft^G-rv/ft^G animals die at the pupal stage and the larvae have overgrown discs.

(Bryant et al., 1988)

Does not show G phenotype. Does not exaggerate ft. Lethal in combination with G. RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^ey.PH, d^GC13, ft^G-rv has abnormal planar polarity | somatic clone | adult stage phenotype, enhanceable by yki^UAS.cHa/Scer\GAL4^ey.PH

(Brittle et al., 2012)

ft^G-rv has hyperplasia phenotype, enhanceable by Myc^UAS.cZa/Scer\GAL4^hh.PU

(Ziosi et al., 2010)

ft⁸/ft^G-rv has abnormal size | third instar larval stage phenotype, enhanceable by ds^UAO71

(Matakatsu and Blair, 2006)

ft⁸/ft^G-rv has partially lethal - majority die phenotype, enhanceable by ex[+]/ex^e1

(Silva, 2006)

ft^G-rv has increased cell number | cell non-autonomous phenotype, enhanceable by Scer\GAL4^dpp.blk1/Raf^UAS.F179

(Garoia et al., 2005)

ft^G-rv has increased cell number phenotype, enhanceable by rho^UAS.cdCa/Scer\GAL4^dpp.blk1

(Garoia et al., 2005)

ft^G-rv/ft¹ has short lived phenotype, enhanceable by Gug¹¹/Gug[+]

(Fanto et al., 2003)

Suppressed by

Statement

Reference

ft^G-rv has lethal phenotype, suppressible by Dlish^c/Dlish^c

(Misra and Irvine, 2016)

ft⁸/ft^G-rv has lethal phenotype, suppressible by wts^UAS.Tag:MYC/Scer\GAL4^αTub84B.PL

(Pan et al., 2013)

ft⁸/ft^G-rv has abnormal planar polarity | third instar larval stage phenotype, suppressible by wts^UAS.Tag:MYC/Scer\GAL4^αTub84B.PL

(Pan et al., 2013)

Scer\GAL4^αTub84B.PL, ft⁸/ft^G-rv, wts^UAS.Tag:MYC has abnormal planar polarity | adult stage phenotype, suppressible by ft^Tag:V5

(Pan et al., 2013)

Scer\GAL4^αTub84B.PL, ft⁸/ft^G-rv, wts^UAS.Tag:MYC has abnormal planar polarity | adult stage phenotype, suppressible | partially by ft^ΔICD.Tag:V5

(Pan et al., 2013)

Scer\GAL4^αTub84B.PL, ft⁸/ft^G-rv, wts^UAS.Tag:MYC has abnormal planar polarity | adult stage phenotype, suppressible | partially by ft::Hsap\FAT4^Tag:V5

(Pan et al., 2013)

ft^ΔF.Tag:V5, ft⁸/ft^G-rv has abnormal planar polarity | adult stage phenotype, suppressible | partially by ft::Hsap\FAT4^Tag:V5

(Pan et al., 2013)

Scer\GAL4^ey.PH, ft^G-rv has abnormal planar polarity | somatic clone | adult stage phenotype, suppressible | partially by d^GC13/d^GC13

(Brittle et al., 2012)

ft⁸/ft^G-rv has abnormal planar polarity phenotype, suppressible | partially by ft^{λftICD.UAS.Tag:HA}/Scer\GAL4^Act.PU

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv has lethal phenotype, suppressible by Scer\GAL4^Tub.PU/wts^UAS.Tag:MYC

(Feng and Irvine, 2009)

ft⁸/ft^G-rv has abnormal size phenotype, suppressible by Scer\GAL4^Tub.PU/wts^UAS.Tag:MYC

(Feng and Irvine, 2009)

ft⁸/ft^G-rv has lethal | pupal stage phenotype, suppressible | partially by app^e6

(Matakatsu and Blair, 2008)

ft⁸/ft^G-rv has abnormal planar polarity | pupal stage phenotype, suppressible | partially by app^e6

(Matakatsu and Blair, 2008)

ft⁸/ft^G-rv has increased cell number | somatic clone phenotype, suppressible by yki^B5

(Willecke et al., 2006)

ft^G-rv has increased cell number phenotype, suppressible by Raf^K497M.UAS/Scer\GAL4^dpp.blk1

(Garoia et al., 2005)

ft⁸/ft^G-rv has hyperplasia phenotype, suppressible | partially by wg^spd-fg

(Cho and Irvine, 2004)

ft^G-rv has abnormal cell polarity | somatic clone phenotype, suppressible | partially by ds^UAO71

(Yang et al., 2002)

NOT suppressed by

Statement

Reference

ft⁸/ft^G-rv has lethal phenotype, non-suppressible by Zyx^Δ41/Zyx^Δ41

(Gaspar et al., 2015)

ft^G-rv has visible | adult stage phenotype, non-suppressible by Zyx^Δ41/Zyx^Δ41

(Gaspar et al., 2015)

ft⁸/ft^G-rv has abnormal size | larval stage phenotype, non-suppressible by Scer\GAL4^αTub84B.PL/Fbxl7^UAS.Tag:FLAG

(Bosch et al., 2014)

ft⁸/ft^G-rv has lethal phenotype, non-suppressible by Scer\GAL4^αTub84B.PL/Fbxl7^UAS.Tag:FLAG

(Bosch et al., 2014)

ft⁸/ft^G-rv has abnormal planar polarity | adult stage phenotype, non-suppressible by wts^UAS.Tag:MYC/Scer\GAL4^αTub84B.PL

(Pan et al., 2013)

ft⁸/ft^G-rv has abnormal planar polarity phenotype, non-suppressible by Scer\GAL4^Act.PU/ds^UAS.cTa

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv has abnormal planar polarity phenotype, non-suppressible by Scer\GAL4^Tub.PU/wts^UAS.Tag:MYC

(Feng and Irvine, 2009)

Enhancer of

Statement

Reference

ft^G-rv is an enhancer | somatic clone of abnormal planar polarity phenotype of Scer\GAL4^dpp.blk1, fz^UAS.cAa

(Ma et al., 2003)

ft^G-rv is an enhancer of visible phenotype of Scer\GAL4^en-e16E, arm^UAS.cWa

(Greaves et al., 1999)

ft^G-rv is an enhancer of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, arm^UAS.cWa

(Greaves et al., 1999)

NOT Enhancer of

Statement

Reference

ft^G-rv/ft^G-rv is a non-enhancer of abnormal size phenotype of Dlish^c

(Misra and Irvine, 2016)

Suppressor of

Statement

Reference

ft^G-rv is a suppressor of visible phenotype of H^Scer\UAS.cMa/H^UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Müller et al., 2005)

ft^G-rv/ft[+] is a suppressor of visible phenotype of CycE^JP

(Brumby et al., 2004)

ft^G-rv is a suppressor of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

ft^G-rv is a suppressor of visible phenotype of Scer\GAL4^en-e16E, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

NOT Suppressor of

Statement

Reference

ft^G-rv is a non-suppressor of lethal | pupal stage phenotype of Csk^j1D8/Csk^S030003

(Read et al., 2004)

Other

Statement

Reference

cno², ft^G-rv/ft[+] has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

Scer\GAL4^Tub.PU, d¹/d^GC13, ft⁸/ft^G-rv, wts^UAS.cUa has abnormal planar polarity | adult stage phenotype

(Brittle et al., 2012)

Scer\GAL4^hh.PU, Myc^UAS.cZa, ft^G-rv has increased cell size phenotype

(Ziosi et al., 2010)

Scer\GAL4^dpp.blk1, ft^G-rv, Raf^K497M.UAS has increased cell death phenotype

(Garoia et al., 2005)

Gug³⁵, ft^G-rv/ft¹ has lethal | dominant phenotype

(Fanto et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^ey.PH, d^GC13, ft^G-rv has ommatidium | somatic clone | adult stage phenotype, enhanceable by yki^UAS.cHa/Scer\GAL4^ey.PH

(Brittle et al., 2012)

ft⁸/ft^G-rv has wing disc phenotype, enhanceable by ds^UAO71

(Matakatsu and Blair, 2006)

ft^G-rv has eye | somatic clone phenotype, enhanceable by rho^UAS.cdCa/Scer\GAL4^ey.PH

(Garoia et al., 2005)

ft^G-rv has wing disc | cell non-autonomous phenotype, enhanceable by Scer\GAL4^dpp.blk1/Raf^UAS.F179

(Garoia et al., 2005)

ft^G-rv has eye disc | cell non-autonomous phenotype, enhanceable by Scer\GAL4^dpp.blk1/Raf^UAS.F179

(Garoia et al., 2005)

ft^G-rv has eye disc phenotype, enhanceable by rho^UAS.cdCa/Scer\GAL4^dpp.blk1

(Garoia et al., 2005)

ft^G-rv has wing disc phenotype, enhanceable by rho^UAS.cdCa/Scer\GAL4^dpp.blk1

(Garoia et al., 2005)

NOT Enhanced by

Statement

Reference

Scer\GAL4^αTub84B.PL, ft⁸/ft^G-rv, wts^UAS.Tag:MYC has wing phenotype, non-enhanceable by ft^ΔEGF.Tag:V5

(Pan et al., 2013)

ft^G-rv has wing disc phenotype, non-enhanceable by Raf^K497M.UAS/Scer\GAL4^dpp.blk1

(Garoia et al., 2005)

ft^G-rv has interommatidial bristle | increased number | somatic clone phenotype, non-enhanceable by Raf^K497M.UAS/Scer\GAL4^ey.PH

(Garoia et al., 2005)

Suppressed by

Statement

Reference

ft^G-rv has interommatidial cell | increased number | somatic clone | pupal stage phenotype, suppressible | partially by Zyx^Δ41/Zyx^Δ41

(Gaspar et al., 2015)

ft⁸/ft^G-rv has wing disc | third instar larval stage phenotype, suppressible by wts^UAS.Tag:MYC/Scer\GAL4^αTub84B.PL

(Pan et al., 2013)

Scer\GAL4^αTub84B.PL, ft⁸/ft^G-rv, wts^UAS.Tag:MYC has wing hair phenotype, suppressible by ft^Tag:V5

(Pan et al., 2013)

Scer\GAL4^αTub84B.PL, ft⁸/ft^G-rv, wts^UAS.Tag:MYC has abdomen phenotype, suppressible by ft^Tag:V5

(Pan et al., 2013)

Scer\GAL4^αTub84B.PL, ft⁸/ft^G-rv, wts^UAS.Tag:MYC has wing hair phenotype, suppressible | partially by ft^ΔICD.Tag:V5

(Pan et al., 2013)

Scer\GAL4^αTub84B.PL, ft⁸/ft^G-rv, wts^UAS.Tag:MYC has abdomen phenotype, suppressible | partially by ft^ΔICD.Tag:V5

(Pan et al., 2013)

Scer\GAL4^αTub84B.PL, ft⁸/ft^G-rv, wts^UAS.Tag:MYC has wing hair phenotype, suppressible | partially by ft::Hsap\FAT4^Tag:V5

(Pan et al., 2013)

Scer\GAL4^αTub84B.PL, ft⁸/ft^G-rv, wts^UAS.Tag:MYC has abdomen phenotype, suppressible by ft::Hsap\FAT4^Tag:V5

(Pan et al., 2013)

ft^ΔF.Tag:V5, ft⁸/ft^G-rv has wing hair phenotype, suppressible | partially by ft::Hsap\FAT4^Tag:V5

(Pan et al., 2013)

Scer\GAL4^ey.PH, ft^G-rv has ommatidium | somatic clone | adult stage phenotype, suppressible | partially by d^GC13/d^GC13

(Brittle et al., 2012)

ft⁸/ft^G-rv has wing disc | pupal stage phenotype, suppressible by app^e6

(Matakatsu and Blair, 2008)

ft⁸/ft^G-rv has eye disc | pupal stage phenotype, suppressible by app^e6

(Matakatsu and Blair, 2008)

ft⁸/ft^G-rv has abdomen | pupal stage phenotype, suppressible | partially by app^e6

(Matakatsu and Blair, 2008)

ft^G-rv has eye disc phenotype, suppressible by Raf^K497M.UAS/Scer\GAL4^dpp.blk1

(Garoia et al., 2005)

ft^G-rv has eye | somatic clone phenotype, suppressible by Raf^K497M.UAS/Scer\GAL4^ey.PH

(Garoia et al., 2005)

ft⁸/ft^G-rv has wing disc phenotype, suppressible | partially by wg^spd-fg

(Cho and Irvine, 2004)

ft^G-rv has ommatidium | somatic clone phenotype, suppressible | partially by ds^UAO71

(Yang et al., 2002)

ft^G-rv has photoreceptor cell R3 | somatic clone phenotype, suppressible | partially by ds^UAO71

(Yang et al., 2002)

ft^G-rv has photoreceptor cell R4 | ectopic | somatic clone phenotype, suppressible | partially by ds^UAO71

(Yang et al., 2002)

NOT suppressed by

Statement

Reference

ft⁸/ft^G-rv has eye disc | third instar larval stage phenotype, non-suppressible by Zyx^Δ41/Zyx^Δ41

(Gaspar et al., 2015)

ft⁸/ft^G-rv has wing disc | third instar larval stage phenotype, non-suppressible by Zyx^Δ41/Zyx^Δ41

(Gaspar et al., 2015)

ft⁸/ft^G-rv has imaginal disc phenotype, non-suppressible by Scer\GAL4^αTub84B.PL/Fbxl7^UAS.Tag:FLAG

(Bosch et al., 2014)

ft⁸/ft^G-rv has wing hair phenotype, non-suppressible by wts^UAS.Tag:MYC/Scer\GAL4^αTub84B.PL

(Pan et al., 2013)

Scer\GAL4^αTub84B.PL, ft⁸/ft^G-rv, wts^UAS.Tag:MYC has wing phenotype, non-suppressible by ft^ΔEGF.Tag:V5

(Pan et al., 2013)

ft^ΔD.Tag:V5, ft⁸/ft^G-rv has wing phenotype, non-suppressible by ft::Hsap\FAT4^Tag:V5

(Pan et al., 2013)

ft^G-rv has wing disc phenotype, non-suppressible by Raf^K497M.UAS/Scer\GAL4^dpp.blk1

(Garoia et al., 2005)

ft^G-rv has interommatidial bristle | increased number | somatic clone phenotype, non-suppressible by Raf^K497M.UAS/Scer\GAL4^ey.PH

(Garoia et al., 2005)

Enhancer of

Statement

Reference

ft^G-rv/ft[+] is an enhancer of eye photoreceptor cell phenotype of Gug^75QN.UAS, Scer\GAL4^ninaE.PT

(Napoletano et al., 2011)

ft^G-rv/ft[+] is an enhancer of crossvein phenotype of fj^{t14.Tag:Golgi(hGALNT3)}

(Strutt et al., 2004)

ft^G-rv/ft[+] is an enhancer of wing phenotype of fj^{t14.Tag:Golgi(hGALNT3)}

(Strutt et al., 2004)

ft^G-rv is an enhancer | somatic clone of wing hair | anterior | P-stage phenotype of Scer\GAL4^dpp.blk1, fz^UAS.cAa

(Ma et al., 2003)

ft^G-rv is an enhancer of wing phenotype of Scer\GAL4^en-e16E, arm^UAS.cWa

(Greaves et al., 1999)

ft^G-rv is an enhancer of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, arm^UAS.cWa

(Greaves et al., 1999)

NOT Enhancer of

Statement

Reference

ft^G-rv/ft^G-rv is a non-enhancer of wing phenotype of Dlish^c

(Misra and Irvine, 2016)

ft^G-rv/ft^G-rv is a non-enhancer of abdominal tergite marginal bristle phenotype of Dlish^c

(Misra and Irvine, 2016)

Suppressor of

Statement

Reference

ft^G-rv is a suppressor of eye phenotype of H^Scer\UAS.cMa/H^UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Müller et al., 2005)

ft^G-rv/ft[+] is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2004)

ft^G-rv is a suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

ft^G-rv is a suppressor of wing phenotype of Scer\GAL4^en-e16E, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

Other

Statement

Reference

cno², ft^G-rv/ft[+] has RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

Scer\GAL4^αTub84B.PL, ft⁸/ft^G-rv, wts^UAS.Tag:MYC has abdomen phenotype

(Pan et al., 2013)

Scer\GAL4^Tub.PU, d¹/d^GC13, ft⁸/ft^G-rv, wts^UAS.cUa has ommatidium | adult stage phenotype

(Brittle et al., 2012)

Scer\GAL4^Tub.PU, ft⁸/ft^G-rv, wts^UAS.Tag:MYC has wing vein phenotype

(Feng and Irvine, 2009)

app^e6, ft⁸/ft^G-rv has wing hair phenotype

(Matakatsu and Blair, 2008)

Scer\GAL4^ey.PH, ft^G-rv, Raf^K497M.UAS has eye | somatic clone phenotype

(Garoia et al., 2005)

Gug³⁵, ft^G-rv/ft¹ has eye phenotype

(Fanto et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The lethality of ft^G-rv homozygotes is suppressed by the additional homozygosity for Dlish^c, but adults are recovered only at about one third of the expected frequency.

Additional homozygosity for ft^G-rv does not exacerbate the small wing area phenotype and mild abdomen hair orientation defects observed in Dlish^c single homozygotes.

(Misra and Irvine, 2016)

The supernumerary inter-ommatidial cells in the pupal retina phenotype characteristic for ft^G-rv/ft^G-rv eyes (created by the EGUF method in otherwise heterozygous animals) can be partially suppressed by combination with Zyx^Δ41/Zyx^Δ41 but this does not affect the size of the mutant adult eyes.

The low rate of survival of ft^G-rv/ft⁸ transheterozygotes to third instar larval stage (and never to adulthood), the loss of photoreceptor cells in the eye discs or the overgrowth of the wing disc cannot be suppressed by combination with Zyx^Δ41/Zyx^Δ41.

(Gaspar et al., 2015)

The proportion of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage is significantly increased in cno²/+;ft^G-rv/+ double heterozygous embryos compared to either of the single heterozygotes or wild type.

(Keder et al., 2015)

Scer\GAL4^αTub84B.PL-mediated expression of Fbxl7^{Scer\UAS.T:Zzzz\FLAG} does not suppress ft⁸/ft^G-rv phenotypes.

(Bosch et al., 2014)

Flies expressing wts^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^αTub84B.PL rescue the lethality and third instar larval wing disc overgrowth phenotypes seen in ft⁸/ft^G-rv mutants, but the wing hair phenotypes are still present. Rather than pointing distally as in wild type, the wing hairs in these flies are misoriented and swirling patterns can be observed. A strong planar cell polarity defect is also seen in the abdominal hairs and the wing anterior-posterior crossvein distance is reduced.

Expression of ft^T:SV5\V5 fully rescues the planar cell polarity defects seen in ft⁸/ft^G-rv mutant wings and abdomens expressing wts^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^αTub84B.PL. The reduced anterior-posterior crossvein distance phenotype is also suppressed.

Flies expressing ft^{ΔEGF.T:SV5\V5} (co-expressed with wts^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^αTub84B.PL) in a ft⁸/ft^G-rv mutant background do not exhibit any wing phenotypes compared to flies expressing wts^{Scer\UAS.T:Hsap\MYC} alone.

Expression of ft^{ΔICD.T:SV5\V5} partially rescues the planar cell polarity defects seen in ft⁸/ft^G-rv mutant wings and abdomens expressing wts^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^αTub84B.PL. The reduction in anterior-posterior crossvein distance appears to be partially rescued, although crossveins are often incomplete, making it difficult to calculate. The abdominal and wing hair polarity defects are also partially suppressed.

(Pan et al., 2013)

Expression of btl::ft^{ftICD.T:Ivir\HA1,T:λ\cI-DD} under the control of Scer\GAL4^Act.PU in ft^G-rv/ft⁸ animals rescues disc overgrowth, allows eclosion and improves hair planar cell polarity defects in the wing and abdomen.

Expression of ds^Scer\UAS.cTa under the control of Scer\GAL4^Act.PU in ft^G-rv/ft⁸ animals does not detectably improve hair planar cell polarity defects in the abdomen.

(Matakatsu and Blair, 2012)

dm^Scer\UAS.cZa overexpression clones (under the control of Scer\GAL4^hh.PU) found in the posterior of the wing disc strongly enhance the proliferative activity of ft^G-rv mutant cells. In addition these cells are larger in dm^Scer\UAS.cZa clones than in a wild-type background.

(Ziosi et al., 2010)

The lethality and overgrowth phenotypes of ft^G-rv/ft⁸ animals are rescued by Scer\GAL4^tub.PU-mediated overexpression of wts^{Scer\UAS.T:Hsap\MYC}. However, these animals still show obvious planar cell polarity phenotypes in multiple tissues.

(Feng and Irvine, 2009)

The disc overgrowth phenotypes of ft⁸/ft^G-rv pupae are suppressed by app^e6 and the abdominal planar cell polarity (PCP) and lethality phenotypes are reduced in the double mutants compared to the ft⁸/ft^G-rv single mutant. The double mutant adults have PCP defects in proximal portions of the wing, but not in the distal wing.

(Matakatsu and Blair, 2008)

ft^G-rv allows recovery of Df(1)su(s)R194/+ clones in the adult eye in animals with mosaic eyes containing two genotypes of cells with respect to RpL36; cells which are Df(1)su(s)R194/+ and cells in which the haplo-insufficiency of Df(1)su(s)R194/+ for RpL36 has been rescued by RpL36^+t4 (in a wild-type background the Df(1)su(s)R194/+ clones are eliminated by cell competition and are not seen in the adult eye in these animals).

(Tyler et al., 2007)

ds^UAO71, ft^G-rv/ft⁸ double mutant larvae show an enhancement of the wing disc overgrowth phenotype of ft^G-rv/ft⁸ single mutants.

(Matakatsu and Blair, 2006)

One copy of ex^e1 enhances the lethality of ft⁸/ft^G-rv animals. Those that are wild-type for ex^e1 but mutant for ft⁸/ft^G-rv emerge as 0.32% of the progeny, whereas those that are also mutant for ex^e1 emerge as 0.269% of the progeny, a small, but statistically significant difference.

(Silva, 2006)

Nearly all ft⁸ yki^B5/ft^G-rv mutant animals develop into adults, although they do not hatch from the pupal case as they have some leg defects and head overgrowths. In contrast, all ft⁸/ft^G-rv mutant animals die during the early stages of pupal development and show severely overgrown imaginal disc derivatives. This indicates that yki^B5 suppresses the overgrowth phenotypes of ft⁸/ft^G-rv mutant imaginal discs.

(Willecke et al., 2006)

When rho^{Scer\UAS.cdCa} is driven by Scer\GAL4^dpp.blk1 in a ft^G-rv background a significant enhancement is seen in the ft^G-rv overgrowth phenotype in the Scer\GAL4^dpp.blk1 expression territory. When phl^{Scer\UAS.F179} is driven by Scer\GAL4^dpp.blk1 in a ft^G-rv background a significant enhancement is seen in the ft^G-rv overgrowth phenotype, throughout the whole imaginal disc. When phl^{K497M.Scer\UAS} is driven by Scer\GAL4^dpp.blk1 in a ft^G-rv background a suppression is seen in the ft^G-rv overgrowth phenotype in the eye disc, but no effect is seen in the wing disc. An increase in cell non-autonomous cell death is seen in these discs. When rho^{Scer\UAS.cdCa} is driven by Scer\GAL4^ey.PH in ft^G-rv mutant eyes, significantly enlarged eyes are seen. When phl^{K497M.Scer\UAS} is driven by Scer\GAL4^ey.PH in ft^G-rv mutant eyes, eyes are significantly smaller than wild-type. However eye bristle duplications are still seen.

(Garoia et al., 2005)

Overgrowth of the proximal wing disc in ft⁸/ft^G-rv animals is suppressed by wg^spd-fg/wg^spd-fg.

(Cho and Irvine, 2004)

Reduction in the distance between anterior and posterior cross-veins in fj^{t14.T:Hsap\GALNT3} flies is enhanced by ft^G-rv/+.

(Strutt et al., 2004)

The short lived phenotype of ft¹/ft^G-rv transheterozygotes is enhanced by Gug¹¹ heterozygosity.

(Fanto et al., 2003)

fz^Scer\UAS.cAa; Scer\GAL4^dpp.blk1 flies have a zone extending anterior to the dpp expression domain in which wing hairs point away from the fz overexpressing cells. When such wings have somatic clones of ft^G-rv in the anterior of the wing, this zone enlarges to fill the clone.

(Ma et al., 2003)

When ft^G-rv/ds^UAO71 homozygous mutant clones are made specifically in the equatorial R3/R4 precursor, most (64%) of the consequent ommatidia are in the reverse polarity. When clones are made specifically in the polar R3/R4 precursor, almost all (97.5%) of the consequent ommatidia are in the wild-type polarity. The mutant photoreceptor precursor eventually becomes an R4 photoreceptor 80% of the time (50% in wild-type).

(Yang et al., 2002)

Xenogenetic Interactions

Statement

Reference

Expression of ft::Hsap\FAT4^T:SV5\V5 partially rescues the planar cell polarity defects seen in ft⁸/ft^G-rv mutant wings expressing wts^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^αTub84B.PL. The abdominal hair defects are completely rescued and the reduction in anterior-posterior crossvein distance is partially suppressed.

Expression of one copy of ft::Hsap\FAT4^T:SV5\V5 fails to suppress the wing overgrowth phenotypes seen in ft⁸/ft^G-rv mutant flies expressing one copy of ft^ΔD.T:SV5\V5.

Expression of one copy of ft::Hsap\FAT4^T:SV5\V5 partially suppresses the wing crossvein spacing and hair polarity phenotypes seen in ft⁸/ft^G-rv mutant flies expressing one copy of ft^ΔF.T:SV5\V5.

(Pan et al., 2013)

Complementation and Rescue Data

Fails to complement

ft^NY1

(Tyler et al., 2007)

Rescued by

ft⁸/ft^G-rv is rescued by ft^Tag:V5

(Bosch et al., 2014)

ft⁸/ft^G-rv is rescued by ft^ΔA.Tag:V5

(Pan et al., 2013)

ft⁸/ft^G-rv is rescued by ft^ΔB.Tag:V5

(Pan et al., 2013)

ft⁸/ft^G-rv is rescued by ft^ΔC.Tag:V5

(Pan et al., 2013)

ft⁸/ft^G-rv is rescued by ft^P32.Tag:V5

(Pan et al., 2013)

ft⁸/ft^G-rv is rescued by ft^mIV.Tag:V5

(Pan et al., 2013)

ft⁸/ft^G-rv is rescued by ft^Tag:V5

(Feng and Irvine, 2009)

ft⁸/ft^G-rv is rescued by ft^UAS.cMa/Scer\GAL4^da.G32

(Matakatsu and Blair, 2006)

ft⁸/ft^G-rv is rescued by ft^UASp.cSa/Scer\GAL4^αTub84B.PL

(Simon, 2004)

Partially rescued by

ft⁸/ft^G-rv is partially rescued by ft^ΔD.Tag:V5

(Bosch et al., 2014)

ft⁸/ft^G-rv is partially rescued by ft^ΔF.Tag:V5

(Bosch et al., 2014)

ft⁸/ft^G-rv is partially rescued by ft^ΔD.Tag:V5

(Pan et al., 2013)

ft⁸/ft^G-rv is partially rescued by ft^ΔD.Tag:V5/ft^ΔF.Tag:V5

(Pan et al., 2013)

ft⁸/ft^G-rv is partially rescued by ft^ΔE.Tag:V5

(Pan et al., 2013)

ft⁸/ft^G-rv is partially rescued by ft^ΔF.Tag:V5

(Pan et al., 2013)

ft⁸/ft^G-rv is partially rescued by ft^mV.Tag:V5

(Pan et al., 2013)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔECD.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by ft^{ΔECD2.UAS.Tag:HA}/Scer\GAL4^Act.PU

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by ft^UAS.cMa/Scer\GAL4^Act.PU

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔECDΔN-1.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by ft^{ΔECDΔN-2.UAS.Tag:HA}/Scer\GAL4^Act.PU

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔECDΔN-4.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔECDΔ9-C.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔECDΔ8-C.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔECDΔ7-C.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by ft^{ΔECDΔ6-C.UAS.Tag:HA}/Scer\GAL4^Act.PU

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔECDΔ5-C.UAS}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by ft^{ΔECDΔ4-C.UAS.Tag:HA}/Scer\GAL4^Act.PU

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔECDΔ2-C.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔECDΔ1-C.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by ft^{ΔECDΔ5-6.UAS.Tag:HA}/Scer\GAL4^Act.PU

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔECDΔ1-3.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔECDΔ3-4.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔECDΔ3-5.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by ft^{ΔECDΔ1-5.UAS.Tag:HA}/Scer\GAL4^Act.PU

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔN-1.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔN-2.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔN-4.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔN-5.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔN-6.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by ft^{Δ9-C.UAS.Tag:HA}/Scer\GAL4^Act.PU

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{Δ8-C.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{Δ7-C.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{Δ6-C.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by ft^Δ5-C.UAS/Scer\GAL4^Act.PU

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act.PU/ft^{ΔICD.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is partially rescued by ft^UAS.cMa/Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI

(Matakatsu and Blair, 2006)

ft⁸/ft^G-rv is partially rescued by ft^UAS.cMa/Scer\GAL4^en-e16E

(Matakatsu and Blair, 2006)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^en-e16E/ft^ΔECD.UAS

(Matakatsu and Blair, 2006)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI/ft^ΔECD.UAS

(Matakatsu and Blair, 2006)

ft⁸/ft^G-rv is partially rescued by Scer\GAL4^da.G32/ft^ΔECD.UAS

(Matakatsu and Blair, 2006)

ft⁸/ft^G-rv is partially rescued by ft^UAS.cMa/Scer\GAL4^da.G32

(Matakatsu and Blair, 2004)

Not rescued by

ft⁸/ft^G-rv is not rescued by ft^ΔEGF.Tag:V5

(Pan et al., 2013)

ft⁸/ft^G-rv is not rescued by ft^ΔICD.Tag:V5

(Pan et al., 2013)

ft⁸/ft^G-rv is not rescued by ft^{ICD.UAS.Tag:HA}/Scer\GAL4^Act.PU

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is not rescued by Scer\GAL4^Act.PU/ft^{ΔECDΔN-5.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is not rescued by Scer\GAL4^Act.PU/ft^{ΔECDΔN-6.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is not rescued by Scer\GAL4^Act.PU/ft^{ΔECDΔICD.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ft⁸/ft^G-rv is not rescued by Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI/ft^{ΔICD.UAS.Tag:HA}

(Matakatsu and Blair, 2006)

ft⁸/ft^G-rv is not rescued by Scer\GAL4^da.G32/ft^{ΔICD.UAS.Tag:HA}

(Matakatsu and Blair, 2006)

ft⁸/ft^G-rv is not rescued by Scer\GAL4^en-e16E/ft^{ΔICD.UAS.Tag:HA}

(Matakatsu and Blair, 2006)

Comments

Expression of ft^ΔA.T:SV5\V5 rescues the lethality associated with ft⁸/ft^G-rv. The rescued animals appear morphologically normal and only a negligible wing hair planar cell polarity phenotype is seen. The abdominal hair polarity phenotype is fully rescued. The intercellular ridges that run from anterior to posterior in the ft⁸/ft^G-rv mutant posterior wings run proximally to distal in rescue animals, as is seen in wild type.

Expression of ft^ΔB.T:SV5\V5 rescues the lethality associated with ft⁸/ft^G-rv. The rescued animals appear morphologically normal and only a negligible wing hair planar cell polarity phenotype is seen. The abdominal hair polarity phenotype is fully rescued. The intercellular ridges that run from anterior to posterior in the ft⁸/ft^G-rv mutant posterior wings run proximally to distal in rescue animals, as is seen in wild type.

Expression of ft^ΔC.T:SV5\V5 rescues the lethality associated with ft⁸/ft^G-rv. The rescued animals appear morphologically normal and only a negligible wing hair planar cell polarity phenotype is seen. The abdominal hair polarity phenotype is fully rescued. The intercellular ridges that run from anterior to posterior in the ft⁸/ft^G-rv mutant posterior wings run proximally to distal in rescue animals, as is seen in wild type.

Expression of ft^ΔD.T:SV5\V5 rescues the lethality associated with ft⁸/ft^G-rv. However the wings of the rescued flies are 29% larger than normal and the distance between the anterior and posterior crossveins in 73% of wild type. Only a negligible wing hair planar cell polarity phenotype is seen. The abdominal hair polarity phenotype is fully rescued. The intercellular ridges continue to run from anterior to posterior as in the ft⁸/ft^G-rv mutant posterior wings, rather than proximally to distal, as is seen in wild type.

Expression of ft^ΔE.T:SV5\V5 rescues the lethality associated with ft⁸/ft^G-rv. However the wings of the rescued flies are 8% larger than normal and the distance between the anterior and posterior crossveins in 87% of wild type. Only a negligible wing hair planar cell polarity phenotype is seen. The abdominal hair polarity phenotype is fully rescued. The intercellular ridges that run from anterior to posterior in the ft⁸/ft^G-rv mutant posterior wings run proximally to distal in rescue animals, as is seen in wild type.

Expression of ft^ΔF.T:SV5\V5 rescues the lethality associated with ft⁸/ft^G-rv. However the wings of the rescued flies are 4% larger than normal and shorter and wider than normal wings. The distance between the anterior and posterior crossveins is also reduced. Wing hair planar cell polarity phenotypes are still present, with the most proximal part of the wing, the costa, the most severely affected. A subtle phenotype is observed in the abdomen. The intercellular ridges continue to run from anterior to posterior as in the ft⁸/ft^G-rv mutant posterior wings, rather than proximally to distal, as is seen in wild type.

Expression of ft^{ΔEGF.T:SV5\V5} fails to rescue the lethality associated with ft⁸/ft^G-rv.

Expression of one copy of ft^ΔF.T:SV5\V5 partially suppresses the wing overgrowth phenotype seen in ft⁸/ft^G-rv mutant flies expressing one copy of ft^ΔD.T:SV5\V5.

Expression of one copy of ft^ΔD.T:SV5\V5 partially suppresses the wing crossvein spacing and hair polarity phenotypes seen in ft⁸/ft^G-rv mutant flies expressing one copy of ft^ΔF.T:SV5\V5.

Expression of ft^{ΔICD.T:SV5\V5} fails to rescue the lethality associated with ft⁸/ft^G-rv and the wing discs these flies are overgrown compared to controls.

Expression of ft^P32.T:SV5\V5 rescues the lethality and wing overgrowth phenotype associated with ft⁸/ft^G-rv.

Expression of ft^mI.T:SV5\V5 rescues the lethality associated with ft⁸/ft^G-rv. However the wings of the rescued flies are 18% larger than normal. Wing hair polarity defects are partially rescued and the abdominal hair defects are fully rescued.

Expression of ft^mV.T:SV5\V5 rescues the lethality associated with ft⁸/ft^G-rv. However the wings of the rescued flies are larger than normal.

Expression of ft^mIV.T:SV5\V5 rescues the lethality associated with ft⁸/ft^G-rv. The abdominal and wing hair polarity phenotypes are fully rescued.

(Pan et al., 2013)

for both ft alleles in GA22:

Expression of ft^Scer\UAS.cMa under the control of Scer\GAL4^Act.PU in ft^G-rv/ft⁸ animals substantially improves hair planar cell polarity defects in the abdomen.

Expression of ft^{ΔECD.Scer\UAS.T:Ivir\HA1} or ft^{ΔECD2.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act.PU in ft^G-rv/ft⁸ animals rescues disc overgrowth, allows eclosion and substantially improves hair planar cell polarity defects in the wing and abdomen.

Expression of ft^{ICD.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act.PU in ft^G-rv/ft⁸ animals does not rescue disc overgrowth or eclosion and does not detectably improve hair planar cell polarity defects in the abdomen.

Expression of ft^{ΔECDΔN-1.Scer\UAS.T:Ivir\HA1} or ft^{ΔECDΔN-2.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act.PU in ft^G-rv/ft⁸ animals rescues eclosion and very weakly improves hair planar cell polarity defects in the abdomen.

Expression of ft^{ΔECDΔN-4.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act.PU in ft^G-rv/ft⁸ animals rescues eclosion but does not detectably improve hair planar cell polarity defects in the abdomen.

Expression of ft^{ΔECDΔN-5.Scer\UAS.T:Ivir\HA1}, ft^{ΔECDΔN-6.Scer\UAS.T:Ivir\HA1} or ft^{ΔECDΔICD.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act.PU in ft^G-rv/ft⁸ animals does not rescue eclosion and does not detectably improve hair planar cell polarity defects in the abdomen.

Expression of ft^{ΔECDΔ9-C.Scer\UAS.T:Ivir\HA1}, ft^{ΔECDΔ8-C.Scer\UAS.T:Ivir\HA1}, ft^{ΔECDΔ7-C.Scer\UAS.T:Ivir\HA1}, ft^{ΔECDΔ6-C.Scer\UAS.T:Ivir\HA1}, ft^{ΔECDΔ1-3.Scer\UAS.T:Ivir\HA1}, ft^{ΔECDΔ3-4.Scer\UAS.T:Ivir\HA1}, ft^{Δ9-C.Scer\UAS.T:Ivir\HA1} or ft^{Δ7-C.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act.PU in ft^G-rv/ft⁸ animals rescues eclosion and strongly improves hair planar cell polarity defects in the abdomen.

Expression of ft^{ΔECDΔ5-C.Scer\UAS}, ft^{ΔECDΔ4-C.Scer\UAS.T:Ivir\HA1}, ft^{ΔECDΔ2-C.Scer\UAS.T:Ivir\HA1}, ft^{ΔECDΔ1-C.Scer\UAS.T:Ivir\HA1}, ft^{ΔECDΔ5-6.Scer\UAS.T:Ivir\HA1}, ft^{ΔECDΔ3-5.Scer\UAS.T:Ivir\HA1}, ft^{ΔECDΔ1-5.Scer\UAS.T:Ivir\HA1}, ft^{Δ6-C.Scer\UAS.T:Ivir\HA1} or ft^{Δ5-C.Scer\UAS} under the control of Scer\GAL4^Act.PU in ft^G-rv/ft⁸ animals does not rescue eclosion but strongly improves hair planar cell polarity defects in the abdomen of pharate adults.

Expression of ft^{ΔECDΔN-1.Scer\UAS.T:Ivir\HA1} or ft^{ΔECDΔN-2.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act.PU in ft^G-rv/ft⁸ animals does not rescue hair planar cell polarity defects in the wing.

Expression of ft^{ΔN-1.Scer\UAS.T:Ivir\HA1} or ft^{ΔN-2.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act.PU in ft^G-rv/ft⁸ animals rescues eclosion and weakly improves hair planar cell polarity defects in the abdomen.

Expression of ft^{ΔN-4.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act.PU in ft^G-rv/ft⁸ animals weakly rescues eclosion and very weakly improves hair planar cell polarity defects in the abdomen.

Expression of ft^{ΔN-5.Scer\UAS.T:Ivir\HA1}, ft^{ΔN-6.Scer\UAS.T:Ivir\HA1} or ft^{ΔICD.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act.PU in ft^G-rv/ft⁸ animals does not rescue eclosion but very weakly improves hair planar cell polarity defects in the abdomen of pharate adults.

Expression of ft^{Δ8-C.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Act.PU in ft^G-rv/ft⁸ animals weakly rescues eclosion and strongly improves hair planar cell polarity defects in the abdomen.

(Matakatsu and Blair, 2012)

Expression of ft^Scer\UAS.cMa or ft^{ΔECD.Scer\UAS} in the posterior wing pouch, driven by Scer\GAL4^en-e16E, rescues the overgrowth phenotype of ft^G-rv/ft⁸ mutants in this region, but does not rescue overgrowth in the anterior.

Expression of ft^{ΔECD.Scer\UAS}, under the control of either Scer\GAL4^Act5C.PI or Scer\GAL4^da.G32, rescues the lethality of ft^G-rv/ft⁸ mutants and is effective in rescuing the wing disc overgrowth phenotype.

Expression of ft^{ΔECD.Scer\UAS} under the control of Scer\GAL4^Act5C.PI in ft^G-rv/ft⁸ mutants partially rescues the abdominal planar cell polarity defect.

Expression of ft^Scer\UAS.cMa under the control of Scer\GAL4^Act5C.PI rescues the lethality and wing disc overgrowth phenotype of ft^G-rv/ft⁸ mutants and partially rescues the abdominal planar cell polarity defect.

(Matakatsu and Blair, 2006)

ft^Scer\UAS.cMa; Scer\GAL4^da.G32 rescues the pupal lethality of ft^G-rv/ft⁸ and substantially rescues planar cell polarity and tarsal segment defects in these animals.

(Matakatsu and Blair, 2004)

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Mutant

Wild-type

Stocks (3)

Bloomington

1894

ft^G-rv/SM5

44258

w^*; ft^G-rv P{neoFRT}40A/CyO; P{UAS-wts.MYC}3/TM6B, Tb¹

Kyoto

106561

ft^G-rv/SM5

Notes on Origin

Discoverer

Bridges, 1930.

Revertant.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

FtG-rv

(Greaves et al., 1999)

G-rv

(Weber et al., 2012)

G^rv

(Mahoney et al., 1991, Bryant et al., 1988)

fat^<up>G-rv</up>

(Bosveld et al., 2012)

fat^G-rv

(Misra and Irvine, 2016, Ambegaonkar et al., 2012, Feng and Irvine, 2009, Sopko et al., 2009, Mao et al., 2006, Müller et al., 2005, Brumby et al., 2004)

fat^Grv

(Bosch et al., 2014)

ft^G-rv

(Matakatsu et al., 2017, Misra and Irvine, 2016, Gaspar et al., 2015, Keder et al., 2015, Bossuyt et al., 2014, Pan et al., 2013, Zhao et al., 2013, Brittle et al., 2012, Matakatsu and Blair, 2012, Kawamori et al., 2011, Ren et al., 2010, Ziosi et al., 2010, Chung et al., 2009, Matakatsu and Blair, 2008, Oh and Irvine, 2008, Sun et al., 2008, Cho et al., 2006, Matakatsu and Blair, 2006, Willecke et al., 2006)

ft^GRV

(Napoletano et al., 2011, Silva, 2006, Fanto et al., 2003)

ft^GrV

(Rodrigues-Campos and Thompson, 2014)

ft^Grv

(Oh and Irvine, 2008, Tyler et al., 2007, Cho et al., 2006)

Name Synonyms

Gull-reverted

Secondary FlyBase IDs

References (46)

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