FlyBase Allele Report: Dmel\ftz[11]

Heterozygotes with ftz^Ual1 exhibit a higher frequency of heat shock induced transformation of abdominal segment 1 than those embryos carrying three wild type copies of ftz (Dp(3;3)D1/+). An addition of another wild type ftz to these embryos results in another modest increase in frequency of transformation.

(Welte et al., 1995)

Parasegments 1 and 2 are fused and the salivary gland placodes occupy the posterior half of the fused parasegment in the Scr expression domain.

(Panzer et al., 1992)

ftz embryos lack even-numbered hh stripes.

(Tabata et al., 1992)

Interacts with RpII140^wimp maternal effect.

(Parkhurst and Ish-Horowicz, 1991)

The eve stripes mature as wild-type.

(Lawrence and Johnston, 1989)

P{ftzK}; ftz¹¹/ftz¹³ individuals die as embryos or larvae. 66% of P{ftzG}; ftz¹¹/ftz¹³ individuals survive to adulthood. P{ftzK}; ftz¹¹/ftz¹³ embryos are identified by weak segmentation defects in the CNS.

(Doe et al., 1988)

Odd numbered denticle bands missing.

(Jack et al., 1988)

ftz¹¹/Df(3R)Scr show abnormal segmentation of the germ band, with at least half the segments missing. The segmentation of the ventral nerve cord is also affected. The labial lobe cannot be seen, and the H piece of the larval mouthparts is missing in late embryos. Dorsal closure is disrupted.

(Wakimoto et al., 1984)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

ftz¹¹ has epidermis phenotype, enhanceable by hb^D1

(Bender et al., 1987)

ftz¹¹ has nervous system phenotype, enhanceable by hb^D1

(Bender et al., 1987)

Enhancer of

Statement

Reference

ftz¹¹ is an enhancer of phenotype of hb^D1

(Bender et al., 1987)

Additional Comments

Genetic Interactions

Statement

Reference

In double mutant with hb^D1 segmentation defects approximate to the expectations of simple additivity of the two mutants but the cuticular element defects and nervous system defects are more severe.

(Bender et al., 1987)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ftz¹¹/ftz¹³ is rescued by ftz^+tDa

(Dong et al., 1998)

Partially rescued by

ftz¹¹/ftz¹³ is partially rescued by ftz^{Δ257-316.αTub84B}

(Argiropoulos et al., 2003)

ftz¹¹/ftz¹³ is partially rescued by ftz^αTub84B.PA

(Argiropoulos et al., 2003)

ftz¹¹/ftz¹³ is partially rescued by ftz^T263D

(Dong et al., 1998)

Not rescued by

ftz¹¹/ftz¹³ is not rescued by ftz^T263A

(Dong et al., 1998)

Comments

21 to 71% of ftz¹¹/ftz¹³ flies are rescued to adulthood by ftz^+tDa. 2 to 5% of ftz¹¹/ftz¹³ flies are rescued to adulthood by ftz^T263D. Larval cuticles of ftz¹¹/ftz¹³ animals rescued by ftz^T263D are indistinguishable from wild-type. ftz¹¹/ftz¹³ flies are not rescued to adulthood by ftz^T263A. Larval cuticles of ftz¹¹/ftz¹³ animals carrying ftz^T263A have pair-wise deletions of even-numbered parasegments. The penetrance of the phenotype is variable and defects in each ftz-dependent parasegment (PS) occur with a characteristic frequency. These range from the most to least frequently affected as follows: PS2 > PS6 > PS10 = PS4 > PS12 = PS14 > PS8.