Open Close
General Information
Symbol
Dmel\ftz11
Species
D. melanogaster
Name
FlyBase ID
FBal0004816
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ftzw20, EfW20
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Insertion of 4.9kb of DNA within a 3.2kb HindIII fragment that hybridizes to the 1.8kb ftz transcription unit.

Insertion components
?{}ftz11
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The maxillary and labial lobes are fused in mutant embryos.

Mutant embryos are deficient for cuticular structures derived from the even numbered parasegments.

Heterozygotes with ftzUal1 exhibit a higher frequency of heat shock induced transformation of abdominal segment 1 than those embryos carrying three wild type copies of ftz (Dp(3;3)D1/+). An addition of another wild type ftz to these embryos results in another modest increase in frequency of transformation.

Parasegments 1 and 2 are fused and the salivary gland placodes occupy the posterior half of the fused parasegment in the Scr expression domain.

ftz embryos lack even-numbered hh stripes.

Interacts with RpII140wimp maternal effect.

The eve stripes mature as wild-type.

P{ftzK}; ftz11/ftz13 individuals die as embryos or larvae. 66% of P{ftzG}; ftz11/ftz13 individuals survive to adulthood. P{ftzK}; ftz11/ftz13 embryos are identified by weak segmentation defects in the CNS.

Odd numbered denticle bands missing.

ftz11/Df(3R)Scr show abnormal segmentation of the germ band, with at least half the segments missing. The segmentation of the ventral nerve cord is also affected. The labial lobe cannot be seen, and the H piece of the larval mouthparts is missing in late embryos. Dorsal closure is disrupted.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

ftz11 has epidermis phenotype, enhanceable by hbD1

ftz11 has nervous system phenotype, enhanceable by hbD1

Enhancer of
Statement
Reference

ftz11 is an enhancer of phenotype of hbD1

Additional Comments
Genetic Interactions
Statement
Reference

In double mutant with hbD1 segmentation defects approximate to the expectations of simple additivity of the two mutants but the cuticular element defects and nervous system defects are more severe.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Partially rescued by
Not rescued by
Comments

21 to 71% of ftz11/ftz13 flies are rescued to adulthood by ftz+tDa. 2 to 5% of ftz11/ftz13 flies are rescued to adulthood by ftzT263D. Larval cuticles of ftz11/ftz13 animals rescued by ftzT263D are indistinguishable from wild-type. ftz11/ftz13 flies are not rescued to adulthood by ftzT263A. Larval cuticles of ftz11/ftz13 animals carrying ftzT263A have pair-wise deletions of even-numbered parasegments. The penetrance of the phenotype is variable and defects in each ftz-dependent parasegment (PS) occur with a characteristic frequency. These range from the most to least frequently affected as follows: PS2 > PS6 > PS10 = PS4 > PS12 = PS14 > PS8.

Images (0)
Mutant
Wild-type
Stocks (5)
Notes on Origin
Discoverer

Wakimoto.

Comments
Comments

The expression of l(1)sc is altered during stage 9 in homozygous mutant embryos.

Wild type embryos under a heat shock regime exhibit homeotic transformations of abdominal segment one, a phenocopy of ftzUal1.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (61)