FlyBase Allele Report: Dmel\fu[57]

General Information

Symbol

Dmel\fu⁵⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0004890

Feature type

allele

Associated gene

Dmel\fu

Associated Insertion(s)

Carried in Construct

Also Known As

fu^W3

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

diepoxybutane

Nature of the Allele

Allele class

Mutagen

diepoxybutane

(Therond et al., 1996, Preat et al., 1993, Busson et al., 1988)

Progenitor genotype

Cytology

Description

Deletion causing frameshift at residue 612 causing deletion of the carboxy terminal 193 amino acids.

(Robbins et al., 1997)

Deletion of genomic sequences 2872-2897, only the first 612 amino acids are present followed by 11 new amino acids.

(Therond et al., 1996)

Mutation in the putative regulatory domain. Class II fu allele, affects the carboxy domain of the protein by changing the open reading frame in the 5' region.

(Preat et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:18,659,807..18,659,832 [+]

Comment:

26bp deletion

(Therond et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Busson et al., 1988)

visible

(Busson et al., 1988)

Phenotype Manifest In

wing vein

(Busson et al., 1988)

Detailed Description

Statement

Reference

strong wing phenotype - veins L3 and L4 fused all along length; strong viability phenotype - ratio of the number of fused flies to wild type in fu/+ X fu/Y is 0.25-0.5; weak fecundity phenotype - ratio of eggs laid by fu/fu versus fu/+ sisters is 0.5-1.0; intermediate maternal effect on segmentation - percent of embryos with all segments entirely duplicated is 25-70%.

(Busson et al., 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

fu⁵⁷ has phenotype, enhanceable by Su(fu)^LP

(Preat et al., 1993)

Other

Statement

Reference

Su(fu)^LP, fu⁵⁷ has wing phenotype

(Preat et al., 1993)

Su(fu)^LP, fu⁵⁷ has leg phenotype

(Preat et al., 1993)

Su(fu)^LP, fu⁵⁷ has haltere phenotype

(Preat et al., 1993)

Su(fu)^LP, fu⁵⁷ has wing blade anterior compartment phenotype

(Preat et al., 1993)

Su(fu)^LP, fu⁵⁷ has leg anterior compartment phenotype

(Preat et al., 1993)

Su(fu)^LP, fu⁵⁷ has haltere anterior compartment phenotype

(Preat et al., 1993)

Additional Comments

Genetic Interactions

Statement

Reference

When in combination with Su(fu)^LP heterozygotes individuals die as pupae. Adult escapers display wings, halteres and legs that have duplication of structures in the anterior compartment and shortening along the proximal-distal axis. Embryos derived from heterozygotes with Su(fu) mutants display a segment polarity phenotype: thoracic denticle belts are absent, last two rows of abdominal denticle belts are absent and a mirror image duplication of anterior rows of abdominal denticle belts.

(Preat et al., 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Class II mutation based on interaction with Su(fu)^LP, suppression of embryonic and adult phenotype but display an additional phenotype.

(Therond et al., 1996)

Class II allele.

(Robbins et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fu⁵⁷

fu^W3

(Robbins et al., 1997, Therond et al., 1996, Preat et al., 1993, Busson et al., 1988)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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