Allele Dmel\fy²

General Information
Symbol	Dmel\fy²	Species	D. melanogaster
Name		FlyBase ID	FBal0004916
Feature type	allele	Associated gene	Dmel\fy

Map ( GBrowse )
Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Collier and Gubb, 1997)
Mutagen	ethyl methanesulfonate (Grell, 1969, Collier and Gubb, 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2L:8,402,433..8,402,433 reported_na_change=G?A reported_pr_change=??@ evidence=experimental na_change=G8402433A pr_change=W197@\|fy-PA (Collier and Gubb, 1997)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Nucleotide substitution: G?A. Amino acid replacement: ??@. Predicted to produce a protein lacking the C-terminal 220 amino acids. (Collier and Gubb, 1997)
Carried on aberration	In(2L)el94 (Roote, 1998.3.17)
Cytology
Phenotypic Data
Phenotypic Class
	planar polarity defective (Lee and Adler, 2002, Grell, 1969) planar polarity defective (with fy⁶) (Lee and Adler, 2002) viable (Collier and Gubb, 1997) visible (Grell, 1969) visible \| recessive (Collier and Gubb, 1997)
Phenotype Manifest In
	macrochaeta (Grell, 1969) microchaeta & adult thorax (Grell, 1969) wing & trichome (Collier and Gubb, 1997) wing cell (Wong and Adler, 1993) wing hair (Wong and Adler, 1993) wing hair (with fy⁶) (Lee and Adler, 2002) wing hair & 1st posterior cell (Lee and Adler, 2002) wing hair & 3rd posterior cell (Lee and Adler, 2002) wing margin bristle (Grell, 1969)
Detailed Description
	Statement Reference Wing hairs in the C region and E region of the wing point in a posterior direction. fy⁶/fy² wings show a weak polarity phenotype with occasional multiple wing hairs. (Lee and Adler, 2002) Hemizygous flies show an altered pattern of hair orientation on the wings. The phenotype is significantly stronger at 18^oC than at 29^oC. Hair polarity of homozygous clones in the wing resembles that seen in the wings of homozygous mutant flies, except near the borders of the clone, where the polarity is intermediate between mutant and wild-type. fy²/fy⁵ and fy²/fy⁶ flies have a stronger phenotype than fy⁵ and fy⁶ hemizygotes respectively, suggesting that fy² shows some antimorphic character in combination with hypomorphic alleles. (Collier and Gubb, 1997) Many wing cells of homozygous flies form two or three hairs. Homozygous flies have disruptions in the pattern of wing hair polarity. The prehair initiation site is along the cell periphery, but not restricted to the distal vertex in pupal wing cells. Double mutants of fy² with fz¹, dsh¹ or pk¹ resemble fy² single mutants. Double mutants of fy² with mwh¹ resemble mwh¹ single mutants. (Wong and Adler, 1993) Rank: RK1 Macrochaetae are somewhat disarranged. Microchaetae on the thorax point towards the midline. Microchaetae on the wing margin stand out and are slightly irregular. The phenotype resembles in and fz mutants. (Grell, 1969)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference fy²/fy⁶ has planar polarity defective phenotype, enhanceable by Scer\GAL4^bi-md653/stan^Scer\UAS.cUa (Lee and Adler, 2002)
NOT Enhanced by
Statement Reference fy²/fy⁶ has planar polarity defective phenotype, non-enhanceable by Scer\GAL4^ptc-559.1/pk^Scer\UAS.cGa (Lee and Adler, 2002)
Enhancer of
Statement Reference fy[+]/fy² is an enhancer of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053 (Djiane and Mlodzik, 2010)
Suppressor of
Statement Reference fy² is a suppressor of planar polarity defective \| heat sensitive phenotype of fz^hs.PP (Lee and Adler, 2002) fy² is a suppressor of planar polarity defective phenotype of Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI, pk^{sple.Scer\UAS} (Lee and Adler, 2002)
Other
Statement Reference Scer\GAL4^ptc-559.1, dsh^Scer\UAS.cAa, fy² has planar polarity defective phenotype (Lee and Adler, 2002, Lee and Adler, 2002)
Phenotype Manifest In
Enhanced by
Statement Reference fy²/fy⁶ has wing hair phenotype, enhanceable by fz²³/fz³⁰ (Lee and Adler, 2002) fy²/fy⁶ has wing hair phenotype, enhanceable by Scer\GAL4^bi-md653/stan^Scer\UAS.cUa (Lee and Adler, 2002) fy² has wing hair & 1st posterior cell phenotype, enhanceable by mwh[+]/mwh¹ (Lee and Adler, 2002)
NOT Enhanced by
Statement Reference fy²/fy⁶ has wing hair phenotype, non-enhanceable by Scer\GAL4^ptc-559.1/pk^Scer\UAS.cGa (Lee and Adler, 2002)
Enhancer of
Statement Reference fy[+]/fy² is an enhancer of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053 (Djiane and Mlodzik, 2010)
Suppressor of
Statement Reference fy² is a suppressor of wing hair \| heat sensitive phenotype of fz^hs.PP (Lee and Adler, 2002) fy² is a suppressor of wing hair phenotype of Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI, pk^{sple.Scer\UAS} (Lee and Adler, 2002)
Other
Statement Reference Scer\GAL4^ptc-559.1, dsh^Scer\UAS.cAa, fy² has macrochaeta phenotype (Lee and Adler, 2002, Lee and Adler, 2002) Scer\GAL4^ptc-559.1, dsh^Scer\UAS.cAa, fy² has wing hair & 1st posterior cell phenotype (Lee and Adler, 2002, Lee and Adler, 2002)
Additional Comments
Genetic Interactions
Statement Reference Over-expression of stan by Scer\GAL4^bi-md653 induces an increase in the number of multiple wing hairs in fy⁶/fy² wings. The multiple hair cell phenotype of dsh^Scer\UAS.cAa expressed from Scer\GAL4^ptc-559.1 is additive with the multiple hair phenotypes of fy² and in^IH56. (Lee and Adler, 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	fy² is rescued by fy^+t3.2 (Collier and Gubb, 1997)
Comments	The fy² phenotype is completely rescued by fy^+t3.2. (Collier and Gubb, 1997) Allelism with fy¹ based on phenotype and location (fy¹ stated to be lost). (Grell, 1969)
Stocks ( 5 )
Bloomington	1298 cl¹ fy² nub² 1025 cl¹ fy² NimA⁶⁷⁶ 1064 T(2;3)ap^Xa, al¹ dpp^s1 cl¹ fy² NimA⁶⁷⁶ ap^Xa/al¹ dpp^s1 cl¹ fy² NimA⁶⁷⁶; rec¹ Ubx^bx-34e
Kyoto	106270 cl¹ fy² nub² 106172 cl¹ fy² NimA⁶⁷⁶
Notes on Origin
Discoverer	E. Grell, 1967

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	fy² (Strutt and Warrington, 2008, Djiane and Mlodzik, 2010, Lu et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 10 )
Research paper	Djiane and Mlodzik, 2010, PLoS ONE 5(6): e11228 The Drosophila GIPC homologue can modulate myosin based processes and planar cell polarity but is not essential for development. [FBrf0211141] Lu et al., 2010, Genetics 185(2): 549--558 The Drosophila planar polarity proteins inturned and multiple wing hairs interact physically and function together. [FBrf0211207] Strutt and Warrington, 2008, Development 135(18): 3103--3111 Planar polarity genes in the Drosophila wing regulate the localisation of the FH3-domain protein Multiple Wing Hairs to control the site of hair production. [FBrf0205732] Lee and Adler, 2004, Mech. Dev. 121(1): 37--49 The grainy head transcription factor is essential for the function of the frizzled pathway in the Drosophila wing. [FBrf0167844] Cohen et al., 2002, Dev. Cell 2(4): 437--448 DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis. [FBrf0146974] Lee and Adler, 2002, Genetics 160(4): 1535--1547 The function of the frizzled pathway in the Drosophila wing is dependent on inturned and fuzzy. [FBrf0147064] Collier and Gubb, 1997, Development 124(20): 4029--4037 Drosophila tissue polarity requires the cell-autonomous activity of the fuzzy gene, which encodes a novel transmembrane protein. [FBrf0099167] Wong and Adler, 1993, J. Cell Biol. 123(1): 209--221 Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells. [FBrf0064754] Grell, 1969, D. I. S. 44: 46--47 [New mutants report.] [FBrf0063488]
Personal communication to FlyBase	Roote, 1998.3.17, A few Adh region amendments/additions. A few Adh region amendments/additions. [FBrf0102081]

Allele Dmel\fy2

Allele Dmel\fy²