Allele Dmel\fz¹

General Information
Symbol	Dmel\fz¹	Species	D. melanogaster
Name		FlyBase ID	FBal0004917
Feature type	allele	Associated gene	Dmel\fz

Allele class	hypomorphic allele - genetic evidence
Mutagen	spontaneous
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Park et al., 1994)
Mutagen	spontaneous
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	planar polarity defective (Taylor et al., 1998, Lee and Adler, 2002) planar polarity defective \| cell non-autonomous \| somatic clone (Lee and Adler, 2002) visible (Adler et al., 1994)
Phenotype Manifest In
	bract (Lee and Adler, 2002) eye (Lee and Adler, 2002) joint (Lee and Adler, 2002) macrochaeta & adult abdomen \| somatic clone \| cell non-autonomous (Lee and Adler, 2002) microchaeta & adult abdomen \| somatic clone \| cell non-autonomous (Lee and Adler, 2002) microchaeta & adult thorax \| somatic clone \| cell non-autonomous (Lee and Adler, 2002) ommatidium (Lee and Adler, 2002) presumptive embryonic salivary gland (Harris and Beckendorf, 2007) RP2 motor neuron (Bhat, 1998) tarsal segment (Lee and Adler, 2002) wing & macrochaeta (Adler et al., 1994) wing disc (Lee and Adler, 2002) wing hair (Taylor et al., 1998)
Detailed Description
	Statement Reference Mutant embryos show salivary gland guidance defects; a large portion of the salivary gland curves towards the central nervous system, instead of lying parallel to the midline as in wild-type embryos. (Harris and Beckendorf, 2007) When mutant clones are made in the developing eye, no R-cell precursor nuclear migration phenotype was seen. (Houalla et al., 2005) Bristles and hairs on the adult abdomen and thorax show altered polarity. Clones reveal the effect shows domineering non-autonomy. fz¹ phenotypes differ from in¹ and fy¹ in two ways. In fz¹ the hairs on the scutellum show a complicated pattern rather than pointing anteriorly, and thorax microchaetae are not routinely split. On the leg, femoral bracts are mispositioned indicating abnormal polarity. Tarsal segments may have parts missing and/or duplicated and show cuticular blebs. Eyes show a rough eye phenotype due to ommatidial disorganisation. Pupal wings show miseversion phenotype - many pupae show an everting wing oriented anteriorly and sometimes dorsally. (Lee and Adler, 2002) Embryos lacking maternal and zygotic fz function (derived from a cross between fz¹/fz³⁰ males and females) are missing the RP2/sib lineage in 1-2 hemisegments in 10% of cases. Embryos lacking maternal and zygotic fz function (derived from a cross between fz¹/fz²³ males and females) are missing the RP2/sib lineage in 1-2 hemisegments in 11% of cases. (Bhat, 1998) Homozygous embryos derived from homozygous females have a negligible segment-polarity phenotype. Injection of dsRNA produced by annealing fz2^L.cKa and fz2^a.L.cKa RNA into these embryos results in segment polarity phenotypes. (Kennerdell and Carthew, 1998) Bristle polarity phenotype. (Adler et al., 1994) moderate thoracic bristle phenotype moderate wing-hair disorientation
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement Reference fz¹ is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl^{Scer\UAS.T:λ\cI-DD}, stumps^{Scer\UAS.T:Zzzz\FLAG} (Zhu et al., 2005)
NOT Suppressor of
Statement Reference fz¹ is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl^{Scer\UAS.T:λ\cI-DD}, stumps^{Scer\UAS.T:Zzzz\FLAG} (Zhu et al., 2005)
Other
Statement Reference fz3^G10, fz¹ has fertile phenotype (Sato et al., 1999, Sato et al., 1999) fz3^G10, fz¹ has viable phenotype (Sato et al., 1999, Sato et al., 1999)
Phenotype Manifest In
Enhanced by
Statement Reference fz¹ has presumptive embryonic salivary gland phenotype, enhanceable by drl^R343 (Harris and Beckendorf, 2007)
NOT Enhanced by
Statement Reference fz¹ has bract phenotype, non-enhanceable by fy¹ (Lee and Adler, 2002) fz¹ has bract phenotype, non-enhanceable by in¹ (Lee and Adler, 2002) fz¹ has joint phenotype, non-enhanceable by fy¹ (Lee and Adler, 2002) fz¹ has joint phenotype, non-enhanceable by in¹ (Lee and Adler, 2002) fz¹ has tarsal segment phenotype, non-enhanceable by fy¹ (Lee and Adler, 2002) fz¹ has tarsal segment phenotype, non-enhanceable by in¹ (Lee and Adler, 2002)
Suppressed by
Statement Reference fz¹ has wing disc \| P-stage phenotype, suppressible by fy¹ (Lee and Adler, 2002) fz¹ has wing disc \| P-stage phenotype, suppressible by in¹ (Lee and Adler, 2002)
NOT suppressed by
Statement Reference fz¹ has bract phenotype, non-suppressible by fy¹ (Lee and Adler, 2002) fz¹ has bract phenotype, non-suppressible by in¹ (Lee and Adler, 2002) fz¹ has eye phenotype, non-suppressible by fy¹ (Lee and Adler, 2002) fz¹ has eye phenotype, non-suppressible by in¹ (Lee and Adler, 2002) fz¹ has joint phenotype, non-suppressible by fy¹ (Lee and Adler, 2002) fz¹ has joint phenotype, non-suppressible by in¹ (Lee and Adler, 2002) fz¹ has microchaeta & adult thorax \| somatic clone \| cell non-autonomous phenotype, non-suppressible by in¹ (Lee and Adler, 2002) fz¹ has ommatidium phenotype, non-suppressible by fy¹ (Lee and Adler, 2002) fz¹ has ommatidium phenotype, non-suppressible by in¹ (Lee and Adler, 2002) fz¹ has tarsal segment phenotype, non-suppressible by fy¹ (Lee and Adler, 2002) fz¹ has tarsal segment phenotype, non-suppressible by in¹ (Lee and Adler, 2002)
Enhancer of
Statement Reference fz¹ is an enhancer of presumptive embryonic salivary gland phenotype of drl^R343 (Harris and Beckendorf, 2007)
NOT Enhancer of
Statement Reference fz¹ is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl^{Scer\UAS.T:λ\cI-DD}, stumps^{Scer\UAS.T:Zzzz\FLAG} (Zhu et al., 2005)
NOT Suppressor of
Statement Reference fz¹ is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl^{Scer\UAS.T:λ\cI-DD}, stumps^{Scer\UAS.T:Zzzz\FLAG} (Zhu et al., 2005) fz¹ is a non-suppressor of microchaeta & adult thorax phenotype of fy¹ (Lee and Adler, 2002) fz¹ is a non-suppressor of microchaeta & adult thorax phenotype of in¹ (Lee and Adler, 2002) fz¹ is a non-suppressor of ommatidium phenotype of Rac1^V12.hs.sev (Fanto et al., 2000)
Other
Statement Reference Df(3L)N2-27, fz¹ has RP2 motor neuron phenotype (Bhat, 1998) Scer\GAL4^hs.2sev, dsh^Scer\UAS.cNa, fz¹ has ommatidium phenotype (Strutt et al., 1997) Vang^A3, fz¹ has wing hair phenotype (Taylor et al., 1998, Taylor et al., 1998) Vang^A5, fz¹ has wing hair phenotype (Taylor et al., 1998, Taylor et al., 1998) Vang^Tbs42, fz¹ has wing hair phenotype (Taylor et al., 1998, Taylor et al., 1998)
Additional Comments
Genetic Interactions
Statement Reference drl^R343 ; fz¹ double mutants have a higher penetrance of salivary gland curving than is seen in either of the single mutants alone. (Harris and Beckendorf, 2007) Domineering non-autonomy of fz¹ clones is not suppressed by in¹. Leg phenotypes of fz¹ and fy¹ or in¹ are additive. (Lee and Adler, 2002) Parp^GMR.PU shows no genetic interaction with fz¹/+. (Uchida et al., 2002) All fz¹/fz¹; Df(3L)N2-27 double mutant embryos show RP2/sib lineage defects, with 6-11 hemisegments per embryo being affected. (Bhat, 1998) In double mutant combinations between Vang^A3, Vang^A5 and Vang^Tbs42 with fz¹, fz²⁵ and fz³⁰, the fz-in type of polarity pattern was slightly less abnormal than in either single mutant. (Taylor et al., 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescued by	fz¹ is partially rescued by Scer\GAL4^Act5C.PI/Scer\GAL4^Act5C.PI/fz^{P278L.Scer\UAS.T:Avic\GFP-EGFP} (Strutt, 2001)
Partially rescues	Scer\GAL4^hs.2sev/fz¹ partially rescues fz^Scer\UAS.cAa (Strutt et al., 1997)
Comments	fz¹ somatic clones in the eye in a fz^{sevE3.SevP.PS} background: In the center of clones, 15%-25% of ommatidia showed dorso-ventral inversions, as observed in eyes wholly mutant for fz in a fz^{sevE3.SevP.PS} background. However, on the polar edge of the clone, 40%-60% of ommatidia are inverted, whereas, on the equatorial edge, only 5% are inverted. These inversions are also seen on outside the clone, near its polar boundary. (Strutt and Strutt, 2002)
Stocks ( 5 )
Bloomington	1676 fz¹/TM1 5408 w^*; l(3)SG11¹ fz¹/TM6B, Tb¹
Kyoto	106445 fz¹/TM1 105945 fz¹ st¹ cp¹ in¹ kni^ri-1 p^p/TM1 106300 In(3LR)LD6, fz¹ st¹ cp¹ in¹ kni^ri-1/TM3, Sb¹ Ser¹
Notes on Origin
Discoverer	Bridges, 18th Feb. 1938.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	fz¹ (Harris and Beckendorf, 2007)
Name Synonym
Secondary FlyBase IDs

References ( 27 )

Generate a list of	All references relating to this allele ( 27 )

List References by type	Research paper ( 23 ) Supplementary material ( 1 ) Review ( 2 ) Book ( 1 )
Recent research papers (0)
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Allele Dmel\fz1

Allele Dmel\fz¹