Open Close
General Information
Symbol
Dmel\fz19
Species
D. melanogaster
Name
FlyBase ID
FBal0004935
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
fzJ22
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C14311901T

Reported nucleotide change:

C?T

Amino acid change:

P278L | fz-PA; P278L | fz-PC

Reported amino acid change:

P278L

Comment:

P278 is in the first cytoplasmic loop of the fz protein.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: P278L.

Mutation is in the first cytoplasmic loop of the fz protein.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

fz19/fz19 disrupted planar polarity is observable as aberrant orientation of ommatidia and wing hairs, compared to wild type controls. fz19/fz21 disrupted planar polarity is observable as the disrupted orientation of ommatidia, compared to wild type controls.

Homozygous fz19 mutants are viable but exhibit planar polarity defects.

Mutant adults have an average of 2.0 +/- 0.2 extra tarsal joints in the leg compared to wild type.

Approximately 16% of ommatidia are symmetrical in fz19/fz21 flies.

fz20/fz19 flies show defects in ommatidial polarity.

In the eyes of fz19/fz20 transheterozygotes, 10% of ommatidia are mispolarized.

fz19 has a moderate multiple wing hair phenotype in combination with fz30.

fz19/fz20 animals exhibit a weak eye phenotype - 9% of ommatidia show polarity defects.

Mutants show no significant disruption of ovarian morphology.

84.8% of ommatidia in fz19/fz20 mutant somatic clones in the eye are normal. 6.3% have rotated ommatidia, 6.1% have chirality defects, 2.5% are achiral (0.3% unscorable).

Mutant animals have a mutant planar cell polarity phenotype.

Autonomous phenotype in wing clones.

Moderate thoracic bristle phenotype; moderate wing-hair disorientation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

fz20/fz19 has cell polarity defective phenotype, enhanceable by dsh1/dsh[+]

fz20/fz19 has cell polarity defective phenotype, enhanceable by dco[+]/dco5B2.6

fz20/fz19 has cell polarity defective phenotype, enhanceable by dcoj3B9/dco[+]

fz20/fz19 has cell polarity defective phenotype, enhanceable by dco2/dco[+]

fz20/fz19 has cell polarity defective phenotype, enhanceable by dco[+]/dco3

NOT Enhanced by
Statement
Reference

fz19 has viable phenotype, non-enhanceable by Ror[+]/Ror4

fz19 has planar polarity defective | adult stage phenotype, non-enhanceable by Ror[+]/Ror4

fz19 has viable phenotype, non-enhanceable by Ror4/Ror4

fz21/fz19 has viable phenotype, non-enhanceable by Ror[+]/Ror4

fz21/fz19 has planar polarity defective | adult stage phenotype, non-enhanceable by Ror[+]/Ror4

fz21/fz19 has viable phenotype, non-enhanceable by Ror4/Ror4

fz23/fz19 has viable phenotype, non-enhanceable by Ror[+]/Ror4

fz23/fz19 has planar polarity defective | adult stage phenotype, non-enhanceable by Ror[+]/Ror4

fz23/fz19 has viable phenotype, non-enhanceable by Ror4/Ror4

Suppressed by
Statement
Reference

fz21/fz19 has planar polarity defective phenotype, suppressible by Egfr[+]/Egfrtop-18A

NOT suppressed by
Statement
Reference

fz19 has viable phenotype, non-suppressible by Ror[+]/Ror4

fz19 has planar polarity defective | adult stage phenotype, non-suppressible by Ror[+]/Ror4

fz19 has viable phenotype, non-suppressible by Ror4/Ror4

fz21/fz19 has viable phenotype, non-suppressible by Ror[+]/Ror4

fz21/fz19 has planar polarity defective | adult stage phenotype, non-suppressible by Ror[+]/Ror4

fz21/fz19 has viable phenotype, non-suppressible by Ror4/Ror4

fz23/fz19 has viable phenotype, non-suppressible by Ror[+]/Ror4

fz23/fz19 has planar polarity defective | adult stage phenotype, non-suppressible by Ror[+]/Ror4

fz23/fz19 has viable phenotype, non-suppressible by Ror4/Ror4

NOT Enhancer of
Statement
Reference

fz[+]/fz19 is a non-enhancer of viable phenotype of Ror4

fz19/fz19 is a non-enhancer of viable phenotype of Ror4

fz23/fz19 is a non-enhancer of viable phenotype of Ror4

fz21/fz19 is a non-enhancer of viable phenotype of Ror4

fz19 is a non-enhancer of visible phenotype of upd1GMR.PB

NOT Suppressor of
Statement
Reference

fz23/fz19 is a non-suppressor of viable phenotype of Ror4

fz21/fz19 is a non-suppressor of viable phenotype of Ror4

fz[+]/fz19 is a non-suppressor of viable phenotype of Ror4

fz19/fz19 is a non-suppressor of viable phenotype of Ror4

fz[+]/fz19 is a non-suppressor of planar polarity defective phenotype of bdgGMREP

fz19 is a non-suppressor of visible phenotype of upd1GMR.PB

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

fz20/fz19 has ommatidium phenotype, enhanceable by ed[+]/ed1X5

fz20/fz19 has ommatidium phenotype, enhanceable by bdg164/bdg164

fz20/fz19 has ommatidium phenotype, enhanceable by dsh1/dsh[+]

fz20/fz19 has ommatidium phenotype, enhanceable by dco[+]/dco5B2.6

fz20/fz19 has ommatidium phenotype, enhanceable by dcoj3B9/dco[+]

fz20/fz19 has ommatidium phenotype, enhanceable by dco2/dco[+]

fz20/fz19 has ommatidium phenotype, enhanceable by dco[+]/dco3

fz20/fz19 has ommatidium phenotype, enhanceable by Ras85D2F4

fz20/fz19 has ommatidium phenotype, enhanceable by styΔ5

fz20/fz19 has ommatidium phenotype, enhanceable by sty226

fz20/fz19 has ommatidium phenotype, enhanceable by styF7

fz20/fz19 has ommatidium phenotype, enhanceable by styX3F7

fz20/fz19 has ommatidium phenotype, enhanceable by styX3J3

fz20/fz19 has ommatidium phenotype, enhanceable by dsh1

fz20/fz19 has ommatidium phenotype, enhanceable by aosΔ7

fz20/fz19 has ommatidium phenotype, enhanceable by aos5F4

fz20/fz19 has ommatidium phenotype, enhanceable by aosA254Δ15

fz20/fz19 has ommatidium phenotype, enhanceable by aosrlt

NOT Enhanced by
Statement
Reference

fz20/fz19 has ommatidium phenotype, non-enhanceable by Rho1k07903

Suppressed by
Statement
Reference

fz21/fz19 has ommatidium phenotype, suppressible by Egfr[+]/Egfrtop-18A

NOT suppressed by
Statement
Reference

fz20/fz19 has ommatidium phenotype, non-suppressible by Rho172R

NOT Enhancer of
Statement
Reference

fz19 is a non-enhancer of eye phenotype of upd1GMR.PB

NOT Suppressor of
Statement
Reference

fz[+]/fz19 is a non-suppressor of ommatidium phenotype of bdgGMREP

fz19 is a non-suppressor of eye phenotype of upd1GMR.PB

Other
Additional Comments
Genetic Interactions
Statement
Reference

Flies double mutant for otkA1/otkA1; fz19/fz19 are viable but exhibit planar polarity defects.

Flies double mutant for otk2C26/otk2C26; fz19/fz19 are viable but exhibit planar polarity defects.

Flies double mutant for Df(2R)D72/+; fz19/fz19 are viable but exhibit planar polarity defects. Flies mutant for Df(2R)D72/Df(2R)D72; fz19/+ are viable and do not exhibit planar polarity defects. Flies double mutant for Df(2R)D72/Df(2R)D72; fz19/fz19 are lethal.

fz19 fz2C1 double homozygous clones in the wing result in wing margin defects.

ed1X5 dominantly enhances the phenotype of mis-rotation of ommatidia that is seen in fz19/fz20 animals, without affecting the chirality phenotype.

The symmetrical ommatidium phenotype seen in fz19/fz21 flies is suppressed by Egfrtop-18A/+.

Homozygosity for bdg164 enhances the ommatidial polarity defects caused by fz20/fz19.

The ommatidial polarity defects seen in bdgGMREP homozygotes are not-suppressed by fz19.

The ommatidial polarity defects of fz19/fz20 mutants are enhanced in a dsh1/+, dco5B2.6/+, dcoj3B9/+, dco2/+ and dco3/+ backgrounds. In each double mutant background, the percentage of mispolarized ommatidia are increased.

Embryos that lack zygotic fz and fz2 function which are derived from fz19/fzGL31 fz2e2 females mated to fzGL31 fz2e2/+ males are modestly shortened and have mild patterning defects in the cuticle.

The addition of dsh1/+ strongly enhances the eye cell polarity phenotype seen in fz19/fz20 animals. The addition of argos5F4/+ , argosΔ7/+, argosA254Δ15/+, or argosrlt/+ , enhances the eye cell polarity phenotype seen in fz19/fz20 animals. The addition of styF7/+, styX3J3/+, styX3F7/+, styΔ5/+, or sty226/+ , enhances the eye cell polarity phenotype seen in fz19/fz20 animals. The addition of Ras85D2F4/+ enhances the eye cell polarity phenotype seen in fz19/fz20 animals.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Adler.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (20)