FlyBase Allele Report: Dmel\fz[19]

General Information

Symbol

Dmel\fz¹⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0004935

Feature type

allele

Associated gene

Dmel\fz

Associated Insertion(s)

Carried in Construct

Also Known As

fz^J22

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Description

Amino acid replacement: P278L.

(Povelones et al., 2005, Jones et al., 1996)

Mutation is in the first cytoplasmic loop of the fz protein.

(Jones et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:14,311,901..14,311,901 [+]

Nucleotide change:

C14311901T

Reported nucleotide change:

C?T

Amino acid change:

P278L | fz-PA; P278L | fz-PC

Reported amino acid change:

P278L

Comment:

P278 is in the first cytoplasmic loop of the fz protein.

(Povelones et al., 2005, Adler et al., 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity (with fz²⁰)

(Strutt et al., 2006, Strutt and Strutt, 2003)

abnormal planar polarity

(Axelrod, 2001, Rousset et al., 2001)

abnormal planar polarity (with fz²⁰)

(Rawls et al., 2007)

abnormal planar polarity (with fz²¹)

(Weber et al., 2008)

abnormal planar polarity | adult stage

(Ripp et al., 2018)

abnormal planar polarity | adult stage (with fz²¹)

(Ripp et al., 2018)

abnormal planar polarity | adult stage (with fz²³)

(Ripp et al., 2018)

abnormal planar polarity | somatic clone (with fz²⁰)

(Strutt et al., 2002)

viable

(Ripp et al., 2018)

viable (with fz²¹)

(Ripp et al., 2018)

viable (with fz²³)

(Ripp et al., 2018)

visible

(Strutt et al., 2012)

visible (with fz³⁰)

(Povelones et al., 2005)

Phenotype Manifest In

eye photoreceptor cell | somatic clone (with fz²⁰)

(Strutt et al., 2002)

leg

(Strutt et al., 2012)

leg joint | ectopic

(Strutt et al., 2012)

macrochaeta & adult thorax

ommatidium

(Ripp et al., 2018)

ommatidium (with fz²⁰)

(Fetting et al., 2009, Rawls et al., 2007, Strutt et al., 2006, Strutt and Strutt, 2003)

ommatidium (with fz²¹)

(Ripp et al., 2018, Weber et al., 2008)

ommatidium | somatic clone (with fz²⁰)

(Strutt et al., 2002)

wing

(Rousset et al., 2001, Jones et al., 1996)

wing hair

(Ripp et al., 2018)

wing hair | increased number (with fz³⁰)

(Povelones et al., 2005)

Detailed Description

Statement

Reference

fz¹⁹/fz¹⁹ disrupted planar polarity is observable as aberrant orientation of ommatidia and wing hairs, compared to wild type controls. fz¹⁹/fz²¹ disrupted planar polarity is observable as the disrupted orientation of ommatidia, compared to wild type controls.

(Ripp et al., 2018)

Homozygous fz¹⁹ mutants are viable but exhibit planar polarity defects.

(Linnemannstöns et al., 2014)

Mutant adults have an average of 2.0 +/- 0.2 extra tarsal joints in the leg compared to wild type.

(Strutt et al., 2012)

Approximately 16% of ommatidia are symmetrical in fz¹⁹/fz²¹ flies.

(Weber et al., 2008)

fz²⁰/fz¹⁹ flies show defects in ommatidial polarity.

(Rawls et al., 2007)

In the eyes of fz¹⁹/fz²⁰ transheterozygotes, 10% of ommatidia are mispolarized.

(Strutt et al., 2006)

fz¹⁹ has a moderate multiple wing hair phenotype in combination with fz³⁰.

(Povelones et al., 2005)

fz¹⁹/fz²⁰ animals exhibit a weak eye phenotype - 9% of ommatidia show polarity defects.

(Strutt and Strutt, 2003)

Mutants show no significant disruption of ovarian morphology.

(Cohen et al., 2002)

84.8% of ommatidia in fz¹⁹/fz²⁰ mutant somatic clones in the eye are normal. 6.3% have rotated ommatidia, 6.1% have chirality defects, 2.5% are achiral (0.3% unscorable).

(Strutt et al., 2002)

Mutant animals have a mutant planar cell polarity phenotype.

(Axelrod, 2001)

Autonomous phenotype in wing clones.

(Jones et al., 1996)

Moderate thoracic bristle phenotype; moderate wing-hair disorientation.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

fz²⁰/fz¹⁹ has abnormal planar polarity phenotype, enhanceable by bdg¹⁶⁴/bdg¹⁶⁴

(Rawls et al., 2007)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by dsh¹/dsh[+]

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by dco[+]/dco^5B2.6

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by dco^j3B9/dco[+]

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by dco²/dco[+]

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by dco[+]/dco³

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by Ras85D^2F4

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by sty^Δ5

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by sty²²⁶

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by sty^F7

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by sty^X3F7

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by sty^X3J3

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by aos^Δ7

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by dsh¹

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by aos^5F4

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by aos^A254Δ15

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by aos^rlt

(Strutt and Strutt, 2003)

NOT Enhanced by

Statement

Reference

fz¹⁹ has viable phenotype, non-enhanceable by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-enhanceable by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz¹⁹ has viable phenotype, non-enhanceable by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-enhanceable by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²¹/fz¹⁹ has viable phenotype, non-enhanceable by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²¹/fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-enhanceable by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²¹/fz¹⁹ has viable phenotype, non-enhanceable by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²¹/fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-enhanceable by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ has viable phenotype, non-enhanceable by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-enhanceable by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ has viable phenotype, non-enhanceable by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-enhanceable by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, non-enhanceable by Rho1^k07903

(Strutt and Strutt, 2003)

Suppressed by

Statement

Reference

fz²¹/fz¹⁹ has abnormal planar polarity phenotype, suppressible by Egfr[+]/Egfr^top-18A

(Weber et al., 2008)

NOT suppressed by

Statement

Reference

fz²¹/fz¹⁹ has viable phenotype, non-suppressible by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²¹/fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-suppressible by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ has viable phenotype, non-suppressible by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-suppressible by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ has viable phenotype, non-suppressible by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-suppressible by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz¹⁹ has viable phenotype, non-suppressible by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-suppressible by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz¹⁹ has viable phenotype, non-suppressible by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-suppressible by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz²¹/fz¹⁹ has viable phenotype, non-suppressible by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²¹/fz¹⁹ has abnormal planar polarity | adult stage phenotype, non-suppressible by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, non-suppressible by Rho1^72R

(Strutt and Strutt, 2003)

NOT Enhancer of

Statement

Reference

fz[+]/fz¹⁹ is a non-enhancer of viable phenotype of Ror⁴

(Ripp et al., 2018)

fz¹⁹/fz¹⁹ is a non-enhancer of viable phenotype of Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ is a non-enhancer of viable phenotype of Ror⁴

(Ripp et al., 2018)

fz²¹/fz¹⁹ is a non-enhancer of viable phenotype of Ror⁴

(Ripp et al., 2018)

fz¹⁹ is a non-enhancer of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

NOT Suppressor of

Statement

Reference

fz[+]/fz¹⁹ is a non-suppressor of viable phenotype of Ror⁴

(Ripp et al., 2018)

fz¹⁹/fz¹⁹ is a non-suppressor of viable phenotype of Ror⁴

(Ripp et al., 2018)

fz²³/fz¹⁹ is a non-suppressor of viable phenotype of Ror⁴

(Ripp et al., 2018)

fz²¹/fz¹⁹ is a non-suppressor of viable phenotype of Ror⁴

(Ripp et al., 2018)

fz[+]/fz¹⁹ is a non-suppressor of abnormal planar polarity phenotype of bdg^GMREP

(Rawls et al., 2007)

fz¹⁹ is a non-suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Other

Statement

Reference

fz¹⁹, otk^A1 has abnormal planar polarity phenotype

(Linnemannstöns et al., 2014)

fz¹⁹, otk2^C26 has abnormal planar polarity phenotype

(Linnemannstöns et al., 2014)

Df(2R)D72, fz¹⁹ has lethal phenotype

(Linnemannstöns et al., 2014)

Df(2R)D72, fz¹⁹ has abnormal planar polarity phenotype

(Linnemannstöns et al., 2014)

Df(2R)D72, fz¹⁵/fz¹⁹ has lethal phenotype

(Linnemannstöns et al., 2014)

fz2^C1, fz¹⁹ has visible | somatic clone phenotype

(Strutt et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by ed[+]/ed^1X5

(Fetting et al., 2009)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by bdg¹⁶⁴/bdg¹⁶⁴

(Rawls et al., 2007)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by dsh¹/dsh[+]

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by dco[+]/dco^5B2.6

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by dco^j3B9/dco[+]

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by dco²/dco[+]

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by dco[+]/dco³

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by Ras85D^2F4

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by sty^Δ5

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by sty²²⁶

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by sty^F7

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by sty^X3F7

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by sty^X3J3

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by dsh¹

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by aos^Δ7

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by aos^5F4

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by aos^A254Δ15

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by aos^rlt

(Strutt and Strutt, 2003)

NOT Enhanced by

Statement

Reference

fz²⁰/fz¹⁹ has ommatidium phenotype, non-enhanceable by Rho1^k07903

(Strutt and Strutt, 2003)

Suppressed by

Statement

Reference

fz²¹/fz¹⁹ has ommatidium phenotype, suppressible by Egfr[+]/Egfr^top-18A

(Weber et al., 2008)

NOT suppressed by

Statement

Reference

fz²⁰/fz¹⁹ has ommatidium phenotype, non-suppressible by Rho1^72R

(Strutt and Strutt, 2003)

NOT Enhancer of

Statement

Reference

fz¹⁹ is a non-enhancer of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

NOT Suppressor of

Statement

Reference

fz[+]/fz¹⁹ is a non-suppressor of ommatidium phenotype of bdg^GMREP

(Rawls et al., 2007)

fz¹⁹ is a non-suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Other

Statement

Reference

fz2^C1, fz¹⁹ has wing margin | somatic clone phenotype

(Strutt et al., 2012)

fz2^e2, fz^GL31/fz¹⁹ has embryonic/first instar larval cuticle | maternal effect phenotype

(Povelones et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Flies double mutant for otk^A1/otk^A1; fz¹⁹/fz¹⁹ are viable but exhibit planar polarity defects.

Flies double mutant for otk2^C26/otk2^C26; fz¹⁹/fz¹⁹ are viable but exhibit planar polarity defects.

Flies double mutant for Df(2R)D72/+; fz¹⁹/fz¹⁹ are viable but exhibit planar polarity defects. Flies mutant for Df(2R)D72/Df(2R)D72; fz¹⁹/+ are viable and do not exhibit planar polarity defects. Flies double mutant for Df(2R)D72/Df(2R)D72; fz¹⁹/fz¹⁹ are lethal.

(Linnemannstöns et al., 2014)

fz¹⁹ fz2^C1 double homozygous clones in the wing result in wing margin defects.

(Strutt et al., 2012)

ed^1X5 dominantly enhances the phenotype of mis-rotation of ommatidia that is seen in fz¹⁹/fz²⁰ animals, without affecting the chirality phenotype.

(Fetting et al., 2009)

The symmetrical ommatidium phenotype seen in fz¹⁹/fz²¹ flies is suppressed by Egfr^top-18A/+.

(Weber et al., 2008)

Homozygosity for bdg¹⁶⁴ enhances the ommatidial polarity defects caused by fz²⁰/fz¹⁹.

The ommatidial polarity defects seen in bdg^GMREP homozygotes are not-suppressed by fz¹⁹.

(Rawls et al., 2007)

The ommatidial polarity defects of fz¹⁹/fz²⁰ mutants are enhanced in a dsh¹/+, dco^5B2.6/+, dco^j3B9/+, dco²/+ and dco³/+ backgrounds. In each double mutant background, the percentage of mispolarized ommatidia are increased.

(Strutt et al., 2006)

Embryos that lack zygotic fz and fz2 function which are derived from fz¹⁹/fz^GL31 fz2^e2 females mated to fz^GL31 fz2^e2/+ males are modestly shortened and have mild patterning defects in the cuticle.

(Povelones et al., 2005)

The addition of dsh¹/+ strongly enhances the eye cell polarity phenotype seen in fz¹⁹/fz²⁰ animals. The addition of argos^5F4/+ , argos^Δ7/+, argos^A254Δ15/+, or argos^rlt/+ , enhances the eye cell polarity phenotype seen in fz¹⁹/fz²⁰ animals. The addition of sty^F7/+, sty^X3J3/+, sty^X3F7/+, sty^Δ5/+, or sty²²⁶/+ , enhances the eye cell polarity phenotype seen in fz¹⁹/fz²⁰ animals. The addition of Ras85D^2F4/+ enhances the eye cell polarity phenotype seen in fz¹⁹/fz²⁰ animals.

(Strutt and Strutt, 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

fz¹⁵/fz¹⁹ is rescued by fz^Act5C.EYFP

(Strutt and Strutt, 2002)

Partially rescued by

Df(3L)fz-GF3b/fz¹⁹ is partially rescued by fz^sevE3.sevP

(Strutt and Strutt, 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Adler.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fz¹⁹

(Strutt et al., 2006)

fz^J22

(Ripp et al., 2018, Linnemannstöns et al., 2014, Capilla et al., 2012, Strutt et al., 2012, Fetting et al., 2009, Weber et al., 2008, Rawls et al., 2007, Amonlirdviman et al., 2005, Povelones et al., 2005, Bach et al., 2003, Cohen et al., 2002, Axelrod, 2001, Rousset et al., 2001, Jones et al., 1996)

Name Synonyms

Secondary FlyBase IDs

References (20)

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