|Feature type||allele||Associated gene||Dmel\fz|
|Also Known As||fzKD4A, KD4a|
|Allele class||amorphic allele - genetic evidence|
|Mutagen||PM hybrid dysgenesis|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Imprecise excision of the P-element, resulting in the deletion of more than 50kb flanking genomic sequences.
|Phenotype Manifest In|
macrochaeta & eye
fz/fz show defects in the orientation of the mitotic spindle in dividing pI sensory precursor cells.
In fz30/fz37 pupae, the mitotic spindles of dividing sensory organ precursor cells in the developing notum are not aligned with the anterior-posterior axis, but instead are randomly oriented.
In fz37/fz30 mutant pupae, unlike wild-type, the pI cells exhibit almost no centrosome rotation before spindle formation. Complete rotation values for the spindle are similar to wild-type, however in 7% of mutant pI cells, the spindle rotates in one direction before rotating in the opposite direction, bidirectional movements are not seen in wild-type. The spindle does not line up properly with the pon crescent, leading to defective partitioning of pon. 5% of fz37/fz30 flies have at least one bristle with two shafts and two sockets on the notum.
The orientation of projections of R1-R6 axons onto the lamina is normal for those ommatidia that are correctly orientated, and rotated for those ommatidia that are rotated.
Dendritic development in homozygous mutants is indistinguishable from wild-type.
Mosaic ommatidia at the boundaries of homozygous clones can show incorrect chirality. In incorrect chiral ommatidia where the mosaic boundary separates the R3/R4 pair, the R4 cell is invariably mutant and the R3 cell is wild type. In these cases the presumptive R3 cell has developed as an R4 cell. The R3/R4 pair can also either both be mutant or both be wild-type in mosaic ommatidia with incorrect chirality. Chirally incorrect ommatidia that have wild-type R3 and R4 cells can occur at any position along the border of the clone, but are predominantly found at the polar side of the clone. Mosaic ommatidia at the boundaries of homozygous clones can show correct chirality. In those ommatidia with mosaicism between R3/R4, the R3 cell is almost always wild type and the R4 cell is almost always mutant. Mosaic ommatidia at the boundaries of homozygous clones are occasionally symmetrical, and in these cases both members of the R3/R4 pair are generally mutant. Expression of fzhs.sev in a fz37 background in either the presumptive R3 or R4 cell in mosaic ommatidia causes the cell expressing fzhs.sev to become an R3 cell and the other to become an R4 cell.
In fz3/fz37 transheterozygotes the socket, shaft and pIIb cells are always localised in the region of the cell in contact with pIIb. The socket cells always occupies an eccentric position.
Rough eye phenotype, facets have lost their normal hexagonal shape and exhibit disarranged bristles. The ommatidial polarity is disrupted due to randomised direction of ommatidial rotation, insufficient degree of rotation and incorrect asymmetry established between R3 and R4 cells.
|NOT suppressed by|
|Phenotype Manifest In|
|NOT suppressed by|
The zone of reversed polarity at the back and behind the anterior compartment of each abdominal segment of stanScer\UAS.cUa; Scer\GAL4ptc-559.1 adults is suppressed by fz37/fz21.
When ft8 homozygous mutant clones are made in the R3/R4 precursors of fz37/fz15 mutant flies, The mutant photoreceptor precursor eventually becomes an R3 photoreceptor 61% of the time (50% in wild-type).
The addition of numb796 to fz37/fz30, leads to pupae that have sense organs composed of four cells with two socket cells but devoid of either sheath or neuronal cells.
fz22-2-2.hs.2sev does not rescue the tissue polarity defect seen in fz37/fz15 eyes. fz::fz22-2-1.hs.2sev does not rescue the tissue polarity defect seen in fz37/fz15 eyes. fz::fz22-1-1.hs.2sev does not rescue the tissue polarity defect seen in fz37/fz15 eyes. fz::fz21-2-2.hs.2sev does not rescue the tissue polarity defect seen in fz37/fz15 eyes. fz::fz21-1-2.hs.2sev significantly rescues the tissue polarity defect seen in fz37/fz15 eyes, such that 93.3 +/- 5.0 % of ommatidia have the correct chiral shape. fz::fz21-2-1.hs.2sev significantly rescues the tissue polarity defect seen in fz37/fz15 eyes, such that 76.5 +/- 6.4 % of ommatidia have the correct chiral shape.
|Complementation & Rescue Data|
|Partially rescued by|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 6 )|
|Secondary FlyBase IDs|
|References ( 21 )|
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|Recent research papers (0)|
|All research papers listed in FlyBase were published before 2011|
|Recent reviews (0)|
|All reviews listed in FlyBase were published before 2011|