Open Close
General Information
Symbol
Dmel\g53d
Species
D. melanogaster
Name
FlyBase ID
FBal0004981
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

No alteration in detected by Southern analysis.

Alleles separable by conversion; g53d to the left of g2.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant flies have reduced red pigment in the eye compared to controls.

g53d mutants have highly reduced levels of red and brown pigment in the eye compared to wild-type flies. g53d mutant male flies show a greater degree of male-male courtship than wild-type flies.

Eyes of flies heterozygous for g53d/Dp(1;f)LJ9 depend on parental derivation of Dp(1;f)LJ9 chromosome. Eyes show variegation if Dp(1;f)LJ9 derived from male parent, and not if Dp(1;f)LJ9 derived from female parent. The variegating phenotype persists for one generation only, i.e. is reset by passage through the germ line. The imprint is a response to the physiological sex of the parent, and does not depend on the particular allele of g opposite Dp(1;f)LJ9. Factors that affect position effect variegation influence the somatic expression but not the establishment of the imprinting.

Eye colour: flies show a fine-grained mottling of red spots on a pale background as they age. Eye colour: red pigments are reduced to 15 +/- 2% of wild-type levels, brown pigments are reduced to 13 +/- 2% of wild-type levels in females. Red pigments are reduced to 21 +/- 3% of wild-type levels, brown pigments are reduced to 7 +/- 4% of wild-type levels in males. Malpighian tubule colour: colourless (wild-type colour is orange). Testis colour: essentially wild type (wild-type colour is bright yellow).

Eye colour: pale orange. Malpighian tubule colour: colourless. Testis colour: wild-type. Ommatidia are well developed but pigment granules are absent.

Lightly pigmented eyes and some pigment deposition in the ocelli.

Orange eyed.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

g53d has eye color defective phenotype, enhanceable by z1

g53d has eye color defective phenotype, enhanceable by we(g)/w1118

g53d has eye color defective phenotype, enhanceable by w1/we(g)

g53d has eye color defective phenotype, enhanceable by wBwx/we(g)

g53d has eye color defective phenotype, enhanceable by wa/we(g)

g53d has eye color defective phenotype, enhanceable by wbf/we(g)

g53d has eye color defective phenotype, enhanceable by wco/we(g)

g53d has eye color defective phenotype, enhanceable by wsat/we(g)

g53d has eye color defective phenotype, enhanceable by za

g53d has eye color defective phenotype, enhanceable by we(g)

g53d/gP has eye color defective phenotype, enhanceable by w[+]/we(g)

g53d/g[+], z1 has eye color defective | female phenotype, enhanceable by E(z)[+]/E(z)1

g53d/gP has eye color defective phenotype, enhanceable by we(g)/we(g)

g53d, z[+]/z1 has eye color defective | female phenotype, enhanceable by E(z)[+]/E(z)1

g53d, z1 has eye color defective | male phenotype, enhanceable by E(z)1

Suppressed by
Statement
Reference

g53d has eye color defective phenotype, suppressible by wHSBJ

Enhancer of
Statement
Reference

g53d is an enhancer of eye color defective phenotype of wa3

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

g53d, z1 has pigment cell phenotype, enhanceable | male by E(z)1

g53d has pigment cell phenotype, enhanceable by z1

g53d has pigment cell phenotype, enhanceable by we(g)/w1118

g53d has pigment cell phenotype, enhanceable by w1/we(g)

g53d has pigment cell phenotype, enhanceable by wBwx/we(g)

g53d has pigment cell phenotype, enhanceable by wa/we(g)

g53d/gP has pigment cell phenotype, enhanceable by w[+]/we(g)

g53d has pigment cell phenotype, enhanceable by wbf/we(g)

g53d has pigment cell phenotype, enhanceable by wco/we(g)

g53d has pigment cell phenotype, enhanceable by wsat/we(g)

g53d has pigment cell phenotype, enhanceable by za

g53d has pigment cell phenotype, enhanceable by we(g)/we(g)

g53d/g[+], z1 has pigment cell | female phenotype, enhanceable by E(z)[+]/E(z)1

g53d/gP has pigment cell phenotype, enhanceable by we(g)/we(g)

g53d, z[+]/z1 has pigment cell | female phenotype, enhanceable by E(z)[+]/E(z)1

g53d, z1 has pigment cell | male phenotype, enhanceable by E(z)1

Suppressed by
Statement
Reference

g53d has pigment cell phenotype, suppressible by wHSBJ

Enhancer of
Statement
Reference

g53d is an enhancer of pigment cell phenotype of wa3

Other
Additional Comments
Genetic Interactions
Statement
Reference

Expression of auxScer\UAS.cHa under the control of Scer\GAL4GMR.PF enhances the loss of red eye pigment that is seen in g53d flies.

we(g), g53d double mutant flies have at least a 50% reduction of brown (ommochrome) pigments deposited in the eye compared to g53d single mutants. There is also a reduction in red (pteridine) pigment to a lesser extent. All of the following w alleles when heterozygous with we(g) enhance the eye colour defective phenotype of g53d mutants, leading to a greater reduction of red pigment within the eye: w1118, w1, wa, wbf, wBwx, wco and wsat. In contrast to g53d homozygotes, gP/g53d transheterozygotes do interact with we(g), as gP/g53d, we(g) and gP/g53d, we(g)/+ flies have a reduced amount of red pigment in the eye compared to gP, we(g) double mutant flies. The wHSBJ transgene is able to increase the amount of red pigment in the eyes of g53d mutant flies. The g53d and following w alleles act additively to reduce eye pigmentation in double mutant male flies: wa, wa3, wbf, wch, wco, we, wi and wt. g53d, za double mutants have a reduced amount of red pigment in the eye comparted to g53d single mutants in both male and female flies. Likewise, g53d, z1 double mutant flies show decreased red eye pigment than g53d mutants, although this reduction is greater in female flies than in male flies. Male E(z)1/+, g53d, z1 triple mutants have less red pigment in the eye than g53d, z1 double mutants. Likewise, female E(z)1/+, g53d/+, z1/+ triple mutants have a reduction in red eye pigment compared to g53d/+, z1/+ double mutants.

Eye colour: lt1 g53d double mutants show a marked reduction in eye pigment. Eye colour: lt1/lt11 g53d double mutants show a reduction in red eye pigment compared to either lt1/lt11 or g53d single mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Hexter, April 1953.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (13)