|Feature type||allele||Associated gene||Dmel\g|
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
No alteration in detected by Southern analysis.
|Phenotype Manifest In|
Mutant flies have reduced red pigment in the eye compared to controls.
g53d mutants have highly reduced levels of red and brown pigment in the eye compared to wild-type flies. g53d mutant male flies show a greater degree of male-male courtship than wild-type flies.
Eyes of flies heterozygous for g53d/Dp(1;f)LJ9 depend on parental derivation of Dp(1;f)LJ9 chromosome. Eyes show variegation if Dp(1;f)LJ9 derived from male parent, and not if Dp(1;f)LJ9 derived from female parent. The variegating phenotype persists for one generation only, i.e. is reset by passage through the germ line. The imprint is a response to the physiological sex of the parent, and does not depend on the particular allele of g opposite Dp(1;f)LJ9. Factors that affect position effect variegation influence the somatic expression but not the establishment of the imprinting.
Eye colour: flies show a fine-grained mottling of red spots on a pale background as they age. Eye colour: red pigments are reduced to 15 +/- 2% of wild-type levels, brown pigments are reduced to 13 +/- 2% of wild-type levels in females. Red pigments are reduced to 21 +/- 3% of wild-type levels, brown pigments are reduced to 7 +/- 4% of wild-type levels in males. Malpighian tubule colour: colourless (wild-type colour is orange). Testis colour: essentially wild type (wild-type colour is bright yellow).
Eye colour: pale orange. Malpighian tubule colour: colourless. Testis colour: wild-type. Ommatidia are well developed but pigment granules are absent.
Lightly pigmented eyes and some pigment deposition in the ocelli.
g53d has eye color defective phenotype, enhanceable by auxScer\UAS.cHa/Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
|Phenotype Manifest In|
Expression of aux[Scer\UAS.cHa] under the control of Scer\GAL4[GMR.PF] enhances the loss of red eye pigment that is seen in g[53d] flies.
we(g), g53d double mutant flies have at least a 50% reduction of brown (ommochrome) pigments deposited in the eye compared to g53d single mutants. There is also a reduction in red (pteridine) pigment to a lesser extent. All of the following w alleles when heterozygous with we(g) enhance the eye colour defective phenotype of g53d mutants, leading to a greater reduction of red pigment within the eye: w1118, w1, wa, wbf, wBwx, wco and wsat. In contrast to g53d homozygotes, gP/g53d transheterozygotes do interact with we(g), as gP/g53d, we(g) and gP/g53d, we(g)/+ flies have a reduced amount of red pigment in the eye compared to gP, we(g) double mutant flies. The wHSBJ transgene is able to increase the amount of red pigment in the eyes of g53d mutant flies. The g53d and following w alleles act additively to reduce eye pigmentation in double mutant male flies: wa, wa3, wbf, wch, wco, we, wi and wt. g53d, za double mutants have a reduced amount of red pigment in the eye comparted to g53d single mutants in both male and female flies. Likewise, g53d, z1 double mutant flies show decreased red eye pigment than g53d mutants, although this reduction is greater in female flies than in male flies. Male E(z)1/+, g53d, z1 triple mutants have less red pigment in the eye than g53d, z1 double mutants. Likewise, female E(z)1/+, g53d/+, z1/+ triple mutants have a reduction in red eye pigment compared to g53d/+, z1/+ double mutants.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
Hexter, April 1953.
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 13 )|