Allele Dmel\g^53d

General Information
Symbol	Dmel\g^53d	Species	D. melanogaster
Name		FlyBase ID	FBal0004981
Feature type	allele	Associated gene	Dmel\g

Allele class
Mutagen	spontaneous
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	spontaneous (Lindsley and Grell, 1968)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference No alteration in detected by Southern analysis. (Lloyd et al., 1999) Alleles separable by conversion; g^53d to the left of g². (Lindsley and Zimm, 1992)
Cytology
Phenotypic Data
Phenotypic Class
	courtship behavior defective \| male (Lloyd et al., 2002) eye color defective (Lloyd et al., 1999, Lloyd et al., 2002, Cheli et al., 2010, Cheli et al., 2010) eye color defective \| recessive (Simpson et al., 1997, Warner et al., 1998)
Phenotype Manifest In
	eye (Simpson et al., 1997) Malpighian tubule (Simpson et al., 1997, Lloyd et al., 1999) pigment cell (Warner et al., 1998, Lloyd et al., 1999, Lloyd et al., 1999, Lloyd et al., 2002) pigment granule (Simpson et al., 1997)
Detailed Description
	Statement Reference Mutant flies have reduced red pigment in the eye compared to controls. (Cheli et al., 2010, Cheli et al., 2010) g^53d mutants have highly reduced levels of red and brown pigment in the eye compared to wild-type flies. g^53d mutant male flies show a greater degree of male-male courtship than wild-type flies. (Lloyd et al., 2002) Eyes of flies heterozygous for g^53d/Dp(1;f)LJ9 depend on parental derivation of Dp(1;f)LJ9 chromosome. Eyes show variegation if Dp(1;f)LJ9 derived from male parent, and not if Dp(1;f)LJ9 derived from female parent. The variegating phenotype persists for one generation only, i.e. is reset by passage through the germ line. The imprint is a response to the physiological sex of the parent, and does not depend on the particular allele of g opposite Dp(1;f)LJ9. Factors that affect position effect variegation influence the somatic expression but not the establishment of the imprinting. (Lloyd et al., 1999) Eye colour: flies show a fine-grained mottling of red spots on a pale background as they age. Eye colour: red pigments are reduced to 15 +/- 2% of wild-type levels, brown pigments are reduced to 13 +/- 2% of wild-type levels in females. Red pigments are reduced to 21 +/- 3% of wild-type levels, brown pigments are reduced to 7 +/- 4% of wild-type levels in males. Malpighian tubule colour: colourless (wild-type colour is orange). Testis colour: essentially wild type (wild-type colour is bright yellow). (Lloyd et al., 1999) Eye colour: pale orange. Malpighian tubule colour: colourless. Testis colour: wild-type. Ommatidia are well developed but pigment granules are absent. (Simpson et al., 1997) Lightly pigmented eyes and some pigment deposition in the ocelli. (Tearle, 1991) RK1. (Lindsley and Grell, 1968) Orange eyed. (Hexter, 1963)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference g^53d, z[+]/z¹ has eye color defective \| female phenotype, enhanceable by E(z)[+]/E(z)¹ (Lloyd et al., 2002) g^53d, z¹ has eye color defective \| male phenotype, enhanceable by E(z)¹ (Lloyd et al., 2002) g^53d/g[+], z¹ has eye color defective \| female phenotype, enhanceable by E(z)[+]/E(z)¹ (Lloyd et al., 2002) g^53d/g^P has eye color defective phenotype, enhanceable by w[+]/w^e(g) (Lloyd et al., 2002) g^53d/g^P has eye color defective phenotype, enhanceable by w^e(g)/w^e(g) (Lloyd et al., 2002) g^53d has eye color defective phenotype, enhanceable by aux^Scer\UAS.cHa/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Cheli et al., 2010) g^53d has eye color defective phenotype, enhanceable by w¹/w^e(g) (Lloyd et al., 2002) g^53d has eye color defective phenotype, enhanceable by w^a/w^e(g) (Lloyd et al., 2002) g^53d has eye color defective phenotype, enhanceable by w^bf/w^e(g) (Lloyd et al., 2002) g^53d has eye color defective phenotype, enhanceable by w^Bwx/w^e(g) (Lloyd et al., 2002) g^53d has eye color defective phenotype, enhanceable by w^co/w^e(g) (Lloyd et al., 2002) g^53d has eye color defective phenotype, enhanceable by w^e(g) (Lloyd et al., 2002) g^53d has eye color defective phenotype, enhanceable by w^e(g)/w¹¹¹⁸ (Lloyd et al., 2002) g^53d has eye color defective phenotype, enhanceable by w^sat/w^e(g) (Lloyd et al., 2002) g^53d has eye color defective phenotype, enhanceable by z¹ (Lloyd et al., 2002) g^53d has eye color defective phenotype, enhanceable by z^a (Lloyd et al., 2002)
Suppressed by
Statement Reference g^53d has eye color defective phenotype, suppressible by w^HSBJ (Lloyd et al., 2002)
Enhancer of
Statement Reference g^53d is an enhancer of eye color defective phenotype of w^a3 (Lloyd et al., 2002)
Other
Statement Reference g^53d, lt¹/lt¹¹ has eye color defective \| recessive phenotype (Warner et al., 1998) g^53d, lt¹ has eye color defective \| recessive phenotype (Warner et al., 1998, Warner et al., 1998) g^53d, lt¹¹ has eye color defective \| recessive phenotype (Warner et al., 1998)
Phenotype Manifest In
Enhanced by
Statement Reference g^53d, z[+]/z¹ has pigment cell \| female phenotype, enhanceable by E(z)[+]/E(z)¹ (Lloyd et al., 2002) g^53d, z¹ has pigment cell \| male phenotype, enhanceable by E(z)¹ (Lloyd et al., 2002) g^53d, z¹ has pigment cell phenotype, enhanceable \| male by E(z)¹ (Lloyd et al., 2002) g^53d/g[+], z¹ has pigment cell \| female phenotype, enhanceable by E(z)[+]/E(z)¹ (Lloyd et al., 2002) g^53d/g^P has pigment cell phenotype, enhanceable by w[+]/w^e(g) (Lloyd et al., 2002) g^53d/g^P has pigment cell phenotype, enhanceable by w^e(g)/w^e(g) (Lloyd et al., 2002) g^53d has pigment cell phenotype, enhanceable by w¹/w^e(g) (Lloyd et al., 2002) g^53d has pigment cell phenotype, enhanceable by w^a/w^e(g) (Lloyd et al., 2002) g^53d has pigment cell phenotype, enhanceable by w^bf/w^e(g) (Lloyd et al., 2002) g^53d has pigment cell phenotype, enhanceable by w^Bwx/w^e(g) (Lloyd et al., 2002) g^53d has pigment cell phenotype, enhanceable by w^co/w^e(g) (Lloyd et al., 2002) g^53d has pigment cell phenotype, enhanceable by w^e(g)/w¹¹¹⁸ (Lloyd et al., 2002) g^53d has pigment cell phenotype, enhanceable by w^e(g)/w^e(g) (Lloyd et al., 2002) g^53d has pigment cell phenotype, enhanceable by w^sat/w^e(g) (Lloyd et al., 2002) g^53d has pigment cell phenotype, enhanceable by z¹ (Lloyd et al., 2002) g^53d has pigment cell phenotype, enhanceable by z^a (Lloyd et al., 2002)
Suppressed by
Statement Reference g^53d has pigment cell phenotype, suppressible by w^HSBJ (Lloyd et al., 2002)
Enhancer of
Statement Reference g^53d is an enhancer of pigment cell phenotype of w^a3 (Lloyd et al., 2002)
Other
Statement Reference g^53d, lt¹/lt¹¹ has pigment cell phenotype (Warner et al., 1998) g^53d, lt¹ has pigment cell phenotype (Warner et al., 1998, Warner et al., 1998) g^53d, lt¹¹ has pigment cell phenotype (Warner et al., 1998)
Additional Comments
Genetic Interactions
Statement Reference Expression of aux[Scer\UAS.cHa] under the control of Scer\GAL4[GMR.PF] enhances the loss of red eye pigment that is seen in g[53d] flies. (Cheli et al., 2010) w^e(g), g^53d double mutant flies have at least a 50% reduction of brown (ommochrome) pigments deposited in the eye compared to g^53d single mutants. There is also a reduction in red (pteridine) pigment to a lesser extent. All of the following w alleles when heterozygous with w^e(g) enhance the eye colour defective phenotype of g^53d mutants, leading to a greater reduction of red pigment within the eye: w¹¹¹⁸, w¹, w^a, w^bf, w^Bwx, w^co and w^sat. In contrast to g^53d homozygotes, g^P/g^53d transheterozygotes do interact with w^e(g), as g^P/g^53d, w^e(g) and g^P/g^53d, w^e(g)/+ flies have a reduced amount of red pigment in the eye compared to g^P, w^e(g) double mutant flies. The w^HSBJ transgene is able to increase the amount of red pigment in the eyes of g^53d mutant flies. The g^53d and following w alleles act additively to reduce eye pigmentation in double mutant male flies: w^a, w^a3, w^bf, w^ch, w^co, w^e, wⁱ and w^t. g^53d, z^a double mutants have a reduced amount of red pigment in the eye comparted to g^53d single mutants in both male and female flies. Likewise, g^53d, z¹ double mutant flies show decreased red eye pigment than g^53d mutants, although this reduction is greater in female flies than in male flies. Male E(z)¹/+, g^53d, z¹ triple mutants have less red pigment in the eye than g^53d, z¹ double mutants. Likewise, female E(z)¹/+, g^53d/+, z¹/+ triple mutants have a reduction in red eye pigment compared to g^53d/+, z¹/+ double mutants. (Lloyd et al., 2002) Eye colour: lt¹ g^53d double mutants show a marked reduction in eye pigment. Eye colour: lt¹/lt¹¹ g^53d double mutants show a reduction in red eye pigment compared to either lt¹/lt¹¹ or g^53d single mutants. (Warner et al., 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	Hexter, April 1953.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	g^53d (Cheli et al., 2010, Cheli et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 13 )
Research paper	Cheli et al., 2010, Hum. Mol. Genet. 19(5): 861--878 Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency. [FBrf0209903] Lloyd et al., 2002, Genome 45(2): 296--312 Enhancer of garnet/δAP-3 is a cryptic allele of the white gene and identifies the intracellular transport system for the white protein. [FBrf0147069] Lloyd et al., 1999, Genome 42(6): 1183--1193 A genetic and molecular characterization of the garnet gene of Drosophila melanogaster. [FBrf0125153] Lloyd et al., 1999, Genetics 151(4): 1503--1516 Genomic imprinting and position-effect variegation in Drosophila melanogaster. [FBrf0107856] Warner et al., 1998, Genome 41(2): 236--243 The light gene of Drosophila melanogaster encodes a homologue of VPS41, a yeast gene involved in cellular-protein trafficking. [FBrf0103059] Simpson et al., 1997, J. Cell Biol. 137(4): 835--845 Characterization of the adaptor-related protein complex, AP-3. [FBrf0093727] Tearle, 1991, Genet. Res. (Camb.) 57: 257--266 Tissue specific effects of ommochrome pathway mutations in Drosophila melanogaster. [FBrf0054090] Hexter, 1963, Proc. Natl. Acad. Sci. U.S.A. 50: 372--379 Nonreciprocal events at the garnet locus in Drosophila melanogaster. [FBrf0015794] Hexter, 1958, Proc. Natl. Acad. Sci. U.S.A. 44: 768--771 On the nature of the garnet locus in Drosophila melanogaster. [FBrf0012284]
Supplementary material	Cheli et al., 2010, Hum. Mol. Genet. 19(5): Supplementary Data. [FBrf0210495]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905] Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp Genetic variations of Drosophila melanogaster. [FBrf0020044]
Teaching note	Hexter, 1999, D. I. S. 82: 128 A two-factor sex-linked cross involving gene interaction. [FBrf0111906]

Allele Dmel\g53d

Allele Dmel\g^53d