Allele Dmel\gl²

General Information
Symbol	Dmel\gl²	Species	D. melanogaster
Name		FlyBase ID	FBal0005041
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\gl

Allele class	amorph, loss of function
Mutagen	spontaneous
Nature of the Allele
Allele class	amorph (Moses et al., 1989) loss of function (Treisman and Rubin, 1996)
Mutagen	spontaneous (Moses et al., 1989)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Deletion of about 1kb within the gl locus. (Moses et al., 1989)
Assay mode
Cytology
Phenotypic Data
Phenotypic Class
	eye color defective locomotor behavior defective (Liu et al., 2007)
Phenotype Manifest In
	eye pigment cell ocellus pigment granule ocellus corpus cardiacum primordium (De Velasco et al., 2004) Bolwig's organ primordium (De Velasco et al., 2004) embryonic corpus cardiacum (De Velasco et al., 2004) Bolwig's nerve (Moses et al., 1989) Bolwig's organ (Moses et al., 1989)
Detailed Description
	Statement Reference Mild allele. Slightly less extreme than gl¹. Eyes reduced to two-thirds normal size, ovoid, glassier and smoother than gl¹. Eye colour: blotchy scarlet in both sexes with rim and eroded patches of colorless material. Ocellus colour: colorless and papillose. Malpighian tubule colour: wild-type. (Bridges and Brehme, 1944) Cephalic complex smaller than wild type at 36 hr after hatching (27^oC); growth rate subsequently normal. (Medvedev, 1935) Cephalic complex smaller than wild type at 36 hr after hatching (27^oC); growth rate subsequently normal. (Medvedev, 1935) Bolwig's nerves are absent in third larval instar. In place of the normal Bolwig's organ is a loosely clustered group of abnormal neurons with random axonal projections. (Moses et al., 1989) Despite the absence of Bolwig's nerve, bsh expression is normal. (Jones and McGinnis, 1993) Displays locomotor activity rhythm with an approximately 24h period. (Vosshall and Young, 1995) Homozygous third instar larvae show a normal response to UVC radiation. e⁴ gl² mutant larvae show an abnormal response to UVC radiation. (Baden et al., 1996) Homozygous larvae disperse randomly among illuminated and dark quadrants of a petri plate in a visual assay (as do wild-type larvae). (Kutzler et al., 1998) The precursors of the corpus cardiacum and Bolwig's organ are reduced in number in stage 12 mutant embryos (this phenotype is a dominant effect). At stage 16, the corpus cardiacum is missing in mutant embryos, although the corpus allatum and stomatogastric nervous system are normal. (De Velasco et al., 2004) Mutant flies maintain a high level of activity in an open field arena over the full 10-minute assay (wild-type flies show a decay in locomotor activity over time in this assay). (Liu et al., 2007)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference gl[+]/gl² is an enhancer of visible \| conditional - heat sensitive phenotype of peb¹ (Wilk et al., 2004)
Phenotype Manifest In
Enhancer of
Statement Reference gl[+]/gl² is an enhancer of eye \| conditional - heat sensitive phenotype of peb¹ (Wilk et al., 2004)
NOT Enhancer of
Statement Reference gl² is a non-enhancer of phenotype of Doa⁷/Doa^HD (Yun et al., 2000) gl² is a non-enhancer of phenotype of Doa^HD/Doa^Dem (Yun et al., 2000)
NOT Suppressor of
Statement Reference gl² is a non-suppressor of phenotype of Doa⁷/Doa^HD (Yun et al., 2000) gl² is a non-suppressor of phenotype of Doa^HD/Doa^Dem (Yun et al., 2000)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	gl^SAE-9 (Mahoney et al., 2006)
Rescued by	gl² is rescued by gl^+t9954 (Moses et al., 1989, Ma et al., 1996)
Comments
Stocks ( 22 )
Bloomington	507 gl² e⁴ 3642 Df(3L)st4, gl² e⁴/TM6 2547 Df(3L)vin2, ru¹ h¹ gl² e⁴ ca¹/TM3, Sb¹ 2612 Df(3L)vin7, h¹ gl² e⁴ ca¹/TM3, Sb¹ Ser¹ 2553 Df(3L)vin6, ru¹ h¹ gl² e⁴ ca¹/TM3, Sb¹ Ser¹ 2611 Df(3L)vin5, ru¹ h¹ gl² e⁴ ca¹/TM3, Sb¹ Ser¹
Kyoto	105947 gl² e⁴ 107151 Df(3L)st4, gl² e⁴/TM6 107396 Df(3L)vin2, ru¹ h¹ gl² e⁴ ca¹/TM3, Sb¹ 107432 Df(3L)vin7, h¹ gl² e⁴ ca¹/TM3, Sb¹ Ser¹ 107398 Df(3L)vin6, ru¹ h¹ gl² e⁴ ca¹/TM3, Sb¹ Ser¹ 107431 Df(3L)vin5, ru¹ h¹ gl² e⁴ ca¹/TM3, Sb¹ Ser¹
	More stocks available...
Notes on Origin
Discoverer	R.L. King, 1927.

Comments
	Strong gl allele. (Moses et al., 1989) No interaction with P{sev-svp1} or P{sev-svp2} exists. (Begemann et al., 1995)
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	gl² (Mahoney et al., 2006, Liu et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 23 )

Generate a list of	All references relating to this allele ( 23 )

List References by type	Research paper ( 20 ) Review ( 1 ) Book ( 2 )
Recent research papers ( 2 )
	Liu et al., 2007, Genetics 175(3): 1197--1212 Exploratory activity in Drosophila requires the kurtz nonvisual arrestin. [FBrf0200160] Mahoney et al., 2006, Genetics 172(4): 2309--2324 Presenilin-based genetic screens in Drosophila melanogaster identify novel Notch pathway modifiers. [FBrf0190744] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2006 Show reviews ...

Allele Dmel\gl2

Allele Dmel\gl²