In gl3 mutants, cellular structure of the retina is disorganized, although photoreceptor neurons survive metamorphosis and are still present in the adult retina, in contrast to previous reports.
gl3/gl3 and gl3/gl60j mutant adults possess fewer and fused ommatidia, and boundaries between ommatidia are difficult to distinguish, as compared to wild type.
gl3/gl3 mutant adults possess few differentiated photoreceptors, but rhabdomeres are morphologically disrupted, smaller and malformed, as compared to wild type. gl3/gl3 mutant third instar larvae display disrupted photoreceptor cluster patterning in the eye imaginal disc. At 48 h APF, gl3/gl3 mutants possess all expected cell types, photoreceptors, cone and pigment cells, as compared to wild type, however no ommatidia contains the correct number of each retinal cell type, there is complete disruption of organization of retinal cells into distinct identifiable ommatidia, and cone and primary pigment cells are either too few or too many in number.
At 96 h APF, gl3/gl60j mutants display increased cell death of photoreceptors in the retina.
In contrast to wild-type, gl3 mutants fail to exhibit any light-dependent temperature preference.
Compound action potentials can be evoked by sound in the antennal nerve of mutant flies, but the sound particle velocities required to elicit the response is increased compared to wild type. Nonlinear mechanical amplification is significantly reduced compared to wild type.
Intermediate eye phenotype.
Displays locomotor activity rhythm with an approximately 24h period.
Weak allele. The eye is disorganised. Corneal hairs and red pigment granules are only present in the centre of the eye. The ocellar lenses are normal in size, but lack the bulge of the wild-type, and have small protuberances. There are no ocellar retinula cells. The lenses of the compound eye and ocelli are roughened with "corneal nipples".
Photoreceptor cells degenerate and die in the mid-pupal stage at the time when they would normally be producing rhabdomeres (FBrf0074259).
Adult eye is rough, reduced and has a glassy texture. Irregular ommatidia pattern, no rhabdomeres and masses of pigment granules.
Malpighian tubule colour: wild-type.
Weak allele. Eyes small and elliptical with surface less rough than gl1 or gl2. Eye colour: homogeneous scarlet. Ocellus colour: colourless. RK1.