Allele Dmel\gl³

General Information
Symbol	Dmel\gl³	Species	D. melanogaster
Name		FlyBase ID	FBal0005042
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\gl

Allele class
Mutagen	spontaneous
Nature of the Allele
Allele class
Mutagen	spontaneous (Moses et al., 1989, Ma et al., 1996)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion of about 2.5kb of unknown DNA into the gl locus. (Moses et al., 1989) Insertion of about 2.5kb of unknown DNA (maybe a transposable element). (Ma et al., 1996)
Assay mode
Carried on aberration	C(3R)RM-SB1
Cytology
Phenotypic Data
Phenotypic Class
	viable visible (Stark and Carlson, 1991) eye color defective fertile
Phenotype Manifest In
	eye (Ma et al., 1996, Stark and Carlson, 1991) pigment cell ocellus pigment granule photoreceptor cell & pupa (Moses et al., 1989) ocellus lens (Stark and Carlson, 1991) ocellus retinula cell (Stark and Carlson, 1991)
Detailed Description
	Statement Reference Weak allele. Eyes small and elliptical with surface less rough than gl¹ or gl². Eye colour: homogeneous scarlet. Ocellus colour: colourless. RK1. Malpighian tubule colour: wild-type. (Bridges and Brehme, 1944) Adult eye is rough, reduced and has a glassy texture. Irregular ommatidia pattern, no rhabdomeres and masses of pigment granules. (Renfranz and Benzer, 1989) Photoreceptor cells degenerate and die in the mid-pupal stage at the time when they would normally be producing rhabdomeres (FBrf0074259). (Moses et al., 1989) Weak allele. The eye is disorganised. Corneal hairs and red pigment granules are only present in the centre of the eye. The ocellar lenses are normal in size, but lack the bulge of the wild-type, and have small protuberances. There are no ocellar retinula cells. The lenses of the compound eye and ocelli are roughened with "corneal nipples". (Stark and Carlson, 1991) Displays locomotor activity rhythm with an approximately 24h period. (Vosshall and Young, 1995) Intermediate eye phenotype. (Ma et al., 1996)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement Reference gl³/gl[+] is a non-enhancer of visible \| conditional - heat sensitive phenotype of peb¹ (Wilk et al., 2004)
Suppressor of
Statement Reference gl³/gl[+] is a suppressor of visible phenotype of os^GMR.PB (Bach et al., 2003)
NOT Suppressor of
Statement Reference gl³/gl[+] is a non-suppressor of visible \| conditional - heat sensitive phenotype of peb¹ (Wilk et al., 2004)
Phenotype Manifest In
Enhanced by
Statement Reference gl³ has phenotype, enhanceable by E(gl)2A^SC1 (Ma et al., 1996) gl³ has phenotype, enhanceable by E(gl)2B^SC1 (Ma et al., 1996) gl³ has phenotype, enhanceable by E(gl)2C^SC1 (Ma et al., 1996) gl³ has phenotype, enhanceable by E(gl)2D^SC1 (Ma et al., 1996) gl³ has phenotype, enhanceable by E(gl)2E^SC1 (Ma et al., 1996) gl³ has phenotype, enhanceable by E(gl)2F^SC1 (Ma et al., 1996) gl³ has phenotype, enhanceable by E(gl)2H^SC1 (Ma et al., 1996) gl³ has phenotype, enhanceable by E(gl)3A^SC1 (Ma et al., 1996) gl³ has phenotype, enhanceable by E(gl)3B^SCG1 (Ma et al., 1996) gl³ has phenotype, enhanceable by E(gl)3C^SCG1 (Ma et al., 1996) gl³ has phenotype, enhanceable by E(gl)3D^SC1 (Ma et al., 1996) gl³ has phenotype, enhanceable by E(gl)3D^SCG1 (Ma et al., 1996) gl³ has phenotype, enhanceable by N^l1N-ts1 (Ma et al., 1996) gl³ has phenotype, enhanceable by N^spl-1 (Ma et al., 1996) gl³ has phenotype, enhanceable by dog^SC1 (Ma et al., 1996) gl³ has phenotype, enhanceable by dog^SC2 (Ma et al., 1996) gl³ has phenotype, enhanceable by h^SCG1 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC10 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC11 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC12 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC13 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC14 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC15 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC16 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC17 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC18 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC19 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC1 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC20 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC21 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC2 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC3 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC4 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC5 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC6 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC7 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC8 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SC9 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SCG1 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SCG2 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^SCG3 (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^fse (Ma et al., 1996) gl³ has phenotype, enhanceable by hh^ts2 (Ma et al., 1996) gl³ has phenotype, enhanceable by Df(3R)rn20 (Ma et al., 1996) gl³ has phenotype, enhanceable by rn^roe-1 (Ma et al., 1996) gl³ has phenotype, enhanceable by rn^roe-3 (Ma et al., 1996) gl³ has phenotype, enhanceable by rn^roe-4 (Ma et al., 1996) gl³ has phenotype, enhanceable by rn^roe-SC1 (Ma et al., 1996)
NOT Enhancer of
Statement Reference gl³/gl[+] is a non-enhancer of eye \| conditional - heat sensitive phenotype of peb¹ (Wilk et al., 2004)
Suppressor of
Statement Reference gl³/gl[+] is a suppressor of eye phenotype of os^GMR.PB (Bach et al., 2003)
NOT Suppressor of
Statement Reference gl³/gl[+] is a non-suppressor of eye \| conditional - heat sensitive phenotype of peb¹ (Wilk et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference The enlarged eye phenotype seen in flies carrying one copy of os^GMR.PB is suppressed by one copy of gl³. (Bach et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	gl^SAE-9 (Mahoney et al., 2006)
Comments
Stocks ( 21 )
Bloomington	508 gl³ 768 Ubx^Cbx-1 Ubx¹ gl³/TM1 4147 w¹¹¹⁸; Opl^SC1/CyO; gl³ 4135 w¹¹¹⁸; E(gl)2B^SC1/CyO; gl³ 4136 w¹¹¹⁸; E(gl)2C^SC1/CyO; gl³ 4137 w¹¹¹⁸; E(gl)2D^SC1/CyO; gl³ 4138 w¹¹¹⁸; E(gl)2E^SC1/CyO; gl³ 4139 w¹¹¹⁸; E(gl)2F^SC1/CyO; gl³ 4140 w¹¹¹⁸; E(gl)2G^SC1/CyO; gl³ 4141 w¹¹¹⁸; E(gl)2H^SC1/CyO; gl³ 4142 w¹¹¹⁸; E(gl)3A^SC1/CyO; gl³
Kyoto	105948 gl³
	More stocks available...
Notes on Origin
Discoverer	Stern.

Comments
	Weak gl allele. (Moses et al., 1989) In a screen for dominant suppressors of hh, 25 out of 84 mutations recovered were at hh. (Ma et al., 1993) No interaction with P{sev-svp1} or P{sev-svp2} exists. (Begemann et al., 1995) Weak gl mutation. (Ma et al., 1996)
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	gl³ (Mahoney et al., 2006) glass₃ (Yarfitz et al., 1991) rh
Name Synonym	rauhig
Secondary FlyBase IDs

References ( 20 )
Research paper	Mahoney et al., 2006, Genetics 172(4): 2309--2324 Presenilin-based genetic screens in Drosophila melanogaster identify novel Notch pathway modifiers. [FBrf0190744] Wilk et al., 2004, Genetics 168(1): 281--300 Dose-sensitive autosomal modifiers identify candidate genes for tissue autonomous and tissue nonautonomous regulation by the Drosophila nuclear zinc-finger protein, hindsight. [FBrf0180294] Bach et al., 2003, Genetics 165(3): 1149--1166 A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway. [FBrf0167623] Ma et al., 1996, Genetics 142(4): 1199--1213 Identification and characterization of autosomal genes that interact with glass in the developing Drosophila eye. [FBrf0087580] van den Dries et al., 1996, Dev. Biol. 173(1): 243--255 orthodenticle is required for photoreceptor cell development in the Drosophila eye. [FBrf0086078] Begemann et al., 1995, Development 121(1): 225--235 The Drosophila orphan nuclear receptor Seven-up requires the Ras pathway for its function in photoreceptor determination. [FBrf0076133] Vosshall and Young, 1995, Neuron 15(2): 345--360 Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells. [FBrf0083505] Ma et al., 1993, Cell 75(5): 927--938 The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye. [FBrf0064592] Vaias et al., 1993, Behav. Genet. 23(1): 91--97 Identification of stimuli that mediate experience-dependent modification of homosexual courtship in Drosophila melanogaster. [FBrf0057805] Moses and Rubin, 1991, Genes Dev. 5: 583--593 Glass encodes a site-specific DNA-binding protein that is regulated in response to positional signals in the developing Drosophila eye. [FBrf0054063] Stark and Carlson, 1991, D. I. S. 70: 217--219 Comparison of the surfaces of 'glnone's' ocelli and compound eyes with those of several glass alleles. [FBrf0053603] Yarfitz et al., 1991, Neuron 7(3): 429--438 A G protein in the Drosophila compound eye is different from that in the brain. [FBrf0054805] Brand and Campos-Ortega, 1990, Roux Arch. dev. Biol. 198(5): 275--285 Second-site modifiers of the split mutation of Notch define genes involved in neurogenesis in Drosophila melanogaster. [FBrf0052914] Moses et al., 1989, Nature 340(6234): 531--536 The glass gene encodes a zinc-finger protein required by Drosophila photoreceptor cells. [FBrf0050650] Renfranz and Benzer, 1989, Dev. Biol. 136(2): 411--429 Monoclonal antibody probes discriminate early and late mutant defects in development of the Drosophila retina. [FBrf0049495] Meyerowitz and Kankel, 1978, Dev. Biol. 62(1): 112--142 A genetic analysis of visual system development in Drosophila melanogaster. [FBrf0031347] Smith and Lucchesi, 1969, Genetics 61: 607--618 The role of sexuality in dosage compensation in Drosophila. [FBrf0020609] Csik, 1929, Biol. Zentbl. 49: 419--421 Ein neuer Erbfaktor bei Drosophila melanogaster. [FBrf0001804]
Book	Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp Genetic variations of Drosophila melanogaster. [FBrf0020044] Bridges and Brehme, 1944, Publs Carnegie Instn 552: vii + 257pp The mutants of Drosophila melanogaster. [FBrf0006100]

Allele Dmel\gl3

Allele Dmel\gl³