|Feature type||allele||Associated gene||Dmel\grk|
|Also Known As||grkDC, grkDC29|
|Map ( GBrowse )|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: A245V. Nucleotide substitution: C2424T.
Amino acid replacement: A245V.
|Phenotype Manifest In|
microtubule & oocyte
In grk2B6/grk1 oocytes the anterior-posterior gradient of microtubule concentration seen in wild-type is abolished. However, concentration of microtubules around the mis-localized nucleus persists.
Ovaries from grk1/grk2B6 mutant females show a range of defects. In mildly affected egg chambers where the germinal vesicle has moved anterior and dorsal, border cells complete posterior migration but fail to migrate dorsally.
Microtubule cytoskeleton in grk2B6/grk1 oocytes is defective due to premature streaming of the microtubules.
grk1/grk2 heterozygous females display fused egg chambers and gaps in the follicular epithelium that uncover the nurse cells. Eggs derived from these females exhibit strong ventralised phenotype.
Reduction or absence of dorsal appendages (ventralization) with increase in main body egg shell. Micropyle at both ends of eggs, embryos ventralized.
An enlarged mass of mesodermal cells invaginates on the ventral side of the embryo, the enlarged mesoderm is often organised into two ventral furrows. Organisation is lost in later stages of development and a mass of mesodermal cells fills the ventral half of the embryo. Respiratory appendages are completely absent and only the ventral most portion of the operculum is present.
phenotype of eggs and embryos: intermediate and strong
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 4 )|
(Schnorrer et al., 2002, Januschke et al., 2002, Dequier et al., 2001, Morisato, 2001, Duchek and Rorth, 2001, Schnorrer et al., 2000, Grammont et al., 2000, Doerflinger et al., 1999, Peri et al., 1999, Neuman-Silberberg and Schupbach, 1996, Roth et al., 1995, Neuman-Silberberg and Schupbach, 1993, Schupbach, 1987, Bokel et al., 2006, Januschke et al., 2006, Cui et al., 2005)
|Secondary FlyBase IDs|
|References ( 25 )|
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|Recent research papers (0)|
|All research papers listed in FlyBase were published before 2011|