Allele Dmel\grk¹

General Information
Symbol	Dmel\grk¹	Species	D. melanogaster
Name		FlyBase ID	FBal0005209
Feature type	allele	Associated gene	Dmel\grk
Also Known As	grk^DC, grk^DC29

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Schupbach, 1987, Schupbach and Wieschaus, 1991, Neuman-Silberberg and Schupbach, 1993, Neuman-Silberberg and Schupbach, 1996)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2L:8,431,693..8,431,693 evidence=experimental na_change=C8431693T pr_change=A246V\|grk-PA reported_na_change=C2424T reported_pr_change=A245V (Thio et al., 2000, Queenan et al., 1999)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: A245V. Nucleotide substitution: C2424T. (Thio et al., 2000) Amino acid replacement: A245V. (Queenan et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile (Schupbach and Wieschaus, 1991) female sterile \| recessive (Neuman-Silberberg and Schupbach, 1993)
Phenotype Manifest In
	border follicle cell (with grk^2B6) (Duchek and Rorth, 2001) dorsal appendage (Schupbach, 1987) egg operculum (Schupbach, 1987) embryo \| ventral (Schupbach, 1987) microtubule & oocyte (Clegg et al., 1997) oocyte & microtubule (with grk^2B6) (Januschke et al., 2002) ovary (with grk^2B6) (Duchek and Rorth, 2001, Januschke et al., 2002) ventral furrow (Schupbach, 1987)
Detailed Description
	Statement Reference In grk^2B6/grk¹ oocytes the anterior-posterior gradient of microtubule concentration seen in wild-type is abolished. However, concentration of microtubules around the mis-localized nucleus persists. (Januschke et al., 2002) Ovaries from grk¹/grk^2B6 mutant females show a range of defects. In mildly affected egg chambers where the germinal vesicle has moved anterior and dorsal, border cells complete posterior migration but fail to migrate dorsally. (Duchek and Rorth, 2001) Microtubule cytoskeleton in grk^2B6/grk¹ oocytes is defective due to premature streaming of the microtubules. (Clegg et al., 1997) grk¹/grk² heterozygous females display fused egg chambers and gaps in the follicular epithelium that uncover the nurse cells. Eggs derived from these females exhibit strong ventralised phenotype. (Goode et al., 1996) Reduction or absence of dorsal appendages (ventralization) with increase in main body egg shell. Micropyle at both ends of eggs, embryos ventralized. (Schupbach and Wieschaus, 1991) An enlarged mass of mesodermal cells invaginates on the ventral side of the embryo, the enlarged mesoderm is often organised into two ventral furrows. Organisation is lost in later stages of development and a mass of mesodermal cells fills the ventral half of the embryo. Respiratory appendages are completely absent and only the ventral most portion of the operculum is present. (Schupbach, 1987) phenotype of eggs and embryos: intermediate and strong
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Strong grk allele. (Schupbach, 1987)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	grk¹ grk^DC9 (Bryant et al., 1999) grk^DC29 (Thio et al., 2000, Jordan et al., 2000, Queenan et al., 1999, Larkin et al., 1999, Clegg et al., 1997, Morimoto et al., 1996, Goode et al., 1996) grk^DC (Schnorrer et al., 2002, Januschke et al., 2002, Dequier et al., 2001, Morisato, 2001, Duchek and Rorth, 2001, Schnorrer et al., 2000, Grammont et al., 2000, Doerflinger et al., 1999, Peri et al., 1999, Neuman-Silberberg and Schupbach, 1996, Roth et al., 1995, Neuman-Silberberg and Schupbach, 1993, Schupbach, 1987, Bokel et al., 2006, Januschke et al., 2006, Cui et al., 2005)
Name Synonym
Secondary FlyBase IDs

References ( 25 )

Generate a list of	All references relating to this allele ( 25 )

List References by type	Research paper ( 24 ) Letter ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...

Allele Dmel\grk1

Allele Dmel\grk¹