|Feature type||allele||Associated gene||Dmel\gro|
|Allele class||hypomorphic allele - genetic evidence|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
The chromosome containing the gro mutation contains two inserts, one of about 4 kb between coordinates -4.8 and -3.8 kb and a much smaller one at approximately +11.5 detected by Preiss et al. The larger of the two is independent of the gro mutation since Df(3R)Pr4, which deletes the region into which the segment is inserted, does not uncover gro; a similar argument for the independence of the insert at 11.5 can be made since gro is rescued by transformation with a segment from 12.7 to 23.1 (Preiss et al.).
|Caused by insertion|
Polytene chromosomes normal.
Polytene chromosomes normal.
|Phenotype Manifest In|
adult head & microchaeta
macrochaeta & abdominal tergite
macrochaeta & head
macrochaeta & thorax
microchaeta & abdominal tergite
microchaeta & head
microchaeta & thorax
groC105/gro1 mutants display enlarged and fused ocelli, and an increased number of fronto-orbital microchaetae.
The wing phenotype of gro1 heterozygous with deletions for gro is of overgrowth and pattern duplications in regions close to the D/V compartment boundary in the anterior compartment. Weak phenotypes include distal bifurcation of vein LIII and thickening of the proximal costa. Extreme phenotypes consist of overgrowth and pattern duplications in proximal or distal regions of the anterior wing margin, including duplication and triplication of LIII and loss of LII. Sensory elements in affected areas are typical of distal regions of the wing. gro1 when heterozygous with deletions for gro also causes the appearance of clusters of macrochaetae and microchaetae in particular regions of the head, thorax and tergites, though at low frequency.
Low penetrance bushes of bristles over compound eyes of homozygous flies. gro1, E(spl)- transheterozygotes are viable and exhibit a large number of bristles on thorax, head and wings.
Homozygotes have clumps of extra bristles above each eye which give impression of bushy eyebrows; also extra bristles on the humerus. Top of head tends to be malformed; ocelli often enlarged and run together. In selected stocks, penetrance approaches 100%, but is low in unselected stocks. Concluded to be an allele of E(spl) on the basis of the visible phenotype of heterozygotes with lethal presumed point mutations at E(spl); however, it does not cause neural hypertrophy and is wild type in combination with E(spl)1.
|Phenotype Manifest In|
|NOT Enhancer of|
|NOT Suppressor of|
The overproliferation of frontal bristles on the head that is seen in gro/gro[C105] adults is enhanced if they are also hemizygous for CG12299[EY01579]. gro/gro[C105] ; CG8924[EY00245] double mutants have missing frontal bristles in 57% of cases. gro/gro[C105] ; CG1832[KG00473]/CG1832[KG00473] adults have extra frontal bristles on the head in 65% of cases and have missing frontal bristles in 14% of cases. gro/gro[C105] ; Ac3[EY10141] double mutants have extra frontal bristles on the head in 55% of cases and have missing frontal bristles in 33% of cases. gro/gro[C105] ; BCL7-like[EY10009]/BCL7-like[EY00880] double mutants have extra frontal bristles on the head in 3% of cases and have missing frontal bristles in 96% of cases.
gro/gro[E48] adults heterozygous for sbb show an enlarged anterior wing compartment. Ectopic longitudinal wing vein L2 and L3 tissue develops, and transformation of the anterior wing margin bristles into more posteriorly located sensory organs is observed.
Egfrt1 enhances the bristle, ocellar, wing and limb phenotypes of homozygotes. Bristle hyperplasia, ocellus enlargement and ocellus fusion are enhanced. Wings are notched, wing margins are hairier, have ectopic vein material and anterior outgrowths. Legs are fused and bifurcated. Egfrf1; gro1/gro1 and Egfrf13; gro1/gro1 flies display an enhanced gro phenotype: ectopic compound eyes, fused or bifurcated legs. These phenotypes are almost exclusively restricted to males. The ectopic eyes are organised into arrays of ommatidia. They are frequently adjacent to the endogenous eye but separated by a discrete border and exhibit defects in ommatidial packing and the distribution of interommatidial bristles. Egfrt1/Df(2R)Egfr18; gro1/gro1 flies display a combination of Egfr and gro phenotypes. The L4 wing vein defect is restored and the ocellar bristles are present but disarrayed. In many cases supernumerary ocellar bristles and/or interocellar bristles are present producing a patch of bristles were the ocelli would normally have been. The ocelli are either reduced or eliminated. Most males display one or more ectopic eye structure dorso-medial to the normal eyes. These structures are small and contain discrete ommatidia but no interommatidial bristles. The lens material of these ectopic eyes is fused into a uniform glaze and they are recessed into the head cuticle.
|Complementation & Rescue Data|
|Stocks ( 2 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 3 )|
|Secondary FlyBase IDs|
|References ( 14 )|
|Personal communication to FlyBase|