Allele Dmel\H¹

General Information
Symbol	Dmel\H¹	Species	D. melanogaster
Name		FlyBase ID	FBal0005292
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\H

Allele class	amorph, loss of function
Mutagen	spontaneous
Nature of the Allele
Allele class	amorph (Nagel et al., 2000) loss of function (Long et al., 1996)
Mutagen	spontaneous (Ashburner, 1982, Maier et al., 1992)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion whose restriction map matches copia inserted into the 2nd intron. (Maier et al., 1992) Insertion of a copia element in the second intron. The insertion occurs in between the T/A at 314/315 base pairs counting from the 5' splice junction. (Harding-Theobald et al., 2007.2.6)
Assay mode
Caused by insertion	copia{}H¹ (Harding-Theobald et al., 2007.2.6)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Diaz-Benjumea and Garcia-Bellido, 1990) visible (Steinberg, 1937, Apidianakis et al., 1999) visible (with H³) (Nagel et al., 2000) visible \| dominant (Fostier et al., 1998, Maier et al., 1992, Verheyen et al., 2001)
Phenotype Manifest In
	macrochaeta & adult postvertical bristle occipital bristle ocellar bristle microchaeta (Fostier et al., 1998) wing vein L2 (Steinberg, 1937) wing vein L4 (Steinberg, 1937) wing vein L5 (Fostier et al., 1998, Steinberg, 1937, Verheyen et al., 2001) macrochaeta (Fostier et al., 1998) posterior crossvein (Steinberg, 1937) dorsal hair (Dickinson and Thatcher, 1997) scutellar bristle (Apidianakis et al., 1999) macrochaeta & scutum (Lyman and Yedvobnick, 1995) microchaeta & scutum (Lyman and Yedvobnick, 1995) mesothoracic tergum & macrochaeta (Verheyen et al., 2001) head bristle (Verheyen et al., 2001) eo neuron (with H^P8) (Nagel et al., 2000) thecogen cell (with H^P8) (Nagel et al., 2000) sensory mother cell (with H³) (Nagel et al., 2000) eo neuron (with H³) (Nagel et al., 2000) thecogen cell \| ectopic (with H³) (Nagel et al., 2000) tormogen cell \| ectopic (with H³) (Nagel et al., 2000)
Detailed Description
	Statement Reference Bristles, especially postverticals and abdominals, missing in heterozygous H¹ flies. Bristle sockets present at some sites, not at others. Expressed most distinctly on head; occipital; postvertical and ocellar bristles affected. Veins L4 and L5 do not reach wing margin; occasionally true of L2 also. Recessive lethal. Homozygotes die during larval and pupal stages Animals surviving to pharate adult are completely devoid of macrochaetes and microchaetes on the head and notum, with occasional 'double sockets' remaining on the abdominal tergites. Bristles on the legs significantly resistant to loss of H⁺ function. Strongly enhanced expression of "N^Ax" alleles. (Siren and Portin, 1989) Terminal gaps in LIV and LV and occasionally short terminal gaps in LII and LIII. (Diaz-Benjumea and Garcia-Bellido, 1990) Mutant flies show shortening of at least one and sometimes more of: wing veins L2, L4 and L5 and the posterior crossvein. (Steinberg, 1937) Dorsal hairs are sparse compared to wild type. Denticle belts are normal. (Dickinson and Thatcher, 1997) Small L5 gap phenotype at low penetrance in heterozygotes. (Fostier et al., 1998) H¹/H² flies produce nota that are bald. (Apidianakis et al., 1999) H³/H¹ flies have a loss of Sensory Organ Precursors (SOP), and thus in nearly bald pharate adults. Remaining SOPs mainly give rise to quadruple sockets. In H¹/H^P8 flies a complete transformation of all external sensory organ neurons into sheath cells. (Nagel et al., 2000) Heterozygotes show shortening of wing vein L5. (Verheyen et al., 2001) Mutant embryos show normal boundary cell differentiation in the hindgut. (Takashima et al., 2002)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference H¹ has visible \| dominant phenotype, enhanceable by nmo^adk2/nmo^adk1 (Verheyen et al., 2001) H¹ has visible \| dominant phenotype, enhanceable by nmo^adk1/nmo^adk1 (Verheyen et al., 2001)
Enhancer of
Statement Reference H¹ is an enhancer of visible phenotype of Dl^Scer\UAS.cJa, Scer\GAL4^{l(3)31-1-31-1} (Jacobsen et al., 1998)
NOT Enhancer of
Statement Reference H¹ is a non-enhancer of visible phenotype of os^GMR.PB (Bach et al., 2003)
Suppressor of
Statement Reference H¹ is a suppressor of visible \| recessive phenotype of nmo^adk2 (Verheyen et al., 2001) H¹ is a suppressor of visible phenotype of Scer\GAL4^bbg-C96, mam^N.Scer\UAS (Helms et al., 1999) H¹ is a suppressor \| partially of lethal phenotype of Dl¹, RpS3[+]/RpS3¹ (Schultz, 1929) H¹ is a suppressor \| partially of lethal phenotype of Dl[+]/Dl¹, RpS3¹ (Schultz, 1929) H[+]/H¹ is a suppressor of visible phenotype of Scer\GAL4^en-e16E, pzg^{dsRNA.Scer\UAS} (Kugler and Nagel, 2007)
NOT Suppressor of
Statement Reference H¹ is a non-suppressor of visible phenotype of os^GMR.PB (Bach et al., 2003)
Phenotype Manifest In
Enhanced by
Statement Reference H¹ has wing vein L5 phenotype, enhanceable by Su(dx)^sp (Fostier et al., 1998) H¹ has macrochaeta phenotype, enhanceable by Su(dx)^sp (Fostier et al., 1998) H¹ has microchaeta phenotype, enhanceable by Su(dx)^sp (Fostier et al., 1998) H¹ has phenotype, enhanceable by Su(H)^E(H) H¹ has head bristle phenotype, enhanceable by nmo^adk2/nmo^adk1 (Verheyen et al., 2001) H¹ has mesothoracic tergum & macrochaeta phenotype, enhanceable by nmo^adk2/nmo^adk1 (Verheyen et al., 2001) H¹ has head bristle phenotype, enhanceable by nmo^adk1/nmo^adk1 (Verheyen et al., 2001) H¹ has mesothoracic tergum & macrochaeta phenotype, enhanceable by nmo^adk1/nmo^adk1 (Verheyen et al., 2001) H¹ has phenotype, enhanceable by Su(H)^eBC11 (Verheyen et al., 1996) H¹ has phenotype, enhanceable by Su(H)^O5 (Fortini and Artavanis-Tsakonas, 1994) H¹ has phenotype, enhanceable by Su(H)^T4 (Fortini and Artavanis-Tsakonas, 1994)
Suppressed by
Statement Reference H¹ has phenotype, suppressible by Su(H)¹¹ (O'Donnell et al., 1977) H¹ has phenotype, suppressible by Su(H)^sA21 (Verheyen et al., 1996) H¹ has phenotype, suppressible by Su(H)^sK2 (Verheyen et al., 1996) H¹ has phenotype, suppressible by Su(H)^sO10 (Verheyen et al., 1996) H¹ has phenotype, suppressible by Su(H)¹² (Furukawa et al., 1992) H¹ has phenotype, suppressible by Su(H)¹³ (Furukawa et al., 1992) H¹ has phenotype, suppressible by Su(H)¹⁴ (Furukawa et al., 1992) H¹ has phenotype, suppressible by Su(H)⁶ (Furukawa et al., 1992) H¹ has phenotype, suppressible by Su(H)⁸ (Furukawa et al., 1992) H¹ has phenotype, suppressible by Su(H)^AM1 (Furukawa et al., 1992) H¹ has phenotype, suppressible by Su(H)^IB115 (Furukawa et al., 1992)
NOT suppressed by
Statement Reference H¹ has phenotype, non-suppressible by su(Hw)² (Lindsley and Grell, 1968)
Enhancer of
Statement Reference H¹ is an enhancer of presutural bristle & trichogen cell phenotype of Dl^Scer\UAS.cJa, Scer\GAL4^{l(3)31-1-31-1} (Jacobsen et al., 1998) H¹ is an enhancer of anterior notopleural bristle & trichogen cell phenotype of Dl^Scer\UAS.cJa, Scer\GAL4^{l(3)31-1-31-1} (Jacobsen et al., 1998) H¹ is an enhancer of posterior notopleural bristle & trichogen cell phenotype of Dl^Scer\UAS.cJa, Scer\GAL4^{l(3)31-1-31-1} (Jacobsen et al., 1998) H¹ is an enhancer of anterior supraalar bristle & trichogen cell phenotype of Dl^Scer\UAS.cJa, Scer\GAL4^{l(3)31-1-31-1} (Jacobsen et al., 1998) H¹ is an enhancer of posterior supraalar bristle & trichogen cell phenotype of Dl^Scer\UAS.cJa, Scer\GAL4^{l(3)31-1-31-1} (Jacobsen et al., 1998) H¹ is an enhancer of posterior postalar bristle & trichogen cell phenotype of Dl^Scer\UAS.cJa, Scer\GAL4^{l(3)31-1-31-1} (Jacobsen et al., 1998) H¹ is an enhancer of anterior dorsocentral bristle & trichogen cell phenotype of Dl^Scer\UAS.cJa, Scer\GAL4^{l(3)31-1-31-1} (Jacobsen et al., 1998) H¹ is an enhancer of posterior dorsocentral bristle & trichogen cell phenotype of Dl^Scer\UAS.cJa, Scer\GAL4^{l(3)31-1-31-1} (Jacobsen et al., 1998) H¹ is an enhancer of anterior scutellar bristle & trichogen cell phenotype of Dl^Scer\UAS.cJa, Scer\GAL4^{l(3)31-1-31-1} (Jacobsen et al., 1998) H¹ is an enhancer of posterior scutellar bristle & trichogen cell phenotype of Dl^Scer\UAS.cJa, Scer\GAL4^{l(3)31-1-31-1} (Jacobsen et al., 1998) H¹ is an enhancer of microchaeta & scutum phenotype of N^60g11 (Lyman and Yedvobnick, 1995) H¹ is an enhancer of phenotype of N^l1N-B (Lyman and Yedvobnick, 1995) H¹ is an enhancer of microchaeta & scutum phenotype of N^l1N-B (Lyman and Yedvobnick, 1995)
NOT Enhancer of
Statement Reference H¹ is a non-enhancer of eye phenotype of os^GMR.PB (Bach et al., 2003)
Suppressor of
Statement Reference H¹ is a suppressor of wing vein \| ectopic phenotype of nmo^adk2 (Verheyen et al., 2001) H¹ is a suppressor of phenotype of Dl¹ H¹ is a suppressor of phenotype of NX¹ H¹ is a suppressor of microchaeta phenotype of N^Ax-9/N^l1N-B (Lyman and Yedvobnick, 1995) H¹ is a suppressor of phenotype of Dl^TM.sev (Sun and Artavanis-Tsakonas, 1996) H¹ is a suppressor of chemosensory ventral triple row & microchaeta \| ectopic phenotype of ed^4.12 (Rawlins et al., 2003) H¹ is a suppressor of dorsal triple row & microchaeta \| ectopic phenotype of ed^4.12 (Rawlins et al., 2003) H¹ is a suppressor of dorsocentral bristle \| ectopic phenotype of ed^4.12 (Rawlins et al., 2003) H¹ is a suppressor of scutellar bristle \| ectopic phenotype of ed^4.12 (Rawlins et al., 2003) H¹ is a suppressor of phenotype of Ser^{TM.sev.T:VSV\G} (Sun and Artavanis-Tsakonas, 1996) H[+]/H¹ is a suppressor of wing phenotype of Scer\GAL4^en-e16E, pzg^{dsRNA.Scer\UAS} (Kugler and Nagel, 2007)
NOT Suppressor of
Statement Reference H¹ is a non-suppressor of eye phenotype of os^GMR.PB (Bach et al., 2003)
Other
Statement Reference Dl^Scer\UAS.cJa, H¹, Scer\GAL4^{l(3)31-1-31-1} has microchaeta phenotype (Jacobsen et al., 1998, Jacobsen et al., 1998)
Additional Comments
Genetic Interactions
Statement Reference The lethality of Dl¹ RpS3¹ heterozygotes is partially suppressed by H¹. (Schultz, 1929) Enhances the microchaetae and macrochaetae loss phenotype of N gain of function heterozygotes. (Lyman and Yedvobnick, 1995) Heterozygous vein L5 gap phenotype is enhanced by hetero- and homozygotes for Su(dx)^sp which also enhances the bristle loss phenotype of H¹. (Fostier et al., 1998) Enhances the transformation of the trichogen to a tormogen fate in the notal macrochaetae caused by Dl^Scer\UAS.cJa expressed under the control of Scer\GAL4^{l(3)31-1-31-1}. Widespread transformation of microchaetae is also seen in this background. (Jacobsen et al., 1998) The addition of H¹ suppresses the wing nicking phenotype seen in mam^N.Scer\UAS, Scer\GAL4^C96 flies producing a range of phenotypes. (Helms et al., 1999) The ectopic wing veins seen in nmo^adk2 flies are completely suppressed by H¹. The loss of bristles on the head and notum seen in H¹/+ flies is dramatically enhanced by nmo^adk1/nmo^adk1 or nmo^adk1/nmo^adk2. (Verheyen et al., 2001) The reduction in wing area seen in flies expressing pzg[dsRNA.Scer\UAS] under the control of Scer\GAL4[en-e16E] is suppressed by N[Ax-M1]/+ or H[1]/+. (Kugler and Nagel, 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 26 )
Bloomington	5440 Df(3R)ME61, H¹/TM6 1698 H¹ Pr¹ Bsb¹/TM6 515 H¹/In(3R)C, sprd¹ e¹ 4212 Gl¹ Sb¹ H¹/In(3L)P, In(3R)P 1927 w^*; Dl¹ H¹ r-l^K1/TM2 516 H¹ Pr¹/In(3R)C, sprd¹ e¹
Kyoto	108236 Df(3R)ME61, H¹/TM6 106459 H¹ Pr¹ Bsb¹/TM6 105955 H¹/In(3R)C, sprd¹ e¹ 101666 In(3R)C, cd¹ / Sb¹ H¹ 107634 Gl¹ Sb¹ H¹/In(3L)P, In(3R)P 106581 w^*; Dl¹ H¹ r-l^K1/TM2
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Notes on Origin
Discoverer	Bridges, 4th March 1916.

Comments
	Phenotypic series of H alleles, progressing from strongest (amorphic) to weakest mutant phenotype: H^B79 = H⁸¹ >> H¹ = H⁹⁹ > H^bob > H^94a > H^88d > H^B8 > H² >= H³ > H^A120. (Maier et al., 1992)
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	H (Steinberg, 1937, Schultz, 1929) H1 (Simonova et al., 1998) H¹ (Kugler and Nagel, 2007)
Name Synonym
Secondary FlyBase IDs

References ( 35 )

Generate a list of	All references relating to this allele ( 35 )

List References by type	Research paper ( 29 ) Personal communication to FlyBase ( 1 ) Abstract ( 3 ) Book ( 2 )
Recent research papers ( 1 )
	Kugler and Nagel, 2007, Molec. Biol. Cell 18(10): 3733--3740 Putzig is required for cell proliferation and regulates notch activity in Drosophila. [FBrf0201686] Show all research papers ...

Allele Dmel\H1

Allele Dmel\H¹