Allele Dmel\H1
| General Information | |||
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| Symbol | Dmel\H1 | Species | D. melanogaster |
| Name | FlyBase ID | FBal0005292 | |
| Feature type | allele | Associated gene | Dmel\H |
| Also Known As | H | ||
| Allele class | loss of function allele, amorphic allele - genetic evidence | ||
| Mutagen | spontaneous | ||
Recent Updates
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| Description |
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| FB2013_03 | |||
| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
Nature of the Allele
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| Allele class | |||
| Mutagen | |||
| Mutations Mapped to the Genome | |||
Type Location Additional Notes References | |||
| Associated Sequence Data | |||
| DDBJ
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EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Progenitor genotype | |||
| Nature of the lesion | Statement Reference Insertion of a copia element in the second intron. The insertion occurs in between the T/A at 314/315 base pairs counting from the 5' splice junction. Insertion whose restriction map matches copia inserted into the 2nd intron. | ||
| Caused by insertion | |||
| Cytology | |||
Phenotypic Data
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Phenotypic Class
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Phenotype Manifest In
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macrochaeta & scutum mesothoracic tergum & macrochaeta microchaeta & scutum sensory mother cell (with H3) thecogen cell (with HP8) | |||
Detailed Description
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Statement Reference Homozygous intestinal stem cell clones lose self-renewing capacity over time, and fail to form large clones at 14 days after clone induction, in contrast to wild-type controls. Mutant embryos show normal boundary cell differentiation in the hindgut. Heterozygotes show shortening of wing vein L5. Small L5 gap phenotype at low penetrance in heterozygotes. Dorsal hairs are sparse compared to wild type. Denticle belts are normal. Terminal gaps in LIV and LV and occasionally short terminal gaps in LII and LIII. Strongly enhanced expression of "NAx" alleles. Mutant flies show shortening of at least one and sometimes more of: wing veins L2, L4 and L5 and the posterior crossvein. Bristles, especially postverticals and abdominals, missing in heterozygous H1 flies. Bristle sockets present at some sites, not at others. Expressed most distinctly on head; occipital; postvertical and ocellar bristles affected. Veins L4 and L5 do not reach wing margin; occasionally true of L2 also. Recessive lethal. Homozygotes die during larval and pupal stages Animals surviving to pharate adult are completely devoid of macrochaetes and microchaetes on the head and notum, with occasional 'double sockets' remaining on the abdominal tergites. Bristles on the legs significantly resistant to loss of H+ function. | |||
External Data
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Interactions
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Phenotypic Class
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Enhanced by | |||
Statement Reference | |||
Enhancer of | |||
Statement Reference | |||
NOT Enhancer of | |||
Statement Reference | |||
Suppressor of | |||
Statement Reference | |||
NOT Suppressor of | |||
Statement Reference | |||
Other | |||
Statement Reference | |||
Phenotype Manifest In
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Enhanced by | |||
Statement Reference H1 has phenotype, enhanceable by Su(H)eBC11 | |||
Suppressed by | |||
Statement Reference H1 has phenotype, suppressible by Su(H)IB115 | |||
NOT suppressed by | |||
Statement Reference | |||
Enhancer of | |||
Statement Reference H1 is an enhancer of anterior dorsocentral bristle & trichogen cell phenotype of DlScer\UAS.cJa, Scer\GAL4l(3)31-1-31-1 H1 is an enhancer of anterior notopleural bristle & trichogen cell phenotype of DlScer\UAS.cJa, Scer\GAL4l(3)31-1-31-1 H1 is an enhancer of anterior scutellar bristle & trichogen cell phenotype of DlScer\UAS.cJa, Scer\GAL4l(3)31-1-31-1 H1 is an enhancer of anterior supraalar bristle & trichogen cell phenotype of DlScer\UAS.cJa, Scer\GAL4l(3)31-1-31-1 H1 is an enhancer of posterior dorsocentral bristle & trichogen cell phenotype of DlScer\UAS.cJa, Scer\GAL4l(3)31-1-31-1 H1 is an enhancer of posterior notopleural bristle & trichogen cell phenotype of DlScer\UAS.cJa, Scer\GAL4l(3)31-1-31-1 H1 is an enhancer of posterior postalar bristle & trichogen cell phenotype of DlScer\UAS.cJa, Scer\GAL4l(3)31-1-31-1 H1 is an enhancer of posterior scutellar bristle & trichogen cell phenotype of DlScer\UAS.cJa, Scer\GAL4l(3)31-1-31-1 H1 is an enhancer of posterior supraalar bristle & trichogen cell phenotype of DlScer\UAS.cJa, Scer\GAL4l(3)31-1-31-1 H1 is an enhancer of presutural bristle & trichogen cell phenotype of DlScer\UAS.cJa, Scer\GAL4l(3)31-1-31-1 | |||
NOT Enhancer of | |||
Statement Reference | |||
Suppressor of | |||
Statement Reference H1 is a suppressor of phenotype of SerTM.sev.T:VSV\G | |||
NOT Suppressor of | |||
Statement Reference | |||
Other | |||
Statement Reference | |||
Additional Comments
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Genetic Interactions
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Statement Reference The reduction in wing area seen in flies expressing pzgdsRNA.Scer\UAS under the control of Scer\GAL4en-e16E is suppressed by NAx-M1/+ or H1/+. The addition of H1 suppresses the wing nicking phenotype seen in mamN.Scer\UAS, Scer\GAL4C96 flies producing a range of phenotypes. Enhances the transformation of the trichogen to a tormogen fate in the notal macrochaetae caused by DlScer\UAS.cJa expressed under the control of Scer\GAL4l(3)31-1-31-1. Widespread transformation of microchaetae is also seen in this background. Enhances the microchaetae and macrochaetae loss phenotype of N gain of function heterozygotes. | |||
Xenogenetic Interactions
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Statement Reference | |||
Complementation & Rescue Data
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| Comments | |||
Stocks
( 23 ) | |||
| Bloomington | 1698 | ||
| Kyoto | 108236 106459 105955 101666 106581 105956 | ||
Notes on Origin
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| Discoverer | Bridges, 4th March 1916. | ||
Comments
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External Crossreferences & Linkouts
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| Other Crossreferences | |||
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Synonyms & Secondary IDs
( 3 ) | |||
| Reported As | |||
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| Name Synonym | |||
| Secondary FlyBase IDs | |||
References
( 41 ) | |||
| Generate a list of | |||
| List References by type |
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Recent research papers ( 5 ) | |||
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Recent Updates
External Crossreferences & Linkouts