A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Allele Dmel\h1

General Information
SymbolDmel\h1SpeciesD. melanogaster
NameFlyBase IDFBal0005318
Feature typealleleCreated / Updated2006-05-15/2006-05-15
Associated geneDmel\h
Allele classloss of function, hypomorph
Mutagenspontaneous
hide Nature of the Allele
Allele class
loss of function
(Long et al., 1996)
hypomorph
(Tearle and Nusslein-Volhard, 1987)
Mutagen
spontaneous
(Ingham et al., 1985, Hooper et al., 1989)
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
      gypsy insertion (Holmgren, 1984).
       
      Insertion of a 7kb gypsy element about 5kb upstream of the h promoter.
      (Hooper et al., 1989)
      Insertion of a gypsy element into the upstream h promoter.
      (Wainwright and Ish-Horowicz, 1992)
      Insert stated as cause: undefined Insertion upstream of the h promoter.
      (Abu-Issa and Cavicchi, 1996)
      Assay mode
      Caused by insertion
      gypsy{}h1
      (Wainwright and Ish-Horowicz, 1992, Hooper et al., 1989)
      Carried on aberration
      C(3L)RM-P1
       
      TM6-h1
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      DcxF-Sse
      (FlyBase Curators, 2006-)
      DcxF
      (FlyBase Curators, 2006-)
      C(3L)RM-H1
       
      Cytology
      Polytene chromosomes normal.
      (Ingham et al., 1985)
      hide Phenotypic Data
      hide Phenotypic Class
      viable
      (Ingham et al., 1985, Abu-Issa and Cavicchi, 1996, Tearle and Nusslein-Volhard, 1987, Zeng et al., 2000, Hooper et al., 1989)
      visible | recessive
      (Rushlow et al., 1989)
      visible | recessive | somatic clone
      (Zeng et al., 2000)
      hide Phenotype Manifest In
      scutellum & macrochaeta
      (Ingham et al., 1985)
      haltere & macrochaeta
      (Ingham et al., 1985)
      head capsule & macrochaeta
      (Ingham et al., 1985)
      macrochaeta | ectopic
      (Ingham et al., 1985, Rushlow et al., 1989)
      larval abdominal segment 4
      (Ingham et al., 1985)
      adult abdominal segment 4
      (Ingham et al., 1985)
      neuron
      (Sturtevant and Bier, 1995)
      wing sensillum | ectopic
      (Abu-Issa and Cavicchi, 1996)
      wing
      (Abu-Issa and Cavicchi, 1996, Giangrande, 1995)
      wing vein L2 & macrochaeta & adult
      (Rushlow et al., 1989)
      microchaeta & mesothoracic tergum | supernumerary
      (Renaud and Simpson, 2002)
      microchaeta | ectopic & scutellum
      (Villa-Cuesta et al., 2003)
      medial triple row
      (Dominguez and Campuzano, 1993)
      wing margin bristle
      (Dominguez and Campuzano, 1993)
      wing hair
      (Dominguez and Campuzano, 1993)
      wing hair & wing vein L2
      (Dominguez and Campuzano, 1993)
      dorsal triple row
      (Dominguez and Campuzano, 1993)
      chemosensory ventral triple row
      (Dominguez and Campuzano, 1993)
      wing & neuron & glial cell
      (Giangrande, 1995)
      neuron | ectopic
      (Giangrande, 1995)
      glial cell | ectopic
      (Giangrande, 1995)
      wing vein
      (Giangrande, 1995)
      wing vein | ectopic
      (Giangrande, 1995)
      wing vein & wing sensillum | ectopic | somatic clone
      (Zeng et al., 2000)
      adult thorax & microchaeta | ectopic | somatic clone
      (Zeng et al., 2000)
      mesothoracic tergum & macrochaeta | ectopic | conditional cs
      (Gibert et al., 2005)
      hide Detailed Description
      Statement
      Reference
      viable
       
      70% of homozygotes survive to adulthood. Homozygous adults have extra bristles. Homozygotes have minor defects in segmentation, that are apparent both in the larva and the adult; a few segments are wholly or partially deleted. The fourth abdominal segment is most frequently affected, although other segments in the head, thorax or abdomen may also be affected. The frequency and severity of the segmentation phenotype is increased in trans with other lethal h alleles. h1/h41 flies have ectopic bristles on the scutellum, halteres and head capsule.
      (Ingham et al., 1985)
      Semilethal when heterozygous with strong h alleles.
      (Hooper et al., 1989)
      Homozygotes display ectopic bristles on the L2 wing vein.
      (Rushlow et al., 1989)
      Extra sense organs formed on wing surface. Campaniform sensillae preferentially form on the proximal end of the L3 vein, bristles form nearer the tip, and sense organs of intermediate size form in between the bristles and campaniform sensillae. Scanning electron microscope measurements of distribution of sense organs along the wing axis suggests that h is active in metamorphosis and has a pattern of expression that is dependent upon the position in the proximal-distal axis.
      (Thompson and Preston, 1992)
      Ectopic glia accompany ectopic nerves in the pupal wing, which occur mostly along the longitudinal wing veins. Ectopic glial cells are present even on those ectopic veins that have reversed polarity.
      (Giangrande, 1995)
      Extra neuron mutant.
      (Sturtevant and Bier, 1995)
      Flies have ectopic bristles on the wing surface.
      (Abu-Issa and Cavicchi, 1996)
      Homozygous clones give rise to ectopic wing vein bristles and thoracic microchaetae.
      (Zeng et al., 2000)
      h1 animals have a higher density of notal microchaetae, however these bristles still approximately align into rows as seen in wild-type.
      (Renaud and Simpson, 2002)
      h1 flies raised at 18oC occasionally have ectopic bristles anterior to the anterior dorso-central bristle, while flies raised at 25oC do not show this phenotype.
      (Gibert et al., 2005)
      hide Interactions
      hide Phenotypic Class
      hideOther
      Statement
      Reference
      h1, nkd3 has visible | somatic clone phenotype
      (Zeng et al., 2000, Zeng et al., 2000)
      h1, nkdunspecified has lethal phenotype
      (Zeng et al., 2000)
      h1, nkd4 has visible | somatic clone phenotype
      (Zeng et al., 2000, Zeng et al., 2000)
      h1/h[-], nkdunspecified has lethal phenotype
      (Zeng et al., 2000)
      hide Phenotype Manifest In
      hideEnhanced by
      Statement
      Reference
      h1 has mesothoracic tergum & macrochaeta | ectopic phenotype, enhanceable by pad1
      (Gibert et al., 2005)
      hideSuppressed by
      Statement
      Reference
      h1 has phenotype, suppressible by ac1
      (Sturtevant, 1970)
      h1 has phenotype, suppressible by ac2
      (Sturtevant, 1970)
      h1 has phenotype, suppressible by ac3
      (Sturtevant, 1970)
      h1 has microchaeta | ectopic & scutellum phenotype, suppressible by amosTft
      (Villa-Cuesta et al., 2003)
      hideEnhancer of
      Statement
      Reference
      h1 is an enhancer of mesothoracic tergum & macrochaeta | ectopic phenotype of pad1
      (Gibert et al., 2005)
      hideOther
      Statement
      Reference
      h1, nkd3 has eye | somatic clone phenotype
      (Zeng et al., 2000, Zeng et al., 2000)
      h1, nkd3 has ommatidium | somatic clone phenotype
      (Zeng et al., 2000, Zeng et al., 2000)
      h1, nkd3 has wing margin bristle | somatic clone phenotype
      (Zeng et al., 2000, Zeng et al., 2000)
      Df(1)ase-1, h1 has wing hair & wing vein L2 phenotype
      (Dominguez and Campuzano, 1993)
      Df(1)sc10-1, acT52.2, h1 has wing vein L5 phenotype
      (van Doren et al., 1994, van Doren et al., 1994)
      h1, nkd4 has eye | somatic clone phenotype
      (Zeng et al., 2000, Zeng et al., 2000)
      h1, nkd4 has ommatidium | somatic clone phenotype
      (Zeng et al., 2000, Zeng et al., 2000)
      h1, nkd4 has wing margin bristle | somatic clone phenotype
      (Zeng et al., 2000, Zeng et al., 2000)
      h1, rhove-1 has wing sensillum | ectopic phenotype
      (Biehs et al., 1998, Biehs et al., 1998)
      h1, rhove-1 has wing phenotype
      (Biehs et al., 1998, Biehs et al., 1998)
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      Df(1)ase-1; h1 double mutants have four-fold fewer bristles in the L2 vein than h1 mutants alone. Although h1 has no effect on the anterior wing margin bristles itself, the recurved bristles of Df(1)ase-1; h1 double mutants are more wild type than those of Df(1)ase-1, though the mutant phenotype of the stout mechanosensory bristles is more extreme.
      (Dominguez and Campuzano, 1993)
      Introduction of acT52.2 construct into an ac- sc- h- background causes ectopic bristles to appear along wing vein L5.
      (van Doren et al., 1994)
      h1 rhove-1 / h1 rhove-1 flies have ectopic bristles running between longitudinal veins.
      (Biehs et al., 1998)
      h1/h- is viable, whereas nkdunspecified h1/h- is lethal. nkd3 h1 or nkd4 h1 clones give rise to a rough eye phenotype and loss of wing margin bristles.
      (Zeng et al., 2000)
      The ectopic microchaetae seen on the scutellum in h1 flies are suppressed by amosTft.
      (Villa-Cuesta et al., 2003)
      pad1 h1 double mutants raised at 25oC display ectopic bristles at positions on the notum where no ectopic bristles are found in either single mutant. These new positions include dorso-central bristles closer to the thoracic midline and additional bristles between the anterior and posterior scutellars. Ectopic bristles on the double mutant are mostly located in the posterior half of the notum, while ectopic bristles tend to be found in the anterior half in pad1 single mutants.
      (Gibert et al., 2005)
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Rescued by
      h1 is rescued by hhs.P1
      (Rushlow et al., 1989)
      Partially rescued by
      h1 is partially rescued by htRa
      (Rushlow et al., 1989)
      h1 is partially rescued by hcosh
      (Rushlow et al., 1989)
      Comments
      When in combination with hhs.P1 the ectopic bristle phenotype is completely suppressed. The temperature sensitive period for the bristle phenotype is 6-11 hours post-pupariation. Segmentation phenotype can be rescued by hcosh and htRa, but the extra bristle phenotype cannot.
      (Rushlow et al., 1989)
      hide Stocks ( 220 )
      Bloomington
      513
      h1
      444
      aa1 h1
      591
      se1 h1
      1410
      In(3LR)216/TM6, h1
      522
      jv1 Hnr h1
      592
      se1 h1 app1
      1404
      In(3L)P, Me1 h1/DcxF
      1066
      y1; Dp(1;3)E3, h1/TM6
      6882
      ru1 Aprt5 h1
      Kyoto
      105953
      h1
      105961
      jv1 Hnr h1
      106301
      In(3L)P, Me1 h1/DcxF
      hide Notes on Origin
      Discoverer
      Mohr, 11th Dec. 1918.
      hide Synonyms & Secondary IDs ( 1 )
      Reported As
      Symbol Synonym
      h1
       
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 33 )
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