Allele Dmel\h²

General Information
Symbol	Dmel\h²	Species	D. melanogaster
Name		FlyBase ID	FBal0005319
Feature type	allele	Associated gene	Dmel\h

Allele class
Mutagen	spontaneous
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	spontaneous (Ingham et al., 1985, Abu-Issa and Cavicchi, 1996)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Carried on aberration	C(3L)RM-LS1 C(3L)RM-P1 F(3L)2
Cytology	Polytene chromosomes normal. (Ingham et al., 1985) Polytene chromosomes normal. (Abu-Issa and Cavicchi, 1996)
Phenotypic Data
Phenotypic Class
	viable (Ingham et al., 1985) visible \| recessive (Rushlow et al., 1989)
Phenotype Manifest In
	macrochaeta \| ectopic (Abu-Issa and Cavicchi, 1996, Rushlow et al., 1989) wing & macrochaeta & adult (Rushlow et al., 1989) wing vein L2 & macrochaeta & adult (Rushlow et al., 1989)
Detailed Description
	Statement Reference Flies have ectopic bristles. (Abu-Issa and Cavicchi, 1996) No effect on the faf eye phenotype. (Huang and Fischer-Vize, 1996) Homozygotes display ectopic bristles on the L2 wing vein. (Rushlow et al., 1989) Transheterozygotes with h^L43a have an extra chaetae phenotype. (Fasano et al., 1988) Homozygotes have a wild-type segmentation pattern. Class I allele: fully complements the lethality and segmentation phenotype of h²⁵, and shows a strong bristle phenotype in trans with h¹. (Ingham et al., 1985) viable Extra hairs on wings but fewer than in h¹. Extra hairs not present on scutellum, pleurae, or top of head. Bristles cylindrical with javelin heads. Some abnormal abdomen effect. RK2.
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	h² is rescued by h^hs.P1 (Rushlow et al., 1989)
Partially rescued by	h² is partially rescued by h^cosh (Rushlow et al., 1989) h² is partially rescued by h^tRa (Rushlow et al., 1989)
Comments	When in combination with h^hs.P1 the ectopic bristle phenotype is completely suppressed. The temperature sensitive period for the bristle phenotype is 6-11 hours post-pupariation. Segmentation phenotype can be rescued by h^cosh and h^tRa, but the extra bristle phenotype cannot. (Rushlow et al., 1989)
Stocks ( 5 )
Bloomington	593 se¹ h² rs² 1118 C(2)EN, c¹ bw¹; C(3L)RM-, h²; C(3R)RM- 4461 F(3L)2, ru¹ h²; F(3R)4, se¹ e^s/TM3, Sb¹
Kyoto	101582 C(3L)RM-H1, se¹ h² rs² / C(3R)RM-P5, Sb^sbd-1 gl¹ e^s 106321 Dp(3;3)S2, ru¹ Hn^r3 h² app¹ cu¹ kar¹/In(3LR)HR33^Lbxd^106R, Sb^sbd-2 Ubx^bx-3
Notes on Origin
Discoverer	Bridges, 23rd April 1928.

Comments
	Does not behave as a genetic suppressor of faf mutations. (Huang and Fischer-Vize, 1996)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	h²
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Abu-Issa and Cavicchi, 1996, J. Neurogenet. 10(4): 239--246 Genetic interactions among vestigial, hairy, and Notch suggest a role of vestigial in the differentiation of epidermal and neural cells of the wing and haltere of Drosophila melanogaster. [FBrf0090425] Huang and Fischer-Vize, 1996, Development 122(10): 3207--3216 Undifferentiated cells in the developing Drosophila eye influence facet assembly and require the Fat facets ubiquitin-specific protease. [FBrf0090618] Rushlow et al., 1989, EMBO J. 8(10): 3095--3104 The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc. [FBrf0049623] Fasano et al., 1988, Rouxs Arch. Dev. Biol. 197(8): 507--512 Expression of a reporter gene resembles that of its neighbour: an insertion in the hairy gene of Drosophila. [FBrf0048996] Ingham et al., 1985, Genetics 111: 463--486 Genetic analysis of the hairy locus of Drosophila melanogaster. [FBrf0042642]
Book	Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp Genetic variations of Drosophila melanogaster. [FBrf0020044]

Allele Dmel\h2

Allele Dmel\h²