Open Close
General Information
Symbol
Dmel\h26
Species
D. melanogaster
Name
FlyBase ID
FBal0005343
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
h7H94, h7H
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

T8677624A

Reported nucleotide change:

T?A

Amino acid change:

L72term | h-PA; L72term | h-PB

Reported amino acid change:

L72term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Nucleotide substitution: T?A.

Amino acid replacement: L72term.

run protein produced is truncated.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Numerous ectopic bristles are present on h1/h26 wings, both in intervein regions (79% penetrance) and on the L2 wing vein (100% penetrance).

Homozygous embryos have segmentation defects; only 18% of embryos have more than 4 segments.

30% of h30/h26 embryos die and do not hatch.

h26/h30 embryos have a pair-rule phenotype, leading to the loss of every second segment.

h26/h30 embryos show a pair-rule cuticle phenotype.

Larvae display an extreme 'lawn' phenotype. h26/h30 transheterozygous larvae display a pair-rule phenotype.

Reduced rate of germ band extension.

Legs from hcosh; h-/h- adults show a bristle patterning defect that correlates with the expression pattern of h in pupal leg imaginal discs.

h26 mutant clones in the eye have very few defective ommatidia.

h19/h26 heterozygote has loss of h expression in the longitudinal preveins L3 and L5, location coincides with the ectopic expression of ac.

Deletion of even denticle bands and odd naked cuticle.

Class IV allele: has a strong segmentation phenotype either when homozygous or in trans with h25, and fails to complement the bristle phenotype of h1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

h1/h26 has visible phenotype, suppressible | partially by dgrn[+]/dgrnDK

h30/h26 has lethal | embryonic stage phenotype, suppressible | maternal effect | partially by dgrn[+]/dgrnDK

NOT Enhancer of
Statement
Reference
Other
Phenotype Manifest In
Enhanced by
Suppressed by
Statement
Reference

h1/h26 has wing cell phenotype, suppressible by dgrn[+]/dgrnDK

h1/h26 has wing sensillum | ectopic phenotype, suppressible | partially by dgrn[+]/dgrnDK

h26 has phenotype, suppressible by CtBP03463

Additional Comments
Genetic Interactions
Statement
Reference

dgrnDK/+ suppresses the formation of ectopic wing bristles seen in h1/h26 flies, predominantly within the intervein regions.

The defects in segmentation which are seen in homozygous h26 embryos are partially suppressed by dgrnDK/+; 50% of the double mutant embryos have more than 4 segments.

A maternal copy of dgrnDK/+ partially suppresses the embryonic lethality of the h30/h26 combination; only 19% of the embryos fail to hatch.

The h26/h30 mutant phenotype is suppressed by ToporsAA/+.

The pair-rule phenotype of h26/h30 embryos is suppressed by one maternal copy of CtBP03463 and is enhanced by one maternal copy of groE47. The enhancement of the pair-rule phenotype of h26/h30 embryos caused by one maternal copy of groE47 is reversed when one copy of CtBP03463 is also present maternally.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Jurgens.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
References (24)