Allele Dmel\h²⁶

General Information
Symbol	Dmel\h²⁶	Species	D. melanogaster
Name		FlyBase ID	FBal0005343
Feature type	allele	Associated gene	Dmel\h
Also Known As	h^7H94, h^7H

Map ( GBrowse )
Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Brown et al., 1991)
Mutagen	ethyl methanesulfonate (Ingham et al., 1985, Tearle and Nusslein-Volhard, 1987, Hooper et al., 1989, Wainwright and Ish-Horowicz, 1992)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3L:8,670,724..8,670,724 evidence=experimental pr_change=L72\|h-PB,L72\|h-PA reported_na_change=T?A reported_pr_change=L72@ na_change=T8670724A (Wainwright and Ish-Horowicz, 1992)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	h¹ (Ingham et al., 1985, Tearle and Nusslein-Volhard, 1987, Wainwright and Ish-Horowicz, 1992)
Nature of the lesion	Statement Reference Amino acid replacement: L72@. Nucleotide substitution: T?A. (Wainwright and Ish-Horowicz, 1992) run protein produced is truncated. (Brown et al., 1991)
Cytology	Polytene chromosomes normal. (Ingham et al., 1985)
Phenotypic Data
Phenotypic Class
	embryonic/larval segmentation phenotype (Abed et al., 2011) lethal lethal \| embryonic stage (with h³⁰) (Abed et al., 2011) lethal \| recessive (Hooper et al., 1989, Ingham et al., 1985, Wainwright and Ish-Horowicz, 1992) visible (with h¹) (Abed et al., 2011)
Phenotype Manifest In
	denticle belt (Carroll and Scott, 1986, Poortinga et al., 1998) embryo \| pair rule expression pattern (Poortinga et al., 1998) embryonic/first instar larval cuticle \| pair rule expression pattern (with h³⁰) (Secombe and Parkhurst, 2004, Phippen et al., 2000) extended germ band embryo (Irvine and Wieschaus, 1994) wing cell (with h¹) (Abed et al., 2011) wing sensillum \| ectopic (with h¹) (Abed et al., 2011) wing vein L2 (with h¹) (Abed et al., 2011)
Detailed Description
	Statement Reference Numerous ectopic bristles are present on h[1]/h[26] wings, both in intervein regions (79% penetrance) and on the L2 wing vein (100% penetrance). Homozygous embryos have segmentation defects; only 18% of embryos have more than 4 segments. 30% of h[30]/h[26] embryos die and do not hatch. (Abed et al., 2011) h²⁶/h³⁰ embryos have a pair-rule phenotype, leading to the loss of every second segment. (Secombe and Parkhurst, 2004) h²⁶/h³⁰ embryos show a pair-rule cuticle phenotype. (Phippen et al., 2000) Larvae display an extreme 'lawn' phenotype. h²⁶/h³⁰ transheterozygous larvae display a pair-rule phenotype. (Poortinga et al., 1998) Reduced rate of germ band extension. (Irvine and Wieschaus, 1994) Legs from h^cosh; h^-/h^- adults show a bristle patterning defect that correlates with the expression pattern of h in pupal leg imaginal discs. (Orenic et al., 1993) h²⁶ mutant clones in the eye have very few defective ommatidia. (Brown et al., 1991) h¹⁹/h²⁶ heterozygote has loss of h expression in the longitudinal preveins L3 and L5, location coincides with the ectopic expression of ac. (Skeath and Carroll, 1991) Deletion of even denticle bands and odd naked cuticle. (Carroll and Scott, 1986) Class IV allele: has a strong segmentation phenotype either when homozygous or in trans with h²⁵, and fails to complement the bristle phenotype of h¹. (Ingham et al., 1985)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference h¹/h²⁶ has visible phenotype, suppressible \| partially by dgrn[+]/dgrn^DK (Abed et al., 2011) h²⁶ has embryonic/larval segmentation phenotype phenotype, suppressible \| partially by dgrn[+]/dgrn^DK (Abed et al., 2011) h³⁰/h²⁶ has lethal \| embryonic stage phenotype, suppressible \| maternal effect \| partially by dgrn[+]/dgrn^DK (Abed et al., 2011)
NOT Enhancer of
Statement Reference h²⁶ is a non-enhancer of lethal \| maternal effect \| embryonic stage phenotype of Gug^unspecified (Zhang et al., 2002)
Other
Statement Reference edl[+]/edl^k06602, h²⁶ has lethal \| partially phenotype (Bianchi-Frias et al., 2004) edl^k06602, h[+]/h²⁶ has lethal \| partially phenotype (Bianchi-Frias et al., 2004) edl^k06602, h²⁶ has lethal \| partially phenotype (Bianchi-Frias et al., 2004, Bianchi-Frias et al., 2004) egh⁷, h[+]/h²⁶ has lethal \| partially phenotype (Bianchi-Frias et al., 2004) egh⁷, h²⁶ has lethal \| partially phenotype (Bianchi-Frias et al., 2004, Bianchi-Frias et al., 2004) h[+]/h²⁶, pnt^Δ88 has lethal \| partially phenotype (Bianchi-Frias et al., 2004) h[+]/h²⁶, prd⁴ has lethal \| partially phenotype (Bianchi-Frias et al., 2004) h[+]/h²⁶, rgr^KG03110 has lethal \| partially phenotype (Bianchi-Frias et al., 2004) h[+]/h²⁶, stg^AR2 has lethal \| partially phenotype (Bianchi-Frias et al., 2004) h²⁶, pnt[+]/pnt^Δ88 has lethal \| partially phenotype (Bianchi-Frias et al., 2004) h²⁶, pnt^Δ88 has lethal \| partially phenotype (Bianchi-Frias et al., 2004, Bianchi-Frias et al., 2004) h²⁶, prd[+]/prd⁴ has lethal \| partially phenotype (Bianchi-Frias et al., 2004) h²⁶, prd⁴ has lethal \| partially phenotype (Bianchi-Frias et al., 2004, Bianchi-Frias et al., 2004) h²⁶, rgr^KG03110/rgr[+] has lethal \| partially phenotype (Bianchi-Frias et al., 2004) h²⁶, rgr^KG03110 has lethal \| partially phenotype (Bianchi-Frias et al., 2004, Bianchi-Frias et al., 2004) h²⁶, stg^AR2/stg[+] has lethal \| partially phenotype (Bianchi-Frias et al., 2004) h²⁶, stg^AR2 has lethal \| partially phenotype (Bianchi-Frias et al., 2004, Bianchi-Frias et al., 2004) ImpL2^KG02223, h[+]/h²⁶ has lethal \| partially phenotype (Bianchi-Frias et al., 2004) ImpL2^KG02223, h²⁶ has lethal \| partially phenotype (Bianchi-Frias et al., 2004, Bianchi-Frias et al., 2004) Sir2^05327a, h[+]/h²⁶ has lethal \| dominant \| maternal effect phenotype (Rosenberg and Parkhurst, 2002) Sir2^05327a, h²⁶ has lethal \| dominant \| maternal effect phenotype (Rosenberg and Parkhurst, 2002)
Phenotype Manifest In
Enhanced by
Statement Reference h³⁰/h²⁶ has embryonic/first instar larval cuticle \| pair rule expression pattern phenotype, enhanceable \| maternal effect by gro^E47/gro[+] (Phippen et al., 2000)
Suppressed by
Statement Reference gro^E47/gro[+], h³⁰/h²⁶ has embryonic/first instar larval cuticle \| pair rule expression pattern phenotype, suppressible \| maternal effect by CtBP[+]/CtBP⁰³⁴⁶³ (Phippen et al., 2000) h¹/h²⁶ has wing cell phenotype, suppressible by dgrn[+]/dgrn^DK (Abed et al., 2011) h¹/h²⁶ has wing sensillum \| ectopic phenotype, suppressible \| partially by dgrn[+]/dgrn^DK (Abed et al., 2011) h²⁶ has phenotype, suppressible by CtBP⁰³⁴⁶³ (Poortinga et al., 1998) h³⁰/h²⁶ has embryonic/first instar larval cuticle \| pair rule expression pattern phenotype, suppressible \| partially by Topors[+]/Topors^AA (Secombe and Parkhurst, 2004)
Additional Comments
Genetic Interactions
Statement Reference dgrn[DK]/+ suppresses the formation of ectopic wing bristles seen in h[1]/h[26] flies, predominantly within the intervein regions. The defects in segmentation which are seen in homozygous h[26] embryos are partially suppressed by dgrn[DK]/+; 50% of the double mutant embryos have more than 4 segments. A maternal copy of dgrn[DK]/+ partially suppresses the embryonic lethality of the h[30]/h[26] combination; only 19% of the embryos fail to hatch. (Abed et al., 2011) The h²⁶/h³⁰ mutant phenotype is suppressed by Topors^AA/+. (Secombe and Parkhurst, 2004) The pair-rule phenotype of h²⁶/h³⁰ embryos is suppressed by one maternal copy of CtBP⁰³⁴⁶³ and is enhanced by one maternal copy of gro^E47. The enhancement of the pair-rule phenotype of h²⁶/h³⁰ embryos caused by one maternal copy of gro^E47 is reversed when one copy of CtBP⁰³⁴⁶³ is also present maternally. (Phippen et al., 2000)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	Jurgens.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	h^7A94 (Azpiazu et al., 1996) h^7H94 (Zhang et al., 2002, Ursuliak et al., 1997, Yu and Pick, 1995, Topol et al., 1991, Hooper et al., 1989, Carroll et al., 1988, DiNardo and O'Farrell, 1987, Carroll and Scott, 1986, Ingham et al., 1985, ) h^7h94 (Irvine and Wieschaus, 1994, Orenic et al., 1993, Brown et al., 1991) h^7H (Bianchi-Frias et al., 2004, Secombe and Parkhurst, 2004, Phippen et al., 2000, Poortinga et al., 1998, Edgar et al., 1994, Wainwright and Ish-Horowicz, 1992, Tearle and Nusslein-Volhard, 1987, Abed et al., 2011) h²⁶ hairy^7H (Rosenberg and Parkhurst, 2002)
Name Synonym
Secondary FlyBase IDs

References ( 24 )

Generate a list of	All references relating to this allele ( 24 )

List References by type	Research paper ( 23 ) Stock list ( 1 )
Recent research papers ( 1 )
	Abed et al., 2011, EMBO J. 30(7): 1289--1301 Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression. [FBrf0213366] Show all research papers ...

Allele Dmel\h26

Allele Dmel\h²⁶