FlyBase Allele Report: Dmel\h[26]

General Information

Symbol

Dmel\h²⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0005343

Feature type

allele

Associated gene

Dmel\h

Associated Insertion(s)

Carried in Construct

Also Known As

h^7H94, h^7H

Genomic Maps

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Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Brown et al., 1991)

Mutagen

ethyl methanesulfonate

(Wainwright and Ish-Horowicz, 1992, Hooper et al., 1989, Tearle and Nusslein-Volhard, 1987, Ingham et al., 1985)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

point mutation

3L:8,677,624..8,677,624 [+]

Nucleotide change:

T8677624A

Reported nucleotide change:

T?A

Amino acid change:

L72term | h-PA; L72term | h-PB

Reported amino acid change:

L72term

(Wainwright and Ish-Horowicz, 1992)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

h¹

(Wainwright and Ish-Horowicz, 1992, Tearle and Nusslein-Volhard, 1987, Ingham et al., 1985)

Cytology

Polytene chromosomes normal.

(Ingham et al., 1985)

Nature of the lesion

Statement

Reference

Nucleotide substitution: T?A.

(Wainwright and Ish-Horowicz, 1992)

Amino acid replacement: L72term.

(Wainwright and Ish-Horowicz, 1992)

run protein produced is truncated.

(Brown et al., 1991)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

denticle belt

(Poortinga et al., 1998, Carroll and Scott, 1986)

embryo

(Poortinga et al., 1998)

embryonic/first instar larval cuticle (with h³⁰)

(Secombe and Parkhurst, 2004, Phippen et al., 2000)

mitotic domain 1 | extended germ band stage

(Irvine and Wieschaus, 1994)

wing cell (with h¹)

(Abed et al., 2011)

wing sensillum | ectopic (with h¹)

(Abed et al., 2011)

wing vein L2 (with h¹)

(Abed et al., 2011)

Detailed Description

Statement

Reference

Numerous ectopic bristles are present on h¹/h²⁶ wings, both in intervein regions (79% penetrance) and on the L2 wing vein (100% penetrance).

Homozygous embryos have segmentation defects; only 18% of embryos have more than 4 segments.

30% of h³⁰/h²⁶ embryos die and do not hatch.

(Abed et al., 2011)

h²⁶/h³⁰ embryos have a pair-rule phenotype, leading to the loss of every second segment.

(Secombe and Parkhurst, 2004)

h²⁶/h³⁰ embryos show a pair-rule cuticle phenotype.

(Phippen et al., 2000)

Larvae display an extreme 'lawn' phenotype. h²⁶/h³⁰ transheterozygous larvae display a pair-rule phenotype.

(Poortinga et al., 1998)

Reduced rate of germ band extension.

(Irvine and Wieschaus, 1994)

Legs from h^cosh; h^-/h^- adults show a bristle patterning defect that correlates with the expression pattern of h in pupal leg imaginal discs.

(Orenic et al., 1993)

h²⁶ mutant clones in the eye have very few defective ommatidia.

(Brown et al., 1991)

h¹⁹/h²⁶ heterozygote has loss of h expression in the longitudinal preveins L3 and L5, location coincides with the ectopic expression of ac.

(Skeath and Carroll, 1991)

Deletion of even denticle bands and odd naked cuticle.

(Carroll and Scott, 1986)

Class IV allele: has a strong segmentation phenotype either when homozygous or in trans with h²⁵, and fails to complement the bristle phenotype of h¹.

(Ingham et al., 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

h¹/h²⁶ has visible phenotype, suppressible | partially by dgrn[+]/dgrn^DK

(Abed et al., 2011)

h²⁶ has embryonic/larval segmentation phenotype phenotype, suppressible | partially by dgrn[+]/dgrn^DK

(Abed et al., 2011)

h³⁰/h²⁶ has lethal | embryonic stage phenotype, suppressible | maternal effect | partially by dgrn[+]/dgrn^DK

(Abed et al., 2011)

NOT Enhancer of

Statement

Reference

h²⁶ is a non-enhancer of lethal | maternal effect | embryonic stage phenotype of Gug^unspecified

(Zhang et al., 2002)

Other

Statement

Reference

h²⁶, pnt^Δ88 has partially lethal phenotype