|Feature type||allele||Associated gene||Dmel\h|
|Also Known As||h7H94, h7H|
|Map ( GBrowse )|
|Allele class||amorphic allele - genetic evidence|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: L72@. Nucleotide substitution: T?A.
Polytene chromosomes normal.
|Phenotype Manifest In|
Numerous ectopic bristles are present on h/h wings, both in intervein regions (79% penetrance) and on the L2 wing vein (100% penetrance). Homozygous embryos have segmentation defects; only 18% of embryos have more than 4 segments. 30% of h/h embryos die and do not hatch.
Larvae display an extreme 'lawn' phenotype. h26/h30 transheterozygous larvae display a pair-rule phenotype.
Reduced rate of germ band extension.
Legs from hcosh; h-/h- adults show a bristle patterning defect that correlates with the expression pattern of h in pupal leg imaginal discs.
h19/h26 heterozygote has loss of h expression in the longitudinal preveins L3 and L5, location coincides with the ectopic expression of ac.
Deletion of even denticle bands and odd naked cuticle.
h26 has embryonic/larval segmentation phenotype phenotype, suppressible | partially by dgrn[+]/dgrnDK
|NOT Enhancer of|
|Phenotype Manifest In|
groE47/gro[+], h30/h26 has embryonic/first instar larval cuticle | pair rule expression pattern phenotype, suppressible | maternal effect by CtBP[+]/CtBP03463
dgrn[DK]/+ suppresses the formation of ectopic wing bristles seen in h/h flies, predominantly within the intervein regions. The defects in segmentation which are seen in homozygous h embryos are partially suppressed by dgrn[DK]/+; 50% of the double mutant embryos have more than 4 segments. A maternal copy of dgrn[DK]/+ partially suppresses the embryonic lethality of the h/h combination; only 19% of the embryos fail to hatch.
The pair-rule phenotype of h26/h30 embryos is suppressed by one maternal copy of CtBP03463 and is enhanced by one maternal copy of groE47. The enhancement of the pair-rule phenotype of h26/h30 embryos caused by one maternal copy of groE47 is reversed when one copy of CtBP03463 is also present maternally.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 6 )|
|Secondary FlyBase IDs|
|References ( 24 )|
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|Recent research papers ( 1 )|