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General Information
Symbol
Dmel\h41
Species
D. melanogaster
Name
FlyBase ID
FBal0005358
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hIL79K, hIL
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

T8677751A

Reported nucleotide change:

T?A

Amino acid change:

C114term | h-PA; C114term | h-PB

Reported amino acid change:

C114term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Nucleotide substitution: T?A.

Amino acid replacement: C114term.

run protein produced is truncated, consisting of 113 amino acids.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

No effect on the faf eye phenotype.

emc1 h22 clones display differentiated photoreceptors that arise in a more anterior position that in adjacent wild type tissue, the morphogenetic furrow has been shifted anteriorly.

Legs from hcosh; h-/h- adults show a bristle patterning defect that correlates with the expression pattern of h in pupal leg imaginal discs.

93% of ommatidia in h41 mutant clones in the eye are defective, with abnormal arrangement of the rhabdomeres.

Parasegment 1 should develop normally, the even-numbered parasegments have only anterior margins that are less sharp and straight compared to wild-type, with the exception of parasegment 8.

Class IV allele: has a strong segmentation phenotype either when homozygous or in trans with h25, and fails to complement the bristle phenotype of h1. Homozygous larvae have a typical pair-rule phenotype; the anterior part of each even-numbered abdominal segment and the posterior part of each odd-numbered abdominal segment is deleted. Similar deletions are seen in the thoracic segments and the head. h1/h41 flies have ectopic bristles on the scutellum, halteres and head capsule.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

h41 has wing margin bristle | ectopic phenotype, non-enhanceable by ttk[+]/ttk1

h41 has wing margin bristle | ectopic phenotype, non-enhanceable by ttk[+]/ttk1e11

Suppressed by
Statement
Reference

h41/h[+], ttkrM730 has wing margin bristle | ectopic phenotype, suppressible by sc[+]/sc1

h41/h[+], ttkrM730 has wing margin bristle | ectopic phenotype, suppressible by scase-1/sc[+]

NOT suppressed by
Statement
Reference

h41 has wing margin bristle | ectopic phenotype, non-suppressible by ttk[+]/ttk1

h41 has wing margin bristle | ectopic phenotype, non-suppressible by ttk[+]/ttk1e11

Enhancer of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

The addition of ttkrM730/+ or Df(3R)awd-KRB to h41/+ animals leads to a ectopic wing margin bristle phenotype. The addition of ttk00219/+ to h41/+ animals leads to a weak ectopic wing margin bristle phenotype. The addition of ttk1e11/+ or ttk1 to h41/+ animals does not lead to a significant ectopic wing margin bristle phenotype. The addition of scase-1/Y to h41/+, ttkrM730/+ animals leads to a complete suppression of the ectopic margin bristle phenotype. The addition ofsc1/Y to h41/+, ttkrM730/+ animals leads to an almost complete suppression of the ectopic margin bristle phenotype. The addition of Df(3R)awd-KRB to h41/+, ttkrM730/+ animals leads to a suppression of the ectopic margin bristle phenotype. CtBP87De-10 combined with h41 leads to an ectopic margin bristle phenotype.

Mutation enhances the ectopic scutellar bristle phenotype seen from Scer\GAL4455.2-mediated expression of l(1)scScer\UAS.cHa.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by

h41/h25 is partially rescued by hcosh

Comments

The segmentation defect of heterozygote h25/h41 can be rescued by hcosh and individuals develop to viable adults, but the strong bristle phenotype is still present.

Images (0)
Mutant
Wild-type
Stocks (4)
Notes on Origin
Discoverer

Jurgens.

Comments
Comments

Does not behave as a genetic suppressor of faf mutations.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
References (19)