Allele Dmel\h⁴²

General Information
Symbol	Dmel\h⁴²	Species	D. melanogaster
Name		FlyBase ID	FBal0005359
Feature type	allele	Associated gene	Dmel\h
Also Known As	h^K1

Allele class	amorphic allele - genetic evidence
Mutagen	X ray
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence (Howard and Ingham, 1986)
Mutagen	X ray (Ingham et al., 1985, Hooper et al., 1989)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Previous localization of breakpoint refined to approximately 3kb upstream of h. (Lardelli and Ish-Horowicz, 1993) Inversion break falls approximately 2.5kb 5' to the start of transcription (Ingham et al., Genetics 111: 463--486, Howard et al., Genes Dev. 2: 1037--1046.) (Orenic et al., 1993) Deletion of upstream regulatory sequences of h, leaving approximately 5.5kb of upstream sequences intact. (Howard and Struhl, 1990) Rearrangement of chromosome upstream of the h promoter. Approximately 3kb of upstream sequences remain intact. (Hooper et al., 1989)
Caused by aberration	In(3L)h⁴² (Ingham et al., 1985, Hooper et al., 1989)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Hooper et al., 1989, Howard and Ingham, 1986, Ingham et al., 1985)
Phenotype Manifest In
	cuticle (Hooper et al., 1989)
Detailed Description
	Statement Reference Cuticle defects. (Hooper et al., 1989) Even numbered denticle bands missing. (Jack et al., 1988) "Pair-rule segmentation phenotype": half the normal number of denticle bands form, due to a deletion of pattern elements from approximately the middle of one segment to a homologous position in the next segment. (Howard and Ingham, 1986) Class IV allele: has a strong segmentation phenotype either when homozygous or in trans with h²⁵, and fails to complement the bristle phenotype of h¹. (Ingham et al., 1985) Regulatory mutation causing alterations in hairy expression in cellular blastoderm that result in a partial version of the wild-type pattern (Howard, Ingham and Rushlow, 1988). viable
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	Ingham.

Comments
	Selected on the basis of its failure to complement the bristle phenotype of either h¹ or h². (Ingham et al., 1985)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	h⁴² h^K1 (Klingler et al., 1996, Small et al., 1996, Tsai and Gergen, 1995, Klingler and Gergen, 1993, Orenic et al., 1993, Lardelli and Ish-Horowicz, 1993, Hooper et al., 1989, Frasch and Levine, 1987, DiNardo and O'Farrell, 1987, Howard and Ingham, 1986, Ingham et al., 1985, ) h^k1 (Howard and Struhl, 1990, Jack et al., 1988, Howard, 1988)
Name Synonym
Secondary FlyBase IDs

References ( 15 )
Research paper	Klingler et al., 1996, Dev. Biol. 177(1): 73--84 Disperse versus compact elements for the regulation of runt stripes in Drosophila. [FBrf0089710] Small et al., 1996, Dev. Biol. 175(2): 314--324 Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo. [FBrf0087716] Tsai and Gergen, 1995, Development 121(2): 453--462 Pair-rule expression of the Drosophila fushi tarasu gene: a nuclear receptor response element mediates the opposing regulatory effects of runt and hairy. [FBrf0076138] Klingler and Gergen, 1993, Mech. Dev. 43(1): 3--19 Regulation of runt transcription by Drosophila segmentation genes. [FBrf0064551] Lardelli and Ish-Horowicz, 1993, Development 118(1): 255--266 Drosophila hairy pair-rule gene regulates embryonic patterning outside its apparent stripe domains. [FBrf0058112] Orenic et al., 1993, Development 118(1): 9--20 The spatial organization of epidermal structures hairy establishes the geometrical pattern of Drosophila leg bristles by delimiting the domains of achaete expression. [FBrf0058124] Howard and Struhl, 1990, Development 110: 1223--1231 Decoding positional information: regulation of the pair-rule gene hairy. [FBrf0051551] Hooper et al., 1989, Development 107(3): 489--504 Spatial control of hairy protein expression during embryogenesis. [FBrf0049555] Howard et al., 1988, Genes Dev. 2: 1037--1046 Region-specific alleles of the Drosophila segmentation gene hairy. [FBrf0048091] Jack et al., 1988, Genes Dev. 2: 635--651 Pair-rule segmentation genes regulate the expression of the homeotic selector gene, Deformed. [FBrf0048119] DiNardo and O'Farrell, 1987, Genes Dev. 1: 1212--1225 Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes. [FBrf0046274] Frasch and Levine, 1987, Genes Dev. 1: 981--995 Complementary patterns of even-skipped and fushi tarazu expression involve their differential regulation by a common set of segmentation genes in Drosophila. [FBrf0046292] Howard and Ingham, 1986, Cell 44: 949--957 Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the Drosophila blastoderm. [FBrf0043929] Ingham et al., 1985, Genetics 111: 463--486 Genetic analysis of the hairy locus of Drosophila melanogaster. [FBrf0042642]
Review	Howard, 1988, French, Ingham, Cooke, Smith, 1988: 35--50 The generation of periodic pattern during early Drosophila embryogenesis. [FBrf0047878]

Allele Dmel\h42

Allele Dmel\h⁴²