Allele Dmel\h⁴⁹

General Information
Symbol	Dmel\h⁴⁹	Species	D. melanogaster
Name		FlyBase ID	FBal0005366
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\h

Allele class
Mutagen	X ray
Nature of the Allele
Allele class
Mutagen	X ray (Ingham et al., 1985, Hooper et al., 1989)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Rearrangement of chromosome upstream of the h promoter. Approximately 10kb of upstream sequences remain intact. (Hooper et al., 1989) Deletion of upstream regulatory sequences of h, leaving approximately 11kb of upstream sequences intact. (Howard and Struhl, 1990) Previous localization of breakpoint refined to approximately 9.5--10.75kb upstream of h. (Lardelli and Ish-Horowicz, 1993)
Assay mode
Caused by aberration	Tp(3;3)h^M3 (Ingham et al., 1985, Hooper et al., 1989)
Cytology
Phenotypic Data
Phenotypic Class
	lethal lethal \| recessive (Hooper et al., 1989, Ingham et al., 1985)
Phenotype Manifest In
	prothoracic segment (Hooper et al., 1989) mesothoracic segment (Hooper et al., 1989) metathoracic segment (Hooper et al., 1989) abdominal segment 1 (Hooper et al., 1989) abdominal segment 2 (Hooper et al., 1989)
Detailed Description
	Statement Reference Regulatory mutation causing alterations in hairy expression in cellular blastoderm that result in a partial version of the wild-type pattern (Howard, Ingham and Rushlow, 1988). Class II allele: shows a strong bristle phenotype in trans with h¹, and a weak segmentation phenotype either when homozygous or in trans with h²⁵. (Ingham et al., 1985) Cuticle defects between T1 and A2. (Hooper et al., 1989) Second thoracic and third abdominal segment is absent in the embryo. T2/A1 and A1/A3 fusions also occur. (Lardelli and Ish-Horowicz, 1993)
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	2197 T(2;3)CyO-TM9, CyO: TM9, l(3)DTS4¹/Tp(3;3)h^M3, h⁴⁹
Kyoto	106736 T(2;3)CyO-TM9, CyO: TM9, l(3)DTS4¹/Tp(3;3)h^M3, h⁴⁹
Notes on Origin
Discoverer	Ingham.

Comments
	Selected on the basis of its failure to complement the bristle phenotype of either h¹ or h². The h⁴⁹ mutation has a maternal effect on h⁴⁹ mutant zygotes. (Ingham et al., 1985)
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	h⁴⁹ h^m3 (Yu and Pick, 1995, Lardelli and Ish-Horowicz, 1993, Howard and Struhl, 1990, Hooper et al., 1989, Howard, 1988, Ingham et al., 1985, )
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Yu and Pick, 1995, Mech. Dev. 50(2-3): 163--175 Non-periodic cues generate seven ftz stripes in the Drosophila embryo. [FBrf0080506] Lardelli and Ish-Horowicz, 1993, Development 118(1): 255--266 Drosophila hairy pair-rule gene regulates embryonic patterning outside its apparent stripe domains. [FBrf0058112] Howard and Struhl, 1990, Development 110: 1223--1231 Decoding positional information: regulation of the pair-rule gene hairy. [FBrf0051551] Hooper et al., 1989, Development 107(3): 489--504 Spatial control of hairy protein expression during embryogenesis. [FBrf0049555] Howard et al., 1988, Genes Dev. 2: 1037--1046 Region-specific alleles of the Drosophila segmentation gene hairy. [FBrf0048091] Ingham et al., 1985, Genetics 111: 463--486 Genetic analysis of the hairy locus of Drosophila melanogaster. [FBrf0042642]
Review	Howard, 1988, French, Ingham, Cooke, Smith, 1988: 35--50 The generation of periodic pattern during early Drosophila embryogenesis. [FBrf0047878]

Allele Dmel\h49

Allele Dmel\h⁴⁹