Allele Dmel\hb⁴

General Information
Symbol	Dmel\hb⁴	Species	D. melanogaster
Name		FlyBase ID	FBal0005395
Feature type	allele	Associated gene	Dmel\hb

Allele class	loss of function allele, amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence (Harding and Levine, 1988, Tautz, 1988, Qian et al., 1991, ) loss of function allele (Lukowitz et al., 1994)
Mutagen	ethyl methanesulfonate (Tearle and Nusslein-Volhard, 1987, Lehmann and Nusslein-Volhard, 1987)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Stop codon before the first finger domain. (Lukowitz et al., 1994)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| gap \| recessive
Phenotype Manifest In
	commissure (Kambadur et al., 1998) embryonic/first instar larval cuticle (Lukowitz et al., 1994) embryonic neuroblast (Kambadur et al., 1998) extended germ band embryo (Irvine and Wieschaus, 1994) longitudinal connective (Kambadur et al., 1998)
Detailed Description
	Statement Reference Stage 13 ventral cords exhibit lack of longitudinal connectives, missing or disorganised commissures. Increase in the number of neuroblast sublineages expressing nub in all CNS ganglia. (Kambadur et al., 1998) hb, kni double mutants show reduced rate of germ band extension. Cell intercalation is reduced in the region where the germ band fails to narrow, i.e. the region where eve and other pair-rule gene expression is uniform. (Irvine and Wieschaus, 1994) Cuticle phenotype. (Lukowitz et al., 1994) kni¹⁰ hb⁴ double mutant embryos fail to undergo normal germ band extension. (Leptin et al., 1992)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference fkh¹, hb⁴, kni¹⁰, tll¹ has cell polarity defective \| gastrula stage phenotype (Zallen and Wieschaus, 2004, Zallen and Wieschaus, 2004, Zallen and Wieschaus, 2004, Zallen and Wieschaus, 2004, Zallen and Wieschaus, 2004, Zallen and Wieschaus, 2004, Zallen and Wieschaus, 2004)
Phenotype Manifest In
Suppressed by
Statement Reference hb⁴, nos^L7 has embryonic abdominal segment phenotype, suppressible \| partially by pho^b (Saget et al., 1998) hb⁴, nos^L7 has embryonic abdominal segment phenotype, suppressible by Df(2R)vg-B (Saget et al., 1998) hb⁴, nos^L7 has embryonic abdominal segment phenotype, suppressible by mxc^G48 (Saget et al., 1998) hb⁴, nos^L7 has tergite phenotype, suppressible by mxc^G48 (Saget et al., 1998)
Suppressor of
Statement Reference hb⁴ is a suppressor \| partially of embryonic abdominal segment phenotype of nos^L7 (Bajusz et al., 2001)
Other
Statement Reference hb⁴, mxc^G48, nos^L7 has tergite phenotype (Saget et al., 1998) hb⁴, nos^L7 has abdominal 1 ventral denticle belt phenotype (Saget et al., 1998, Saget et al., 1998) hb⁴, nos^L7 has abdominal 2 ventral denticle belt phenotype (Saget et al., 1998, Saget et al., 1998) hb⁴, nos^L7 has abdominal 3 ventral denticle belt phenotype (Saget et al., 1998, Saget et al., 1998) hb⁴, nos^L7 has abdominal 4 ventral denticle belt phenotype (Saget et al., 1998, Saget et al., 1998) hb⁴, nos^L7 has abdominal 5 ventral denticle belt phenotype (Saget et al., 1998, Saget et al., 1998) hb⁴, nos^L7 has abdominal 6 ventral denticle belt phenotype (Saget et al., 1998, Saget et al., 1998) hb⁴, nos^L7 has abdominal 7 ventral denticle belt phenotype (Saget et al., 1998, Saget et al., 1998) hb⁴, nos^L7 has abdominal 8 ventral denticle belt phenotype (Saget et al., 1998, Saget et al., 1998) hb⁴, nos^L7 has embryonic abdominal segment phenotype (Saget et al., 1998, Saget et al., 1998) hb⁴, nos^L7 has tergite phenotype (Saget et al., 1998)
Additional Comments
Genetic Interactions
Statement Reference Anterior-posterior polarization of cells in the extending germband is disrupted in kni¹⁰ hb⁴ fkh¹ tll¹ homozygous embryos. (Zallen and Wieschaus, 2004) 3.69% of embryos derived from hb⁴ nos^L7/nos^L7 females have at least 3 abdominal segments. (Bajusz et al., 2001) Embryos derived from hb⁴ nos^L7/nos^L7 females differentiate only a few abdominal denticle belts. No rescue of abdominal segments is seen if the females also carry Df(1)10-70d, Df(1)mxc-1, mxc^22a-6 or mxc¹. Rescue of abdominal segments in embryos derived from hb⁴ nos^L7/nos^L7 females is seen if the females are also carrying mxc^G48. Adult escapers have abnormal tergites and are mostly fertile. Rescue of abdominal segments in embryos derived from hb⁴ nos^L7/nos^L7 females is seen if the females are also carrying Df(2R)vg-B or pho^b. (Saget et al., 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescued by	hb⁴ is partially rescued by hb^{Dvir\hb.0.8bcd} (Lukowitz et al., 1994) hb⁴ is partially rescued by hb^hb.0.7bcd (Lukowitz et al., 1994)
Comments	Head segments and thoracic segments (except for T2) can be rescued by hb^hb.0.7bcd or hb^{Dvir\hb.0.8bcd}. (Lukowitz et al., 1994)
Stocks ( 3 )
Bloomington	5339 P{ftz/lacC}4; kni¹⁰ hb⁴/TM3, Sb¹ 3307 kni¹⁰ hb⁴ cu¹ sr¹ e^s ca¹/TM3, Sb¹ Ser¹
Kyoto	106971 kni¹⁰ hb⁴ cu¹ sr¹ e^s ca¹ / TM3, Sb¹
Notes on Origin
Discoverer

Comments
	Phenotypic class I. (Lehmann and Nusslein-Volhard, 1987) hb^Drv2 fails to complement hb⁴. (Duncan, 1986) Class I allele.
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	hb⁴ hb^7M48 (Zallen and Wieschaus, 2004, Kuhnlein et al., 1998, Kuhnlein et al., 1997, Wimmer et al., 1995, Irvine and Wieschaus, 1994, Jack and McGinnis, 1990, Hooper et al., 1989, Harding and Levine, 1988, Frasch and Levine, 1987, Riede, 2004) hb^7m48 (Langeland et al., 1994, Duncan, 1986) hb^7M (Bajusz et al., 2001, Wimmer et al., 2000, Saget et al., 1998, Pelegri and Lehmann, 1994, Lukowitz et al., 1994, Hartmann et al., 1994, Zhang and Bienz, 1992, Leptin et al., 1992, Hoch et al., 1991, Qian et al., 1991, Zhang et al., 1991, Tautz, 1988, Lehmann and Nusslein-Volhard, 1987, Tearle and Nusslein-Volhard, 1987, )
Name Synonym
Secondary FlyBase IDs

References ( 28 )

Generate a list of	All references relating to this allele ( 28 )

List References by type	Research paper ( 27 ) Stock list ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...

Allele Dmel\hb4

Allele Dmel\hb⁴