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General Information
Symbol
Dmel\hb4
Species
D. melanogaster
Name
FlyBase ID
FBal0005395
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hb7M, hb7M48
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Stop codon before the first finger domain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Stage 13 ventral cords exhibit lack of longitudinal connectives, missing or disorganised commissures. Increase in the number of neuroblast sublineages expressing nub in all CNS ganglia.

hb, kni double mutants show reduced rate of germ band extension. Cell intercalation is reduced in the region where the germ band fails to narrow, i.e. the region where eve and other pair-rule gene expression is uniform.

Cuticle phenotype.

kni10 hb4 double mutant embryos fail to undergo normal germ band extension.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Anterior-posterior polarization of cells in the extending germband is disrupted in kni10 hb4 fkh1 tll1 homozygous embryos.

3.69% of embryos derived from hb4 nosL7/nosL7 females have at least 3 abdominal segments.

Embryos derived from hb4 nosL7/nosL7 females differentiate only a few abdominal denticle belts. No rescue of abdominal segments is seen if the females also carry Df(1)10-70d, Df(1)mxc-1, mxc22a-6 or mxc1. Rescue of abdominal segments in embryos derived from hb4 nosL7/nosL7 females is seen if the females are also carrying mxcG48. Adult escapers have abnormal tergites and are mostly fertile. Rescue of abdominal segments in embryos derived from hb4 nosL7/nosL7 females is seen if the females are also carrying Df(2R)vg-B or phob.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by

hb4 is partially rescued by hbhb.0.7bcd

hb4 is partially rescued by hbDvir\hb.0.8bcd

Comments

Head segments and thoracic segments (except for T2) can be rescued by hbhb.0.7bcd or hbDvir\hb.0.8bcd.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

Class I allele.

hbDrv2 fails to complement hb4.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (28)