FlyBase Allele Report: Dmel\hop[27]

General Information

Symbol

Dmel\hop²⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0005538

Feature type

allele

Associated gene

Dmel\hop

Associated Insertion(s)

Carried in Construct

Also Known As

hop^M4

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl nitrosourea

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Perrimon and Mahowald, 1986)

Mutagen

ethyl nitrosourea

Progenitor genotype

Cytology

Description

Amino acid replacement: I1011T. The mutation is within the kinase domain.

(Luo et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:11,362,455..11,362,455 [-]

Nucleotide change:

T11362455C

Amino acid change:

I1011T | hop-PA

Reported amino acid change:

I1011T

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Luo et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | third instar larval stage

(Recasens-Alvarez et al., 2017)

increased cell number | oogenesis (with hop²⁵)

(McGregor et al., 2002)

increased occurrence of cell division | larval stage

(Recasens-Alvarez et al., 2017)

lethal | rescuable maternal effect

(Perrimon and Mahowald, 1986)

viable (with hop²⁵)

(Harrison et al., 1998)

Phenotype Manifest In

egg chamber (with hop²⁵)

(McGregor et al., 2002)

polar follicle cell | increased number (with hop²⁵)

(McGregor et al., 2002)

wing disc | third instar larval stage

(Recasens-Alvarez et al., 2017)

wing disc posterior compartment | larval stage

(Recasens-Alvarez et al., 2017)

Detailed Description

Statement

Reference

hop²⁷ hemizygotes show a significant reduction in the size of the third instar larval wing disc, which is particularly evident on the posterior compartment, as compared to controls; second to late instar larval wing disc posterior compartments also show an obvious increase in the amount of apoptotic cells, as compared to either the anterior compartment or wild-type controls.

(Recasens-Alvarez et al., 2017)

The mean ln (natural logarithm) circulating hemocyte concentration (CHC) value of hemizygous larvae is significantly higher than that of control siblings. The ability of hemizygous larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.

(Sorrentino et al., 2004)

hop²⁵/hop²⁷ non-fused egg chambers sometimes have extra polar follicle cells (generally having 3 rather than the normal number of 2 polar cells at both the anterior and posterior ends of the egg chamber). At stage 8/9, 13% of egg chambers have extra polar cells at the anterior end and 36% of egg chambers have extra polar cells at the posterior end. The extra polar cells do not appear to be due to continued proliferation of the polar cell population. 5% of hop²⁵/hop²⁷ egg chambers are fused.

(McGregor et al., 2002)

100% viable in transheterozygous combination with hop²⁵.

(Harrison et al., 1998)

Paternal rescue of the maternal effect. Germline clone analysis demonstrates that embryos have one abdominal segment missing and A4 appears wider than wild type, and partial or complete fusion of T1 and T2.

(Perrimon and Mahowald, 1986)

larval/pupal lethal hop²⁷/hop²⁵ 100% viable

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

hop²⁷/hop[+] is an enhancer of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

Other

Statement

Reference

hop²⁷, upd1^YM55 has partially lethal | recessive phenotype

(Harrison et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

hop²⁷/hop²⁵ has egg chamber phenotype, enhanceable by os[+]/upd1^YM55

(McGregor et al., 2002)

hop²⁷/hop²⁵ has polar follicle cell | increased number phenotype, enhanceable by os[+]/upd1^YM55

(McGregor et al., 2002)

hop²⁷/hop²⁵ has egg chamber phenotype, enhanceable by upd1^YC43/os[+]

(McGregor et al., 2002)

Enhancer of

Statement

Reference

hop²⁷/hop[+] is an enhancer of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

75% of hop²⁵ upd1^YC43/hop²⁷ egg chambers are fused.

92% of hop²⁵ upd1^YM55/hop²⁷ egg chambers are fused and the number of extra polar cells is increased compared to hop²⁵/hop²⁷ single mutants.

(McGregor et al., 2002)

Viability of hop²⁷/hop²⁵ flies is reduced if the flies also carry os^upd-4.

(Harrison et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8493

y¹ hop²⁷/FM7c

Notes on Origin

Discoverer

Voelker.

Comments

Fully complement hop²⁵.

(Perrimon and Mahowald, 1986)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

(Luo et al., 1999)

hop²⁷

(Xu et al., 2019, Recasens-Alvarez et al., 2017, Fregoso Lomas et al., 2016, Santabárbara-Ruiz et al., 2015, Popodi et al., 2010-, Oishi et al., 2006)

hop^M4

(Oh et al., 2004, Sorrentino et al., 2004, McGregor et al., 2002, Harrison et al., 1998)

l(1)M4

l(1)hop^M4

(Perrimon and Mahowald, 1986)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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