|Feature type||allele||Associated gene||Dmel\hop|
|Also Known As||hopM4|
|Map ( GBrowse )|
|Allele class||amorphic allele - genetic evidence|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: I1011T. The mutation is within the kinase domain.
|Phenotype Manifest In|
The mean ln (natural logarithm) circulating hemocyte concentration (CHC) value of hemizygous larvae is significantly higher than that of control siblings. The ability of hemizygous larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.
hop25/hop27 non-fused egg chambers sometimes have extra polar follicle cells (generally having 3 rather than the normal number of 2 polar cells at both the anterior and posterior ends of the egg chamber). At stage 8/9, 13% of egg chambers have extra polar cells at the anterior end and 36% of egg chambers have extra polar cells at the posterior end. The extra polar cells do not appear to be due to continued proliferation of the polar cell population. 5% of hop25/hop27 egg chambers are fused.
Paternal rescue of the maternal effect. Germline clone analysis demonstrates that embryos have one abdominal segment missing and A4 appears wider than wild type, and partial or complete fusion of T1 and T2.
|Phenotype Manifest In|
75% of hop25 osupd-3/hop27 egg chambers are fused. 92% of hop25 osupd-4/hop27 egg chambers are fused and the number of extra polar cells is increased compared to hop25/hop27 single mutants.
|Complementation & Rescue Data|
|Stocks ( 1 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 5 )|
|Secondary FlyBase IDs|
|References ( 8 )|
|Personal communication to FlyBase|