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General Information
Symbol
Dmel\hop29
Species
D. melanogaster
Name
FlyBase ID
FBal0005540
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
hopM13
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C11363742A

Amino acid change:

S773term | hop-PA

Reported amino acid change:

S773term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Mutation is within the kinase-like domain.

Amino acid replacement: S773term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

hop29 somatic clones in the eye are rare and have a cell autonomous growth disadvantage when compared to their wildtype twins. They occasionally have missing photoreceptor cells and polarity defects. In the rare larger clones a striking cell non-autonomous effect is seen. Ommatidia at the polar margin of the clones reverse their polarity such that the ommatidia point away rather than toward the equator, thus creating an ectopic equator. When a clone is observed very close to the dorso-ventral midline, the equator was deflected away and formed along the border of the clone. Most of the ommatidia with reversed polarity were composed entirely of wild-type photoreceptor cells. This effect was seen in both dorsal and ventral halves of the eye.

2% viable in transheterozygous combination with hop25.

Paternal rescue of the maternal effect. Germline clone analysis demonstrates that embryos have one abdominal segment missing and A4 appears wider than wild type, and partial or complete fusion of T1 and T2.

larval/pupal lethal hop29/hop25 12% viable

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

hop25/hop29 has lethal phenotype, enhanceable by upd1YM55

Enhancer of
Statement
Reference

hop29 is an enhancer of visible phenotype of upd11

Phenotype Manifest In
Enhancer of
Statement
Reference

hop29 is an enhancer of eye phenotype of upd11

Additional Comments
Genetic Interactions
Statement
Reference

Df(1)os1, hop29/Y pharates have very small eyes.

Viability of hop25/hop29 flies is reduced to 0% if the flies also carry osupd-4.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Voelker.

Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)