A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Allele Dmel\KrIf-1

General Information
SymbolDmel\KrIf-1SpeciesD. melanogaster
NameFlyBase IDFBal0005583
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\Kr
Allele classneomorph
Mutagenspontaneous
hide Nature of the Allele
Allele class
Mutagen
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
       
       
      Assay mode
      Cytology
      hide Phenotypic Data
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      hide Phenotype Manifest In
      hide Detailed Description
      Statement
      Reference
      In heterozygote, eye area about one-half normal; narrow and pointed ventrally; facets irregular and often missing across middle of eyes, sometimes fused or absent in ventral portion. In homozygote, eyes are narrow slits with smooth glossy surface. In the eye disk of late third instar larvae, fairly large number of cell clusters in irregular arrangement, especially in ventral half of disk (Renfranz and Benzer, 1989). Viability and fertility good. RK1.
       
      The mutant phenotype of KrIf-1 is due to a developmental defect in precursor cells. When heterozygous with apx1 the adult eye is half the normal size, the ventral half more prone to irregularities. Eye disc has a fairly large number of clusters with irregular arrangements. When heterozygous with st adult eye is narrow and ventral half is devoid of facets. Rhabdomeres are fused and only 20 ommatidia are present. Eye disc size is reduced with few clusters.
      KrIf-1 results in a rough eye phenotype which is more extreme in homozygotes. Eye discs are deeply folded and smaller than wild type. Ommatidia begin to form posterior to the morphogenetic furrow but later stages of ommatidial development are more rarely seen. The adult eye is greatly reduced in size and is made up of pigment cells and lacunae. Photoreceptor rhabdomeres are only rarely found, and have unusual morphology. The eye region sometimes differentiates cuticle.
      The eye area is reduced to approximately one-half that of wild-type in heterozygotes, it is oblong and generally pointed ventrally. The facets are irregularly distributed, are frequently missing across the middle of the eye, and are sometimes fused or absent in the ventral portion. The eye is a narrow slit in homozygotes and has a smooth glossy surface. Viability and fecundity of both hetero- and homozygotes is good to excellent.
      KrIf-1 males that are also mutant for mle4 show a more severe phenotype than their mle4/+ sibs.
      Displays locomotor activity rhythm with an approximately 24h period.
      The number of ommatidia is abnormal in heterozygotes.
      Heterozygotes have small, narrow eyes that are pointed ventrally. In the ventral portion of the eye the facets are fused or absent and dorsally they are irregularly arranged. Eyes are further reduced in size in homozygotes, forming narrow slits with a glossy surface lacking most ommatidia.
      The size of the eye is reduced and the ommatidia ared fused or absent in the ventral part of the eye and irregularly arranged dorsally.
      KrIf-1/+ flies have small rough eyes.
      hide Interactions
      hide Phenotypic Class
      hideEnhanced by
      Statement
      Reference
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(2L)E55
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(2L)Prl
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(2R)PC4
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(2R)Px2
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(2R)bw-S46
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(2R)bw5
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(2R)cn9
      KrIf-1 has visible | dominant phenotype, enhanceable by GstS104227
      KrIf-1 has visible | dominant phenotype, enhanceable by In(2LR)Px4
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(2R)pk78s
      KrIf-1 has visible | dominant phenotype, enhanceable by Kr-h110642
      KrIf-1 has visible | dominant phenotype, enhanceable by Mi-21
      KrIf-1 has visible | dominant phenotype, enhanceable by Rab608323
      KrIf-1 has visible | dominant phenotype, enhanceable by S05671
      KrIf-1 has visible | dominant phenotype, enhanceable by S07056
      KrIf-1 has visible | dominant phenotype, enhanceable by Sema-2a03021
      KrIf-1 has visible | dominant phenotype, enhanceable by crol10639
      KrIf-1 has visible | dominant phenotype, enhanceable by dpp10638
      KrIf-1 has visible | dominant phenotype, enhanceable by ex01270
      KrIf-1 has visible | dominant phenotype, enhanceable by ex02278
      KrIf-1 has visible | dominant phenotype, enhanceable by l(2)0399603996
      KrIf-1 has visible | dominant phenotype, enhanceable by chinmo04111
      KrIf-1 has visible | dominant phenotype, enhanceable by l(2)0454804548
      KrIf-1 has visible | dominant phenotype, enhanceable by l(2)0849208492
      KrIf-1 has visible | dominant phenotype, enhanceable by osa00090
      KrIf-1 has visible | dominant phenotype, enhanceable by styΔ5
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(3L)brm11
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(3R)P115
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(3R)kar-D3
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(3R)GB104
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(3R)p712
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(3L)R-G7
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(3L)fz-GF3b
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(3L)W10
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(3L)W4
      KrIf-1 has visible | dominant phenotype, enhanceable by Df(3L)kto2
      KrIf-1 has visible | dominant phenotype, enhanceable by osa[+]/osa04539
      KrIf-1 has visible | dominant phenotype, enhanceable by Mi-21/Mi-2[+]
      KrIf-1 has visible | dominant phenotype, enhanceable by osa00090/osa[+]
      KrIf-1 has visible | dominant phenotype, enhanceable by Fer2LCH[+]/Fer2LCH07016
      hideSuppressed by
      Statement
      Reference
      KrIf-1 has visible | dominant phenotype, suppressible by Df(2R)trix
      KrIf-1 has visible | dominant phenotype, suppressible by Eip75B07041
      KrIf-1 has visible | dominant phenotype, suppressible by In(2L)05887
      KrIf-1 has visible | dominant phenotype, suppressible by Sc205634
      KrIf-1 has visible | dominant phenotype, suppressible by Vha55j2E9
      KrIf-1 has visible | dominant phenotype, suppressible by bun05479
      KrIf-1 has visible | dominant phenotype, suppressible by bun06475
      KrIf-1 has visible | dominant phenotype, suppressible by caps02937
      KrIf-1 has visible | dominant phenotype, suppressible by emc05592
      KrIf-1 has visible | dominant phenotype, suppressible by styL1
      KrIf-1 has visible | dominant phenotype, suppressible by bun02687
      KrIf-1 has visible | dominant phenotype, suppressible by Df(3L)Ar12-1
      KrIf-1 has visible | dominant phenotype, suppressible by Df(3L)Ar14-8
      KrIf-1 has visible | dominant phenotype, suppressible by Df(3L)GN19
      KrIf-1 has visible | dominant phenotype, suppressible by Df(3L)M21
      KrIf-1 has visible | dominant phenotype, suppressible by Df(3L)HR119
      KrIf-1 has visible | dominant phenotype, suppressible by Df(3L)AC1
      KrIf-1 has visible | dominant phenotype, suppressible by Df(3L)Ly
      KrIf-1 has visible | dominant phenotype, suppressible by Df(3L)H99
      KrIf-1 has visible | dominant phenotype, suppressible by Df(3R)M-Kx1
      KrIf-1 has visible | dominant phenotype, suppressible by l(3)06240[+]/l(3)0624006240
      KrIf-1 has visible | dominant phenotype, suppressible by l(3)05967[+]/l(3)0596705967
      KrIf-1 has visible | dominant phenotype, suppressible by l(3)neo3[+]/l(3)neo31
      KrIf-1 has visible | dominant phenotype, suppressible by emc[+]/emc05592
      KrIf-1 has visible | dominant phenotype, suppressible by Sc2[+]/Sc205634
      KrIf-1 has visible | dominant phenotype, suppressible by l(3)0692406924/l(3)06924[+]
      KrIf-1 has visible | dominant phenotype, suppressible by caps02937/caps[+]
      KrIf-1 has visible | dominant phenotype, suppressible by Eip75B[+]/Eip75B07041
      KrIf-1 has visible | dominant phenotype, suppressible by rept[+]/rept06945
      KrIf-1 has visible | dominant phenotype, suppressible by Vha55j2E9/Vha55[+]
      KrIf-1 has visible | dominant phenotype, suppressible by l(3)j2C3[+]/l(3)j2C3j2C3
      KrIf-1 has visible | dominant phenotype, suppressible by l(3)neo391/l(3)neo39[+]
      KrIf-1 has visible | dominant phenotype, suppressible by l(3)neo47[+]/l(3)neo471
      hide Phenotype Manifest In
      hideEnhanced by
      Statement
      Reference
      KrIf-1 has eye phenotype, enhanceable by Df(2L)E55
      KrIf-1 has ommatidium phenotype, enhanceable by Df(2L)E55
      KrIf-1 has eye phenotype, enhanceable by Df(2L)Prl
      KrIf-1 has ommatidium phenotype, enhanceable by Df(2L)Prl
      KrIf-1 has eye phenotype, enhanceable by Df(2R)PC4
      KrIf-1 has ommatidium phenotype, enhanceable by Df(2R)PC4
      KrIf-1 has eye phenotype, enhanceable by Df(2R)Px2
      KrIf-1 has ommatidium phenotype, enhanceable by Df(2R)Px2
      KrIf-1 has eye phenotype, enhanceable by Df(2R)bw-S46
      KrIf-1 has ommatidium phenotype, enhanceable by Df(2R)bw-S46
      KrIf-1 has eye phenotype, enhanceable by Df(2R)bw5
      KrIf-1 has ommatidium phenotype, enhanceable by Df(2R)bw5
      KrIf-1 has eye phenotype, enhanceable by Df(2R)cn9
      KrIf-1 has ommatidium phenotype, enhanceable by Df(2R)cn9
      KrIf-1 has eye phenotype, enhanceable by GstS104227
      KrIf-1 has ommatidium phenotype, enhanceable by GstS104227
      KrIf-1 has eye phenotype, enhanceable by In(2LR)Px4
      KrIf-1 has ommatidium phenotype, enhanceable by In(2LR)Px4
      KrIf-1 has eye phenotype, enhanceable by Df(2R)pk78s
      KrIf-1 has ommatidium phenotype, enhanceable by Df(2R)pk78s
      KrIf-1 has eye phenotype, enhanceable by Kr-h110642
      KrIf-1 has ommatidium phenotype, enhanceable by Kr-h110642
      KrIf-1 has eye phenotype, enhanceable by Mi-21
      KrIf-1 has ommatidium phenotype, enhanceable by Mi-21
      KrIf-1 has eye phenotype, enhanceable by Rab608323
      KrIf-1 has ommatidium phenotype, enhanceable by Rab608323
      KrIf-1 has eye phenotype, enhanceable by S05671
      KrIf-1 has ommatidium phenotype, enhanceable by S05671
      KrIf-1 has eye phenotype, enhanceable by S07056
      KrIf-1 has ommatidium phenotype, enhanceable by S07056
      KrIf-1 has eye phenotype, enhanceable by Sema-2a03021
      KrIf-1 has ommatidium phenotype, enhanceable by Sema-2a03021
      KrIf-1 has eye phenotype, enhanceable by crol10639
      KrIf-1 has ommatidium phenotype, enhanceable by crol10639
      KrIf-1 has eye phenotype, enhanceable by dpp10638
      KrIf-1 has ommatidium phenotype, enhanceable by dpp10638
      KrIf-1 has eye phenotype, enhanceable by ex01270
      KrIf-1 has ommatidium phenotype, enhanceable by ex01270
      KrIf-1 has eye phenotype, enhanceable by ex02278
      KrIf-1 has ommatidium phenotype, enhanceable by ex02278
      KrIf-1 has eye phenotype, enhanceable by l(2)0399603996
      KrIf-1 has ommatidium phenotype, enhanceable by l(2)0399603996
      KrIf-1 has eye phenotype, enhanceable by chinmo04111
      KrIf-1 has ommatidium phenotype, enhanceable by chinmo04111
      KrIf-1 has eye phenotype, enhanceable by l(2)0454804548
      KrIf-1 has ommatidium phenotype, enhanceable by l(2)0454804548
      KrIf-1 has eye phenotype, enhanceable by l(2)0849208492
      KrIf-1 has ommatidium phenotype, enhanceable by l(2)0849208492
      KrIf-1 has eye phenotype, enhanceable by osa00090
      KrIf-1 has ommatidium phenotype, enhanceable by osa00090
      KrIf-1 has eye phenotype, enhanceable by styΔ5
      KrIf-1 has ommatidium phenotype, enhanceable by styΔ5
      KrIf-1 has eye phenotype, enhanceable by Df(3L)brm11
      KrIf-1 has eye phenotype, enhanceable by Df(3R)P115
      KrIf-1 has eye phenotype, enhanceable by Df(3R)kar-D3
      KrIf-1 has eye phenotype, enhanceable by Df(3R)GB104
      KrIf-1 has eye phenotype, enhanceable by Df(3R)p712
      KrIf-1 has eye phenotype, enhanceable by Df(3L)R-G7
      KrIf-1 has eye phenotype, enhanceable by Df(3L)fz-GF3b
      KrIf-1 has eye phenotype, enhanceable by Df(3L)W10
      KrIf-1 has eye phenotype, enhanceable by Df(3L)W4
      KrIf-1 has eye phenotype, enhanceable by Df(3L)kto2
      KrIf-1 has eye phenotype, enhanceable by osa[+]/osa04539
      KrIf-1 has eye phenotype, enhanceable by Mi-21/Mi-2[+]
      KrIf-1 has eye phenotype, enhanceable by osa00090/osa[+]
      KrIf-1 has eye phenotype, enhanceable by Fer2LCH[+]/Fer2LCH07016
      hideNOT Enhanced by
      Statement
      Reference
      KrIf-1 has eye phenotype, non-enhanceable by Low1
      hideSuppressed by
      Statement
      Reference
      KrIf-1 has eye phenotype, suppressible by Df(2R)trix
      KrIf-1 has ommatidium phenotype, suppressible by Df(2R)trix
      KrIf-1 has eye phenotype, suppressible by Eip75B07041
      KrIf-1 has ommatidium phenotype, suppressible by Eip75B07041
      KrIf-1 has eye phenotype, suppressible by In(2L)05887
      KrIf-1 has ommatidium phenotype, suppressible by In(2L)05887
      KrIf-1 has eye phenotype, suppressible by Sc205634
      KrIf-1 has ommatidium phenotype, suppressible by Sc205634
      KrIf-1 has eye phenotype, suppressible by Vha55j2E9
      KrIf-1 has ommatidium phenotype, suppressible by Vha55j2E9
      KrIf-1 has eye phenotype, suppressible by bun05479
      KrIf-1 has ommatidium phenotype, suppressible by bun05479
      KrIf-1 has eye phenotype, suppressible by bun06475
      KrIf-1 has ommatidium phenotype, suppressible by bun06475
      KrIf-1 has eye phenotype, suppressible by caps02937
      KrIf-1 has ommatidium phenotype, suppressible by caps02937
      KrIf-1 has eye phenotype, suppressible by emc05592
      KrIf-1 has ommatidium phenotype, suppressible by emc05592
      KrIf-1 has eye phenotype, suppressible by styL1
      KrIf-1 has ommatidium phenotype, suppressible by styL1
      KrIf-1 has eye phenotype, suppressible by bun02687
      KrIf-1 has ommatidium phenotype, suppressible by bun02687
      KrIf-1 has eye phenotype, suppressible by Df(3L)Ar12-1
      KrIf-1 has eye phenotype, suppressible by Df(3L)Ar14-8
      KrIf-1 has eye phenotype, suppressible by Df(3L)GN19
      KrIf-1 has eye phenotype, suppressible by Df(3L)M21
      KrIf-1 has eye phenotype, suppressible by Df(3L)HR119
      KrIf-1 has eye phenotype, suppressible by Df(3L)AC1
      KrIf-1 has eye phenotype, suppressible by Df(3L)Ly
      KrIf-1 has eye phenotype, suppressible by Df(3L)H99
      KrIf-1 has eye phenotype, suppressible by Df(3R)M-Kx1
      KrIf-1 has eye phenotype, suppressible by l(3)06240[+]/l(3)0624006240
      KrIf-1 has eye phenotype, suppressible by l(3)05967[+]/l(3)0596705967
      KrIf-1 has eye phenotype, suppressible by l(3)neo3[+]/l(3)neo31
      KrIf-1 has eye phenotype, suppressible by emc[+]/emc05592
      KrIf-1 has eye phenotype, suppressible by Sc2[+]/Sc205634
      KrIf-1 has eye phenotype, suppressible by l(3)0692406924/l(3)06924[+]
      KrIf-1 has eye phenotype, suppressible by caps02937/caps[+]
      KrIf-1 has eye phenotype, suppressible by Eip75B[+]/Eip75B07041
      KrIf-1 has eye phenotype, suppressible by rept[+]/rept06945
      KrIf-1 has eye phenotype, suppressible by Vha55j2E9/Vha55[+]
      KrIf-1 has eye phenotype, suppressible by l(3)j2C3[+]/l(3)j2C3j2C3
      KrIf-1 has eye phenotype, suppressible by l(3)neo391/l(3)neo39[+]
      KrIf-1 has eye phenotype, suppressible by l(3)neo47[+]/l(3)neo471
      KrIf-1 has eye phenotype, suppressible by exba[+]/exba03022
      hideNOT suppressed by
      Statement
      Reference
      KrIf-1 has eye phenotype, non-suppressible by Low1
      hideOther
      Statement
      Reference
      Hsp83[+]/Hsp83e6A, KrIf-1 has eye phenotype
      Hsp83e6D/Hsp83[+], KrIf-1 has eye phenotype
      KrIf-1, Trl[+]/TrlR85 has eye phenotype
      KrIf-1, brm[+]/brm2 has eye phenotype
      KrIf-1, btldev2/btl[+] has eye phenotype
      KrIf-1, fs(1)h1/fs(1)h[+] has eye phenotype
      KrIf-1, kto[+]/kto1 has eye phenotype
      KrIf-1, osa2/osa[+] has eye phenotype
      KrIf-1, skd2/skd[+] has eye phenotype
      KrIf-1, urd2/urd[+] has eye phenotype
      KrIf-1, vtd[+]/vtd3 has eye phenotype
      KrIf-1, z[+]/zv77h has eye phenotype
      Hsp83e4A/Hsp83[+], KrIf-1 has eye phenotype
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      The eye phenotype is unaffected by Low1.
      KrIf-1, ex01270 flies develop smaller eyes and fewer ommatidia than KrIf-1 flies. KrIf-1, S05671 eyes show a severe enhancement of the KrIf-1 phenotype; the eyes only have only remnants of a few ommatidia.
      15+/-4% of KrIf-1/+ flies born to Hsp83e1D/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers. 11+/-3% of KrIf-1/+ flies born to Hsp83e3A/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers. 6+/-2% of KrIf-1/+ flies born to Hsp83e4A/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers. 6+/-2% of KrIf-1/+ flies born to Hsp83e6A/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers. 13+/-4% of KrIf-1/+ flies born to Hsp83e6D/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers. 5+/-1% of KrIf-1/+ flies born to brm2/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers. 10+/-2% of KrIf-1/+ flies born to fs(1)h1/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers. 15+/-4% of KrIf-1/+ flies born to kto1/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers. 10+/-2% of KrIf-1/+ flies born to osa2/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers. 2+/-1% of KrIf-1/+ flies born to skd2/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers. 5+/-2% of KrIf-1/+ flies born to urd2/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers. 55+/-8% of KrIf-1/+ flies born to vtd3/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers. 5+/-2% of KrIf-1/+ flies born to zv77h/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers. 10+/-3% of KrIf-1/+ flies born to btldev2/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.