Allele Dmel\Kr^If-1

General Information
Symbol	Dmel\Kr^If-1	Species	D. melanogaster
Name		FlyBase ID	FBal0005583
Feature type	allele	Associated gene	Dmel\Kr
Also Known As	If

Allele class	neomorphic allele - genetic evidence
Mutagen	spontaneous
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	neomorphic allele - genetic evidence (Hiebert and Birchler, 1994)
Mutagen	spontaneous (Ives, 1967)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	visible (Baker et al., 1992, Gangaraju et al., 2011) visible \| dominant (Bhadra et al., 1997, Abrell et al., 2000, Hiebert and Birchler, 1994, Ives, 1967, Carrera et al., 1998)
Phenotype Manifest In
	adult cuticle \| ectopic (Baker et al., 1992) eye (Bhadra et al., 1997, Sollars et al., 2003, Baker et al., 1992, Abrell et al., 2000, Hiebert and Birchler, 1994, Ives, 1967, Carrera et al., 1998, Gangaraju et al., 2011) eye disc (Baker et al., 1992) ommatidium (Bhadra et al., 1997, Baker et al., 1992, Abrell et al., 2000, Carrera et al., 1998) rhabdomere (Baker et al., 1992)
Detailed Description
	Statement Reference Mutants have an eye outgrowth phenotype. Feeding geldanamycin to homozygous females increases the frequency of the ectopic eye outgrowth phenotype by approximately 10-fold. (Gangaraju et al., 2011) Kr^If-1/+ flies have small rough eyes. (Sollars et al., 2003) The size of the eye is reduced and the ommatidia ared fused or absent in the ventral part of the eye and irregularly arranged dorsally. (Abrell et al., 2000) Heterozygotes have small, narrow eyes that are pointed ventrally. In the ventral portion of the eye the facets are fused or absent and dorsally they are irregularly arranged. Eyes are further reduced in size in homozygotes, forming narrow slits with a glossy surface lacking most ommatidia. (Carrera et al., 1998) The number of ommatidia is abnormal in heterozygotes. (Bhadra et al., 1997) Displays locomotor activity rhythm with an approximately 24h period. (Vosshall and Young, 1995) Kr^If-1 males that are also mutant for mle⁴ show a more severe phenotype than their mle⁴/+ sibs. (Hiebert and Birchler, 1994) Kr^If-1 results in a rough eye phenotype which is more extreme in homozygotes. Eye discs are deeply folded and smaller than wild type. Ommatidia begin to form posterior to the morphogenetic furrow but later stages of ommatidial development are more rarely seen. The adult eye is greatly reduced in size and is made up of pigment cells and lacunae. Photoreceptor rhabdomeres are only rarely found, and have unusual morphology. The eye region sometimes differentiates cuticle. (Baker et al., 1992) The mutant phenotype of Kr^If-1 is due to a developmental defect in precursor cells. When heterozygous with apx¹ the adult eye is half the normal size, the ventral half more prone to irregularities. Eye disc has a fairly large number of clusters with irregular arrangements. When heterozygous with st adult eye is narrow and ventral half is devoid of facets. Rhabdomeres are fused and only 20 ommatidia are present. Eye disc size is reduced with few clusters. (Renfranz and Benzer, 1989) The eye area is reduced to approximately one-half that of wild-type in heterozygotes, it is oblong and generally pointed ventrally. The facets are irregularly distributed, are frequently missing across the middle of the eye, and are sometimes fused or absent in the ventral portion. The eye is a narrow slit in homozygotes and has a smooth glossy surface. Viability and fecundity of both hetero- and homozygotes is good to excellent. (Ives, 1967) In heterozygote, eye area about one-half normal; narrow and pointed ventrally; facets irregular and often missing across middle of eyes, sometimes fused or absent in ventral portion. In homozygote, eyes are narrow slits with smooth glossy surface. In the eye disk of late third instar larvae, fairly large number of cell clusters in irregular arrangement, especially in ventral half of disk (Renfranz and Benzer, 1989). Viability and fertility good. RK1.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Kr^If-1 has visible \| dominant phenotype, enhanceable by chinmo⁰⁴¹¹¹ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by crol¹⁰⁶³⁹ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(2L)E55 (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(2L)Prl (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(2R)bw5 (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(2R)bw-S46 (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(2R)cn9 (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(2R)PC4 (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(2R)pk78s (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(2R)Px2 (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(3L)brm11 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(3L)fz-GF3b (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(3L)kto2 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(3L)R-G7 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(3L)W4 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(3L)W10 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(3R)GB104 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(3R)kar-D3 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(3R)P115 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, enhanceable by Df(3R)p712 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, enhanceable by dpp¹⁰⁶³⁸ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by ex⁰¹²⁷⁰ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by ex⁰²²⁷⁸ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by Fer2LCH[+]/Fer2LCH⁰⁷⁰¹⁶ (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, enhanceable by GstS1⁰⁴²²⁷ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by In(2LR)Px⁴ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by Kr-h1¹⁰⁶⁴² (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by l(2)03996⁰³⁹⁹⁶ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by l(2)04548⁰⁴⁵⁴⁸ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by l(2)08492⁰⁸⁴⁹² (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by Mi-2¹ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by Mi-2¹/Mi-2[+] (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, enhanceable by osa[+]/osa⁰⁴⁵³⁹ (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, enhanceable by osa⁰⁰⁰⁹⁰ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by osa⁰⁰⁰⁹⁰/osa[+] (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, enhanceable by Rab6⁰⁸³²³ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by S⁰⁵⁶⁷¹ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by S⁰⁷⁰⁵⁶ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by Sema-2a⁰³⁰²¹ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, enhanceable by sty^Δ5 (Abrell et al., 2000) Kr^If-1 has visible phenotype, enhanceable by Hop[+]/Hop^k00616 (Gangaraju et al., 2011) Kr^If-1 has visible phenotype, enhanceable by piwi[+]/piwi¹ (Gangaraju et al., 2011) Kr^If-1 has visible phenotype, enhanceable by piwi[+]/piwi² (Gangaraju et al., 2011)
Suppressed by
Statement Reference Kr^If-1 has visible \| dominant phenotype, suppressible by bun⁰²⁶⁸⁷ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, suppressible by bun⁰⁵⁴⁷⁹ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, suppressible by bun⁰⁶⁴⁷⁵ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, suppressible by caps⁰²⁹³⁷ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, suppressible by caps⁰²⁹³⁷/caps[+] (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by Df(2R)trix (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, suppressible by Df(3L)AC1 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by Df(3L)Ar12-1 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by Df(3L)Ar14-8 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by Df(3L)GN19 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by Df(3L)H99 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by Df(3L)HR119 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by Df(3L)Ly (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by Df(3L)M21 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by Df(3R)M-Kx1 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by Eip75B[+]/Eip75B⁰⁷⁰⁴¹ (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by Eip75B⁰⁷⁰⁴¹ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, suppressible by emc[+]/emc⁰⁵⁵⁹² (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by emc⁰⁵⁵⁹² (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, suppressible by In(2L)05887 (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, suppressible by l(3)05967[+]/l(3)05967⁰⁵⁹⁶⁷ (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by l(3)06240[+]/Psa⁰⁶²⁴⁰ (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by l(3)j2C3[+]/l(3)j2C3^j2C3 (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by l(3)neo3[+]/l(3)neo3¹ (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by l(3)neo39¹/l(3)neo39[+] (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by l(3)neo47[+]/l(3)neo47¹ (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by rept[+]/rept⁰⁶⁹⁴⁵ (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by Sap130⁰⁶⁹²⁴/l(3)06924[+] (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by Sc2[+]/Sc2⁰⁵⁶³⁴ (Carrera et al., 1998) Kr^If-1 has visible \| dominant phenotype, suppressible by Sc2⁰⁵⁶³⁴ (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, suppressible by sty^L1 (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, suppressible by Vha55^j2E9 (Abrell et al., 2000) Kr^If-1 has visible \| dominant phenotype, suppressible by Vha55^j2E9/Vha55[+] (Carrera et al., 1998)
Phenotype Manifest In
Enhanced by
Statement Reference Kr^If-1 has eye phenotype, enhanceable by chinmo⁰⁴¹¹¹ (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by crol¹⁰⁶³⁹ (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by Df(2L)E55 (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by Df(2L)Prl (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by Df(2R)bw5 (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by Df(2R)bw-S46 (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by Df(2R)cn9 (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by Df(2R)PC4 (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by Df(2R)pk78s (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by Df(2R)Px2 (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by Df(3L)brm11 (Carrera et al., 1998) Kr^If-1 has eye phenotype, enhanceable by Df(3L)fz-GF3b (Carrera et al., 1998) Kr^If-1 has eye phenotype, enhanceable by Df(3L)kto2 (Carrera et al., 1998) Kr^If-1 has eye phenotype, enhanceable by Df(3L)R-G7 (Carrera et al., 1998) Kr^If-1 has eye phenotype, enhanceable by Df(3L)W4 (Carrera et al., 1998) Kr^If-1 has eye phenotype, enhanceable by Df(3L)W10 (Carrera et al., 1998) Kr^If-1 has eye phenotype, enhanceable by Df(3R)GB104 (Carrera et al., 1998) Kr^If-1 has eye phenotype, enhanceable by Df(3R)kar-D3 (Carrera et al., 1998) Kr^If-1 has eye phenotype, enhanceable by Df(3R)P115 (Carrera et al., 1998) Kr^If-1 has eye phenotype, enhanceable by Df(3R)p712 (Carrera et al., 1998) Kr^If-1 has eye phenotype, enhanceable by dpp¹⁰⁶³⁸ (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by ex⁰¹²⁷⁰ (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by ex⁰²²⁷⁸ (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by Fer2LCH[+]/Fer2LCH⁰⁷⁰¹⁶ (Carrera et al., 1998) Kr^If-1 has eye phenotype, enhanceable by GstS1⁰⁴²²⁷ (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by Hop[+]/Hop^k00616 (Gangaraju et al., 2011) Kr^If-1 has eye phenotype, enhanceable by In(2LR)Px⁴ (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by Kr-h1¹⁰⁶⁴² (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by l(2)03996⁰³⁹⁹⁶ (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by l(2)04548⁰⁴⁵⁴⁸ (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by l(2)08492⁰⁸⁴⁹² (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by Mi-2¹ (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by Mi-2¹/Mi-2[+] (Carrera et al., 1998) Kr^If-1 has eye phenotype, enhanceable by osa[+]/osa⁰⁴⁵³⁹ (Carrera et al., 1998) Kr^If-1 has eye phenotype, enhanceable by osa⁰⁰⁰⁹⁰ (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by osa⁰⁰⁰⁹⁰/osa[+] (Carrera et al., 1998) Kr^If-1 has eye phenotype, enhanceable by piwi[+]/piwi¹ (Gangaraju et al., 2011) Kr^If-1 has eye phenotype, enhanceable by piwi[+]/piwi² (Gangaraju et al., 2011) Kr^If-1 has eye phenotype, enhanceable by Rab6⁰⁸³²³ (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by S⁰⁵⁶⁷¹ (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by S⁰⁷⁰⁵⁶ (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by Sema-2a⁰³⁰²¹ (Abrell et al., 2000) Kr^If-1 has eye phenotype, enhanceable by sty^Δ5 (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by chinmo⁰⁴¹¹¹ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by crol¹⁰⁶³⁹ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by Df(2L)E55 (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by Df(2L)Prl (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by Df(2R)bw5 (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by Df(2R)bw-S46 (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by Df(2R)cn9 (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by Df(2R)PC4 (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by Df(2R)pk78s (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by Df(2R)Px2 (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by dpp¹⁰⁶³⁸ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by ex⁰¹²⁷⁰ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by ex⁰²²⁷⁸ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by GstS1⁰⁴²²⁷ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by In(2LR)Px⁴ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by Kr-h1¹⁰⁶⁴² (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by l(2)03996⁰³⁹⁹⁶ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by l(2)04548⁰⁴⁵⁴⁸ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by l(2)08492⁰⁸⁴⁹² (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by Mi-2¹ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by osa⁰⁰⁰⁹⁰ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by Rab6⁰⁸³²³ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by S⁰⁵⁶⁷¹ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by S⁰⁷⁰⁵⁶ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by Sema-2a⁰³⁰²¹ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, enhanceable by sty^Δ5 (Abrell et al., 2000)
NOT Enhanced by
Statement Reference Kr^If-1 has eye phenotype, non-enhanceable by Low¹ (Bhadra et al., 1997)
Suppressed by
Statement Reference Kr^If-1 has eye phenotype, suppressible by bun⁰²⁶⁸⁷ (Abrell et al., 2000) Kr^If-1 has eye phenotype, suppressible by bun⁰⁵⁴⁷⁹ (Abrell et al., 2000) Kr^If-1 has eye phenotype, suppressible by bun⁰⁶⁴⁷⁵ (Abrell et al., 2000) Kr^If-1 has eye phenotype, suppressible by caps⁰²⁹³⁷ (Abrell et al., 2000) Kr^If-1 has eye phenotype, suppressible by caps⁰²⁹³⁷/caps[+] (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by Df(2R)trix (Abrell et al., 2000) Kr^If-1 has eye phenotype, suppressible by Df(3L)AC1 (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by Df(3L)Ar12-1 (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by Df(3L)Ar14-8 (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by Df(3L)GN19 (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by Df(3L)H99 (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by Df(3L)HR119 (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by Df(3L)Ly (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by Df(3L)M21 (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by Df(3R)M-Kx1 (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by Eip75B[+]/Eip75B⁰⁷⁰⁴¹ (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by Eip75B⁰⁷⁰⁴¹ (Abrell et al., 2000) Kr^If-1 has eye phenotype, suppressible by emc[+]/emc⁰⁵⁵⁹² (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by emc⁰⁵⁵⁹² (Abrell et al., 2000) Kr^If-1 has eye phenotype, suppressible by exba[+]/exba⁰³⁰²² (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by In(2L)05887 (Abrell et al., 2000) Kr^If-1 has eye phenotype, suppressible by l(3)05967[+]/l(3)05967⁰⁵⁹⁶⁷ (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by l(3)06240[+]/Psa⁰⁶²⁴⁰ (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by l(3)j2C3[+]/l(3)j2C3^j2C3 (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by l(3)neo3[+]/l(3)neo3¹ (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by l(3)neo39¹/l(3)neo39[+] (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by l(3)neo47[+]/l(3)neo47¹ (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by rept[+]/rept⁰⁶⁹⁴⁵ (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by Sap130⁰⁶⁹²⁴/l(3)06924[+] (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by Sc2[+]/Sc2⁰⁵⁶³⁴ (Carrera et al., 1998) Kr^If-1 has eye phenotype, suppressible by Sc2⁰⁵⁶³⁴ (Abrell et al., 2000) Kr^If-1 has eye phenotype, suppressible by sty^L1 (Abrell et al., 2000) Kr^If-1 has eye phenotype, suppressible by Vha55^j2E9 (Abrell et al., 2000) Kr^If-1 has eye phenotype, suppressible by Vha55^j2E9/Vha55[+] (Carrera et al., 1998) Kr^If-1 has ommatidium phenotype, suppressible by bun⁰²⁶⁸⁷ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, suppressible by bun⁰⁵⁴⁷⁹ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, suppressible by bun⁰⁶⁴⁷⁵ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, suppressible by caps⁰²⁹³⁷ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, suppressible by Df(2R)trix (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, suppressible by Eip75B⁰⁷⁰⁴¹ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, suppressible by emc⁰⁵⁵⁹² (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, suppressible by In(2L)05887 (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, suppressible by Sc2⁰⁵⁶³⁴ (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, suppressible by sty^L1 (Abrell et al., 2000) Kr^If-1 has ommatidium phenotype, suppressible by Vha55^j2E9 (Abrell et al., 2000)
NOT suppressed by
Statement Reference Kr^If-1 has eye phenotype, non-suppressible by Low¹ (Bhadra et al., 1997)
Enhancer of
Statement Reference Kr^If-1/Kr[+] is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, fru^NP0021 (Goto et al., 2011)
Other
Statement Reference Hsp83[+]/Hsp83^e6A, Kr^If-1 has eye phenotype (Sollars et al., 2003) Hsp83^e4A, Kr^If-1 has eye phenotype (Sollars et al., 2003) Hsp83^e4A/Hsp83[+], Kr^If-1 has eye phenotype (Sollars et al., 2003) Hsp83^e6A, Kr^If-1 has eye phenotype (Sollars et al., 2003) Hsp83^e6D, Kr^If-1 has eye phenotype (Sollars et al., 2003) Hsp83^e6D/Hsp83[+], Kr^If-1 has eye phenotype (Sollars et al., 2003) Kr^If-1, brm[+]/brm² has eye phenotype (Sollars et al., 2003) Kr^If-1, brm² has eye phenotype (Sollars et al., 2003) Kr^If-1, btl^dev2/btl[+] has eye phenotype (Sollars et al., 2003) Kr^If-1, btl^dev2 has eye phenotype (Sollars et al., 2003) Kr^If-1, fs(1)h¹/fs(1)h[+] has eye phenotype (Sollars et al., 2003) Kr^If-1, fs(1)h¹ has eye phenotype (Sollars et al., 2003) Kr^If-1, kto[+]/kto¹ has eye phenotype (Sollars et al., 2003) Kr^If-1, kto¹ has eye phenotype (Sollars et al., 2003) Kr^If-1, osa²/osa[+] has eye phenotype (Sollars et al., 2003) Kr^If-1, osa² has eye phenotype (Sollars et al., 2003) Kr^If-1, skd²/skd[+] has eye phenotype (Sollars et al., 2003) Kr^If-1, skd² has eye phenotype (Sollars et al., 2003) Kr^If-1, Trl[+]/Trl^R85 has eye phenotype (Sollars et al., 2003) Kr^If-1, Trl^R85 has eye phenotype (Sollars et al., 2003) Kr^If-1, urd²/urd[+] has eye phenotype (Sollars et al., 2003) Kr^If-1, urd² has eye phenotype (Sollars et al., 2003) Kr^If-1, vtd[+]/vtd³ has eye phenotype (Sollars et al., 2003) Kr^If-1, vtd³ has eye phenotype (Sollars et al., 2003) Kr^If-1, z[+]/z^v77h has eye phenotype (Sollars et al., 2003) Kr^If-1, z^v77h has eye phenotype (Sollars et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference piwi[1]/+ and piwi[2]/+ enhance the eye outgrowth phenotype phenotype of Kr[If-1]; approximately 7% of the progeny have an eye outgrowth phenotype in a cross of piwi[1]/+ or piwi[2]/+ females to Kr[If-1]/+ males. However, the reciprocal cross of Kr[If-1]/+ females to piwi[1]/+ or piwi[2]/+ males does not result in progeny with an eye outgrowth phenotype, indicating a maternal effect. In addition, the expression of the eye outgrowth phenotype depends on the presence of the piwi[2] mutation in the progeny, indicating a zygotic effect. The ability of geldanamycin to increase the frequency of the ectopic eye outgrowth phenotype in Kr[If-1] homozygous females is reduced if the females are also carrying piwi[5'T:Hsap\MYC]. Maternal Hop[k00616] is a dominant enhancer of the eye outgrowth phenotype phenotype of Kr[If-1]. (Gangaraju et al., 2011) A Kr[If-1] background strongly enhances the rough eye phenotype found upon expression of fru[NP0021] under the control of Scer\GAL4[GMR.PF]. (Goto et al., 2011) 15+/-4% of Kr^If-1/+ flies born to Hsp83^e1D/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers. 11+/-3% of Kr^If-1/+ flies born to Hsp83^e3A/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers. 6+/-2% of Kr^If-1/+ flies born to Hsp83^e4A/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers. 6+/-2% of Kr^If-1/+ flies born to Hsp83^e6A/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers. 13+/-4% of Kr^If-1/+ flies born to Hsp83^e6D/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers. 5+/-1% of Kr^If-1/+ flies born to brm²/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers. 10+/-2% of Kr^If-1/+ flies born to fs(1)h¹/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers. 15+/-4% of Kr^If-1/+ flies born to kto¹/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers. 10+/-2% of Kr^If-1/+ flies born to osa²/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers. 2+/-1% of Kr^If-1/+ flies born to skd²/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers. 5+/-2% of Kr^If-1/+ flies born to urd²/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers. 55+/-8% of Kr^If-1/+ flies born to vtd³/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers. 5+/-2% of Kr^If-1/+ flies born to z^v77h/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers. 10+/-3% of Kr^If-1/+ flies born to btl^dev2/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers. 10+/-2% of Kr^If-1/+ flies born to Trl^R85/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers. (Sollars et al., 2003) Kr^If-1, ex⁰¹²⁷⁰ flies develop smaller eyes and fewer ommatidia than Kr^If-1 flies. Kr^If-1, S⁰⁵⁶⁷¹ eyes show a severe enhancement of the Kr^If-1 phenotype; the eyes only have only remnants of a few ommatidia. (Abrell et al., 2000) The eye phenotype is unaffected by Low¹. (Bhadra et al., 1997)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Complements	Kr^unspecified (Carrera et al., 1998)
Comments
Stocks ( 28 )
Bloomington	4194 b¹ Kr^If-1 9937 w^; Kr^If-1/CyO; P{UAS-SoxN.O}3 41808 w^; Kr^If-1/CyO; P{UAS-Stam.CD}3 2 w^; βTub60D² Kr^If-1/CyO 29731 y¹ w^; Kr^If-1/CyO; P{UASp-FLP.G}3 7198 w^; Kr^If-1/CyO; D¹/TM3, Ser¹ 29714 y¹ w^; Kr^If-1/CyO; P{UASp-γCop.mRFP}3 25028 w^; Kr^If-1/CyO; P{UAS-PV-Myc}3a P{UAS-PV-Myc}3b 7225 w^; Kr^If-1/CyO; P{UAS-Axn.GFP}3/TM3, Sb¹
Kyoto	105667 w^*; βTub60D² Kr^If-1/CyO 108648 Df(2R)tid, b¹ Kr^If-1/CyO, bw¹ 101457 Df(2R)x32, b¹ Kr^If-1 / CyO, bw¹
	More stocks available...
Notes on Origin
Discoverer	Casey, 16th Dec. 1965. Casey.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	If (Carrera et al., 1998, Bhadra et al., 1997, Vosshall and Young, 1995, Ives, 1967, Baker et al., 1992, Preiss et al., 1985) If¹ Kr^If-1 (Gangaraju et al., 2011, Goto et al., 2011, Kuzin et al., 2011) Kr^If (Carrera and Jaeckle, 1996)
Name Synonym	Irregular facets (Abrell et al., 1997)
Secondary FlyBase IDs

References ( 17 )
Research paper	Gangaraju et al., 2011, Nat. Genet. 43(2): 153--158 Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation. [FBrf0212873] Goto et al., 2011, J. Neurosci. 31(14): 5454--5459 Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. [FBrf0213400] Kuzin et al., 2011, Mech. Dev. 128(3-4): 165--177 Functional analysis of conserved sequences within a temporally restricted neural precursor cell enhancer. [FBrf0213297] Sollars et al., 2003, Nat. Genet. 33(1): 70--74 Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution. [FBrf0156004] Abrell et al., 2000, Chromosoma 109(5): 334--342 A modifier screen of ectopic Kruppel activity identifies autosomal Drosophila chromosomal sites and genes required for normal eye development. [FBrf0129693] Carrera et al., 1998, Proc. Natl. Acad. Sci. U.S.A. 95(18): 10779--10784 A modifier screen in the eye reveals control genes for Kruppel activity in the Drosophila embryo. [FBrf0104417] Bhadra et al., 1997, Genetics 146(3): 903--917 A sex-influenced modifier in Drosophila that affects a broad spectrum of target loci including the histone repeats. [FBrf0094158] Vosshall and Young, 1995, Neuron 15(2): 345--360 Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells. [FBrf0083505] Hiebert and Birchler, 1994, Genetics 136(3): 913--926 Effects of the maleless mutation on X and autosomal gene expression in Drosophila melanogaster. [FBrf0073338] Baker et al., 1992, J. Neurogenet. 8(2): 85--100 Mutations on the second chromosome affecting the Drosophila eye. [FBrf0056571] Renfranz and Benzer, 1989, Dev. Biol. 136(2): 411--429 Monoclonal antibody probes discriminate early and late mutant defects in development of the Drosophila retina. [FBrf0049495] Preiss et al., 1985, Nature 313: 27--32 Molecular genetics of Kruppel, a gene required for segmentation of the Drosophila embryo. [FBrf0043323] Ives, 1967, D. I. S. 42: 39 [New mutants report.] [FBrf0063542]
Review	Sangster et al., 2004, BioEssays 26(4): 348--362 Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance. [FBrf0174370] Thomas and Wassarman, 1999, Trends Genet. 15(5): 184--190 A fly's eye view of biology. [FBrf0108464]
Abstract	Abrell et al., 1997, A. Dros. Res. Conf. 38: 227B Search for Kruppel-dependent genes. [FBrf0092254] Carrera and Jaeckle, 1996, A. Dros. Res. Conf. 37: 176 Screening for Kruppel (Kr) target genes using ectopic Kr expression. [FBrf0084835]

Allele Dmel\KrIf-1

Allele Dmel\Kr^If-1