Allele Dmel\KrIf-1
| General Information | |||
|---|---|---|---|
| Symbol | Dmel\KrIf-1 | Species | D. melanogaster |
| Name | FlyBase ID | FBal0005583 | |
| Feature type | allele | Created / Updated | 2006-08-22/2006-08-22 |
| Associated gene | Dmel\Kr | ||
| Allele class | neomorph | ||
| Mutagen | spontaneous | ||
Nature of the Allele
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| Allele class | |||
| Mutagen | |||
| Mapped Features and Mutations | |||
Type Symbol & Location Additional Notes References | |||
| Associated Sequence Data | |||
| DDBJ
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EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Progenitor genotype | |||
| Nature of the lesion | Statement Reference | ||
| Assay mode | |||
| Cytology | |||
Phenotypic Data
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Phenotypic Class
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Phenotype Manifest In
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Detailed Description
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Statement Reference In heterozygote, eye area about one-half normal; narrow and pointed ventrally; facets irregular and often missing across middle of eyes, sometimes fused or absent in ventral portion. In homozygote, eyes are narrow slits with smooth glossy surface. In the eye disk of late third instar larvae, fairly large number of cell clusters in irregular arrangement, especially in ventral half of disk (Renfranz and Benzer, 1989). Viability and fertility good. RK1. The mutant phenotype of KrIf-1 is due to a developmental defect in precursor cells. When heterozygous with apx1 the adult eye is half the normal size, the ventral half more prone to irregularities. Eye disc has a fairly large number of clusters with irregular arrangements. When heterozygous with st adult eye is narrow and ventral half is devoid of facets. Rhabdomeres are fused and only 20 ommatidia are present. Eye disc size is reduced with few clusters. KrIf-1 results in a rough eye phenotype which is more extreme in homozygotes. Eye discs are deeply folded and smaller than wild type. Ommatidia begin to form posterior to the morphogenetic furrow but later stages of ommatidial development are more rarely seen. The adult eye is greatly reduced in size and is made up of pigment cells and lacunae. Photoreceptor rhabdomeres are only rarely found, and have unusual morphology. The eye region sometimes differentiates cuticle. The eye area is reduced to approximately one-half that of wild-type in heterozygotes, it is oblong and generally pointed ventrally. The facets are irregularly distributed, are frequently missing across the middle of the eye, and are sometimes fused or absent in the ventral portion. The eye is a narrow slit in homozygotes and has a smooth glossy surface. Viability and fecundity of both hetero- and homozygotes is good to excellent. Displays locomotor activity rhythm with an approximately 24h period. The number of ommatidia is abnormal in heterozygotes. Heterozygotes have small, narrow eyes that are pointed ventrally. In the ventral portion of the eye the facets are fused or absent and dorsally they are irregularly arranged. Eyes are further reduced in size in homozygotes, forming narrow slits with a glossy surface lacking most ommatidia. The size of the eye is reduced and the ommatidia ared fused or absent in the ventral part of the eye and irregularly arranged dorsally. KrIf-1/+ flies have small rough eyes. | |||
Interactions
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Phenotypic Class
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Enhanced by | |||
Statement Reference | |||
Suppressed by | |||
Statement Reference | |||
Phenotype Manifest In
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Enhanced by | |||
Statement Reference | |||
NOT Enhanced by | |||
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Suppressed by | |||
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NOT suppressed by | |||
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Other | |||
Statement Reference | |||
Additional Comments
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Genetic Interactions
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Statement Reference The eye phenotype is unaffected by Low1. 15+/-4% of KrIf-1/+ flies born to Hsp83e1D/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye,
compared to less than 0.1% of KrIf-1/+ flies born to isogenised
wild-type mothers.
11+/-3% of KrIf-1/+ flies born to Hsp83e3A/+ mothers have outgrowths
with ectopic vibrissae protruding from the ventral region of the eye,
compared to less than 0.1% of KrIf-1/+ flies born to isogenised
wild-type mothers.
6+/-2% of KrIf-1/+ flies born to Hsp83e4A/+ mothers have outgrowths
with ectopic vibrissae protruding from the ventral region of the eye,
compared to less than 0.1% of KrIf-1/+ flies born to isogenised
wild-type mothers.
6+/-2% of KrIf-1/+ flies born to Hsp83e6A/+ mothers have outgrowths
with ectopic vibrissae protruding from the ventral region of the eye,
compared to less than 0.1% of KrIf-1/+ flies born to isogenised
wild-type mothers.
13+/-4% of KrIf-1/+ flies born to Hsp83e6D/+ mothers have outgrowths
with ectopic vibrissae protruding from the ventral region of the eye,
compared to less than 0.1% of KrIf-1/+ flies born to isogenised
wild-type mothers.
5+/-1% of KrIf-1/+ flies born to brm2/+ mothers have outgrowths
with ectopic vibrissae protruding from the ventral region of the eye,
compared to less than 0.1% of KrIf-1/+ flies born to isogenised
wild-type mothers.
10+/-2% of KrIf-1/+ flies born to fs(1)h1/+ mothers have outgrowths
with ectopic vibrissae protruding from the ventral region of the eye,
compared to less than 0.1% of KrIf-1/+ flies born to isogenised
wild-type mothers.
15+/-4% of KrIf-1/+ flies born to kto1/+ mothers have outgrowths
with ectopic vibrissae protruding from the ventral region of the eye,
compared to less than 0.1% of KrIf-1/+ flies born to isogenised
wild-type mothers.
10+/-2% of KrIf-1/+ flies born to osa2/+ mothers have outgrowths
with ectopic vibrissae protruding from the ventral region of the eye,
compared to less than 0.1% of KrIf-1/+ flies born to isogenised
wild-type mothers.
2+/-1% of KrIf-1/+ flies born to skd2/+ mothers have outgrowths
with ectopic vibrissae protruding from the ventral region of the eye,
compared to less than 0.1% of KrIf-1/+ flies born to isogenised
wild-type mothers.
5+/-2% of KrIf-1/+ flies born to urd2/+ mothers have outgrowths
with ectopic vibrissae protruding from the ventral region of the eye,
compared to less than 0.1% of KrIf-1/+ flies born to isogenised
wild-type mothers.
55+/-8% of KrIf-1/+ flies born to vtd3/+ mothers have outgrowths
with ectopic vibrissae protruding from the ventral region of the eye,
compared to less than 0.1% of KrIf-1/+ flies born to isogenised
wild-type mothers.
5+/-2% of KrIf-1/+ flies born to zv77h/+ mothers have outgrowths
with ectopic vibrissae protruding from the ventral region of the eye,
compared to less than 0.1% of KrIf-1/+ flies born to isogenised
wild-type mothers.
10+/-3% of KrIf-1/+ flies born to btldev2/+ mothers have outgrowths
with ectopic vibrissae protruding from the ventral region of the eye,
compared to less than 0. | |||
Nature of the Allele