FlyBase Allele Report: Dmel\jvl[1]

General Information

Symbol

Dmel\jvl¹

Species

D. melanogaster

Name

FlyBase ID

FBal0005653

Feature type

allele

Associated gene

Dmel\jvl

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

No mutations are apparent in the jvl coding region.

(Dubin-Bar et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female fertile

(Dubin-Bar et al., 2011)

female sterile (with Df(3R)Exel6275)

(Baskar et al., 2019, Dubin-Bar et al., 2011)

female sterile (with jvl^f00590)

(Dubin-Bar et al., 2011)

male fertile

(Dubin-Bar et al., 2011)

partially lethal

semi-fertile

visible

visible | adult stage

(Otani et al., 2015)

Phenotype Manifest In

actin cytoskeleton (with Df(3R)Exel6275)

(Dubin-Bar et al., 2011)

egg (with Df(3R)Exel6275)

(Dubin-Bar et al., 2011)

egg (with jvl^f00590)

(Dubin-Bar et al., 2011)

macrochaeta

(Dubin-Bar et al., 2011)

macrochaeta (with Df(3R)Exel6275)

(Dubin-Bar et al., 2011)

macrochaeta (with jvl^f00590)

(Baskar et al., 2019, Dubin-Bar et al., 2011)

macrochaeta | pupal stage (with Df(3R)Exel6275)

(Baskar et al., 2019)

mesothoracic bristle

(Otani et al., 2015)

microchaeta

microchaeta & actin filament

(Tilney et al., 2003)

microtubule | pupal stage (with Df(3R)Exel6275)

(Baskar et al., 2019)

microtubule cytoskeleton (with Df(3R)Exel6275)

(Dubin-Bar et al., 2011)

Detailed Description

Statement

Reference

jvl¹/Df(3R)Exel6275 pupal bristle fail to taper and is much wider and swollen compared to controls. It also exhibit a decrease in microtubule (MT) number at the abnormally wide upper region of the bristle and defects in the dynamic MT organization throughout the bristle shaft (with a significantly wider width of the tip) when compared to controls.

jvl¹/jvl^f00590 adults exhibit bristle defects with a swollen tip containing misoriented actin ridges compared to controls.

(Baskar et al., 2019)

jvl¹/jvl¹ mutants exhibit bristles with disorganized distal tips, as compared to controls.

(Otani et al., 2015)

jvl¹ homozygotes, jvl¹ hemizygotes and jvl¹/jvl^f00590 trans-heterozygotes show defective bristle tip morphology.

jvl¹ animals are fertile, but jvl¹ hemizygotes and jvl¹/jvl^f00590 trans-heterozygotes are sterile and lay ventralized eggs.

Actin and microtubule organization is disrupted in jvl¹ hemizygous egg chambers.

(Dubin-Bar et al., 2011)

Longitudinal actin bundles in the bristle cells of jvl¹ mutants are larger than in wild type and extend deeply into the cytoplasm. The filaments are packed hexagonally, like in wild type.

(Tilney et al., 2003)

Resembles jv¹ but bristles sometimes more crooked. Viability and productivity somewhat lower than normal. RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference