Allele Dmel\jvl¹

General Information
Symbol	Dmel\jvl¹	Species	D. melanogaster
Name		FlyBase ID	FBal0005653
Feature type	allele	Associated gene	Dmel\jvl

Allele class
Mutagen	spontaneous
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	spontaneous
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference No mutations are apparent in the jvl coding region. (Dubin-Bar et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	female fertile (Dubin-Bar et al., 2011) female sterile (with Df(3R)Exel6275) (Dubin-Bar et al., 2011) female sterile (with jvl^f00590) (Dubin-Bar et al., 2011) fertile \| reduced male fertile (Dubin-Bar et al., 2011) viable \| reduced visible
Phenotype Manifest In
	actin cytoskeleton (with Df(3R)Exel6275) (Dubin-Bar et al., 2011) egg (with Df(3R)Exel6275) (Dubin-Bar et al., 2011) egg (with jvl^f00590) (Dubin-Bar et al., 2011) macrochaeta (Dubin-Bar et al., 2011) macrochaeta (with Df(3R)Exel6275) (Dubin-Bar et al., 2011) macrochaeta (with jvl^f00590) (Dubin-Bar et al., 2011) microchaeta microchaeta & actin filament (Tilney et al., 2003) microtubule cytoskeleton (with Df(3R)Exel6275) (Dubin-Bar et al., 2011)
Detailed Description
	Statement Reference jvl[1] homozygotes, jvl[1] hemizygotes and jvl[1]/jvl[f00590] trans-heterozygotes show defective bristle tip morphology. jvl[1] animals are fertile, but jvl[1] hemizygotes and jvl[1]/jvl[f00590] trans-heterozygotes are sterile and lay ventralized eggs. Actin and microtubule organization is disrupted in jvl[1] hemizygous egg chambers. (Dubin-Bar et al., 2011) Longitudinal actin bundles in the bristle cells of jvl¹ mutants are larger than in wild type and extend deeply into the cytoplasm. The filaments are packed hexagonally, like in wild type. (Tilney et al., 2003) Resembles jv¹ but bristles sometimes more crooked. Viability and productivity somewhat lower than normal. RK2.
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	jvl¹/Df(3R)Exel6275 is rescued by Scer\GAL4^nos.PG/jvl^{RA.Scer\UAS.P\T.T:Avic\GFP} (Dubin-Bar et al., 2011) jvl^f00590/jvl¹ is rescued by Scer\GAL4^nos.PG/jvl^{RA.Scer\UAS.P\T.T:Avic\GFP} (Dubin-Bar et al., 2011)
Comments	Expression of jvl[RA.Scer\UAS.P\T.T:Avic\GFP] using Scer\GAL4[nos.PG] rescues the female sterility of jvl[1]/Df(3R)Exel6275 and jvl[1]/jvl[f00590] flies. (Dubin-Bar et al., 2011)
Stocks ( 6 )
Bloomington	523 jvl¹ 1405 red¹ cv-c¹ jvl¹ Sb^sbd-2 ss¹ Ubx^bx-34e/In(3R)Ubx⁸⁰, Ubx⁸⁰
Kyoto	105962 jvl¹ 107048 kni^ri-1 cu¹ kar¹ su(Hw)² jvl¹ Ubx^bx-34e/TM1 106013 th¹ st¹ pb¹ p^p cu¹ kar¹ su(Hw)² jvl¹ ss¹ Ubx^bx-1 sr¹ gl¹/TM6 101763 th¹ st¹ pb¹ p^p cu¹ kar¹ su(Hw)² jvl¹ ss¹ Ubx^bx-1 sr¹ gl¹ / TM6, (Hn^P) ss^aP88 Ubx^bx-34e Ubx^P15 e¹
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	jvl¹ (Dubin-Bar et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Dubin-Bar et al., 2011, Development 138(21): 4661--4671 Drosophila javelin-like encodes a novel microtubule-associated protein and is required for mRNA localization during oogenesis. [FBrf0216406] Tilney et al., 2003, Mol. Biol. Cell 14(10): 3953--3966 Actin filament turnover regulated by cross-linking accounts for the size, shape, location, and number of actin bundles in Drosophila bristles. [FBrf0167860] Dickinson and Thatcher, 1997, Cell Motility Cytoskel. 38(1): 9--21 Morphogenesis of denticles and hairs in Drosophila embryos: involvement of actin-associated proteins that also affect adult structures. [FBrf0098231]

Allele Dmel\jvl1

Allele Dmel\jvl¹