Allele Dmel\kis²

General Information
Symbol	Dmel\kis²	Species	D. melanogaster
Name		FlyBase ID	FBal0005694
Feature type	allele	Associated gene	Dmel\kis

Allele class	loss of function allele, hypomorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Gindhart and Kaufman, 1995) loss of function allele (Daubresse et al., 1999)
Mutagen	ethyl methanesulfonate (Kennison and Tamkun, 1988)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Kennison and Tamkun, 1988) visible \| cell autonomous \| homeotic \| recessive \| somatic clone (Daubresse et al., 1999)
Phenotype Manifest In
	adult abdominal segment 5 \| cell autonomous \| somatic clone (Daubresse et al., 1999)
Detailed Description
	Statement Reference Homozygous clones in the fifth adult abdominal segment show transformation to a more anterior identity, as shown by the loss of the black pigmentation characteristic of this segment. The effect is cell autonomous. (Daubresse et al., 1999) brm² shows little if any interaction in double heterozygous combination with kis²; less than 3% of flies have held-out wings. (Vazquez et al., 1999) No effect on the eye pigment phenotype of w^T81. (Netter et al., 1998) Pairing sensitive repression is unchanged in iab-7 PRE lines that carry kis². (Hagstrom et al., 1997) Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is lighter. (Fauvarque et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference kis² is an enhancer of eye color defective phenotype of w¹¹¹⁸, w^mC.ph-d.826 (Bloyer et al., 2003) kis² is an enhancer of eye color defective phenotype of w¹¹¹⁸, w^mC.ph-p.418 (Bloyer et al., 2003) kis² is an enhancer of eye color defective phenotype of w¹¹¹⁸, w^{mC.ph-p.418bis} (Bloyer et al., 2003) kis² is an enhancer of eye color defective phenotype of w¹¹¹⁸, w^mC.ph-p.812 (Bloyer et al., 2003) kis² is an enhancer of eye color defective phenotype of w¹¹¹⁸, w^mC.ph-p.813 (Bloyer et al., 2003) kis² is an enhancer of eye color defective phenotype of w¹¹¹⁸, w^{mC.ph-p.813bis} (Bloyer et al., 2003) kis² is an enhancer of eye color defective phenotype of w^ph-p.lac+3/w¹¹¹⁸ (Bloyer et al., 2003)
Suppressor of
Statement Reference kis² is a suppressor of lethal phenotype of Ras85D^V12.sev, sev^{S11.T:Hsap\MYC} (Maixner et al., 1998)
Other
Statement Reference corto[+]/corto⁴²⁰, kis² has visible phenotype (Lopez et al., 2001) corto⁴²⁰, kis² has visible phenotype (Lopez et al., 2001) Ras85D^V12.sev, kis², sev^{S11.T:Hsap\MYC} has viable phenotype (Maixner et al., 1998, Maixner et al., 1998)
Phenotype Manifest In
Suppressor of
Statement Reference kis² is a suppressor of phenotype of Pc⁴ (Kennison and Tamkun, 1988)
Other
Statement Reference corto[+]/corto⁴²⁰, kis² has posterior crossvein phenotype (Lopez et al., 2001) corto⁴²⁰, kis² has posterior crossvein phenotype (Lopez et al., 2001)
Additional Comments
Genetic Interactions
Statement Reference kis² corto⁴²⁰ double heterozygotes show posterior crossvein defects. (Lopez et al., 2001) The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by kis². (Maixner et al., 1998) Suppresses the extra sex comb phenotype of Pc⁴, Ts(YLt;2Lt)L124. Causes between 50% and 100% suppression of the Pc⁴/+ extra sex combs phenotype. (Kennison and Tamkun, 1988)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	kis² (Vázquez et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 13 )
Research paper	Vázquez et al., 2008, Genetics 180(2): 835--843 γTub23C Interacts Genetically With Brahma Chromatin-Remodeling Complexes in Drosophila melanogaster. [FBrf0206007] Bloyer et al., 2003, Dev. Biol. 261(2): 426--442 Identification and characterization of polyhomeotic PREs and TREs. [FBrf0167457] Boivin et al., 2003, Genetics 164(1): 195--208 Telomeric associated sequences of Drosophila recruit Polycomb-group proteins in vivo and can induce pairing-sensitive repression. [FBrf0158993] Lopez et al., 2001, Mol. Genet. Genomics 266(4): 572--583 corto genetically interacts with Pc-G and trx-G genes and maintains the anterior boundary of Ultrabithorax expression in Drosophila larvae. [FBrf0145129] Rusch and Kaufman, 2000, Genetics 156(1): 183--194 Regulation of proboscipedia in Drosophila by homeotic selector genes. [FBrf0130058] Daubresse et al., 1999, Development 126(6): 1175--1187 The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identity. [FBrf0107669] Vazquez et al., 1999, Development 126(4): 733--742 The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcription. [FBrf0107412] Maixner et al., 1998, Dev. Genet. 23(4): 347--361 A screen for mutations that prevent lethality caused by expression of activated Sevenless and Ras1 in the Drosophila embryo. [FBrf0105879] Netter et al., 1998, Genetics 149(1): 257--275 white+ transgene insertions presenting a dorsal/ventral pattern define a single cluster of homeobox genes that is silenced by the polycomb-group proteins in Drosophila melanogaster. [FBrf0102846] Hagstrom et al., 1997, Genetics 146(4): 1365--1380 A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex. [FBrf0094838] Fauvarque et al., 1995, Mech. Dev. 52(2-3): 343--355 Regulation of polyhomeotic transcription may involve local changes in chromatin activity in Drosophila. [FBrf0083917] Gindhart and Kaufman, 1995, Genetics 139(2): 797--814 Identification of Polycomb and trithorax group responsive elements in the regulatory region of the Drosophila homeotic gene sex combs reduced. [FBrf0080053] Kennison and Tamkun, 1988, Proc. Natl. Acad. Sci. U.S.A. 85: 8136--8140 Dosage-dependent modifiers of Polycomb and Antennapedia mutations in Drosophila. [FBrf0048952]

Allele Dmel\kis2

Allele Dmel\kis²