Allele Dmel\kni³

General Information
Symbol	Dmel\kni³	Species	D. melanogaster
Name		FlyBase ID	FBal0005773
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\kni

Allele class
Mutagen	ethyl methanesulfonate
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Tearle and Nusslein-Volhard, 1987, Gerwin et al., 1994)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference 245bp deletion. (Ruden and Jaeckle, 1995) 245bp deletion from 3489 to 3733bp. This results in a frameshift, producing a protein with the N-terminal 232 amino acids of kni followed by an additional 105 amino acids. (Gerwin et al., 1994)
Assay mode
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Ruden and Jaeckle, 1995)
Phenotype Manifest In
	abdomen (Nauber et al., 1988)
Detailed Description
	Statement Reference weak Homozygous embryos exhibit 3 abdominal segments. (Nauber et al., 1988) Homozygotes can be propagated as fertile stocks when on copy of Res is present. kni³/kni⁸ transheterozygotes are viable. kni³ Res¹ double homozygous mutants have a wild type abdominal segmentation phenotype, defective head skeleton and are embryonic lethal. (Ruden and Jaeckle, 1995) Weak phenotype. (Gerwin et al., 1994)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement Reference kni³ has lethal phenotype, non-suppressible by Res^1r1 (Ruden and Jaeckle, 1995) kni³ has lethal phenotype, non-suppressible by Res^1r2 (Ruden and Jaeckle, 1995) kni³ has lethal phenotype, non-suppressible by Res^1r3 (Ruden and Jaeckle, 1995)
Phenotype Manifest In
Suppressed by
Statement Reference kni³ has embryonic abdominal segment phenotype, suppressible by Res^1r1 (Ruden and Jaeckle, 1995)
NOT suppressed by
Statement Reference kni³ has embryonic abdominal segment phenotype, non-suppressible by Res^1r2 (Ruden and Jaeckle, 1995) kni³ has embryonic abdominal segment phenotype, non-suppressible by Res^1r3 (Ruden and Jaeckle, 1995)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments	kni³ fails to complement kni^ri-1 when it is carried on a chromosome such as TM3 or In(3LR)LD6 that is rearranged with respect to the kni³ mutant chromosome. kni³ fully complements kni^ri-1 when the kni^ri-1 and kni³ alleles are carried on non-rearranged chromosomes. (Lunde et al., 1998)
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Intermediate kni allele. (Nauber et al., 1988, Ruden and Jaeckle, 1995)
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	kni³ kni^14F (Gerwin et al., 1994, Ruden and Jaeckle, 1995, Nauber et al., 1988, Lehmann, 1988, Tearle and Nusslein-Volhard, 1987, )
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Lunde et al., 1998, Development 125(21): 4145--4154 The knirps and knirps-related genes organize development of the second wing vein in Drosophila. [FBrf0104917] Ruden and Jaeckle, 1995, Development 121(1): 63--73 Mitotic delay dependent survival identifies components of cell cycle control in the Drosophila blastoderm. [FBrf0076145] Gerwin et al., 1994, Molec. Cell. Biol. 14(12): 7899--7908 Functional and conserved domains of the Drosophila transcription factor encoded by the segmentation gene knirps. [FBrf0076956] Lehmann, 1988, French, Ingham, Cooke, Smith, 1988: 17--28 Phenotypic comparison between maternal and zygotic genes controlling the segmental pattern of the Drosophila embryo. [FBrf0047866]
Letter	Nauber et al., 1988, Nature 336: 489--492 Abdominal segmentation of the Drosophila embryo requires a hormone receptor-like protein encoded by the gap gene knirps. [FBrf0048760]
Stock list	Tearle and Nusslein-Volhard, 1987, D. I. S. 66: 209--269 Tubingen mutants and stock list. [FBrf0045941]

Allele Dmel\kni3

Allele Dmel\kni³