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General Information
Symbol
Dmel\kni8
Species
D. melanogaster
Name
FlyBase ID
FBal0005778
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
kniFC13, kniFC
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
sequence variant
Linked to:
EcoRI-BamHI restriction fragment
Comment:

The approximately 2kb kni8 deletion lies within the EcoRI-BamHI fragment.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of transcription unit.

2kb deletion in the 5' region that encodes the embryo specific transcription unit.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Tracheal metameres in remaining 5 abdominal segments develop many aspects of a wild type branching pattern. Phenotype is much less disrupted than that of Df(3L)ri-XT1, where both kni and knrl are deleted.

Homozygotes with one copy of Res1 show partial rescue, one or two additional abdominal segments are present. kni3/kni8 transheterozygotes are viable.

Defective in gonad assembly.

Abdominal segments A1 to 7 are fused andreplaced by a single segment, segment 8 is normal.

Strong phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference

kni8 has lethal phenotype, non-suppressible by Res1r1

kni8 has lethal phenotype, non-suppressible by Res1r2

kni8 has lethal phenotype, non-suppressible by Res1r3

Phenotype Manifest In
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by

kni8 is partially rescued by knitRa

kni8 is partially rescued by knitRa

Comments

kni8 fails to complement kniri-1 when it is carried on a chromosome such as TM3 or In(3LR)LD6 that is rearranged with respect to the kni8 mutant chromosome. kni8 fully complements kniri-1 when the kniri-1 and kni8 alleles are carried on non-rearranged chromosomes.

Mutant abdominal phenotype of kni8 embryos can be rescued by knitRa but head defects are only weakly rescued.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (23)