Allele Dmel\kni⁸

General Information
Symbol	Dmel\kni⁸	Species	D. melanogaster
Name		FlyBase ID	FBal0005778
Feature type	allele	Associated gene	Dmel\kni
Also Known As	kni^FC13, kni^FC

Map ( GBrowse )
Allele class	amorphic allele - genetic evidence, loss of function allele
Mutagen	X ray
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Nauber et al., 1988, Ruden and Jaeckle, 1995) loss of function allele (Gonzalez-Gaitan et al., 1994, Gerwin et al., 1994)
Mutagen	X ray (Tearle and Nusslein-Volhard, 1987, Nauber et al., 1988, Gerwin et al., 1994)
Mutations Mapped to the Genome

Type Location Additional Notes References sequence variant 3L:20,688,019..20,690,019 evidence=experimental linked_to=EcoRI-BamHI_rfrag comment=The approximately 2kb kni⁸ deletion lies within the EcoRI-BamHI fragment. (Nauber et al., 1988, Ruden and Jaeckle, 1995)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference 2kb deficiency. (Ruden and Jaeckle, 1995) Deletion of transcription unit. (Gerwin et al., 1994) 2kb deletion in the kni transcription unit. (Oro et al., 1989) 2kb deletion in the 5' region that encodes the embryo specific transcription unit. (Nauber et al., 1988) 2 kb deletion; no transcripts.
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	abdominal segment 1 (Nauber et al., 1988) abdominal segment 2 (Nauber et al., 1988) abdominal segment 3 (Nauber et al., 1988) abdominal segment 4 (Nauber et al., 1988) abdominal segment 5 (Nauber et al., 1988) abdominal segment 6 (Nauber et al., 1988) abdominal segment 7 (Nauber et al., 1988)
Detailed Description
	Statement Reference Tracheal metameres in remaining 5 abdominal segments develop many aspects of a wild type branching pattern. Phenotype is much less disrupted than that of Df(3L)ri-XT1, where both kni and knrl are deleted. (Chen et al., 1998) Homozygotes with one copy of Res¹ show partial rescue, one or two additional abdominal segments are present. kni³/kni⁸ transheterozygotes are viable. (Ruden and Jaeckle, 1995) SNS is normal. (Gonzalez-Gaitan et al., 1994) Defective in gonad assembly. (Warrior, 1994) Abdominal segments A1 to 7 are fused andreplaced by a single segment, segment 8 is normal. (Nauber et al., 1988) Strong phenotype.
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement Reference kni⁸ has lethal phenotype, non-suppressible by Res^1r1 (Ruden and Jaeckle, 1995) kni⁸ has lethal phenotype, non-suppressible by Res^1r2 (Ruden and Jaeckle, 1995) kni⁸ has lethal phenotype, non-suppressible by Res^1r3 (Ruden and Jaeckle, 1995)
Phenotype Manifest In
Suppressed by
Statement Reference kni⁸ has embryonic abdominal segment phenotype, suppressible by Res^1r1 (Ruden and Jaeckle, 1995)
NOT suppressed by
Statement Reference kni⁸ has embryonic abdominal segment phenotype, non-suppressible by Res^1r2 (Ruden and Jaeckle, 1995) kni⁸ has embryonic abdominal segment phenotype, non-suppressible by Res^1r3 (Ruden and Jaeckle, 1995)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescued by	kni⁸ is partially rescued by kni^tRa (Chen et al., 1998, Rothe et al., 1992)
Comments	kni⁸ fails to complement kni^ri-1 when it is carried on a chromosome such as TM3 or In(3LR)LD6 that is rearranged with respect to the kni⁸ mutant chromosome. kni⁸ fully complements kni^ri-1 when the kni^ri-1 and kni⁸ alleles are carried on non-rearranged chromosomes. (Lunde et al., 1998) Mutant abdominal phenotype of kni⁸ embryos can be rescued by kni^tRa but head defects are only weakly rescued. (Rothe et al., 1992)
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Strong kni allele. (Ruden and Jaeckle, 1995)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	FC¹³ (Oro et al., 1989) kni⁸ kni^FC13 (Fusse and Hoch, 2002, Fuss et al., 2001, Chen et al., 1998, Tsai et al., 1998, Gerwin et al., 1994, Ruden and Jaeckle, 1995, Gonzalez-Gaitan et al., 1994, Rothe et al., 1994, Hartmann et al., 1994, Rothe et al., 1992, Zhang et al., 1991, Nauber et al., 1988, ) kni^FC (Moore et al., 1998, Klingler et al., 1996, Gao et al., 1996, Harbecke and Lengyel, 1995, Warrior, 1994, Klingler and Gergen, 1993, Lehmann, 1988, Tearle and Nusslein-Volhard, 1987)
Name Synonym
Secondary FlyBase IDs

References ( 23 )

Generate a list of	All references relating to this allele ( 23 )

List References by type	Research paper ( 20 ) Review ( 1 ) Letter ( 1 ) Stock list ( 1 )
Recent research papers (0)
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Recent reviews (0)
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Allele Dmel\kni8

Allele Dmel\kni⁸