FlyBase Allele Report: Dmel\kni[8]

General Information

Symbol

Dmel\kni⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0005778

Feature type

allele

Associated gene

Dmel\kni

Associated Insertion(s)

Carried in Construct

Also Known As

kni^FC13, kni^FC

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Ruden and Jäckle, 1995, Nauber et al., 1988)

loss of function allele

(Gerwin et al., 1994, Gonzalez-Gaitan et al., 1994)

Mutagen

X ray

(Gerwin et al., 1994, Nauber et al., 1988, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Deletion of transcription unit.

(Gerwin et al., 1994)

2kb deletion in the 5' region that encodes the embryo specific transcription unit.

(Nauber et al., 1988)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal segment 1

(Nauber et al., 1988)

abdominal segment 2

(Nauber et al., 1988)

abdominal segment 3

(Nauber et al., 1988)

abdominal segment 4

(Nauber et al., 1988)

abdominal segment 5

(Nauber et al., 1988)

abdominal segment 6

(Nauber et al., 1988)

abdominal segment 7

(Nauber et al., 1988)

Detailed Description

Statement

Reference

Tracheal metameres in remaining 5 abdominal segments develop many aspects of a wild type branching pattern. Phenotype is much less disrupted than that of Df(3L)ri-XT1, where both kni and knrl are deleted.

(Chen et al., 1998)

Homozygotes with one copy of Res¹ show partial rescue, one or two additional abdominal segments are present. kni³/kni⁸ transheterozygotes are viable.

(Ruden and Jäckle, 1995)

SNS is normal.

(Gonzalez-Gaitan et al., 1994)

Defective in gonad assembly.

(Warrior, 1994)

Abdominal segments A1 to 7 are fused andreplaced by a single segment, segment 8 is normal.

(Nauber et al., 1988)

Strong phenotype.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

kni⁸ has lethal phenotype, non-suppressible by Res^1r1

(Ruden and Jäckle, 1995)

kni⁸ has lethal phenotype, non-suppressible by Res^1r2

(Ruden and Jäckle, 1995)

kni⁸ has lethal phenotype, non-suppressible by Res^1r3

(Ruden and Jäckle, 1995)

Phenotype Manifest In

Suppressed by

Statement

Reference

kni⁸ has embryonic abdominal segment phenotype, suppressible by Res^1r1

(Ruden and Jäckle, 1995)

NOT suppressed by

Statement

Reference

kni⁸ has embryonic abdominal segment phenotype, non-suppressible by Res^1r2

(Ruden and Jäckle, 1995)

kni⁸ has embryonic abdominal segment phenotype, non-suppressible by Res^1r3

(Ruden and Jäckle, 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

kni⁸ is partially rescued by kni^tRa

(Chen et al., 1998)

kni⁸ is partially rescued by kni^tRa

(Rothe et al., 1992)

Comments

kni⁸ fails to complement kni^ri-1 when it is carried on a chromosome such as TM3 or In(3LR)LD6 that is rearranged with respect to the kni⁸ mutant chromosome. kni⁸ fully complements kni^ri-1 when the kni^ri-1 and kni⁸ alleles are carried on non-rearranged chromosomes.

(Lunde et al., 1998)

Mutant abdominal phenotype of kni⁸ embryos can be rescued by kni^tRa but head defects are only weakly rescued.

(Rothe et al., 1992)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Strong kni allele.

(Ruden and Jäckle, 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

FC¹³

(Oro et al., 1989)

kni⁸

kni^FC13

(Fusse and Hoch, 2002, Fuss et al., 2001, Chen et al., 1998, Tsai et al., 1998, Ruden and Jäckle, 1995, Gerwin et al., 1994, Gonzalez-Gaitan et al., 1994, Hartmann et al., 1994, Rothe et al., 1994, Rothe et al., 1992, Zhang et al., 1991, Nauber et al., 1988)

kni^FC

(Moore et al., 1998, Gao et al., 1996, Klingler et al., 1996, Harbecke and Lengyel, 1995, Warrior, 1994, Klingler and Gergen, 1993, Lehmann, 1988, Tearle and Nusslein-Volhard, 1987)

Name Synonyms

Secondary FlyBase IDs

References (23)

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