Allele Dmel\kni¹⁰

General Information
Symbol	Dmel\kni¹⁰	Species	D. melanogaster
Name		FlyBase ID	FBal0005780
Feature type	allele	Associated gene	Dmel\kni

Allele class	amorphic allele - genetic evidence, loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence (Harding and Levine, 1988, Irish et al., 1989) loss of function allele (Kraut and Levine, 1991)
Mutagen	ethyl methanesulfonate (Tearle and Nusslein-Volhard, 1987)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	extended germ band embryo (Irvine and Wieschaus, 1994)
Detailed Description
	Statement Reference hb, kni double mutants show reduced rate of germ band extension. Cell intercalation is reduced in the region where the germ band fails to narrow, i.e. the region where eve and other pair-rule gene expression is uniform. (Irvine and Wieschaus, 1994) kni¹⁰ hb⁴ double mutant embryos fail to undergo normal germ band extension. (Leptin et al., 1992) Premature reduction of gt protein in the posterior domain. In the head region the middle stripe persists as an unbroken band covering the entire ventral side. (Kraut and Levine, 1991) Interacts with RpII140^wimp maternal effect. (Parkhurst and Ish-Horowicz, 1991) Posterior gt expression domain fails to narrow completely to a stripe during cellularization. (Mohler et al., 1989) strong
External Data
Linkouts
Interactions
Phenotypic Class
Other
Statement Reference fkh¹, hb⁴, kni¹⁰, tll¹ has cell polarity defective \| gastrula stage phenotype (Zallen and Wieschaus, 2004, Zallen and Wieschaus, 2004, Zallen and Wieschaus, 2004, Zallen and Wieschaus, 2004, Zallen and Wieschaus, 2004, Zallen and Wieschaus, 2004, Zallen and Wieschaus, 2004)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference Anterior-posterior polarization of cells in the extending germband is disrupted in kni¹⁰ hb⁴ fkh¹ tll¹ homozygous embryos. (Zallen and Wieschaus, 2004)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 3 )
Bloomington	5339 P{ftz/lacC}4; kni¹⁰ hb⁴/TM3, Sb¹ 3307 kni¹⁰ hb⁴ cu¹ sr¹ e^s ca¹/TM3, Sb¹ Ser¹
Kyoto	106971 kni¹⁰ hb⁴ cu¹ sr¹ e^s ca¹ / TM3, Sb¹
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	IID (Shimell et al., 2000) kni^2D48 (Casares and Sanchez-Herrero, 1995, Irish et al., 1989) kni^2D (Mohler et al., 1989) kni¹⁰ (Clyde et al., 2003) kni^IID48 (Zallen and Wieschaus, 2004, Small et al., 1996, Langeland et al., 1994, Irvine and Wieschaus, 1994, Gonzalez-Crespo and Levine, 1994, Riddihough and Ish-Horowicz, 1991, Parkhurst and Ish-Horowicz, 1991, Kraut and Levine, 1991, Riley et al., 1991, Hooper et al., 1989, Goto et al., 1989, Harding and Levine, 1988, Frasch and Levine, 1987) kni^IID (Wimmer et al., 2000, Halfon et al., 1995, Busturia and Bienz, 1993, Gutjahr et al., 1993, Leptin et al., 1992, Lehmann and Nusslein-Volhard, 1987, Tearle and Nusslein-Volhard, 1987, )
Name Synonym
Secondary FlyBase IDs

References ( 26 )

Generate a list of	All references relating to this allele ( 26 )

List References by type	Research paper ( 25 ) Stock list ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...

Allele Dmel\kni10

Allele Dmel\kni¹⁰