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General Information
Symbol
Dmel\Kr2
Species
D. melanogaster
Name
FlyBase ID
FBal0005791
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Kr2 mutants exhibit a loss of malpighian tubules.

One copy of Kr2 has no effect on hemocyte proliferation in third instar larvae.

Malpighian tubule buds are absent in homozygous embryos, although cells at the hindgut/midgut junction form a slightly distended tube. Midgut constrictions do not form normally.

Presence of Kr2 increases the frequency of abdominal segment 1 transformations due to ftzUal1 and increases the frequency of heat shock phenocopy in wild type embryos.

Nondefective in gonad assembly.

Interacts with RpII140wimp maternal effect.

No changes in phenotype of tor13D embryos.

Thoracic and abdominal segments 1 to 5 are missing, abdominal segment 5 is duplicated.

Strong allele.

strong allele Segments T1-3 and A1-5 deleted; A6 and sometimes A7 and 8 duplicated with reverse polarity.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

Kr2 has Malpighian tubule phenotype, enhanceable by srp2

Enhancer of
Statement
Reference

Kr2 is an enhancer of midgut phenotype of srp2

Kr2/Kr[+] is an enhancer of wing margin phenotype of Bx2

Suppressor of
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Kr2 srp2 double mutants exhibit a loss of midgut, malpighian tubules and small intestine tissue.

Xenogenetic Interactions
Statement
Reference

One copy of Kr2 strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1Scer\UAS.cSa is expressed under the control of Scer\GAL4Hml.Δ.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
Comments
Comments

Strong allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (27)