FlyBase Allele Report: Dmel\kto[1]

General Information

Symbol

Dmel\kto¹

Species

D. melanogaster

Name

FlyBase ID

FBal0005833

Feature type

allele

Associated gene

Dmel\kto

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)

Mutagen

ethyl methanesulfonate

(Kennison and Tamkun, 1988)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(3L)ED228)

(Miller et al., 2020)

lethal | recessive

(Kennison and Tamkun, 1988)

Phenotype Manifest In

Detailed Description

Statement

Reference

Pairing sensitive repression is unchanged in iab-7 PRE lines that carry kto¹.

(Hagstrom et al., 1997)

Mutation does not affect the level of w expression in ph-p^lac+3 flies.

(Fauvarque et al., 1995)

Isolated as a dominant suppressor of Pc mutations. Also suppresses Pcl alleles as well as Msc, Mrt and Antp^Scx. Associated with recessive larval lethality.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

kto[+]/kto¹ is an enhancer of visible phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Suppressor of

Statement

Reference

kto¹ is a suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

kto¹ is a suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

Other

Statement

Reference

corto⁴²⁰, kto¹ has visible phenotype

(Lopez et al., 2001)

corto[+]/corto⁴²⁰, kto¹ has visible phenotype

(Lopez et al., 2001)

Ras85D^V12.sev, kto¹, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

kto[+]/kto¹ is an enhancer of adult abdominal segment 4 | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

kto[+]/kto¹ is an enhancer of adult abdominal segment 5 phenotype of E(z)^Trm

(Bajusz et al., 2001)

kto[+]/kto¹ is an enhancer of eye phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Suppressor of

Statement

Reference

kto¹ is a suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

kto¹ is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

kto[+]/kto¹ is a suppressor of adult mesothoracic segment | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

kto[+]/kto¹ is a suppressor of adult metathoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

kto¹ is a suppressor of phenotype of Pc⁴

(Kennison and Tamkun, 1988)

NOT Suppressor of

Statement

Reference

kto[+]/kto¹ is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, asf1^UAS.cMa

(Moshkin et al., 2002)

Other

Statement

Reference

Kr^If-1, kto[+]/kto¹ has eye phenotype

(Sollars et al., 2003)

Kr^If-1, kto¹ has eye phenotype

(Sollars et al., 2003)

corto⁴²⁰, kto¹ has posterior crossvein phenotype

(Lopez et al., 2001)

corto[+]/corto⁴²⁰, kto¹ has posterior crossvein phenotype

(Lopez et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

15+/-4% of Kr^If-1/+ flies born to kto¹/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers.

(Sollars et al., 2003)

Mutant weakly suppresses the CycE^JP rough eye phenotype.

(Brumby et al., 2002)

kto¹/+ does not suppress the rough eye phenotype due to Scer\GAL4^ey.PH; asf1^Scer\UAS.cMa.

(Moshkin et al., 2002)

kto¹ corto⁴²⁰ double heterozygotes show posterior crossvein defects.

(Lopez et al., 2001)

The rough eye phenotype caused by expression of BEAF-32^Scer\UAS.cYa under the control of Scer\GAL4^GMR.PS is enhanced by kto¹/+.

(Yamaguchi et al., 2001)

Has little or no effect on the phenotype of E2f^GMR.PD Dp^GMR.PD BacA\p35^GMR.PH flies.

(Staehling-Hampton et al., 1999)

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by kto¹.

(Maixner et al., 1998)

Suppresses the extra sex comb phenotype of Pc⁴, Ts(YLt;2Lt)L124. Causes between 50% and 100% suppression of the Pc⁴/+ extra sex combs phenotype.

(Kennison and Tamkun, 1988)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

kto^33AC9

(de Ayala Alonso et al., 2007)

kto^33D19

(de Ayala Alonso et al., 2007)

kto^32E16

(de Ayala Alonso et al., 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

3618

107132

101675

Notes on Origin

Discoverer

Kennison, 1983.

Associated with: a linked undefined second site cell-lethal mutation.

(Treisman, 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

kto⁰¹

(Vasanthi et al., 2013)

kto¹

(Ihry and Bashirullah, 2014, Bhatia et al., 2010, Cooper et al., 2010, Swaminathan et al., 2010, Christensen et al., 2008.4.15, Christensen et al., 2008.7.11, Vázquez et al., 2008, Chang et al., 2007, de Ayala Alonso et al., 2007, Hirose et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (35)

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