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General Information
Symbol
Dmel\kto1
Species
D. melanogaster
Name
FlyBase ID
FBal0005833
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Pairing sensitive repression is unchanged in iab-7 PRE lines that carry kto1.

Mutation does not affect the level of w expression in ph-plac+3 flies.

Isolated as a dominant suppressor of Pc mutations. Also suppresses Pcl alleles as well as Msc, Mrt and AntpScx. Associated with recessive larval lethality.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

kto[+]/kto1 is an enhancer of visible phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS

Suppressor of
Statement
Reference

kto1 is a suppressor of visible phenotype of upd1GMR.PB

kto1 is a suppressor of lethal phenotype of Ras85DV12.sev, sevS11.Tag:MYC

Other
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

kto[+]/kto1 is an enhancer of adult abdominal segment 4 | ectopic phenotype of E(z)Trm

kto[+]/kto1 is an enhancer of adult abdominal segment 5 phenotype of E(z)Trm

kto[+]/kto1 is an enhancer of eye phenotype of BEAF-32UAS.cYa, Scer\GAL4GMR.PS

Suppressor of
Statement
Reference

kto1 is a suppressor of eye phenotype of upd1GMR.PB

kto1 is a suppressor | partially of eye phenotype of CycEJP

kto[+]/kto1 is a suppressor | partially of adult mesothoracic segment | ectopic phenotype of E(z)Trm

kto[+]/kto1 is a suppressor | partially of adult metathoracic segment phenotype of E(z)Trm

kto1 is a suppressor of phenotype of Pc4

NOT Suppressor of
Statement
Reference

kto[+]/kto1 is a non-suppressor of eye phenotype of Scer\GAL4ey.PH, asf1UAS.cMa

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

15+/-4% of KrIf-1/+ flies born to kto1/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of KrIf-1/+ flies born to isogenised wild-type mothers.

Mutant weakly suppresses the CycEJP rough eye phenotype.

kto1/+ does not suppress the rough eye phenotype due to Scer\GAL4ey.PH; asf1Scer\UAS.cMa.

kto1 corto420 double heterozygotes show posterior crossvein defects.

The rough eye phenotype caused by expression of BEAF-32Scer\UAS.cYa under the control of Scer\GAL4GMR.PS is enhanced by kto1/+.

Has little or no effect on the phenotype of E2fGMR.PD DpGMR.PD BacA\p35GMR.PH flies.

The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by kto1.

Suppresses the extra sex comb phenotype of Pc4, Ts(YLt;2Lt)L124. Causes between 50% and 100% suppression of the Pc4/+ extra sex combs phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer

Kennison, 1983.

Associated with: a linked undefined second site cell-lethal mutation.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
References (31)