A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Allele Dmel\L2

General Information
SymbolDmel\L2SpeciesD. melanogaster
NameFlyBase IDFBal0005882
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\L
Allele classneomorph
Mutagenspontaneous
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Allele class
Mutagen
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
       
       
      Assay mode
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      hide Phenotype Manifest In
      hide Detailed Description
      Statement
      Reference
      Eyes of L2/+ as small as or smaller than L1/L1. L2 homozygotes have tiny eyes and are poorly viable or completely lethal, depending on background.
       
      L2 flies do not differ from wild type in speed of development.
      Heterozygotes have a nick near the anterior midline of the eye and the overall size of the eye is reduced.
      Heterozygotes show loss of almost all ventral ommatidia; apart from a few cells along the ventral eye margin, nearly all ommatidia in L2/+ flies are dorsal in fate. This loss of ventral eye pattern is also seen in heterozygous eye discs.
      L[2]/+ flies show a loss of the ventral eye cells both at the eye disc and adult eye level. Use of the TUNEL assay reveals that cell death occurs predominantly in the ventral eye margin of the L[2]/+ eye disc but not in the dorsal half of the eye.
      hide Interactions
      hide Phenotypic Class
      hideEnhanced by
      Statement
      Reference
      L2 has visible | dominant phenotype, enhanceable by aopEP598/Scer\GAL4ey.PH
      L2 has visible | dominant phenotype, enhanceable by B[+]/B1
      L2 has visible | dominant phenotype, enhanceable by +/Df(2L)BSC7
      L2 has visible | dominant phenotype, enhanceable by emcEP415/Scer\GAL4ey.PH
      L2 has visible | dominant phenotype, enhanceable by esg05729/esg[+]
      L2 has visible | dominant phenotype, enhanceable by hhbar3/hhbar3
      L2 has visible | dominant phenotype, enhanceable by sgg[+]/sgg1
      hideNOT Enhanced by
      Statement
      Reference
      hideSuppressed by
      Statement
      Reference
      L2 has visible | dominant phenotype, suppressible by pygounspecified
      L2 has visible | dominant phenotype, suppressible | partially by Df(1)B/+
      L2 has visible | dominant phenotype, suppressible | partially by Df(3L)iro-DFM3
      L2 has visible | dominant phenotype, suppressible | partially by emc[+]/emc12
      L2 has visible | dominant phenotype, suppressible | partially by pnr[+]/pnrVX6
      hideNOT suppressed by
      Statement
      Reference
      hideEnhancer of
      Statement
      Reference
      L2/L[+] is an enhancer of visible phenotype of Scer\GAL4ey.PH, pnrD4.Scer\UAS
      L2/L[+] is an enhancer of visible phenotype of Scer\GAL4bi-omb-Gal4, pnrD4.Scer\UAS
      hideOther
      Statement
      Reference
      L2, M(2)24F1/M(2)24F[+] has lethal | dominant phenotype
      hide Phenotype Manifest In
      hideEnhanced by
      Statement
      Reference
      L2 has eye phenotype, enhanceable by rodEP3408/Scer\GAL4ey.PH
      L2 has eye phenotype, enhanceable by DadEP3196/Scer\GAL4ey.PH
      L2 has eye phenotype, enhanceable by aopEP2500/Scer\GAL4ey.PH
      L2 has eye phenotype, enhanceable by aopEP598/Scer\GAL4ey.PH
      L2 has eye phenotype, enhanceable by B[+]/B1
      L2 has eye phenotype, enhanceable by +/Df(2L)BSC7
      L2 has eye phenotype, enhanceable by Scer\GAL4ey.PH/EP1350EP1350
      L2 has eye phenotype, enhanceable by Scer\GAL4ey.PH/EP1410EP1410
      L2 has eye phenotype, enhanceable by EP3087EP3087/Scer\GAL4ey.PH
      L2 has eye phenotype, enhanceable by EP950EP950/Scer\GAL4ey.PH
      L2 has eye phenotype, enhanceable by araScer\UAS.cGa/Scer\GAL4ey.PH
      L2 has eye phenotype, enhanceable by Scer\GAL4ey.PH/dallyEP3168
      L2 has eye phenotype, enhanceable by emcEP3166/Scer\GAL4ey.PH
      L2 has eye phenotype, enhanceable by emcEP3614/Scer\GAL4ey.PH
      L2 has eye phenotype, enhanceable by emcEP3620/Scer\GAL4ey.PH
      L2 has eye phenotype, enhanceable by emcEP415/Scer\GAL4ey.PH
      L2 has eye phenotype, enhanceable by esg05729/esg[+]
      L2 has eye phenotype, enhanceable by hhbar3/hhbar3
      L2 has eye phenotype, enhanceable by nejEP1149/Scer\GAL4ey.PH
      L2 has eye phenotype, enhanceable by nejEP1179/Scer\GAL4ey.PH
      L2 has eye phenotype, enhanceable by sgg[+]/sgg1
      hideNOT Enhanced by
      Statement
      Reference
      L2 has eye disc | ventral phenotype, non-enhanceable by p53Scer\UAS.Ex/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, non-enhanceable by p53Scer\UAS.Ex/Scer\GAL4ey.PH
      hideSuppressed by
      Statement
      Reference
      L2 has eye | ventral phenotype, suppressible by pygounspecified
      L2 has eye | ventral phenotype, suppressible | partially by CBPEP1643/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by Df(1)B/+
      L2 has eye | ventral phenotype, suppressible | partially by Df(3L)iro-DFM3
      L2 has eye | ventral phenotype, suppressible | partially by NFATEP1353/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by NFATEP1508/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by dcoEP3280/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by emc[+]/emc12
      L2 has eye | ventral phenotype, suppressible | partially by esgEP2159/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by esgEP2408/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by esgEP633/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by esgEP683/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by fngEP3082/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by hhEP3521/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by Scer\GAL4ey.PH/kek1EP655
      L2 has eye | ventral phenotype, suppressible | partially by nocEP2173/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by nrv1EP2454/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by pnr[+]/pnrVX6
      L2 has eye | ventral phenotype, suppressible | partially by rasEP1235/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by rasEP1427/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by smoEP1220/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by wunEP2208/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, suppressible | partially by sggEP1576/Scer\GAL4ey.PH
      L2 has eye disc | ventral phenotype, suppressible | partially by Df(3L)H99/+
      L2 has eye | ventral phenotype, suppressible | partially by Df(3L)H99/+
      L2 has eye | ventral phenotype, suppressible by wg1
      L2 has eye disc | ventral phenotype, suppressible by wg1
      L2 has second instar larva & eye disc | ventral phenotype, suppressible | conditional ts by wgl-12
      L2 has eye disc | ventral phenotype, suppressible | partially by hep[+]/hepr75
      L2 has eye | ventral phenotype, suppressible | partially by hep[+]/hepr75
      hideNOT suppressed by
      Statement
      Reference
      L2 has eye disc | ventral phenotype, non-suppressible by p53259H.GUS/Scer\GAL4ey.PH
      L2 has eye | ventral phenotype, non-suppressible by p53259H.GUS/Scer\GAL4ey.PH
      L2 has first instar larva & eye disc | ventral phenotype, non-suppressible by wgl-12
      L2 has third instar larva & eye disc | ventral phenotype, non-suppressible by wgl-12
      hideEnhancer of
      Statement
      Reference
      L2/L[+] is an enhancer of eye phenotype of Scer\GAL4ey.PH, pnrD4.Scer\UAS
      L2/L[+] is an enhancer of eye phenotype of Scer\GAL4bi-omb-Gal4, pnrD4.Scer\UAS
      L2/L[+] is an enhancer of eye phenotype of Scer\GAL4ey.PH, wgScer\UAS.cAa