FlyBase Allele Report: Dmel\br[2Bc-1]

General Information

Symbol

Dmel\br^2Bc-1

Species

D. melanogaster

Name

FlyBase ID

FBal0006656

Feature type

allele

Associated gene

Dmel\br

Associated Insertion(s)

Carried in Construct

Also Known As

2Bc¹, l(1)t10, l(1)2Bc¹

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Choi et al., 2006, Bayer et al., 1997, Gonzy-Treboul et al., 1995, Restifo and Merrill, 1994, Gotwals and Fristrom, 1991, Kiss et al., 1988)

loss of function allele

(Liu and Restifo, 1998)

Mutagen

ethyl methanesulfonate

(Bayer et al., 1997, Restifo and Merrill, 1994, Gotwals and Fristrom, 1991, Kiss et al., 1988, Belyaeva et al., 1982)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

br^2Bc-1/+ flies show the same susceptibility to methoprene as wild-type flies.

(Wilson et al., 2006)

At 25^oC, about 25% of br^BC3/br^2Bc-1 females have malformed third legs, while at 29^oC, 40% have malformed legs. br^25.4/br^2Bc-1 escapers have malformed third legs and wings and sometimes have deformed heads.

(Gonzy et al., 2002)

br^2Bc-1/Y eye discs do not show any defects. Homozygous clones in the eye disc appear normal.

(Brennan et al., 2001)

Homozygotes arrest development in late prepupae or in early pupae just after head eversion.

(Bayer et al., 1997)

Homozygotes die as late prepupae or early pupae.

(D'Avino et al., 1995)

The Pig1 to Sgs4 switch fails to occur during mid-third instar.

(von Kalm et al., 1994)

Lethality acts at the late prepupal or early pupal stage.

(Karim et al., 1993)

Failure of salivary gland degeneration. Reduction in dorso-ventral class of indirect flight muscles. Proventriculus abnormality: foregut-midgut junction less proventriculus-like in appearance. Malpighian tubules and yellow body failed to develop, pupae and pharate adults contain multiple convoluted tubules.

(Restifo and White, 1992)

There is no significant interaction between zip and br^2Bc-1.

(Gotwals and Fristrom, 1991)

38% penetrance of abnormal SEG-TG separation phenotype, 34% of individuals have an abnormal optic lobe position and 64% with brain fusion failure. A few individuals also showed failure of head eversion and overt holes in the cuticle.

(Restifo and White, 1991)

br^2Bab-1/br^2Bc-1 heterozygotes have malformations of the basitarsus on the third pair of legs.

(Kiss et al., 1988)

Puparium formation delayed by 6 hours. Many of the late ecdysone puffs in both larvae and prepupae are either absent or underdeveloped.

(Belyaeva et al., 1982)

Puparium formation delayed 6 hr. Many late ecdysone puffs both in larvae and prepupae either absent or underdeveloped (FBrf0037666).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

br[+]/br^2Bc-1 is a suppressor of visible | dominant phenotype of Bar¹

(Brennan et al., 2001)

Other

Statement

Reference

Met²⁷, br^rbp-1/br^2Bc-1 has lethal phenotype

(Wilson et al., 2006)

Met²⁷, br¹/br^2Bc-1 has viable phenotype

(Wilson et al., 2006)

Met²⁷, br^rbp-2/br^2Bc-1 has viable phenotype

(Wilson et al., 2006)

Met²⁷, br⁵/br^2Bc-1 has partially lethal phenotype

(Wilson et al., 2006)

Phenotype Manifest In

Suppressor of

Statement

Reference

br[+]/br^2Bc-1 is a suppressor of eye phenotype of Bar¹

(Brennan et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

br⁵

Partially complements

br^25.4

(Gonzy et al., 2002)

br^BC3

(Gonzy et al., 2002)

Fails to complement

br^23RL

(Gonzy et al., 2002)

br^38JL

(Gonzy et al., 2002)

br^80BL

(Gonzy et al., 2002)

br^npr-6

(Tzolovsky et al., 1999)

Rescued by

br^2Bc-1 is rescued by br^{BRcore.NS.Z3.hs}

(Bayer et al., 1997)

Partially rescued by

br^2Bc-1 is partially rescued by br^{BRcore.NS.Z3.hs}

(Wilson et al., 2006)

br^2Bc-1 is partially rescued by br^Z2.hs

(Bayer et al., 1997)

Not rescued by

br^2Bc-1 is not rescued by br^{BRcore.Q1.Z1.hs}

(Bayer et al., 1997)

br^2Bc-1 is not rescued by br^{BRcore.TNT.Q1.Z1.hs}

(Bayer et al., 1997)

Comments

The br^2Bc-1/br^npr-6 heteroallelic combination is lethal. The offspring die as 2nd to 3rd instar larvae.

(Tzolovsky et al., 1999)

br^2Bc-1 animals are rescued by expression of br^{BRcore.NS.Z3.hs} during larval development. Rescued flies that eclose have wild-type legs and wings and live for several days as fertile adults. br^2Bc-1 animals are partially rescued by expression of br^Z2.hs during larval development. Rescued flies that eclose have malformed wings and legs and die very soon after eclosing. br^2Bc-1 animals are not rescued by expression of br^{BRcore.Q1.Z1.hs} or br^{BRcore.TNT.Q1.Z1.hs} during larval development.

(Bayer et al., 1997)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

29970

y¹ br^2Bc-1 w¹/Binsn

Notes on Origin

Discoverer

Comments

Defects in the activity of early puffs may cause underdevelopment of late puffs.

(Zhimulev et al., 1982)

No change in ecdysone late gene expression in br^2Bc-1 individuals.

(Guay and Guild, 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

2Bc¹

(Choi et al., 2006, Wilson et al., 2006, Gonzy et al., 2002, Brennan et al., 2001, Renault et al., 2001, Peronnet et al., 2000, Richards et al., 1999, Tzolovsky et al., 1999, Liu and Restifo, 1998, Bayer et al., 1997, Dubrovsky et al., 1996)

br^2Bc-1

l(1)2Bc¹

(Huet et al., 1996, D'Avino et al., 1995, Dubrovsky et al., 1994)

l(1)pp-1

l(1)pp-1^t10

(Belyaeva et al., 1980)

l(1)pp1^t10

(Aizenzon and Belyaeva, 1982)

l(1)t10

(Solov'eva, 1992, Mazina et al., 1991, Dubrovsky et al., 1990, Mazina et al., 1990, Solovyeva and Belyaeva, 1989, Demakova et al., 1988, Zhimulev et al., 1982)

lt10

t10

(Belyaeva et al., 1982)

Name Synonyms

Secondary FlyBase IDs

References (37)

Report Sections

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