Imaginal discs of homozygous larvae are missing or degenerate. Defects in the cell cycle: few or no dividing cells, arrest of the cell cycle at metaphase and cell division failures that result in highly polyploid cells.
Discs missing or degenerate; mitotic index of larval ganglion cells and chromosome condensation normal; 43.5% of metaphases polyploid; cells containing 500 to 1000 chromosomes encountered; some chromosome fragmentation seen (Gatti and Baker, 1989). Homozygous cells in ovary lethal (Perrimon, Engstrom, and Mahowald, 1984). late pupal lethal mitotic phenotype: highly polyploid cells, many anaphases, some multipolar