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General Information
Symbol
Dmel\l(1)dd31
Species
D. melanogaster
Name
FlyBase ID
FBal0007454
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Imaginal discs of homozygous larvae are missing or degenerate. Defects in the cell cycle: few or no dividing cells, affects chromosome condensation, arrest of the cell cycle at metaphase and cell division failures that result in highly polyploid cells.

    Mutant larvae tend to be smaller than usual, and show signs of degeneration to varying degrees in most tissues, this degeneration increasing with age. Hemizygous second instar larvae have small, degenerate and disorganised imaginal discs, which progressively worsen with age. Third instar larvae have smaller than normal brains and as the larvae age, vacuolated areas are observed in the brain lobes. There is no organised optic lobe complex, and the imaginal ring of the foregut is absent. The salivary glands and male gonads are reduced in size, and hemopoietic cells normally associated with the dorsal vessel are almost completely absent.

    Discs missing or degenerate; mitotic index of larval ganglion cells three times that of controls; chromosomes highly condensed as seen in colchicine-treated cells; 20% of metaphases polyploid; chromosome fragmentation common; no anaphase figures seen (Gatti and Baker, 1989). Homozygous cells in ovary lethal (Perrimon, Engstrom and Mahowald, 1984). pupal lethal mitotic phenotype: hypercontracted chromosomes, no anaphase, polyploid cells

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    Comments
    Comments

    Maternal germline clonal analysis demonstrates cell lethality in homozygous clones.

    Mosaic analysis suggests that l(1)dd31 acts autonomously in the imaginal discs and imaginal neural cells. The optic lobe development patterns observed in the larval mosaics provide evidence for an eye disc-optic lobe interaction during the late third instar larval stage.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    l(1)d deg-3
    l(1)dd31
    Name Synonyms
    Secondary FlyBase IDs
      References (3)