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General Information
Symbol
Dmel\Grip911
Species
D. melanogaster
Name
FlyBase ID
FBal0007455
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Larvae die during the third instar stage. Larval brains show a very abnormal, and associated imaginal discs are also abnormal. Larval brains show cells with extreme chromatin condensation, catastrophic anaphases, and polyploidy. Mutants have a mitotic index approximately 7 times that of wild-type with more than half of these exhibiting a polyploid metaphase. In mutant mitotic cells spindles show abnormal centrosomes. Various centrosomal components show varied and abnormal organisation. The γ-tubulin localisation normally seen as the γ-tubulin ring complex is dispersed, cnn localisation remains in discrete bodies but often appears more broadly distributed than in wild-type. The normal juxtaposition of asp and γ-tubulin is no longer seen in mutant spindles and asp is now distributed in a punctate fashion. Cp190 is lost from the poles and accumulates around chromosomes. Centrioles are not always present at the spindle pole, when they are present, there are up to four of them, they vary in size and are not consistently arranged as perpendicular pairs. The numbers of microtubules associating with the poles is also greatly reduced.

Imaginal discs of homozygous larvae are missing or degenerate. Defects in the cell cycle: few or no dividing cells and cell division failures that result in highly polyploid cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The slight increase in lymph gland size seen in Zfrp8SM206/+ larvae is dominantly enhanced by l(1)dd41.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

l(1)dd4 Mutations can be placed in an allelic series based on relative severity of phenotype: l(1)dd4S < l(1)dd42 = l(1)dd4xr16 l(1)dd41 < Df(1)LCD.

Maternal germline clonal analysis demonstrates there is no maternal effect.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)