Imaginal discs of homozygous larvae are missing or degenerate. Defects in the cell cycle: few or no dividing cells, affects chromosome condensation, arrest of the cell cycle at metaphase and cell division failures that result in highly polyploid cells.
Discs missing or degenerate; mitotic index of larval ganglion reduced; chromosomes unevenly condensed, appear fuzzy; sister chromatids often closely apposed; heterochromatic regions elongated; tetraploid cells and some chromosome breakage seen (Gatti and Baker, 1989). No maternal effect of homozygosis in ovarian clones on phenotype of offspring (Perrimon, Engstrom and Mahowald, 1984). late pupal lethal mitotic phenotype: condensation abnormal, chromosomes swollen