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General Information
Symbol
Dmel\lola00642
Species
D. melanogaster
Name
FlyBase ID
FBal0007954
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{PZ} insertion 438bp downstream of 5'UTR "c" and 54bp upstream of 5'UTR "d" of lola.

Insertion components
P{PZ}lola00642
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Females containing homozygous germline clones show defects in stage 14 egg chambers, including dumpless egg chambers (egg chambers in which the nurse cells have failed to transfer their cytoplasmic contents to the oocyte, have intact nuclei and do not appear to be undergoing programmed cell death) and egg chambers with persisting nurse cell nuclei (egg chambers in which nurse cells have transferred their cytoplasmic contents to the oocyte, but their nuclei have failed to undergo programmed cell death including nuclear condensation).

Mutants have a strong mutant neuronal phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

lola[+]/lola00642 is a suppressor of visible | dominant phenotype of gcmPyx

lola[+]/lola00642 is a suppressor of lethal phenotype of JIL-1EP3657, Scer\GAL4[-]

Other
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference

lola[+]/lola00642 is a suppressor of chaeta | supernumerary phenotype of gcmPyx

Other
Additional Comments
Genetic Interactions
Statement
Reference

lola00642/+, SoxNGA1192/+ double heterozygous embryos show defects in axon scaffolding, such as fusion of commissures, axonal tangles, disruption and/or reduction of longitudinal connectives. This phenotype is not seen in either single mutant heterozygote.

The hatch rate of lola00642/+ ; JIL-1EP3657/JIL-1EP3657 embryos is 20%.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

A. Spradling.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (14)